MX2012007676A - Nueva formulacion de anticuerpo. - Google Patents

Nueva formulacion de anticuerpo.

Info

Publication number
MX2012007676A
MX2012007676A MX2012007676A MX2012007676A MX2012007676A MX 2012007676 A MX2012007676 A MX 2012007676A MX 2012007676 A MX2012007676 A MX 2012007676A MX 2012007676 A MX2012007676 A MX 2012007676A MX 2012007676 A MX2012007676 A MX 2012007676A
Authority
MX
Mexico
Prior art keywords
antibody formulation
formulation
egfr
preparation
growth factor
Prior art date
Application number
MX2012007676A
Other languages
English (en)
Inventor
Hanns-Christian Mahler
Michael Adler
Ulla Grauschopf
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2012007676A publication Critical patent/MX2012007676A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators

Abstract

La presente invención se refiere a una formulación farmacéutica de un anticuerpo contra el receptor del factor de crecimiento epidérmico (EGFR), a un procedimiento para la preparación de la misma y a usos de la formulación.
MX2012007676A 2009-12-29 2010-12-23 Nueva formulacion de anticuerpo. MX2012007676A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09180840 2009-12-29
PCT/EP2010/070625 WO2011080209A2 (en) 2009-12-29 2010-12-23 Novel antibody formulation

Publications (1)

Publication Number Publication Date
MX2012007676A true MX2012007676A (es) 2012-08-03

Family

ID=43618150

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012007676A MX2012007676A (es) 2009-12-29 2010-12-23 Nueva formulacion de anticuerpo.

Country Status (16)

Country Link
US (1) US20110158987A1 (es)
EP (1) EP2519262A2 (es)
JP (1) JP2013515754A (es)
KR (1) KR20120110175A (es)
CN (1) CN102686241A (es)
AR (1) AR079746A1 (es)
AU (1) AU2010338305A1 (es)
BR (1) BR112012013148A2 (es)
CA (1) CA2783715A1 (es)
IL (1) IL219592A0 (es)
MX (1) MX2012007676A (es)
RU (1) RU2012131099A (es)
SG (1) SG182304A1 (es)
TW (1) TW201200152A (es)
WO (1) WO2011080209A2 (es)
ZA (1) ZA201204266B (es)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
US11857625B2 (en) 2017-11-23 2024-01-02 UCB Biopharma SRL Pharmaceutical compositions

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UA117466C2 (uk) * 2012-12-13 2018-08-10 Мерк Шарп Енд Доме Корп. СТАБІЛЬНИЙ СКЛАД У ВИГЛЯДІ РОЗЧИНУ АНТИТІЛА ДО IL-23p19
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US10745475B2 (en) 2013-08-30 2020-08-18 Takeda Gmbh Antibodies neutralizing GM-CSF for use in the treatment of rheumatoid arthritis or as analgesics
WO2015134406A1 (en) * 2014-03-03 2015-09-11 La Jolla Biologics, Inc. Stable aqueous recombinant protein formulations
BR112016025126B1 (pt) * 2014-05-07 2024-02-15 Takeda Pharmaceutical Company Limited Composição aquosa compreendendo anticorpo neutralizante de gmcsf, e uso da mesma
CN105651848A (zh) * 2014-11-13 2016-06-08 浙江海正药业股份有限公司 一种含有保护剂的毛细管凝胶电泳检测试剂盒
KR101776879B1 (ko) * 2015-01-19 2017-09-08 주식회사 녹십자 항-egfr 항체를 포함하는 약학 제제
EA037532B1 (ru) * 2015-05-07 2021-04-08 Новиммун Са Способы и композиции для диагностики и лечения заболеваний у пациентов, имеющих повышенные уровни cxcl9 и других биомаркеров
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US11229702B1 (en) 2015-10-28 2022-01-25 Coherus Biosciences, Inc. High concentration formulations of adalimumab
ES2823279T3 (es) * 2015-12-07 2021-05-06 Merck Patent Gmbh Formulación farmacéutica acuosa que comprende el anticuerpo anti-PD-1 Avelumab
CN109311986A (zh) * 2016-03-25 2019-02-05 威特拉公司 登革热病毒抗体分子的制剂
US11071782B2 (en) 2016-04-20 2021-07-27 Coherus Biosciences, Inc. Method of filling a container with no headspace
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CN107773755B (zh) * 2016-08-31 2021-06-22 上海津曼特生物科技有限公司 抗表皮生长因子受体单克隆抗体的注射液制剂
BR112019005328A2 (pt) * 2016-09-27 2019-06-18 Fresenius Kabi Deutschland Gmbh composição farmacêutica líquida
CN107987161B (zh) * 2016-10-26 2021-04-16 泰州迈博太科药业有限公司 一种抗egfr单克隆抗体制剂
US11845798B2 (en) 2017-05-02 2023-12-19 Merck Sharp & Dohme Llc Formulations of anti-LAG3 antibodies and co-formulations of anti-LAG3 antibodies and anti-PD-1 antibodies
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CN110869050A (zh) * 2017-07-28 2020-03-06 豪夫迈·罗氏有限公司 双特异性抗体配制剂
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WO2022166918A1 (zh) * 2021-02-05 2022-08-11 百奥泰生物制药股份有限公司 一种抗il-5抗体制剂及其制备方法和应用
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Publication number Priority date Publication date Assignee Title
US11857625B2 (en) 2017-11-23 2024-01-02 UCB Biopharma SRL Pharmaceutical compositions

Also Published As

Publication number Publication date
ZA201204266B (en) 2014-11-26
WO2011080209A2 (en) 2011-07-07
IL219592A0 (en) 2012-06-28
KR20120110175A (ko) 2012-10-09
AR079746A1 (es) 2012-02-15
JP2013515754A (ja) 2013-05-09
CA2783715A1 (en) 2011-07-07
RU2012131099A (ru) 2014-02-10
BR112012013148A2 (pt) 2017-03-21
US20110158987A1 (en) 2011-06-30
SG182304A1 (en) 2012-08-30
AU2010338305A1 (en) 2012-05-24
CN102686241A (zh) 2012-09-19
TW201200152A (en) 2012-01-01
WO2011080209A3 (en) 2012-03-15
EP2519262A2 (en) 2012-11-07

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