SG163620A1 - Crystalline forms of 4-methyl-n-[3-(4-methyl-imidazol-1-yl)-5- trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide - Google Patents

Crystalline forms of 4-methyl-n-[3-(4-methyl-imidazol-1-yl)-5- trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide

Info

Publication number
SG163620A1
SG163620A1 SG201005165-4A SG2010051654A SG163620A1 SG 163620 A1 SG163620 A1 SG 163620A1 SG 2010051654 A SG2010051654 A SG 2010051654A SG 163620 A1 SG163620 A1 SG 163620A1
Authority
SG
Singapore
Prior art keywords
methyl
ylamino
benzamide
imidazol
pyrimidin
Prior art date
Application number
SG201005165-4A
Other languages
English (en)
Inventor
Paul W Manley
Wen-Chung Shieh
Paul Allen Sutton
Piotr H Karpinski
Raeann Wu
Stephanie Monnier
Joerg Brozio
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37451227&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG163620(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of SG163620A1 publication Critical patent/SG163620A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SG201005165-4A 2005-07-20 2006-07-18 Crystalline forms of 4-methyl-n-[3-(4-methyl-imidazol-1-yl)-5- trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide SG163620A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70140505P 2005-07-20 2005-07-20
US71621405P 2005-09-12 2005-09-12

Publications (1)

Publication Number Publication Date
SG163620A1 true SG163620A1 (en) 2010-08-30

Family

ID=37451227

Family Applications (1)

Application Number Title Priority Date Filing Date
SG201005165-4A SG163620A1 (en) 2005-07-20 2006-07-18 Crystalline forms of 4-methyl-n-[3-(4-methyl-imidazol-1-yl)-5- trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide

Country Status (43)

Country Link
US (4) US8343984B2 (hu)
EP (5) EP2284167B2 (hu)
JP (3) JP5289948B2 (hu)
KR (3) KR20130077915A (hu)
CN (2) CN103804356A (hu)
AR (1) AR054846A1 (hu)
AU (3) AU2006276204A1 (hu)
BR (1) BRPI0613615B1 (hu)
CA (1) CA2614334C (hu)
CR (1) CR9657A (hu)
CU (1) CU23916B1 (hu)
CY (2) CY1113076T1 (hu)
DK (2) DK2284167T4 (hu)
EA (2) EA016856B1 (hu)
EC (1) ECSP088119A (hu)
ES (3) ES2386974T3 (hu)
GE (1) GEP20115302B (hu)
GT (1) GT200600315A (hu)
HK (1) HK1116783A1 (hu)
HN (1) HN2008000311A (hu)
HR (2) HRP20120573T1 (hu)
HU (1) HUE031791T2 (hu)
IL (2) IL188189A0 (hu)
JO (1) JO3308B1 (hu)
LT (1) LT2284167T (hu)
MA (1) MA29626B1 (hu)
MX (1) MX2008000899A (hu)
MY (1) MY148554A (hu)
NI (1) NI200800017A (hu)
NO (1) NO341930B1 (hu)
NZ (1) NZ564409A (hu)
PE (1) PE20070214A1 (hu)
PH (1) PH12013501590A1 (hu)
PL (2) PL2284167T5 (hu)
PT (2) PT2284167T (hu)
RS (1) RS55929B2 (hu)
SG (1) SG163620A1 (hu)
SI (2) SI1912973T1 (hu)
SM (1) SMP200800011B (hu)
TN (1) TNSN08029A1 (hu)
TW (1) TWI406661B (hu)
UA (1) UA94234C2 (hu)
WO (1) WO2007015870A2 (hu)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GT200600315A (es) 2005-07-20 2007-03-19 Formas cristalinas de 4-metilo-n-[3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo]-3-(4-pyridina-3-ilo-pirimidina-2-iloamino)-benzamida
GT200600316A (es) 2005-07-20 2007-04-02 Sales de 4-metilo-n-(3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo)-3-(4-piridina-3-ilo-pirimidina-2-iloamino)- benzamida.
US20100152198A1 (en) * 2006-04-07 2010-06-17 Manley Paul W Use of c-src inhibitors in combination with a pyrimidylaminobenzamide compound for the treatment of leukemia
EP1923053A1 (en) * 2006-09-27 2008-05-21 Novartis AG Pharmaceutical compositions comprising nilotinib or its salt
EP2240172B1 (en) 2007-12-21 2014-03-19 Novartis AG Combination of nilotinib and chlorambucil for the treatment of chronic lymphocytic leukemia
WO2010009402A2 (en) * 2008-07-17 2010-01-21 Teva Pharmaceutical Industries Ltd. Nilotinib intermediates and preparation thereof
ES2394258T3 (es) 2008-11-05 2013-01-30 Teva Pharmaceutical Industries Ltd. Formas cristalinas de Nilotinib HCL
EP2186514B1 (en) 2008-11-14 2016-06-29 Kinki University Treatment of Malignant Peripheral Nerve Sheath Tumors
EP2403492A1 (en) 2009-03-06 2012-01-11 Novartis AG Use of pyrimidylaminobenzamide derivatives for the treatment of disorders mediated by the leucine zipper- and sterile alpha motif-containing kinase (zak)
TW201102068A (en) 2009-06-02 2011-01-16 Novartis Ag Treatment of ophthalmologic disorders mediated by alpha-carbonic anhydrase isoforms
KR101853596B1 (ko) 2009-10-23 2018-04-30 노파르티스 아게 Ｂｃｒ-ａｂｌ, ｃ-ｋｉｔ, ｄｄｒ1, ｄｄｒ2 또는 ｐｄｇｆ-ｒ 키나제 활성에 의해 매개된 증식성 장애 및 다른 병적 상태의 치료 방법
JO3634B1 (ar) 2009-11-17 2020-08-27 Novartis Ag طريقة لعلاج اضطرابات تكاثرية وحالات مرضية أخرى متوسطة بنشاط كيناز bcr-abl، c-kit، ddr1، ddr2، أو pdgf-r
IN2010KO00035A (hu) * 2010-01-15 2016-09-02
EP2558098A2 (en) 2010-04-16 2013-02-20 Novartis AG Treatment of endocrine resistant breast cancer
EP2382976A1 (en) 2010-04-30 2011-11-02 Hiroshima University Use of pdgf-r inhibitors for the treatment of lymph node metastasis of gastric cancer
PL2571863T3 (pl) 2010-06-21 2016-03-31 Teva Pharma Sole nilotynibu i ich postacie krystaliczne
CN102453024B (zh) * 2010-10-27 2014-09-03 浙江九洲药业股份有限公司 一种尼罗替尼盐酸盐晶型及其制备方法
IN2010CH03577A (hu) * 2010-11-26 2012-07-20 Hetero Research Foundation
AR086913A1 (es) * 2011-06-14 2014-01-29 Novartis Ag 4-metil-3-[[4-(3-piridinil)-2-pirimidinil]-amino]-n-[5-(4-metil-1h-imidazol-1-il)-3-(trifluoro-metil)-fenil]-benzamida amorfa, forma de dosificacion que la contiene y metodo para prepararlas
JP2014532647A (ja) 2011-10-28 2014-12-08 ノバルティス アーゲー 消化管間質腫瘍を治療する方法
WO2013063003A1 (en) 2011-10-28 2013-05-02 Novartis Ag Method of treating gastrointestinal stromal tumors
SG10201707768RA (en) 2011-11-14 2017-10-30 Novartis Ag Immediate release 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-n-[5-(4-methyl- 1h-imidazol-1-yl)-3-(trifluoromethyl)phenyl] benzamide formulation
ES2564969T3 (es) * 2012-02-09 2016-03-30 Natco Pharma Limited Proceso para la preparación de clorhidrato de nilotinib
GB2514285B (en) 2012-02-13 2018-07-18 Grindeks Jsc Intermediates for a novel process of preparing imatinib and related tyrosine kinase inhibitors
US9061028B2 (en) 2012-02-15 2015-06-23 Natco Pharma Limited Process for the preparation of Nilotinib
AU2013289175A1 (en) 2012-07-11 2015-01-22 Novartis Ag Method of treating gastrointestinal stromal tumors
AU2013332205B2 (en) * 2012-10-15 2017-08-31 Apotex Inc. Solid forms of Nilotinib hydrochloride
EP2909191B1 (en) * 2012-10-19 2019-03-20 Basf Se Multicomponent crystalline system comprising nilotinib and selected co-crystal formers
KR20150107872A (ko) * 2013-02-21 2015-09-23 화이자 인코포레이티드 고체 형태의 선택적인 cdk4/6 억제제
EP2792360A1 (en) 2013-04-18 2014-10-22 IP Gesellschaft für Management mbH (1aR,12bS)-8-cyclohexyl-11-fluoro-N-((1-methylcyclopropyl)sulfonyl)-1a-((3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,2b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide for use in treating HCV
WO2014174456A2 (en) * 2013-04-24 2014-10-30 Dr. Reddys Laboratories Limited Polymorphic forms of nilotinib hydrochloride
RU2551359C9 (ru) * 2013-11-28 2021-08-20 Общество с ограниченной ответственностью "Мамонт Фарм" Наноразмерная слабо закристаллизованная модификация 4-метил-N-[3-(4-метилимидазол-1-ил)-5-(трифторметил)фенил]-3-[(4-пиридин-3-илпиримидин-2-ил)амино]бензамида гидрохлорида моногидрата, способ ее получения и фармацевтическая композиция на ее основе
WO2015092624A1 (en) 2013-12-16 2015-06-25 Ranbaxy Laboratories Limited Nilotinib mono-oxalate and its crystalline form
WO2016020891A1 (en) 2014-08-08 2016-02-11 Dr. Reddy’S Laboratories Limited Process for the preparation of polymorphic forms of nilotinib
US10016423B2 (en) * 2014-10-16 2018-07-10 Apotex Inc. Solid forms of nilotinib hydrochloride
SI3408264T1 (sl) 2016-01-26 2020-07-31 Farma Grs, D.O.O. Nilotinibijev dinitrat (V) in njegove kristalne oblike
WO2017149550A1 (en) * 2016-03-02 2017-09-08 Msn Laboratories Private Limited Amorphous form of 4-methyl-n-[3-(4-methyl-1h-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-benzamide
WO2017160703A1 (en) 2016-03-14 2017-09-21 Pliva Hrvatska D.O.O. Solid state forms of nilotinib salts
CN106496193A (zh) * 2016-09-13 2017-03-15 福格森（武汉）生物科技股份有限公司 一种高纯度尼罗替尼的制备方法
EP3404025B1 (en) 2017-05-16 2019-12-04 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Process for the preparation of pure nilotinib and its salt
CZ2017821A3 (cs) 2017-12-20 2019-07-03 Zentiva, K.S. Léková forma obsahující krystalický nilotinib
JP7409696B2 (ja) * 2018-06-15 2024-01-09 ハンダ ファーマシューティカルズ インコーポレイテッド キナーゼ阻害剤の塩およびその組成物
JP2020007240A (ja) * 2018-07-04 2020-01-16 住友化学株式会社 ベンズアミド化合物の製造方法
US20210380557A1 (en) * 2018-11-05 2021-12-09 Laurus Labs Limited Crystalline form of nilotinib hydrochloride, process for its preparation and pharmaceutical composition containing the same
WO2021155254A1 (en) 2020-01-31 2021-08-05 Nanocopoeia, Llc Amorphous nilotinib microparticles and uses thereof
IL297776A (en) 2020-04-30 2022-12-01 Nanocopoeia Llc Orally disintegrating tablets containing an amorphous solid dispersion of nalotinib
CN114133378B (zh) * 2020-09-04 2023-08-15 成都苑东生物制药股份有限公司 一种盐酸尼洛替尼共晶及其制备方法
CA3224750A1 (en) 2021-06-19 2022-12-22 Helm Ag Granulate composition comprising nilotinib
EP4122452A1 (en) 2021-07-23 2023-01-25 KRKA, d.d., Novo mesto Pharmaceutical composition comprising nilotinib and method of manufacturing the same
EP4260848A1 (en) 2022-04-11 2023-10-18 Lotus Pharmaceutical Co., Ltd. Pharmaceutical composition for solid dosage form containing nilotinib and process for its preparation
CN116102540A (zh) * 2023-01-05 2023-05-12 浙江工业大学 两种尼洛替尼游离碱新晶型及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US701406A (en) 1901-07-16 1902-06-03 Thomas K Jones Cut-off-valve mechanism.
US701405A (en) 1902-02-17 1902-06-03 Archibald White Maconochie Ejecting device for stamping-machines.
GB0215676D0 (en) * 2002-07-05 2002-08-14 Novartis Ag Organic compounds
GB0325031D0 (en) * 2003-10-27 2003-12-03 Novartis Ag Organic compounds
SG139747A1 (en) * 2003-11-18 2008-02-29 Novartis Ag Inhibitors of the mutant form of kit
GT200600316A (es) 2005-07-20 2007-04-02 Sales de 4-metilo-n-(3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo)-3-(4-piridina-3-ilo-pirimidina-2-iloamino)- benzamida.
GT200600315A (es) 2005-07-20 2007-03-19 Formas cristalinas de 4-metilo-n-[3-(4-metilo-imidazol-1-ilo)-5-trifluorometilo-fenilo]-3-(4-pyridina-3-ilo-pirimidina-2-iloamino)-benzamida

Also Published As

Publication number Publication date
NI200800017A (es) 2009-03-03
TWI406661B (zh) 2013-09-01
HRP20170634T1 (hr) 2017-06-30
JP2013018789A (ja) 2013-01-31
KR101651288B1 (ko) 2016-08-25
CR9657A (es) 2008-04-16
EP2284167B1 (en) 2017-02-01
CA2614334C (en) 2015-04-21
PL1912973T3 (pl) 2012-09-28
US20130165465A1 (en) 2013-06-27
DK2284167T3 (en) 2017-05-01
WO2007015870A3 (en) 2007-06-07
HUE031791T2 (hu) 2017-08-28
RS55929B1 (sr) 2017-09-29
KR20130085444A (ko) 2013-07-29
EP1912973A2 (en) 2008-04-23
DK1912973T3 (da) 2012-07-23
EA200800201A1 (ru) 2008-06-30
PT2284167T (pt) 2017-05-15
BRPI0613615A2 (pt) 2011-01-18
TNSN08029A1 (en) 2009-07-14
BRPI0613615B1 (pt) 2022-02-08
EP2284167A2 (en) 2011-02-16
TW200740793A (en) 2007-11-01
EP2284167A3 (en) 2011-03-02
JP5798101B2 (ja) 2015-10-21
AU2006276204A1 (en) 2007-02-08
EP2543665A2 (en) 2013-01-09
IL188189A0 (en) 2008-03-20
US8829015B2 (en) 2014-09-09
PH12013501590A1 (en) 2015-09-21
US8415363B2 (en) 2013-04-09
JP2009502795A (ja) 2009-01-29
SI2284167T2 (sl) 2020-03-31
AU2012201453B2 (en) 2013-09-05
IL214659A0 (en) 2011-09-27
EP1912973B1 (en) 2012-06-13
ES2623608T3 (es) 2017-07-11
LT2284167T (lt) 2017-04-25
KR20080027853A (ko) 2008-03-28
HRP20170634T4 (hr) 2020-02-07
AU2012201453C1 (en) 2024-05-23
CN103804356A (zh) 2014-05-21
GT200600315A (es) 2007-03-19
JP2014221831A (ja) 2014-11-27
US20080269269A1 (en) 2008-10-30
US20130023548A1 (en) 2013-01-24
EP2535337B1 (en) 2017-08-23
CY1119624T1 (el) 2018-04-04
GEP20115302B (en) 2011-10-10
US20140343087A1 (en) 2014-11-20
EA016856B1 (ru) 2012-08-30
MX2008000899A (es) 2008-03-18
JP5289948B2 (ja) 2013-09-11
UA94234C2 (uk) 2011-04-26
ES2623608T5 (es) 2020-06-18
CY1113076T1 (el) 2016-04-13
AU2011202047A1 (en) 2011-05-26
US8343984B2 (en) 2013-01-01
HK1116783A1 (hu) 2009-01-02
CU20080006A7 (es) 2011-02-24
EA013464B1 (ru) 2010-04-30
HRP20120573T1 (hr) 2012-08-31
RS55929B2 (sr) 2020-12-31
CA2614334A1 (en) 2007-02-08
EP2284168A2 (en) 2011-02-16
AR054846A1 (es) 2007-07-18
MY148554A (en) 2013-04-30
PE20070214A1 (es) 2007-04-02
HN2008000311A (es) 2011-01-24
SI2284167T1 (sl) 2017-05-31
ES2386974T3 (es) 2012-09-10
NO20080820L (no) 2008-04-15
AU2012201453A1 (en) 2012-04-05
ES2648288T3 (es) 2017-12-29
JO3308B1 (ar) 2018-09-16
WO2007015870A2 (en) 2007-02-08
DK2284167T4 (da) 2020-03-02
NZ564409A (en) 2011-07-29
ECSP088119A (es) 2008-02-20
SI1912973T1 (sl) 2012-08-31
EP2535337A1 (en) 2012-12-19
EA201000145A1 (ru) 2010-06-30
KR20130077915A (ko) 2013-07-09
EP2543665A3 (en) 2013-05-29
PL2284167T5 (pl) 2020-07-27
NO341930B1 (no) 2018-02-19
MA29626B1 (fr) 2008-07-01
CU23916B1 (es) 2013-07-31
SMAP200800011A (it) 2008-02-27
EP2284167B2 (en) 2019-11-27
PL2284167T3 (pl) 2017-07-31
SMP200800011B (it) 2008-02-27
PT1912973E (pt) 2012-09-03
EP2284168A3 (en) 2011-04-13
CN102358736A (zh) 2012-02-22

Similar Documents

Publication Publication Date Title
IL214659A0 (en) Crystalline forms of 4-methyl-n-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide
IL187787A0 (en) Salts of 4-methyl-n-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide
EP1954277A4 (en) AMINOPYRIMIDINES SUITABLE AS KINASEINHIBITORS
ATE521238T1 (de) Kristalline modifikationen des pyraclostrobins
EP1921052A4 (en) SEMICONDUCTOR CERAMIC COMPOSITION
IL183380A0 (en) Crystalline forms of linezolid intermediate
HK1121760A1 (en) Novel n-(fluoro-pyrazinyl)-phenylsulfonamides as moodulators of chemokine receptor ccr4.
DE502006007792D1 (de) Temperaturkompensation bei endstufen
ZA200710799B (en) Crystalline forms of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoromethylphenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide
ZA200710457B (en) Salts of 4-methyl-N-[3-(4-methyl-imidazol-1-yl)-5-trifluoro-methyl-phenyl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide
DE602006005524D1 (de) dingskompensation
ZA200804599B (en) Aminopyrimidines useful as kinase inhibitors
ZA200800245B (en) JNK inhibitors for the treatment of endometriosis
GB0526357D0 (en) Porous silicon composition