MA29626B1 - Formes cristallines de 4-methyl-n-[3-(4-methyl -imidazol-1-yl)-5-trifluromethyl-phenyl]-3-(4- pyridin-3-yl-pyrimidin-2-ylamino)-benzamide - Google Patents

Formes cristallines de 4-methyl-n-[3-(4-methyl -imidazol-1-yl)-5-trifluromethyl-phenyl]-3-(4- pyridin-3-yl-pyrimidin-2-ylamino)-benzamide

Info

Publication number
MA29626B1
MA29626B1 MA30566A MA30566A MA29626B1 MA 29626 B1 MA29626 B1 MA 29626B1 MA 30566 A MA30566 A MA 30566A MA 30566 A MA30566 A MA 30566A MA 29626 B1 MA29626 B1 MA 29626B1
Authority
MA
Morocco
Prior art keywords
methyl
ylamino
benzamide
imidazol
pyrimidin
Prior art date
Application number
MA30566A
Other languages
English (en)
Inventor
Paul W Manley
Wen-Chung Shieh
Paul Allen Sutton
Piotr H Karpinski
Raeann Wu
Stephanie Monnier
Joerg Brozio
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37451227&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA29626(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA29626B1 publication Critical patent/MA29626B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Les formes cristallines de la base libre 4-méthyl-N-[3-(4-méthyl-imidazol-1-yl)-5-trifluorométhyl-phényl]-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-benzamide et de ses sels sont préparées à l'aide de différents procédés.
MA30566A 2005-07-20 2008-01-09 Formes cristallines de 4-methyl-n-[3-(4-methyl -imidazol-1-yl)-5-trifluromethyl-phenyl]-3-(4- pyridin-3-yl-pyrimidin-2-ylamino)-benzamide MA29626B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70140505P 2005-07-20 2005-07-20
US71621405P 2005-09-12 2005-09-12

Publications (1)

Publication Number Publication Date
MA29626B1 true MA29626B1 (fr) 2008-07-01

Family

ID=37451227

Family Applications (1)

Application Number Title Priority Date Filing Date
MA30566A MA29626B1 (fr) 2005-07-20 2008-01-09 Formes cristallines de 4-methyl-n-[3-(4-methyl -imidazol-1-yl)-5-trifluromethyl-phenyl]-3-(4- pyridin-3-yl-pyrimidin-2-ylamino)-benzamide

Country Status (43)

Country Link
US (4) US8343984B2 (fr)
EP (5) EP2543665A3 (fr)
JP (3) JP5289948B2 (fr)
KR (3) KR20130077915A (fr)
CN (2) CN103804356A (fr)
AR (1) AR054846A1 (fr)
AU (3) AU2006276204A1 (fr)
BR (1) BRPI0613615B1 (fr)
CA (1) CA2614334C (fr)
CR (1) CR9657A (fr)
CU (1) CU23916B1 (fr)
CY (2) CY1113076T1 (fr)
DK (2) DK2284167T4 (fr)
EA (2) EA013464B1 (fr)
EC (1) ECSP088119A (fr)
ES (3) ES2648288T3 (fr)
GE (1) GEP20115302B (fr)
GT (1) GT200600315A (fr)
HK (1) HK1116783A1 (fr)
HN (1) HN2008000311A (fr)
HR (2) HRP20120573T1 (fr)
HU (1) HUE031791T2 (fr)
IL (2) IL188189A0 (fr)
JO (1) JO3308B1 (fr)
LT (1) LT2284167T (fr)
MA (1) MA29626B1 (fr)
MX (1) MX2008000899A (fr)
MY (1) MY148554A (fr)
NI (1) NI200800017A (fr)
NO (1) NO341930B1 (fr)
NZ (1) NZ564409A (fr)
PE (1) PE20070214A1 (fr)
PH (1) PH12013501590A1 (fr)
PL (2) PL2284167T5 (fr)
PT (2) PT1912973E (fr)
RS (1) RS55929B2 (fr)
SG (1) SG163620A1 (fr)
SI (2) SI2284167T2 (fr)
SM (1) SMP200800011B (fr)
TN (1) TNSN08029A1 (fr)
TW (1) TWI406661B (fr)
UA (1) UA94234C2 (fr)
WO (1) WO2007015870A2 (fr)

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JO3634B1 (ar) 2009-11-17 2020-08-27 Novartis Ag طريقة لعلاج اضطرابات تكاثرية وحالات مرضية أخرى متوسطة بنشاط كيناز bcr-abl، c-kit، ddr1، ddr2، أو pdgf-r
IN2010KO00035A (fr) * 2010-01-15 2016-09-02
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AU2012328979B2 (en) 2011-10-28 2016-04-21 Novartis Ag Method of treating gastrointestinal stromal tumors
WO2013063003A1 (fr) 2011-10-28 2013-05-02 Novartis Ag Méthode de traitement des tumeurs stromales gastro-intestinales
KR20140093230A (ko) 2011-11-14 2014-07-25 노파르티스 아게 즉시 방출 4-메틸-3-[[4-(3-피리디닐)-2-피리미디닐]아미노]-n-[5-(4-메틸-1h-이미다졸-1-일)-3-(트리플루오로메틸)페닐] 벤즈아미드 제제
EP2626355B1 (fr) * 2012-02-09 2016-02-03 Natco Pharma Limited Procédé de préparation d'hydrochlorure de nilotinib
WO2013120852A1 (fr) 2012-02-13 2013-08-22 Grindeks, A Joint Stock Company Intermédiaires pour un nouveau procédé de préparation d'imatinib et d'inhibiteurs de tyrosine kinase associés
US9061028B2 (en) 2012-02-15 2015-06-23 Natco Pharma Limited Process for the preparation of Nilotinib
JP2015522070A (ja) 2012-07-11 2015-08-03 ノバルティス アーゲー 消化管間質腫瘍を治療する方法
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CA2887540A1 (fr) * 2012-10-19 2014-04-24 Basf Se Systeme cristallin multicomposant comprenant du nilotinib et des formateurs de co-cristal selectionnes
RU2619944C2 (ru) * 2013-02-21 2017-05-22 Пфайзер Инк. Твердые формы селективного ингибитора CDK4/6
EP2792360A1 (fr) 2013-04-18 2014-10-22 IP Gesellschaft für Management mbH (1aR,12bS)-8-cyclohexyl-11-fluoro-N-((1-methylcyclopropyl)sulfonyl)-1a-((3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,2b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide pour utilisation dans le traitement de HCV
MX2015014897A (es) * 2013-04-24 2016-03-07 Reddys Lab Ltd Dr Formas polimorficas de clorhidrato de nilotinib.
RU2551359C9 (ru) * 2013-11-28 2021-08-20 Общество с ограниченной ответственностью "Мамонт Фарм" Наноразмерная слабо закристаллизованная модификация 4-метил-N-[3-(4-метилимидазол-1-ил)-5-(трифторметил)фенил]-3-[(4-пиридин-3-илпиримидин-2-ил)амино]бензамида гидрохлорида моногидрата, способ ее получения и фармацевтическая композиция на ее основе
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JP2020007240A (ja) * 2018-07-04 2020-01-16 住友化学株式会社 ベンズアミド化合物の製造方法
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WO2021155254A1 (fr) 2020-01-31 2021-08-05 Nanocopoeia, Llc Microparticules de nilotinib amorphe et leurs utilisations
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CA2614334C (fr) 2015-04-21
EP2543665A3 (fr) 2013-05-29
JP5289948B2 (ja) 2013-09-11
SI2284167T2 (sl) 2020-03-31
JP2014221831A (ja) 2014-11-27
ES2623608T3 (es) 2017-07-11
JP2013018789A (ja) 2013-01-31
PT1912973E (pt) 2012-09-03
HRP20170634T4 (hr) 2020-02-07
IL188189A0 (en) 2008-03-20
GT200600315A (es) 2007-03-19
US20130023548A1 (en) 2013-01-24
HN2008000311A (es) 2011-01-24
DK2284167T4 (da) 2020-03-02
CY1113076T1 (el) 2016-04-13
HRP20120573T1 (hr) 2012-08-31
ES2386974T3 (es) 2012-09-10
EP2535337A1 (fr) 2012-12-19
UA94234C2 (uk) 2011-04-26
HUE031791T2 (en) 2017-08-28
EP1912973B1 (fr) 2012-06-13
US8415363B2 (en) 2013-04-09
CU23916B1 (es) 2013-07-31
JO3308B1 (ar) 2018-09-16
LT2284167T (lt) 2017-04-25
SMAP200800011A (it) 2008-02-27
EP2284168A2 (fr) 2011-02-16
BRPI0613615B1 (pt) 2022-02-08
EP2284167B2 (fr) 2019-11-27
EA016856B1 (ru) 2012-08-30
HRP20170634T1 (hr) 2017-06-30
EP2284167B1 (fr) 2017-02-01
EP2543665A2 (fr) 2013-01-09
EP2284168A3 (fr) 2011-04-13
US20130165465A1 (en) 2013-06-27
JP5798101B2 (ja) 2015-10-21
CA2614334A1 (fr) 2007-02-08
EA013464B1 (ru) 2010-04-30
CU20080006A7 (es) 2011-02-24
AU2012201453A1 (en) 2012-04-05
NO341930B1 (no) 2018-02-19
BRPI0613615A2 (pt) 2011-01-18
RS55929B1 (sr) 2017-09-29
TW200740793A (en) 2007-11-01
EP2284167A2 (fr) 2011-02-16
CR9657A (es) 2008-04-16
TWI406661B (zh) 2013-09-01
SMP200800011B (it) 2008-02-27
AU2011202047A1 (en) 2011-05-26
MY148554A (en) 2013-04-30
TNSN08029A1 (en) 2009-07-14
ES2648288T3 (es) 2017-12-29
EP2284167A3 (fr) 2011-03-02
US8343984B2 (en) 2013-01-01
NI200800017A (es) 2009-03-03
JP2009502795A (ja) 2009-01-29
SG163620A1 (en) 2010-08-30
KR20080027853A (ko) 2008-03-28
PH12013501590A1 (en) 2015-09-21
NO20080820L (no) 2008-04-15
EP2535337B1 (fr) 2017-08-23
AR054846A1 (es) 2007-07-18
KR101651288B1 (ko) 2016-08-25
EA200800201A1 (ru) 2008-06-30
NZ564409A (en) 2011-07-29
ES2623608T5 (es) 2020-06-18
AU2006276204A1 (en) 2007-02-08
DK1912973T3 (da) 2012-07-23
RS55929B2 (sr) 2020-12-31
KR20130085444A (ko) 2013-07-29
DK2284167T3 (en) 2017-05-01
EP1912973A2 (fr) 2008-04-23
WO2007015870A3 (fr) 2007-06-07
EA201000145A1 (ru) 2010-06-30
WO2007015870A2 (fr) 2007-02-08
ECSP088119A (es) 2008-02-20
HK1116783A1 (fr) 2009-01-02
GEP20115302B (en) 2011-10-10
KR20130077915A (ko) 2013-07-09
IL214659A0 (en) 2011-09-27
MX2008000899A (es) 2008-03-18
US20080269269A1 (en) 2008-10-30
AU2012201453C1 (en) 2024-05-23
CN103804356A (zh) 2014-05-21
PL2284167T5 (pl) 2020-07-27
PT2284167T (pt) 2017-05-15
CY1119624T1 (el) 2018-04-04
PL2284167T3 (pl) 2017-07-31
PL1912973T3 (pl) 2012-09-28
CN102358736A (zh) 2012-02-22
AU2012201453B2 (en) 2013-09-05
US20140343087A1 (en) 2014-11-20
SI2284167T1 (sl) 2017-05-31
SI1912973T1 (sl) 2012-08-31
PE20070214A1 (es) 2007-04-02
US8829015B2 (en) 2014-09-09

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