SG11202002931VA - Portable molecular diagnostic device and methods for the detection of target viruses - Google Patents

Portable molecular diagnostic device and methods for the detection of target viruses

Info

Publication number
SG11202002931VA
SG11202002931VA SG11202002931VA SG11202002931VA SG11202002931VA SG 11202002931V A SG11202002931V A SG 11202002931VA SG 11202002931V A SG11202002931V A SG 11202002931VA SG 11202002931V A SG11202002931V A SG 11202002931VA SG 11202002931V A SG11202002931V A SG 11202002931VA
Authority
SG
Singapore
Prior art keywords
detection
methods
diagnostic device
molecular diagnostic
target viruses
Prior art date
Application number
SG11202002931VA
Other languages
English (en)
Inventor
Boris Andreyev
Victor Briones
Ryan T Cena
La Zerda Adam De
Colin Kelly
Gregory Loney
Gary Schoolnik
David Swenson
Original Assignee
Visby Medical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Visby Medical Inc filed Critical Visby Medical Inc
Publication of SG11202002931VA publication Critical patent/SG11202002931VA/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/028—Modular arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/04—Exchange or ejection of cartridges, containers or reservoirs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0663—Stretching or orienting elongated molecules or particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883—Serpentine channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1805—Conductive heating, heat from thermostatted solids is conducted to receptacles, e.g. heating plates, blocks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
SG11202002931VA 2017-11-09 2018-11-09 Portable molecular diagnostic device and methods for the detection of target viruses SG11202002931VA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762583789P 2017-11-09 2017-11-09
US201762594905P 2017-12-05 2017-12-05
PCT/US2018/060117 WO2019094784A1 (en) 2017-11-09 2018-11-09 Portable molecular diagnostic device and methods for the detection of target viruses

Publications (1)

Publication Number Publication Date
SG11202002931VA true SG11202002931VA (en) 2020-04-29

Family

ID=66438684

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202002931VA SG11202002931VA (en) 2017-11-09 2018-11-09 Portable molecular diagnostic device and methods for the detection of target viruses

Country Status (10)

Country Link
US (3) US11162130B2 (ja)
EP (1) EP3707276A4 (ja)
JP (1) JP7239568B2 (ja)
KR (1) KR20200079264A (ja)
CN (1) CN111655866A (ja)
AU (2) AU2018364741B2 (ja)
CA (1) CA3078976A1 (ja)
MX (1) MX2020004783A (ja)
SG (1) SG11202002931VA (ja)
WO (1) WO2019094784A1 (ja)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015138343A1 (en) 2014-03-10 2015-09-17 Click Diagnostics, Inc. Cartridge-based thermocycler
EP4029606A1 (en) 2014-12-31 2022-07-20 Visby Medical, Inc. Molecular diagnostic testing
WO2017185067A1 (en) 2016-04-22 2017-10-26 Click Diagnostics, Inc. Printed circuit board heater for an amplification module
WO2017197040A1 (en) 2016-05-11 2017-11-16 Click Diagnostics, Inc. Devices and methods for nucleic acid extraction
MX2018015889A (es) 2016-06-29 2019-05-27 Click Diagnostics Inc Dispositivos y metodos para la deteccion de moleculas usando una celda de flujo.
CN111655866A (zh) 2017-11-09 2020-09-11 维斯比医学公司 便携式分子诊断装置和检测靶病毒的方法
WO2021108266A1 (en) * 2019-11-27 2021-06-03 Juno Diagnostics, Inc. Systems and devices for sample preparation and analyte detection
BR112022013201A2 (pt) * 2019-12-30 2022-09-13 Illumina Inc Conjuntos de célula de fluxo e válvulas seletoras de reagente relacionadas
US11352675B2 (en) 2020-01-03 2022-06-07 Visby Medical, Inc. Devices and methods for antibiotic susceptability testing
US20230105360A1 (en) * 2020-03-09 2023-04-06 Nuclein, Llc Apparatus and methods for molecular diagnostics
WO2021195150A1 (en) * 2020-03-23 2021-09-30 Visby Medical, Inc. Devices and methods for detection of target viruses
WO2022018741A1 (en) * 2020-07-23 2022-01-27 Indian Institute Of Technology, Kharagpur A point of care (poc) device for nucleic acid based testing and method thereof
CN112625890B (zh) * 2020-12-23 2021-08-31 广州和实生物技术有限公司 一种核酸poct检测装置及其检测方法
CN112662815B (zh) * 2021-01-25 2023-04-11 中国疾病预防控制中心病毒病预防控制所 用于检测塔卡里伯病毒和太米阿米病毒的引物探针组合、试剂盒及方法
KR102555474B1 (ko) * 2021-05-14 2023-07-14 성균관대학교산학협력단 등온 핵산 증폭 및 검출 장치 및 이를 이용한 등온 핵산 증폭 및 검출 방법
TWI785636B (zh) 2021-06-07 2022-12-01 新加坡商克雷多生醫有限公司 檢測卡匣
WO2023018896A1 (en) * 2021-08-13 2023-02-16 Visby Medical, Inc. Molecular diagnostic devices and methods for retaining and mixing reagents
WO2023235875A1 (en) * 2022-06-03 2023-12-07 Autonomous Medical Devices Incorporated Methods for sample preparation

Family Cites Families (315)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3697227A (en) 1966-05-13 1972-10-10 Westinghouse Electric Corp Chemical constituent sampler
US4710355A (en) 1984-06-14 1987-12-01 Olympus Optical Co., Ltd. Reagent delivery device
US4889692A (en) 1984-11-05 1989-12-26 Holtzman Marc E Disposable sample preparation container
USRE33858E (en) 1985-01-25 1992-03-24 Mallinckrodt Sensor Systems Inc. Apparatus for measuring a chemical entity in a liquid
US4789630A (en) 1985-10-04 1988-12-06 Cetus Corporation Ionic compounds containing the cationic meriquinone of a benzidine
IE64511B1 (en) 1988-03-11 1995-08-09 Takeda Chemical Industries Ltd Automated synthesizing apparatus
US5229297A (en) 1989-02-03 1993-07-20 Eastman Kodak Company Containment cuvette for PCR and method of use
US6645758B1 (en) 1989-02-03 2003-11-11 Johnson & Johnson Clinical Diagnostics, Inc. Containment cuvette for PCR and method of use
US5270183A (en) 1991-02-08 1993-12-14 Beckman Research Institute Of The City Of Hope Device and method for the automated cycling of solutions between two or more temperatures
US5273905A (en) 1991-02-22 1993-12-28 Amoco Corporation Processing of slide mounted material
US7297313B1 (en) 1991-08-31 2007-11-20 The Regents Of The University Of California Microfabricated reactor, process for manufacturing the reactor, and method of amplification
US5726026A (en) 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US5587128A (en) 1992-05-01 1996-12-24 The Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification devices
US5498392A (en) 1992-05-01 1996-03-12 Trustees Of The University Of Pennsylvania Mesoscale polynucleotide amplification device and method
WO1994001215A1 (en) 1992-07-06 1994-01-20 Beckman Instruments, Inc. Fluid delivery system utilizing multiple port valve
US5503985A (en) 1993-02-18 1996-04-02 Cathey; Cheryl A. Disposable device for diagnostic assays
US5429807A (en) 1993-10-28 1995-07-04 Beckman Instruments, Inc. Method and apparatus for creating biopolymer arrays on a solid support surface
US5631165A (en) 1994-08-01 1997-05-20 Abbott Laboratories Method for performing automated hematology and cytometry analysis
US5633168A (en) 1995-06-07 1997-05-27 Glasscock; Larry M. Controlled dispersion flow analysis system
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US20050100946A1 (en) 1995-06-29 2005-05-12 Affymetrix, Inc. Integrated nucleic acid diagnostic device and method for in-situ confocal microscopy
US6153425A (en) 1995-07-13 2000-11-28 Xtrana, Inc. Self-contained device integrating nucleic acid extraction, amplification and detection
US5773234A (en) 1995-08-07 1998-06-30 Quidel Corporation Method and device for chlamydia detection
AU6720096A (en) 1995-08-09 1997-03-05 Quidel Corporation Test strip and method for one step lateral flow assay
US7635597B2 (en) 1995-08-09 2009-12-22 Bayer Healthcare Llc Dry reagent particle assay and device having multiple test zones and method therefor
US7244622B2 (en) 1996-04-03 2007-07-17 Applera Corporation Device and method for multiple analyte detection
ATE295427T1 (de) 1996-06-04 2005-05-15 Univ Utah Res Found Überwachung der hybridisierung während pcr
US5800784A (en) 1996-07-09 1998-09-01 Horn; Marcus J. Chemical sample treatment system and cassette, and methods for effecting multistep treatment process
US5882903A (en) 1996-11-01 1999-03-16 Sarnoff Corporation Assay system and method for conducting assays
DE29623597U1 (de) 1996-11-08 1999-01-07 Eppendorf Geraetebau Netheler Temperierblock mit Temperiereinrichtungen
US5952664A (en) 1997-01-17 1999-09-14 Imaging Diagnostic Systems, Inc. Laser imaging apparatus using biomedical markers that bind to cancer cells
US6924153B1 (en) 1997-03-06 2005-08-02 Quidel Corporation Quantitative lateral flow assays and devices
US20030027203A1 (en) 1997-03-24 2003-02-06 Fields Robert E. Biomolecular processor
US6126804A (en) 1997-09-23 2000-10-03 The Regents Of The University Of California Integrated polymerase chain reaction/electrophoresis instrument
EP1179585B1 (en) 1997-12-24 2008-07-09 Cepheid Device and method for lysis
US6369893B1 (en) 1998-05-19 2002-04-09 Cepheid Multi-channel optical detection system
US6303081B1 (en) 1998-03-30 2001-10-16 Orasure Technologies, Inc. Device for collection and assay of oral fluids
US6146591A (en) 1998-05-01 2000-11-14 Miller; C David Biochemical detection system for rapid determination of the presence of toxins, bacteria, and other substances
US5976470A (en) 1998-05-29 1999-11-02 Ontogen Corporation Sample wash station assembly
US7799521B2 (en) 1998-06-24 2010-09-21 Chen & Chen, Llc Thermal cycling
US6780617B2 (en) 2000-12-29 2004-08-24 Chen & Chen, Llc Sample processing device and method
US6313471B1 (en) 1998-08-18 2001-11-06 Molecular Devices Corporation Scanning fluorometer
US20010055799A1 (en) 1998-12-15 2001-12-27 David Baunoch Method and apparatus for automated reprocessing of tissue samples
US6261431B1 (en) 1998-12-28 2001-07-17 Affymetrix, Inc. Process for microfabrication of an integrated PCR-CE device and products produced by the same
US6235479B1 (en) 1999-04-13 2001-05-22 Bio Merieux, Inc. Methods and devices for performing analysis of a nucleic acid sample
US20020177135A1 (en) 1999-07-27 2002-11-28 Doung Hau H. Devices and methods for biochip multiplexing
DE60022025T2 (de) 1999-05-28 2006-06-29 Cepheid, Sunnyvale Anlage zum brechen von zellen
GB9922971D0 (en) 1999-09-29 1999-12-01 Secr Defence Reaction system
JP2001186881A (ja) 1999-10-22 2001-07-10 Ngk Insulators Ltd Ｄｎａチップの製造方法
US6699713B2 (en) 2000-01-04 2004-03-02 The Regents Of The University Of California Polymerase chain reaction system
FR2812306B1 (fr) 2000-07-28 2005-01-14 Gabriel Festoc Systeme d'amplification en chaine par polymerse de sequences nucleiques cibles
US6374684B1 (en) 2000-08-25 2002-04-23 Cepheid Fluid control and processing system
US8048386B2 (en) 2002-02-25 2011-11-01 Cepheid Fluid processing and control
US6610499B1 (en) 2000-08-31 2003-08-26 The Regents Of The University Of California Capillary array and related methods
US6911181B1 (en) 2000-10-03 2005-06-28 Isis Pharmaceuticals, Inc. Self-dispensing storage device
SE0004297D0 (sv) 2000-11-23 2000-11-23 Gyros Ab Device for thermal cycling
US6780380B2 (en) 2001-01-16 2004-08-24 Triangle Biomedical Sciences, Inc. Tissue processor
WO2002064253A2 (en) 2001-02-09 2002-08-22 Microchem Solutions Method and apparatus for sample injection in microfabricated devices
US6426215B1 (en) 2001-04-06 2002-07-30 Pe Corporation (Ny) PCR plate cover and maintaining device
US6905885B2 (en) 2001-06-12 2005-06-14 The Regents Of The University Of California Portable pathogen detection system
US20040018502A1 (en) 2001-06-14 2004-01-29 Yoshihiko Makino Method for analyzing a target nucleic acid fragment and a kit for analyzing a target nucleic acid fragment
US6514750B2 (en) 2001-07-03 2003-02-04 Pe Corporation (Ny) PCR sample handling device
EP1952886B1 (en) 2001-07-16 2021-06-23 BioFire Defense, LLC Thermal cycling system and method of use
US7280207B2 (en) 2001-07-25 2007-10-09 Applera Corporation Time-delay integration in a flow cytometry system
AUPR707101A0 (en) 2001-08-16 2001-09-06 Corbett Research Pty Ltd Continuous flow thermal device
US6855561B2 (en) 2001-09-10 2005-02-15 Quidel Corporation Method for adding an apparent non-signal line to a lateral flow assay
US7879293B2 (en) 2001-09-28 2011-02-01 Orasure Technologies, Inc. Sample collector and test device
ATE551606T1 (de) 2001-10-01 2012-04-15 Leica Biosystems Melbourne Pty Gewebeprozessor zur behandlung histologischer gewebepräparate
WO2003029397A1 (en) 2001-10-02 2003-04-10 Stratagene Side-wall heater for thermocycler device
US7691333B2 (en) 2001-11-30 2010-04-06 Fluidigm Corporation Microfluidic device and methods of using same
US20030116552A1 (en) 2001-12-20 2003-06-26 Stmicroelectronics Inc. Heating element for microfluidic and micromechanical applications
US6813568B2 (en) 2002-01-09 2004-11-02 Memorial Sloan-Kettering Cancer Center System and process for microfluidics-based automated chemistry
US6677151B2 (en) 2002-01-30 2004-01-13 Applera Corporation Device and method for thermal cycling
US8030000B2 (en) 2002-02-21 2011-10-04 Alere San Diego, Inc. Recombinase polymerase amplification
JP3892743B2 (ja) 2002-03-01 2007-03-14 日本碍子株式会社 反応セルおよびその使用方法
US7179639B2 (en) 2002-03-05 2007-02-20 Raveendran Pottathil Thermal strip thermocycler
EP1376131A1 (en) 2002-06-27 2004-01-02 Inverness Medical Switzerland GmbH Assay device for liquid sample
JP4013671B2 (ja) 2002-07-05 2007-11-28 松下電器産業株式会社 ポリメラーゼ連鎖反応容器及びその製造方法
US7452712B2 (en) 2002-07-30 2008-11-18 Applied Biosystems Inc. Sample block apparatus and method of maintaining a microcard on a sample block
US8349276B2 (en) 2002-09-24 2013-01-08 Duke University Apparatuses and methods for manipulating droplets on a printed circuit board
US7291459B2 (en) 2002-12-10 2007-11-06 University Of Alabama At Huntsville Nucleic acid detector and method of detecting targets within a sample
US7560272B2 (en) 2003-01-04 2009-07-14 Inverness Medical Switzerland Gmbh Specimen collection and assay container
US7416892B2 (en) 2003-01-21 2008-08-26 Micronics, Inc. Method and system for microfluidic manipulation, amplification and analysis of fluids, for example, bacteria assays and antiglobulin testing
US6781056B1 (en) 2003-02-28 2004-08-24 Motorola, Inc. Heater for temperature control integrated in circuit board and method of manufacture
US6901217B2 (en) 2003-02-28 2005-05-31 Motorolr, Inc. Conduits integrated in circuit board and method of manufacture
US7041481B2 (en) 2003-03-14 2006-05-09 The Regents Of The University Of California Chemical amplification based on fluid partitioning
US7151270B2 (en) 2003-05-02 2006-12-19 Leica Microsystems Cms Gmbh Method for classifying object image regions of an object to be detected using a scanning microscope
US7148043B2 (en) 2003-05-08 2006-12-12 Bio-Rad Laboratories, Inc. Systems and methods for fluorescence detection with a movable detection module
US7648835B2 (en) 2003-06-06 2010-01-19 Micronics, Inc. System and method for heating, cooling and heat cycling on microfluidic device
JP4773348B2 (ja) 2003-07-12 2011-09-14 アクセラー８ テクノロジー コーポレイション 高感度かつ迅速なバイオ検出法
US7517495B2 (en) 2003-08-25 2009-04-14 Inverness Medical Switzerland Gmbh Biological specimen collection and analysis system
US7491527B2 (en) 2003-09-19 2009-02-17 Microfluidic Systems, Inc. Microfluidic differential extraction cartridge
JP4933258B2 (ja) 2003-09-22 2012-05-16 クイデル コーポレーション 試料中の複数分析物の検出装置
CN1898374B (zh) * 2003-10-24 2012-12-05 埃格尼股份有限公司 集成的生物-分析和样品制备系统
DE212004000058U1 (de) 2003-11-14 2006-09-28 Oakville Hong Kong Co., Ltd. Probensammelbehälter mit integriertem aktivierbaren Probenanalysesystem
DE602004031253D1 (de) 2003-11-14 2011-03-10 Alere Switzerland Gmbh Flüssigprobenanalysevorrichtung mit verschliessbarem probenaufbewahrungsreservoir
CA2545135C (en) 2003-11-14 2013-01-08 Oakville Hong Kong Co., Limited Sample collection cup with integrated sample analysis system
US7767439B2 (en) 2003-12-10 2010-08-03 Samsung Electronics Co., Ltd. Real-time PCR monitoring apparatus and method
KR100750586B1 (ko) 2003-12-26 2007-08-20 한국전자통신연구원 미소유체 가열 시스템
CN1942590B (zh) 2004-02-18 2012-09-05 周小川 多元化学和生化反应的流体装置和方法
EP1716404A4 (en) 2004-02-20 2010-05-05 Univ New York State Res Found METHOD AND DEVICE FOR HANDLING LIQUIDS IN MICROFLUIDIC SYSTEMS
KR100552706B1 (ko) 2004-03-12 2006-02-20 삼성전자주식회사 핵산 증폭 방법 및 장치
EP1733232A1 (en) 2004-03-23 2006-12-20 Quidel Corporation Hybrid phase lateral flow assay
WO2006041524A2 (en) 2004-04-07 2006-04-20 Access Bio, Inc. Nucleic acid detection system
CA2502549C (en) 2004-04-23 2016-02-16 Becton, Dickinson And Company Use of an extraction control in a method of extracting nucleic acids
EP1598429A1 (en) 2004-05-19 2005-11-23 Amplion Ltd. Detection of amplicon contamination during PCR exhibiting two different annealing temperatures
US7662562B2 (en) 2004-08-10 2010-02-16 Becton, Dickinson And Company Method for rapid identification of microorganisms
US7192721B1 (en) 2004-08-26 2007-03-20 Chembio Diagnostic Systems, Inc. Universal rapid test and method for detection of tuberculosis in multiple host species
US7592139B2 (en) 2004-09-24 2009-09-22 Sandia National Laboratories High temperature flow-through device for rapid solubilization and analysis
CA2584569C (en) 2004-10-18 2014-09-30 Brandeis University Primers, probes and methods for nucleic acid amplification
CN101068932B (zh) 2004-10-27 2013-02-13 塞弗德公司 封闭系统多阶段核酸扩增反应
EP2418018B1 (en) 2004-12-23 2013-05-22 Abbott Point of Care Inc. Methods for the separation nucleic acids
KR100601982B1 (ko) 2005-01-20 2006-07-18 삼성전자주식회사 흡열반응을 통한 가열-냉각 과정에 의한 세포 용해 방법
WO2006094149A2 (en) 2005-03-01 2006-09-08 Exact Sciences Corporation Methods and compositions for detecting adenoma
US7189522B2 (en) 2005-03-11 2007-03-13 Chembio Diagnostic Systems, Inc. Dual path immunoassay device
US20060246493A1 (en) 2005-04-04 2006-11-02 Caliper Life Sciences, Inc. Method and apparatus for use in temperature controlled processing of microfluidic samples
US20070026391A1 (en) 2005-04-11 2007-02-01 Ghc Technologies, Inc. Methods and compositions for identifying chemical or biological agents using multiplexed labeling and colocalization detection
US7235216B2 (en) 2005-05-01 2007-06-26 Iba Molecular North America, Inc. Apparatus and method for producing radiopharmaceuticals
KR100695148B1 (ko) 2005-05-02 2007-03-14 삼성전자주식회사 중합효소 연쇄반응용 모듈 및 이를 채용한 다중 중합효소 연쇄반응 장치
US20070042427A1 (en) 2005-05-03 2007-02-22 Micronics, Inc. Microfluidic laminar flow detection strip
AU2006244187B2 (en) 2005-05-09 2011-10-13 Biofire Diagnostics, Llc Self-contained biological analysis
WO2006122312A2 (en) 2005-05-11 2006-11-16 The Trustees Of The University Of Pennsylvania Methods of testing using a microfluidic cassette
JP2008539759A (ja) 2005-05-11 2008-11-20 ナノリティックス・インコーポレイテッド 多数の温度で生化学的又は化学的な反応を実施する方法及び装置
CA2610793A1 (en) 2005-05-31 2007-05-10 Labnow, Inc. Methods and compositions related to determination and use of white blood cell counts
CA2613078A1 (en) 2005-06-24 2007-01-04 Board Of Regents, The University Of Texas System Systems and methods including self-contained cartridges with detection systems and fluid delivery systems
TW200714898A (en) 2005-08-02 2007-04-16 3M Innovative Properties Co Apparatus and method for detecting an analyte
US7618588B2 (en) 2005-08-10 2009-11-17 Microfluidic Systems, Inc. Disposable integrated heater and tube assembly for thermally-driven chemical reactions
US7569382B2 (en) 2005-10-05 2009-08-04 Instantlabs Medical Diagnostic Corp. Disposable reactor module and detection system
WO2007047336A2 (en) 2005-10-12 2007-04-26 University Of Virginia Patent Foundation Integrated microfluidic analysis systems
US7754148B2 (en) 2006-12-27 2010-07-13 Progentech Limited Instrument for cassette for sample preparation
US8372340B2 (en) 2005-10-19 2013-02-12 Luminex Corporation Apparatus and methods for integrated sample preparation, reaction and detection
CN100478671C (zh) 2005-10-25 2009-04-15 艾康生物技术(杭州)有限公司 用于液体样本的检测装置和方法
US7858396B2 (en) 2005-10-31 2010-12-28 Orasure Technologies, Inc. Lateral flow assay device with multiple equidistant capture zones
EP1957989B1 (en) 2005-11-30 2014-09-03 Alere Switzerland GmbH A device for detecting the presence or amount of an analyte in a fluid sample and method thereof
US8173077B2 (en) 2005-12-16 2012-05-08 The Curators Of The University Of Missouri Reusable PCR amplification system and method
US7959877B2 (en) 2005-12-22 2011-06-14 Chembio Diagnostic Systems, Inc. Immunoassay apparatus and kit
US7377291B2 (en) 2005-12-28 2008-05-27 Serveron Corporation Multiport rotary valve
JP5178528B2 (ja) 2005-12-29 2013-04-10 アボット ポイント オブ ケア インコーポレイテッド 分子診断用増幅システムおよび方法
US7794656B2 (en) 2006-01-23 2010-09-14 Quidel Corporation Device for handling and analysis of a biological sample
US7871568B2 (en) 2006-01-23 2011-01-18 Quidel Corporation Rapid test apparatus
US20080050735A1 (en) 2006-02-01 2008-02-28 Elena Pushnova Nucleic acid testing method for point-of-care diagnostics and genetic self-monitoring
GB0603965D0 (en) 2006-02-28 2006-04-05 Centeo Biosciences Ltd Incubator apparatus and method
AU2007225038B2 (en) * 2006-03-15 2013-08-29 Perkinelmer Health Sciences, Inc. Integrated nucleic acid assays
US8088616B2 (en) 2006-03-24 2012-01-03 Handylab, Inc. Heater unit for microfluidic diagnostic system
US7998708B2 (en) * 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
ES2692380T3 (es) 2006-03-24 2018-12-03 Handylab, Inc. Método para realizar PCR con un cartucho con varias pistas
WO2008036121A2 (en) 2006-04-25 2008-03-27 University Of South Florida Portable reactor for real-time nucleic acid amplification and detection
US8900828B2 (en) 2006-05-01 2014-12-02 Cepheid Methods and apparatus for sequential amplification reactions
US8232091B2 (en) 2006-05-17 2012-07-31 California Institute Of Technology Thermal cycling system
US8137626B2 (en) 2006-05-19 2012-03-20 California Institute Of Technology Fluorescence detector, filter device and related methods
US20080153078A1 (en) 2006-06-15 2008-06-26 Braman Jeffrey C System for isolating biomolecules from a sample
US20080026451A1 (en) 2006-06-15 2008-01-31 Braman Jeffrey C System for isolating biomolecules from a sample
EP2041573B1 (en) 2006-06-23 2019-09-04 PerkinElmer Health Sciences, Inc. Methods and devices for microfluidic point-of-care immunoassays
US8163535B2 (en) 2006-06-26 2012-04-24 Blood Cell Storage, Inc. Devices and processes for nucleic acid extraction
US7629124B2 (en) 2006-06-30 2009-12-08 Canon U.S. Life Sciences, Inc. Real-time PCR in micro-channels
US8187557B2 (en) 2006-07-13 2012-05-29 Cepheid Reagent reservoir system for analytical instruments
EP1878802A1 (en) 2006-07-14 2008-01-16 Roche Diagnostics GmbH Disposable device for analysing a liquid sample containing a nucleic acid with a nucleic acid amplification apparatus
US8980561B1 (en) 2006-08-22 2015-03-17 Los Alamos National Security, Llc. Nucleic acid detection system and method for detecting influenza
US20090047673A1 (en) 2006-08-22 2009-02-19 Cary Robert B Miniaturized lateral flow device for rapid and sensitive detection of proteins or nucleic acids
GB0617035D0 (en) 2006-08-30 2006-10-11 Inverness Medical Switzerland Fluidic indicator device
GB0718250D0 (en) 2007-08-29 2007-10-31 B G Res Ltd Improvements in and relating to reaction apparatus
US7985716B2 (en) 2006-09-22 2011-07-26 Uchicago Argonne, Llc Nucleic acid sample purification and enrichment with a thermo-affinity microfluidic sub-circuit
WO2008147382A1 (en) 2006-09-27 2008-12-04 Micronics, Inc. Integrated microfluidic assay devices and methods
EP2082061B8 (en) 2006-10-06 2020-10-07 Applied DNA Sciences, Inc. Method for a continuous rapid thermal cycle system
US8765076B2 (en) 2006-11-14 2014-07-01 Handylab, Inc. Microfluidic valve and method of making same
US20080113391A1 (en) 2006-11-14 2008-05-15 Ian Gibbons Detection and quantification of analytes in bodily fluids
WO2008061129A2 (en) 2006-11-14 2008-05-22 University Of Utah Research Foundation Methods and compositions related to continuous flow thermal gradient pcr
US8735103B2 (en) 2006-12-05 2014-05-27 Electronics And Telecommunications Research Institute Natural convection-driven PCR apparatus and method using disposable polymer chip
GB0625309D0 (en) 2006-12-19 2007-01-24 Inverness Medical Switzerland Device
US8338166B2 (en) 2007-01-04 2012-12-25 Lawrence Livermore National Security, Llc Sorting, amplification, detection, and identification of nucleic acid subsequences in a complex mixture
US7998757B2 (en) 2007-01-22 2011-08-16 Orasure Technologies, Inc. Container and method for supporting home testing and diagnosis of infectious diseases
EP2109666A4 (en) 2007-02-05 2011-09-14 Integenx Inc MICROFLUIDIC AND NANOFLUIDIC DEVICES, SYSTEMS, AND APPLICATIONS
US8298763B2 (en) 2007-03-02 2012-10-30 Lawrence Livermore National Security, Llc Automated high-throughput flow-through real-time diagnostic system
KR20150143860A (ko) 2007-04-04 2015-12-23 네트바이오, 인코포레이티드 표적 핵산의 신속한 다중화 적용 방법
JP4992524B2 (ja) 2007-04-13 2012-08-08 株式会社島津製作所 反応容器プレート及び反応処理方法
US8580575B2 (en) 2007-04-13 2013-11-12 Shimadzu Corporation Reactor plate and reaction processing method
US8435461B2 (en) 2007-04-20 2013-05-07 Quidel Corporation Analytical devices with integrated desiccant
KR101228308B1 (ko) 2007-05-23 2013-01-31 삼성전자주식회사 미세유동 칩을 이용한 디스크형 미세유동장치 및 생체물질마이크로어레이 칩을 이용한 디스크형 미세유동장치
GB0710957D0 (en) 2007-06-07 2007-07-18 Norchip As A device for carrying out cell lysis and nucleic acid extraction
EP2384432B1 (en) 2007-06-21 2016-12-28 Gen-Probe Incorporated Instrument and receptacles for performing processes
JP5045268B2 (ja) 2007-06-28 2012-10-10 ソニー株式会社 反応処理装置
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
US8076129B2 (en) 2007-07-26 2011-12-13 Shimadzu Corporation Reactor plate and reaction processing method
WO2009018473A1 (en) 2007-07-31 2009-02-05 Micronics, Inc. Sanitary swab collection system, microfluidic assay device, and methods for diagnostic assays
US7955840B2 (en) 2007-08-23 2011-06-07 Akonni Biosystems Thermal cycler for PCR including temperature control bladder
CL2008003008A1 (es) 2007-10-12 2009-10-02 Bigtec Private Ltd Un micro dispositivo portatil de reaccion en cadena de polimerasa (pcr) basado en un micro chip de ceramica de coccion conjunta de baja temperatura (ltcc) que comprende camara de reaccion, calentador, control de temperatura del calentador, deteccion optica de interfaz de comunicacion, y el metodo para monitorearlo y controlarlo.
JP5523327B2 (ja) 2007-10-12 2014-06-18 レオニックス，インコーポレイテッド 統合型マイクロ流体デバイスおよび方法
US8222048B2 (en) 2007-11-05 2012-07-17 Abbott Laboratories Automated analyzer for clinical laboratory
US8075854B2 (en) 2007-11-08 2011-12-13 The Ohio State University Research Foundation Bioprocessing Innovative Company Microfluidic chips for rapid multiplex ELISA
DE102007062441A1 (de) 2007-12-20 2009-06-25 Aj Innuscreen Gmbh Mobiles Schnelltestsystem für die Nukleinsäureanalytik
US20090253181A1 (en) 2008-01-22 2009-10-08 Microchip Biotechnologies, Inc. Universal sample preparation system and use in an integrated analysis system
KR101465701B1 (ko) 2008-01-22 2014-11-28 삼성전자 주식회사 핵산 증폭 장치
US20090186344A1 (en) 2008-01-23 2009-07-23 Caliper Life Sciences, Inc. Devices and methods for detecting and quantitating nucleic acids using size separation of amplicons
EP2238459B1 (en) 2008-01-23 2019-05-08 Roche Diagnostics GmbH Integrated instrument performing synthesis and amplification
US20090215050A1 (en) 2008-02-22 2009-08-27 Robert Delmar Jenison Systems and methods for point-of-care amplification and detection of polynucleotides
CN101538567B (zh) 2008-03-20 2012-09-19 杭州优思达生物技术有限公司 过滤式微量核酸临床样品快速处理方法
WO2009137055A1 (en) 2008-05-05 2009-11-12 Los Alamos National Security, Llc Nanocrystal-based lateral flow microarrays and low-voltage signal detection systems
EP3067694A1 (en) 2008-05-05 2016-09-14 Los Alamos National Security, LLC Lateral flow-based nucleic acid sample preparation device, integrated with passive fluid flow control
WO2010011828A1 (en) 2008-07-23 2010-01-28 Ancora Pharmaceuticals Inc. Automated oligosaccharide synthesizer
EP2163620A1 (de) 2008-09-03 2010-03-17 Qiagen GmbH Verfahren zum Isolieren und Reinigen von Nukleinsäuren
US8408421B2 (en) 2008-09-16 2013-04-02 Tandem Diabetes Care, Inc. Flow regulating stopcocks and related methods
US9156010B2 (en) 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system
CN102164674B (zh) 2008-09-23 2014-07-16 皇家飞利浦电子股份有限公司 热循环设备
EP2172703A1 (en) 2008-10-03 2010-04-07 J & H ApS Emergency light device for marine environments
US8058005B2 (en) 2008-10-23 2011-11-15 Honeywell International Inc. Method for single nucleotide polymorphism and mutation detection using real time polymerase chain reaction microarray
CA2742598A1 (en) 2008-11-04 2010-05-14 Blood Cell Storage, Inc. Nucleic acid extraction on curved glass surfaces
US8110148B2 (en) 2008-11-06 2012-02-07 Siemens Medical Solutions Usa, Inc. Apparatus and method using rotary flow distribution mechanisms
JP5798487B2 (ja) 2008-11-20 2015-10-21 ネーデルランドセ・オルガニサティ・フォール・トゥーヘパスト−ナトゥールウェテンスハッペライク・オンデルズーク・テーエヌオー Ｆｒｅｔに基づく病原体の迅速診断
CN101556277B (zh) 2009-01-05 2012-12-26 艾博生物医药(杭州)有限公司 检测装置
US8058630B2 (en) 2009-01-16 2011-11-15 Fluidigm Corporation Microfluidic devices and methods
WO2010088514A1 (en) 2009-01-30 2010-08-05 Micronics, Inc. Portable high gain fluorescence detection system
US20120064534A1 (en) 2009-03-10 2012-03-15 Juergen Pipper Apparatus for processing a biological and/or chemical sample
US9415392B2 (en) 2009-03-24 2016-08-16 The University Of Chicago Slip chip device and methods
EP3586945A3 (en) 2009-06-05 2020-03-04 IntegenX Inc. Universal sample preparation system and use in an integrated analysis system
US9057097B2 (en) 2009-06-05 2015-06-16 Alere San Diego Inc. Recombinase polymerase amplification reagents and kits
US9625454B2 (en) * 2009-09-04 2017-04-18 The Research Foundation For The State University Of New York Rapid and continuous analyte processing in droplet microfluidic devices
US8008080B2 (en) 2009-09-23 2011-08-30 Ecolab Usa Inc. Valve analytical system
EE201000013A (et) 2010-01-29 2011-10-17 Selfdiagnostics O� Meetod ja kiirtesti seade sihtm„rk-molekuli proovimaterjalist detekteerimiseks
US8791675B2 (en) 2010-03-22 2014-07-29 Pine Valley Investments, Inc. Mobile wireless communications device including removable electrical power supply module and related methods
WO2011127386A2 (en) 2010-04-09 2011-10-13 Life Technologies Corporation Improved thermal uniformity for thermal cycler instrumentation using dynamic control
US8435737B2 (en) 2010-06-02 2013-05-07 Cal Poly Corporation Primers for the rapid and specific detection of propane-oxidizing and butane-oxidizing microorganisms and methods of using same
US20110312751A1 (en) * 2010-06-17 2011-12-22 Geneasys Pty Ltd Microfluidic device for detection of mitochondrial dna via fluorescence modulated by hybridization
US9725754B2 (en) 2010-07-29 2017-08-08 Sean F. Boyle Generic sample preparation
KR20120020528A (ko) 2010-08-30 2012-03-08 삼성전자주식회사 중합효소 연쇄반응 장치
EP2426201A1 (en) 2010-09-06 2012-03-07 Qiagen GmbH Method of isolating purified RNA with reduced DNA contaminations
US20130149710A1 (en) 2010-09-07 2013-06-13 The Arizona Board Of Regents On Behalf Of The University Of Arizona Microdroplet-manipulation systems and methods for automated execution of molecular biological protocols
WO2012039994A1 (en) 2010-09-22 2012-03-29 Corning Incorporated Microporous microfluidic device
US8795592B2 (en) 2010-09-23 2014-08-05 Analogic Corporation Sample thermal cycling
US8945843B2 (en) 2010-12-09 2015-02-03 Analogic Corporation Thermocooler with thermal breaks that thermally isolate a thermocycling region from at least one guard heat region
ES2745140T3 (es) 2011-01-27 2020-02-27 Invisible Sentinel Inc Dispositivos de detección de analitos, dispositivos multiplex y de sobremesa para la detección de analitos y usos de los mismos
US8603835B2 (en) 2011-02-10 2013-12-10 Chembio Diagnostic Systems, Inc. Reduced step dual path immunoassay device and method
WO2012121225A1 (ja) 2011-03-04 2012-09-13 株式会社カネカ 核酸の検出方法及びその方法に用いるデバイス、キット
EP2502674A1 (en) * 2011-03-22 2012-09-26 Koninklijke Philips Electronics N.V. Method for performing molecular reactions by using immiscible intermediate fluids
US20120264202A1 (en) 2011-03-23 2012-10-18 Walker Christopher I System for performing polymerase chain reaction nucleic acid amplification
US9469871B2 (en) 2011-04-14 2016-10-18 Corporos Inc. Methods and apparatus for point-of-care nucleic acid amplification and detection
US8911941B2 (en) 2011-04-14 2014-12-16 Kenneth J. Michlitsch Methods and apparatus for point-of-care nucleic acid amplification and detection
EP2699698B9 (en) * 2011-04-20 2020-07-15 Mesa Biotech, Inc. Oscillating amplification reaction for nucleic acids
WO2013040008A1 (en) 2011-09-12 2013-03-21 University Of Notre Dame Du Lac Systems and methods for bead-free detection of nucleotides
CN104023834B (zh) * 2011-05-04 2016-09-28 卢米耐克斯公司 用于集成的样品制备、反应和检测的设备与方法
JP2012242118A (ja) 2011-05-16 2012-12-10 Canon Inc 流体デバイスを用いる熱処理装置、および流体の処理方法
WO2012159063A2 (en) 2011-05-19 2012-11-22 Blood Cell Strorage, Inc. Gravity flow fluidic device for nucleic acid extraction
US9435765B2 (en) 2011-07-22 2016-09-06 Tecan Trading Ag Cartridge and system for manipulating samples in liquid droplets
US20150258273A1 (en) 2011-08-31 2015-09-17 Forrest W. Payne Electrochemically-Actuated Microfluidic Devices
US9352312B2 (en) 2011-09-23 2016-05-31 Alere Switzerland Gmbh System and apparatus for reactions
US20150136604A1 (en) * 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
US8894946B2 (en) 2011-10-21 2014-11-25 Integenx Inc. Sample preparation, processing and analysis systems
CN104040238B (zh) 2011-11-04 2017-06-27 汉迪拉布公司 多核苷酸样品制备装置
CN108715890A (zh) 2011-11-11 2018-10-30 爱库倍特公司 用于进行扩增子挽救多重聚合酶链式反应(pcr)的系统和方法
CN103988082B (zh) 2011-11-25 2016-09-07 凸版印刷株式会社 试样分析芯片和试样分析方法以及基因分析方法
CN103184143A (zh) 2011-12-29 2013-07-03 三星电子株式会社 固体试剂溶解器件以及使用其溶解固体试剂的方法
WO2013112755A1 (en) 2012-01-24 2013-08-01 The Trustees Of Columbia University In The City Of New York Field optimized assay devices, methods, and systems
US9533308B2 (en) 2012-02-10 2017-01-03 California Institute Of Technology PC board-based polymerase chain reaction systems, methods and materials
US9322054B2 (en) 2012-02-22 2016-04-26 Lockheed Martin Corporation Microfluidic cartridge
US9035204B2 (en) 2012-02-29 2015-05-19 Reliance Controls Corporation Switch assembly with sequentially actuated power and neutral switching
US9207181B2 (en) 2012-03-01 2015-12-08 Quidel Corporation System and apparatus for point-of-care diagnostics
WO2013132645A1 (ja) 2012-03-09 2013-09-12 独立行政法人産業技術総合研究所 核酸増幅方法
US9238833B2 (en) 2012-04-17 2016-01-19 California Institute Of Technology Thermally controlled chamber with optical access for high-performance PCR
US9150907B2 (en) 2012-04-27 2015-10-06 General Electric Company Microfluidic flow cell assemblies and method of use
US9044729B2 (en) 2012-07-27 2015-06-02 International Park Of Creativity Methods and devices for electromagnetic amplification of nucleic acids
CA2879729A1 (en) 2012-08-07 2014-02-13 California Institute Of Technology Ultrafast thermal cycler
US9364833B2 (en) 2012-08-17 2016-06-14 Lexmark International, Inc. Micro-fluidic modules on a chip for diagnostic applications
EP2890966B1 (en) 2012-08-28 2018-03-07 Akonni Biosystems, Inc. Method and kit for purifying nucleic acids
WO2014039703A1 (en) 2012-09-05 2014-03-13 Cepheid Universal docking bay and data door in a fluidic analysis system
WO2014042979A1 (en) 2012-09-11 2014-03-20 Cornell University Apparatus and method for point-of-collection measurement of a biomolecular reaction
US9580679B2 (en) 2012-09-21 2017-02-28 California Institute Of Technology Methods and devices for sample lysis
WO2014085926A1 (en) 2012-12-03 2014-06-12 Vladimir Evtodienko Pressure assisted lateral flow diagnostic device
KR20150097764A (ko) 2012-12-21 2015-08-26 마이크로닉스 인코포레이티드. 휴대형 형광 검출 시스템 및 미량분석 카트리지
WO2014113770A1 (en) 2013-01-21 2014-07-24 Cornell University Smartphone-based apparatus and method for obtaining repeatable, quantitative colorimetric measurement
US20150361419A1 (en) 2013-01-21 2015-12-17 Nanobiosys Inc. Microfluidic chip for extracting nucleic acids, device for extracting nucleic acids comprising same, and method for extracting nucleic acids using same
CA2903382A1 (en) * 2013-03-01 2014-09-12 Wave 80 Biosciences, Inc. Methods and systems for enhanced microfluidic processing
US9995412B2 (en) 2013-03-01 2018-06-12 Wave 80 Biosciences, Inc. Long-throw microfluidic actuator
US9623409B2 (en) 2013-03-11 2017-04-18 Cue Inc. Cartridges, kits, and methods for enhanced mixing for detection and quantification of analytes
US20140274770A1 (en) 2013-03-13 2014-09-18 Quidel Corporation Pcr assays and reagents for molecular detection of infectious agents
KR102529007B1 (ko) 2013-03-15 2023-05-03 나노바이오심 인크. 핵산들 및 단백질들의 모바일 디바이스 분석을 위한 시스템들 및 방법들
CN113025732A (zh) 2013-07-03 2021-06-25 克维拉公司 靶向抗生素敏感性测试的方法
WO2015019522A1 (ja) 2013-08-08 2015-02-12 パナソニック株式会社 核酸増幅デバイス、核酸増幅装置及び核酸増幅方法
WO2015095491A1 (en) 2013-12-19 2015-06-25 The Trustees Of The University Of Pennsylvania Plasma separator apparatus and associated methods
WO2015095853A1 (en) 2013-12-20 2015-06-25 Spot On Sciences, Inc. Whole blood separation sampling apparatus
JP2017503175A (ja) 2013-12-31 2017-01-26 キヤノン ユー．エス． ライフ サイエンシズ， インコーポレイテッドＣａｎｏｎ Ｕ．Ｓ． Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ， Ｉｎｃ． 現場配置可能な小型フォーマットの迅速一次結果マイクロ流体システム
US20180135108A1 (en) 2014-01-20 2018-05-17 Board Of Trustees Of Michigan State University Method for detecting bacterial and fungal pathogens
CN103789198B (zh) * 2014-02-27 2015-09-16 苏州天隆生物科技有限公司 全自动核酸提取仪
WO2015138343A1 (en) 2014-03-10 2015-09-17 Click Diagnostics, Inc. Cartridge-based thermocycler
EP3116651B1 (en) 2014-03-11 2020-04-22 Illumina, Inc. Disposable, integrated microfluidic cartridge and methods of making it
KR102502083B1 (ko) 2014-04-14 2023-02-21 에스알아이 인터내셔널 휴대용 핵산 분석 시스템 및 고성능 미세유체 전기활성 중합체 작동기
DK3134553T3 (da) 2014-04-24 2019-11-18 Lucira Health Inc Kolorimetrisk detektering af nukleinsyreamplifikation
EP2942394A1 (en) 2014-05-09 2015-11-11 Molzym GmbH & Co. KG New method for isolating microbial DNA
US10697007B2 (en) 2014-06-27 2020-06-30 The Regents Of The University Of California PCR-activated sorting (PAS)
EP3167045A4 (en) * 2014-07-11 2018-01-17 Advanced Theranostics Inc. Point of care polymerase chain reaction device for disease detection
WO2016040523A1 (en) 2014-09-12 2016-03-17 Click Diagnostics, Inc. Multiplex optical detection
USD776290S1 (en) 2014-12-31 2017-01-10 W.H.P.M. Bioresearch And Technology Fecal occult blood detector
EP4029606A1 (en) 2014-12-31 2022-07-20 Visby Medical, Inc. Molecular diagnostic testing
ES2784361T3 (es) 2015-01-22 2020-09-24 Becton Dickinson Co Dispositivos y sistemas para la creación de códigos de barras moleculares de dianas de ácido nucleico en células individuales
WO2016172724A1 (en) 2015-04-24 2016-10-27 Mesa Biotech, Inc. Fluidic test cassette
GB201510723D0 (en) 2015-06-18 2015-08-05 Alere Switzerland Gmbh High throughput isothermal nucleic acid amplification
GB2557028A (en) 2015-06-23 2018-06-13 Poc Medical Systems Inc Device and methods to detect biomarkers using ologonucleotides
CN105239164B (zh) 2015-07-22 2017-12-08 广州市达瑞生物技术股份有限公司 一种胎儿游离dna文库定量的标准品及其制备方法
US10040069B2 (en) 2015-07-23 2018-08-07 General Electric Company Amplification and detection of nucleic acids
CN114740213A (zh) 2015-07-24 2022-07-12 塞弗德公司 分子诊断化验系统
IL242807A0 (en) * 2015-11-26 2016-04-21 Novamed Ltd Test facility
CN105349530B (zh) * 2015-12-11 2018-02-27 杭州优思达生物技术有限公司 一种核酸检测方法及检测管
CN109563462B (zh) 2016-01-08 2022-04-22 先进诊疗公司 检测特定核酸序列的完全集成的手持式设备
WO2017151195A1 (en) 2016-02-29 2017-09-08 The Penn State Research Foundation Nucleic acid molecular diagnosis
AU2017232343B2 (en) 2016-03-14 2022-03-31 Pfizer Inc. Devices and methods for modifying optical properties
US11125661B2 (en) 2016-03-14 2021-09-21 Lucira Health. Inc. Devices and methods for biological assay sample preparation and delivery
US11123736B2 (en) 2016-03-14 2021-09-21 Lucira Health, Inc. Systems and methods for performing biological assays
JP2019509740A (ja) 2016-03-14 2019-04-11 ディアスセス インコーポレイテッド 選択的に通気される生物学的アッセイ装置および関連の方法
WO2017185067A1 (en) 2016-04-22 2017-10-26 Click Diagnostics, Inc. Printed circuit board heater for an amplification module
WO2017197040A1 (en) 2016-05-11 2017-11-16 Click Diagnostics, Inc. Devices and methods for nucleic acid extraction
MX2018015889A (es) 2016-06-29 2019-05-27 Click Diagnostics Inc Dispositivos y metodos para la deteccion de moleculas usando una celda de flujo.
CA3029682A1 (en) 2016-06-30 2018-01-04 Click Diagnostics, Inc. Devices and methods for nucleic acid extraction
US11915795B2 (en) 2016-12-23 2024-02-27 The Regents Of The University Of California Method and device for digital high resolution melt
US10146909B2 (en) 2017-04-06 2018-12-04 Diassess Inc. Image-based disease diagnostics using a mobile device
AU2018255430B2 (en) 2017-04-21 2022-12-08 Mesa Biotech, Inc. Fluidic test cassette
US10549275B2 (en) 2017-09-14 2020-02-04 Lucira Health, Inc. Multiplexed biological assay device with electronic readout
CN111655866A (zh) 2017-11-09 2020-09-11 维斯比医学公司 便携式分子诊断装置和检测靶病毒的方法

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