SG11201703376QA - Combination therapy comprising ox40 binding agonists and tigit inhibitors - Google Patents
Combination therapy comprising ox40 binding agonists and tigit inhibitorsInfo
- Publication number
- SG11201703376QA SG11201703376QA SG11201703376QA SG11201703376QA SG11201703376QA SG 11201703376Q A SG11201703376Q A SG 11201703376QA SG 11201703376Q A SG11201703376Q A SG 11201703376QA SG 11201703376Q A SG11201703376Q A SG 11201703376QA SG 11201703376Q A SG11201703376Q A SG 11201703376QA
- Authority
- SG
- Singapore
- Prior art keywords
- combination therapy
- tigit inhibitors
- binding agonists
- agonists
- binding
- Prior art date
Links
- 101100369641 Mus musculus Tigit gene Proteins 0.000 title 1
- 239000000556 agonist Substances 0.000 title 1
- 238000002648 combination therapy Methods 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462076152P | 2014-11-06 | 2014-11-06 | |
PCT/US2015/058087 WO2016073282A1 (en) | 2014-11-06 | 2015-10-29 | Combination therapy comprising ox40 binding agonists and tigit inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201703376QA true SG11201703376QA (en) | 2017-05-30 |
Family
ID=54704069
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201703376QA SG11201703376QA (en) | 2014-11-06 | 2015-10-29 | Combination therapy comprising ox40 binding agonists and tigit inhibitors |
Country Status (15)
Country | Link |
---|---|
US (3) | US20160152720A1 (es) |
EP (1) | EP3215536A1 (es) |
JP (1) | JP2017534633A (es) |
KR (1) | KR20170072343A (es) |
CN (1) | CN107073126A (es) |
AR (1) | AR102553A1 (es) |
AU (1) | AU2015343494A1 (es) |
BR (1) | BR112017008628A2 (es) |
CA (1) | CA2963974A1 (es) |
IL (1) | IL251618A0 (es) |
MX (1) | MX2017005929A (es) |
RU (1) | RU2017119428A (es) |
SG (1) | SG11201703376QA (es) |
TW (1) | TW201628650A (es) |
WO (1) | WO2016073282A1 (es) |
Families Citing this family (36)
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DE60335552D1 (de) | 2002-09-11 | 2011-02-10 | Genentech Inc | Neue zusammensetzung und verfahren zur behandlung von immunerkrankungen |
SG10201402815VA (en) | 2008-04-09 | 2014-09-26 | Genentech Inc | Novel compositions and methods for the treatment of immune related diseases |
MX2015013288A (es) | 2013-03-18 | 2016-04-07 | Biocerox Prod Bv | Anticuerpos anti-cd134 (ox40) humanizados y usos de los mismos. |
US9873740B2 (en) | 2013-07-16 | 2018-01-23 | Genentech, Inc. | Methods of treating cancer using PD-1 axis binding antagonists and TIGIT inhibitors |
EP3126386A1 (en) * | 2014-03-31 | 2017-02-08 | F. Hoffmann-La Roche AG | Combination therapy comprising anti-angiogenesis agents and ox40 binding agonists |
CN113583131B (zh) | 2014-08-19 | 2024-09-03 | 默沙东有限责任公司 | 抗tigit抗体 |
SG11201703448QA (en) | 2014-11-03 | 2017-05-30 | Genentech Inc | Assays for detecting t cell immune subsets and methods of use thereof |
MX2017005751A (es) | 2014-11-03 | 2018-04-10 | Genentech Inc | Métodos y biomarcadores para predecir la eficacia y evaluación de un tratamiento con agonista de ox40. |
MY189692A (en) | 2015-05-07 | 2022-02-26 | Memorial Sloan Kettering Cancer Center | Anti-ox40 antibodies and methods of use thereof |
TWI715587B (zh) | 2015-05-28 | 2021-01-11 | 美商安可美德藥物股份有限公司 | Tigit結合劑和彼之用途 |
US9644032B2 (en) | 2015-05-29 | 2017-05-09 | Bristol-Myers Squibb Company | Antibodies against OX40 and uses thereof |
CN115925931A (zh) | 2015-08-14 | 2023-04-07 | 默沙东公司 | 抗tigit抗体 |
TWI811892B (zh) | 2015-09-25 | 2023-08-11 | 美商建南德克公司 | 抗tigit抗體及使用方法 |
RU2020124191A (ru) | 2015-10-01 | 2020-08-27 | Потенза Терапевтикс, Инк. | Анти-tigit антиген-связывающие белки и способы их применения |
MA43017A (fr) | 2015-10-02 | 2018-08-08 | Hoffmann La Roche | Anticorps bispécifiques spécifiques d'un récepteur de co-stimulation du tnf |
IL299072A (en) | 2015-12-02 | 2023-02-01 | Memorial Sloan Kettering Cancer Center | Antibodies and methods for using them |
CA3014934A1 (en) | 2016-03-04 | 2017-09-08 | JN Biosciences, LLC | Antibodies to tigit |
CN109414490A (zh) * | 2016-07-01 | 2019-03-01 | 小利兰·斯坦福大学理事会 | 抑制性免疫受体抑制方法和组合物 |
JP2019530434A (ja) | 2016-08-05 | 2019-10-24 | ジェネンテック, インコーポレイテッド | アゴニスト活性を有する多価及び多重エピトープ抗体ならびに使用方法 |
WO2018089628A1 (en) | 2016-11-09 | 2018-05-17 | Agenus Inc. | Anti-ox40 antibodies, anti-gitr antibodies, and methods of use thereof |
EP3548071A4 (en) | 2016-11-30 | 2020-07-15 | OncoMed Pharmaceuticals, Inc. | METHOD FOR TREATING CANCER WITH TIGIT-BINDING ACTIVE SUBSTANCES |
JOP20190203A1 (ar) | 2017-03-30 | 2019-09-03 | Potenza Therapeutics Inc | بروتينات رابطة لمولد ضد مضادة لـ tigit وطرق استخدامها |
TWI805582B (zh) | 2017-05-01 | 2023-06-21 | 美商艾吉納斯公司 | 抗tigit抗體類和使用彼等之方法 |
MX2019012076A (es) | 2017-05-30 | 2019-12-09 | Bristol Myers Squibb Co | Composiciones que comprenden un anticuerpo anti gen-3 de activacion del linfocito (lag-3) o un anticuerpo anti-lag-3 y un anticuerpo anti muerte celular programada 1 (pd-1) o anti ligando 1 de muerte celular programada (pd-l1). |
CA3060989A1 (en) * | 2017-05-30 | 2018-12-06 | Bristol-Myers Squibb Company | Compositions comprising a combination of an anti-lag-3 antibody, a pd-1 pathway inhibitor, and an immunotherapeutic agent |
MX2019012032A (es) | 2017-05-30 | 2019-10-30 | Bristol Myers Squibb Co | Tratamiento de tumores positivos a gen 3 de activacion de linfocitos (lag-3). |
WO2018229163A1 (en) | 2017-06-14 | 2018-12-20 | King's College London | Methods of activating v delta 2 negative gamma delta t cells |
US20200407445A1 (en) | 2017-07-27 | 2020-12-31 | Iteos Therapeutics Sa | Anti-tigit antibodies |
BR112020023746A2 (pt) | 2018-05-23 | 2021-02-17 | Beigene, Ltd. | anticorpo, composição farmacêutica, método para tratar câncer, ácido nucleico isolado, vetor, célula hospedeira, processo para a produção de um anticorpo e reagente de diagnóstico |
TWI831792B (zh) * | 2018-06-12 | 2024-02-11 | 合一生技股份有限公司 | 靶向淋巴細胞活化基因3(lag-3)的核酸適體及其用途 |
CN112638401A (zh) | 2018-06-29 | 2021-04-09 | 璟尚生物制药公司 | 抗肿瘤拮抗剂 |
CN112638944A (zh) | 2018-08-23 | 2021-04-09 | 西进公司 | 抗tigit抗体 |
JP2023502323A (ja) * | 2019-11-21 | 2023-01-24 | ベイジーン リミテッド | 抗tigit抗体との組合せで抗ox40抗体を用いる癌治療の方法 |
US20230002499A1 (en) * | 2019-11-21 | 2023-01-05 | Beigene (Beijing) Co., Ltd. | Methods of cancer treatment with anti-ox40 antibody in combination with chemotherapeutic agents |
US11820824B2 (en) | 2020-06-02 | 2023-11-21 | Arcus Biosciences, Inc. | Antibodies to TIGIT |
AR125753A1 (es) | 2021-05-04 | 2023-08-09 | Agenus Inc | Anticuerpos anti-tigit, anticuerpos anti-cd96 y métodos de uso de estos |
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-
2015
- 2015-10-29 RU RU2017119428A patent/RU2017119428A/ru not_active Application Discontinuation
- 2015-10-29 SG SG11201703376QA patent/SG11201703376QA/en unknown
- 2015-10-29 AU AU2015343494A patent/AU2015343494A1/en not_active Abandoned
- 2015-10-29 JP JP2017523893A patent/JP2017534633A/ja active Pending
- 2015-10-29 EP EP15801009.0A patent/EP3215536A1/en not_active Withdrawn
- 2015-10-29 MX MX2017005929A patent/MX2017005929A/es unknown
- 2015-10-29 CA CA2963974A patent/CA2963974A1/en not_active Abandoned
- 2015-10-29 US US14/927,110 patent/US20160152720A1/en not_active Abandoned
- 2015-10-29 KR KR1020177014991A patent/KR20170072343A/ko unknown
- 2015-10-29 WO PCT/US2015/058087 patent/WO2016073282A1/en active Application Filing
- 2015-10-29 BR BR112017008628A patent/BR112017008628A2/pt not_active Application Discontinuation
- 2015-10-29 CN CN201580059476.5A patent/CN107073126A/zh active Pending
- 2015-11-05 AR ARP150103599A patent/AR102553A1/es unknown
- 2015-11-06 TW TW104136746A patent/TW201628650A/zh unknown
-
2017
- 2017-04-06 IL IL251618A patent/IL251618A0/en unknown
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2018
- 2018-06-26 US US16/019,065 patent/US20190194339A1/en not_active Abandoned
-
2019
- 2019-02-08 US US16/271,520 patent/US20190169304A1/en not_active Abandoned
Also Published As
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CA2963974A1 (en) | 2016-05-12 |
RU2017119428A (ru) | 2018-12-06 |
US20160152720A1 (en) | 2016-06-02 |
EP3215536A1 (en) | 2017-09-13 |
WO2016073282A1 (en) | 2016-05-12 |
JP2017534633A (ja) | 2017-11-24 |
MX2017005929A (es) | 2017-11-20 |
TW201628650A (zh) | 2016-08-16 |
CN107073126A (zh) | 2017-08-18 |
KR20170072343A (ko) | 2017-06-26 |
IL251618A0 (en) | 2017-06-29 |
BR112017008628A2 (pt) | 2018-01-30 |
US20190169304A1 (en) | 2019-06-06 |
RU2017119428A3 (es) | 2019-10-25 |
US20190194339A1 (en) | 2019-06-27 |
AU2015343494A1 (en) | 2017-04-27 |
AR102553A1 (es) | 2017-03-08 |
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