SG11201601885WA - Complex containing oligonucleotide having immunopotentiating activity and use thereof - Google Patents

Complex containing oligonucleotide having immunopotentiating activity and use thereof

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Publication number
SG11201601885WA
SG11201601885WA SG11201601885WA SG11201601885WA SG11201601885WA SG 11201601885W A SG11201601885W A SG 11201601885WA SG 11201601885W A SG11201601885W A SG 11201601885WA SG 11201601885W A SG11201601885W A SG 11201601885WA SG 11201601885W A SG11201601885W A SG 11201601885WA
Authority
SG
Singapore
Prior art keywords
complex containing
containing oligonucleotide
immunopotentiating activity
immunopotentiating
activity
Prior art date
Application number
SG11201601885WA
Other languages
English (en)
Inventor
Ken Ishii
Kouji Kobiyama
Taiki Aoshi
Fumihiko Takeshita
Yuji Kasuya
Takako Niwa
Makoto Koizumi
Original Assignee
Nat Inst Of Biomedical Innovation Health And Nutrition
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nat Inst Of Biomedical Innovation Health And Nutrition, Daiichi Sankyo Co Ltd filed Critical Nat Inst Of Biomedical Innovation Health And Nutrition
Publication of SG11201601885WA publication Critical patent/SG11201601885WA/en

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    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
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    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
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    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
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    • A61K47/6939—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being a polysaccharide, e.g. starch, chitosan, chitin, cellulose or pectin
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/17—Immunomodulatory nucleic acids
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
    • C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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SG11201601885WA 2013-09-20 2014-09-19 Complex containing oligonucleotide having immunopotentiating activity and use thereof SG11201601885WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2013196206 2013-09-20
PCT/JP2014/074835 WO2015041318A1 (ja) 2013-09-20 2014-09-19 免疫賦活活性を有するオリゴヌクレオチド含有複合体及びその用途

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SG11201601885WA true SG11201601885WA (en) 2016-04-28

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US (2) US10202606B2 (ja)
EP (3) EP3572511B1 (ja)
JP (4) JP6525455B2 (ja)
KR (2) KR102400963B1 (ja)
CN (3) CN114762695A (ja)
AU (2) AU2014322046B2 (ja)
BR (1) BR112016005966B1 (ja)
CA (1) CA2923806C (ja)
ES (2) ES2749627T3 (ja)
MX (2) MX2016003668A (ja)
MY (1) MY178288A (ja)
NZ (1) NZ718900A (ja)
PH (1) PH12016500464A1 (ja)
PL (1) PL3048170T3 (ja)
RU (2) RU2723943C2 (ja)
SG (2) SG10201802199TA (ja)
TW (3) TWI798557B (ja)
WO (1) WO2015041318A1 (ja)

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EP3103807B1 (en) * 2014-02-06 2021-08-25 Japan Science And Technology Agency Peptide/ beta-1,3-glucan complex and production method therefor, and pharmaceutical composition containing peptide/ beta-1,3-glucan complex
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