SG11201507223TA - Macrocyclic and bicyclic inhibitors of hepatitis c virus - Google Patents

Macrocyclic and bicyclic inhibitors of hepatitis c virus

Info

Publication number
SG11201507223TA
SG11201507223TA SG11201507223TA SG11201507223TA SG11201507223TA SG 11201507223T A SG11201507223T A SG 11201507223TA SG 11201507223T A SG11201507223T A SG 11201507223TA SG 11201507223T A SG11201507223T A SG 11201507223TA SG 11201507223T A SG11201507223T A SG 11201507223TA
Authority
SG
Singapore
Prior art keywords
macrocyclic
hepatitis
virus
bicyclic inhibitors
bicyclic
Prior art date
Application number
SG11201507223TA
Other languages
English (en)
Inventor
Kyla Bjornson
Kapil K Karki
John O Link
Hyung-Jung Pyun
Adam J Schrier
Kirk L Stevens
James G Taylor
Randall W Vivian
Jeff Zablocki
Sheila Zipfel
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of SG11201507223TA publication Critical patent/SG11201507223TA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64Cyclic peptides containing only normal peptide links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D203/00Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/02Preparation by ring-closure
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
SG11201507223TA 2013-03-15 2014-03-14 Macrocyclic and bicyclic inhibitors of hepatitis c virus SG11201507223TA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361798961P 2013-03-15 2013-03-15
PCT/US2014/029765 WO2014145095A1 (en) 2013-03-15 2014-03-14 Macrocyclic and bicyclic inhibitors of hepatitis c virus

Publications (1)

Publication Number Publication Date
SG11201507223TA true SG11201507223TA (en) 2015-10-29

Family

ID=50694007

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201507223TA SG11201507223TA (en) 2013-03-15 2014-03-14 Macrocyclic and bicyclic inhibitors of hepatitis c virus

Country Status (15)

Country Link
US (2) US9617310B2 (zh)
EP (1) EP2970335B1 (zh)
JP (2) JP6511432B2 (zh)
KR (1) KR102215400B1 (zh)
CN (1) CN105073758B (zh)
AU (1) AU2014233390B2 (zh)
BR (1) BR112015021768A2 (zh)
CA (1) CA2902569A1 (zh)
EA (1) EA029088B1 (zh)
ES (1) ES2735355T3 (zh)
HK (1) HK1217196A1 (zh)
IL (1) IL240662A0 (zh)
MX (1) MX2015013224A (zh)
SG (1) SG11201507223TA (zh)
WO (1) WO2014145095A1 (zh)

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* Cited by examiner, † Cited by third party
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UA119315C2 (uk) 2012-07-03 2019-06-10 Гіліад Фармассет Елелсі Інгібітори вірусу гепатиту с
ES2892123T3 (es) 2014-12-26 2022-02-02 Univ Emory Derivados antivíricos de N4-hidroxicitidina
CN105503751B (zh) * 2015-12-22 2018-06-05 广西师范大学 一种喹喔啉衍生物的高效合成方法
GB2581936B (en) 2017-12-07 2021-02-10 Univ Emory N4-hydroxycytidine and derivatives and anti-viral uses related thereto
CN108329332A (zh) * 2018-03-16 2018-07-27 安徽华昌高科药业有限公司 一种制备Glecaprevir的方法
CN111004188B (zh) * 2019-12-18 2021-04-20 安徽红杉生物医药科技有限公司 Ns3/4a蛋白酶抑制剂中间体及其合成方法、应用
CN111018795B (zh) * 2019-12-25 2023-03-28 上海彩迩文生化科技有限公司 一种碱性条件下合成喹喔啉-3-酮的方法

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Also Published As

Publication number Publication date
IL240662A0 (en) 2015-10-29
US20170313745A1 (en) 2017-11-02
ES2735355T3 (es) 2019-12-18
EA201591456A1 (ru) 2016-02-29
JP2019059775A (ja) 2019-04-18
BR112015021768A2 (pt) 2016-02-02
CN105073758B (zh) 2017-08-11
US9617310B2 (en) 2017-04-11
EP2970335B1 (en) 2019-05-08
CA2902569A1 (en) 2014-09-18
EA029088B1 (ru) 2018-02-28
AU2014233390B2 (en) 2018-03-01
JP2016516069A (ja) 2016-06-02
MX2015013224A (es) 2015-12-11
HK1217196A1 (zh) 2016-12-30
JP6511432B2 (ja) 2019-05-15
KR20150130456A (ko) 2015-11-23
AU2014233390A1 (en) 2015-09-03
CN105073758A (zh) 2015-11-18
KR102215400B1 (ko) 2021-02-10
US20140274884A1 (en) 2014-09-18
WO2014145095A1 (en) 2014-09-18
EP2970335A1 (en) 2016-01-20

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