US3773919A
(en)
|
1969-10-23 |
1973-11-20 |
Du Pont |
Polylactide-drug mixtures
|
US3710795A
(en)
|
1970-09-29 |
1973-01-16 |
Alza Corp |
Drug-delivery device with stretched, rate-controlling membrane
|
US4044126A
(en)
|
1972-04-20 |
1977-08-23 |
Allen & Hanburys Limited |
Steroidal aerosol compositions and process for the preparation thereof
|
GB1429184A
(en)
|
1972-04-20 |
1976-03-24 |
Allen & Hanburys Ltd |
Physically anti-inflammatory steroids for use in aerosols
|
USRE28819E
(en)
|
1972-12-08 |
1976-05-18 |
Syntex (U.S.A.) Inc. |
Dialkylated glycol compositions and medicament preparations containing same
|
US4444887A
(en)
|
1979-12-10 |
1984-04-24 |
Sloan-Kettering Institute |
Process for making human antibody producing B-lymphocytes
|
US4328245A
(en)
|
1981-02-13 |
1982-05-04 |
Syntex (U.S.A.) Inc. |
Carbonate diester solutions of PGE-type compounds
|
US4410545A
(en)
|
1981-02-13 |
1983-10-18 |
Syntex (U.S.A.) Inc. |
Carbonate diester solutions of PGE-type compounds
|
US4358603A
(en)
|
1981-04-16 |
1982-11-09 |
Syntex (U.S.A.) Inc. |
Acetal stabilized prostaglandin compositions
|
US4485045A
(en)
|
1981-07-06 |
1984-11-27 |
Research Corporation |
Synthetic phosphatidyl cholines useful in forming liposomes
|
US4409239A
(en)
|
1982-01-21 |
1983-10-11 |
Syntex (U.S.A.) Inc. |
Propylene glycol diester solutions of PGE-type compounds
|
EP0092918B1
(fr)
|
1982-04-22 |
1988-10-19 |
Imperial Chemical Industries Plc |
Formulations à libération continue
|
US4522811A
(en)
|
1982-07-08 |
1985-06-11 |
Syntex (U.S.A.) Inc. |
Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
|
US4716111A
(en)
|
1982-08-11 |
1987-12-29 |
Trustees Of Boston University |
Process for producing human antibodies
|
GB8308235D0
(en)
|
1983-03-25 |
1983-05-05 |
Celltech Ltd |
Polypeptides
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
US4544545A
(en)
|
1983-06-20 |
1985-10-01 |
Trustees University Of Massachusetts |
Liposomes containing modified cholesterol for organ targeting
|
US5807715A
(en)
|
1984-08-27 |
1998-09-15 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
|
US5128326A
(en)
|
1984-12-06 |
1992-07-07 |
Biomatrix, Inc. |
Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same
|
US4980286A
(en)
|
1985-07-05 |
1990-12-25 |
Whitehead Institute For Biomedical Research |
In vivo introduction and expression of foreign genetic material in epithelial cells
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
JP3101690B2
(ja)
|
1987-03-18 |
2000-10-23 |
エス・ビィ・2・インコーポレイテッド |
変性抗体の、または変性抗体に関する改良
|
US4880078A
(en)
|
1987-06-29 |
1989-11-14 |
Honda Giken Kogyo Kabushiki Kaisha |
Exhaust muffler
|
US5336603A
(en)
|
1987-10-02 |
1994-08-09 |
Genentech, Inc. |
CD4 adheson variants
|
DE68921982T4
(de)
|
1988-06-14 |
1996-04-25 |
Cetus Oncology Corp |
Kupplungsmittel und sterisch gehinderte, mit disulfid gebundene konjugate daraus.
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
DE768377T1
(de)
|
1988-09-02 |
1998-01-02 |
Dyax Corp |
Herstellung und Auswahl von Rekombinantproteinen mit verschiedenen Bindestellen
|
KR900005995A
(ko)
|
1988-10-31 |
1990-05-07 |
우메모또 요시마사 |
변형 인터류킨-2 및 그의 제조방법
|
US5734033A
(en)
|
1988-12-22 |
1998-03-31 |
The Trustees Of The University Of Pennsylvania |
Antisense oligonucleotides inhibiting human bcl-2 gene expression
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
EP0394827A1
(fr)
|
1989-04-26 |
1990-10-31 |
F. Hoffmann-La Roche Ag |
Polypeptides chimériques de CD4-immunoglobuline
|
IE63847B1
(en)
|
1989-05-05 |
1995-06-14 |
Res Dev Foundation |
A novel antibody delivery system for biological response modifiers
|
US5112946A
(en)
|
1989-07-06 |
1992-05-12 |
Repligen Corporation |
Modified pf4 compositions and methods of use
|
US5413923A
(en)
|
1989-07-25 |
1995-05-09 |
Cell Genesys, Inc. |
Homologous recombination for universal donor cells and chimeric mammalian hosts
|
WO1991005548A1
(fr)
|
1989-10-10 |
1991-05-02 |
Pitman-Moore, Inc. |
Composition a liberation entretenue pour proteines macromoleculaires
|
US5013556A
(en)
|
1989-10-20 |
1991-05-07 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
WO1991006570A1
(fr)
|
1989-10-25 |
1991-05-16 |
The University Of Melbourne |
MOLECULES RECEPTRICES Fc HYBRIDES
|
EP0550436A1
(fr)
|
1989-11-06 |
1993-07-14 |
Alkermes Controlled Therapeutics, Inc. |
Microspheres de proteines et leurs procedes d'utilisation
|
GB8928874D0
(en)
|
1989-12-21 |
1990-02-28 |
Celltech Ltd |
Humanised antibodies
|
US5585112A
(en)
|
1989-12-22 |
1996-12-17 |
Imarx Pharmaceutical Corp. |
Method of preparing gas and gaseous precursor-filled microspheres
|
WO1991010737A1
(fr)
|
1990-01-11 |
1991-07-25 |
Molecular Affinities Corporation |
Production d'anticorps utilisant des librairies de genes
|
US5780225A
(en)
|
1990-01-12 |
1998-07-14 |
Stratagene |
Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
|
EP0463151B1
(fr)
|
1990-01-12 |
1996-06-12 |
Cell Genesys, Inc. |
Generation d'anticorps xenogeniques
|
US5314995A
(en)
|
1990-01-22 |
1994-05-24 |
Oncogen |
Therapeutic interleukin-2-antibody based fusion proteins
|
CA2078689C
(fr)
|
1990-03-20 |
2003-02-11 |
Sherie L. Morrison |
Anticorps chimeriques dont des ligands se liant au recepteur remplacent une partie de la region constante de la chaine
|
IT1246382B
(it)
|
1990-04-17 |
1994-11-18 |
Eurand Int |
Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
US5349053A
(en)
|
1990-06-01 |
1994-09-20 |
Protein Design Labs, Inc. |
Chimeric ligand/immunoglobulin molecules and their uses
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
US5814318A
(en)
|
1990-08-29 |
1998-09-29 |
Genpharm International Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
ES2108048T3
(es)
|
1990-08-29 |
1997-12-16 |
Genpharm Int |
Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos.
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
US5698426A
(en)
|
1990-09-28 |
1997-12-16 |
Ixsys, Incorporated |
Surface expression libraries of heteromeric receptors
|
US5543390A
(en)
|
1990-11-01 |
1996-08-06 |
State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University |
Covalent microparticle-drug conjugates for biological targeting
|
CA2095836C
(fr)
|
1990-11-09 |
1999-04-06 |
Stephen D. Gillies |
Immunoconjugues de la cytokine
|
DE69129154T2
(de)
|
1990-12-03 |
1998-08-20 |
Genentech Inc |
Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften
|
CA2074825C
(fr)
|
1990-12-14 |
2005-04-12 |
Daniel J. Capon |
Chaines chimeriques pour cheminements de signaux de recepteurs
|
ES2315612T3
(es)
|
1991-04-10 |
2009-04-01 |
The Scripps Research Institute |
Genotecas de receptores heterodimericos usando fagemidos.
|
US5290540A
(en)
|
1991-05-01 |
1994-03-01 |
Henry M. Jackson Foundation For The Advancement Of Military Medicine |
Method for treating infectious respiratory diseases
|
DE69233482T2
(de)
|
1991-05-17 |
2006-01-12 |
Merck & Co., Inc. |
Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
|
EP1400536A1
(fr)
|
1991-06-14 |
2004-03-24 |
Genentech Inc. |
Procédé pour fabriquer des anticorps humanisés
|
EP0590067A1
(fr)
|
1991-06-14 |
1994-04-06 |
Xoma Corporation |
Fragments d'anticorps produits par des microbes et leurs conjugues
|
US5844095A
(en)
|
1991-06-27 |
1998-12-01 |
Bristol-Myers Squibb Company |
CTLA4 Ig fusion proteins
|
US5565332A
(en)
|
1991-09-23 |
1996-10-15 |
Medical Research Council |
Production of chimeric antibodies - a combinatorial approach
|
ES2341666T3
(es)
|
1991-12-02 |
2010-06-24 |
Medimmune Limited |
Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos.
|
DE69233204T2
(de)
|
1991-12-13 |
2004-07-15 |
Xoma Corp., Berkeley |
Verfahren und materialien zur herstellung von modifizierten variablen antikörperdomänen und ihre therapeutische verwendung
|
US5824307A
(en)
|
1991-12-23 |
1998-10-20 |
Medimmune, Inc. |
Human-murine chimeric antibodies against respiratory syncytial virus
|
US5622929A
(en)
|
1992-01-23 |
1997-04-22 |
Bristol-Myers Squibb Company |
Thioether conjugates
|
US6271242B1
(en)
|
1992-02-10 |
2001-08-07 |
Bristol-Myers Squibb Co. |
Method for treating cancer using a tyrosine protein kinase inhibitor
|
GB9203459D0
(en)
|
1992-02-19 |
1992-04-08 |
Scotgen Ltd |
Antibodies with germ-line variable regions
|
US5912015A
(en)
|
1992-03-12 |
1999-06-15 |
Alkermes Controlled Therapeutics, Inc. |
Modulated release from biocompatible polymers
|
US5733743A
(en)
|
1992-03-24 |
1998-03-31 |
Cambridge Antibody Technology Limited |
Methods for producing members of specific binding pairs
|
US6010715A
(en)
|
1992-04-01 |
2000-01-04 |
Bertek, Inc. |
Transdermal patch incorporating a polymer film incorporated with an active agent
|
US5447851B1
(en)
|
1992-04-02 |
1999-07-06 |
Univ Texas System Board Of |
Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells
|
US6024975A
(en)
|
1992-04-08 |
2000-02-15 |
Americare International Diagnostics, Inc. |
Method of transdermally administering high molecular weight drugs with a polymer skin enhancer
|
US6005079A
(en)
|
1992-08-21 |
1999-12-21 |
Vrije Universiteit Brussels |
Immunoglobulins devoid of light chains
|
DE69334305D1
(de)
|
1992-08-21 |
2010-01-28 |
Univ Bruxelles |
Immunoglobuline ohne leichte Ketten
|
US5639641A
(en)
|
1992-09-09 |
1997-06-17 |
Immunogen Inc. |
Resurfacing of rodent antibodies
|
US5441050A
(en)
|
1992-12-18 |
1995-08-15 |
Neoprobe Corporation |
Radiation responsive surgical instrument
|
US5934272A
(en)
|
1993-01-29 |
1999-08-10 |
Aradigm Corporation |
Device and method of creating aerosolized mist of respiratory drug
|
US6274552B1
(en)
|
1993-03-18 |
2001-08-14 |
Cytimmune Sciences, Inc. |
Composition and method for delivery of biologically-active factors
|
US5985307A
(en)
|
1993-04-14 |
1999-11-16 |
Emory University |
Device and method for non-occlusive localized drug delivery
|
US5523092A
(en)
|
1993-04-14 |
1996-06-04 |
Emory University |
Device for local drug delivery and methods for using the same
|
DK0698097T3
(da)
|
1993-04-29 |
2001-10-08 |
Unilever Nv |
Produktion af antistoffer eller (funktionaliserede) fragmenter deraf afledt af Camelidae-immunoglobuliner med tung kæde
|
US5728868A
(en)
|
1993-07-15 |
1998-03-17 |
Cancer Research Campaign Technology Limited |
Prodrugs of protein tyrosine kinase inhibitors
|
US6004534A
(en)
|
1993-07-23 |
1999-12-21 |
Massachusetts Institute Of Technology |
Targeted polymerized liposomes for improved drug delivery
|
US5821332A
(en)
|
1993-11-03 |
1998-10-13 |
The Board Of Trustees Of The Leland Stanford Junior University |
Receptor on the surface of activated CD4+ T-cells: ACT-4
|
WO1995015982A2
(fr)
|
1993-12-08 |
1995-06-15 |
Genzyme Corporation |
Procede de generation d'anticorps specifiques
|
US5925376C1
(en)
|
1994-01-10 |
2001-03-20 |
Madalene C Y Heng |
Method for treating psoriasis using selected phosphorylase kinase inhibitor and additional compounds
|
US5618709A
(en)
|
1994-01-14 |
1997-04-08 |
University Of Pennsylvania |
Antisense oligonucleotides specific for STK-1 and method for inhibiting expression of the STK-1 protein
|
ES2201097T3
(es)
|
1994-01-31 |
2004-03-16 |
Trustees Of Boston University |
Bibliotecas de anticuerpos policlonales.
|
US5759546A
(en)
|
1994-02-04 |
1998-06-02 |
Weinberg; Andrew D. |
Treatment of CD4 T-cell mediated conditions
|
US6242566B1
(en)
|
1994-02-10 |
2001-06-05 |
Board Of Trustees Of The Leland Stanford Junior University |
Ligand (ACT-4-L) to a receptor on the surface of activated CD4+ T-cells
|
US5837458A
(en)
|
1994-02-17 |
1998-11-17 |
Maxygen, Inc. |
Methods and compositions for cellular and metabolic engineering
|
US5834252A
(en)
|
1995-04-18 |
1998-11-10 |
Glaxo Group Limited |
End-complementary polymerase reaction
|
US5605793A
(en)
|
1994-02-17 |
1997-02-25 |
Affymax Technologies N.V. |
Methods for in vitro recombination
|
US5516637A
(en)
|
1994-06-10 |
1996-05-14 |
Dade International Inc. |
Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage
|
GB9415379D0
(en)
|
1994-07-29 |
1994-09-21 |
Smithkline Beecham Plc |
Novel compounds
|
AU3382595A
(en)
|
1994-07-29 |
1996-03-04 |
Smithkline Beecham Corporation |
Novel compounds
|
US5759542A
(en)
|
1994-08-05 |
1998-06-02 |
New England Deaconess Hospital Corporation |
Compositions and methods for the delivery of drugs by platelets for the treatment of cardiovascular and other diseases
|
US5587459A
(en)
|
1994-08-19 |
1996-12-24 |
Regents Of The University Of Minnesota |
Immunoconjugates comprising tyrosine kinase inhibitors
|
US5911995A
(en)
|
1994-08-19 |
1999-06-15 |
Regents Of The University Of Minnesota |
EGF-genistein conjugates for the treatment of cancer
|
US5660854A
(en)
|
1994-11-28 |
1997-08-26 |
Haynes; Duncan H |
Drug releasing surgical implant or dressing material
|
DE69630514D1
(de)
|
1995-01-05 |
2003-12-04 |
Univ Michigan |
Oberflächen-modifizierte nanopartikel und verfahren für ihre herstellung und verwendung
|
EP1323346B1
(fr)
|
1995-01-17 |
2006-06-28 |
The Brigham And Women's Hospital, Inc. |
Transport épithélial spécifique de récepteurs d'immunogènes
|
US6030613A
(en)
|
1995-01-17 |
2000-02-29 |
The Brigham And Women's Hospital, Inc. |
Receptor specific transepithelial transport of therapeutics
|
GB9501567D0
(en)
|
1995-01-26 |
1995-03-15 |
Pharmacia Spa |
Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors
|
US5998596A
(en)
|
1995-04-04 |
1999-12-07 |
The United States Of America As Represented By The Department Of Health And Human Services |
Inhibition of protein kinase activity by aptameric action of oligonucleotides
|
US6019968A
(en)
|
1995-04-14 |
2000-02-01 |
Inhale Therapeutic Systems, Inc. |
Dispersible antibody compositions and methods for their preparation and use
|
US5983134A
(en)
|
1995-04-23 |
1999-11-09 |
Electromagnetic Bracing Systems Inc. |
Electrophoretic cuff apparatus drug delivery system
|
CA2219361C
(fr)
|
1995-04-27 |
2012-02-28 |
Abgenix, Inc. |
Anticorps humains derives d'une xenosouris immunisee
|
WO1996034096A1
(fr)
|
1995-04-28 |
1996-10-31 |
Abgenix, Inc. |
Anticorps humains derives de xeno-souris immunisees
|
EP0841068B1
(fr)
|
1995-06-01 |
2006-07-12 |
Kishimoto, Tadamitsu |
Inhibiteur de la croissance de cellules leucemiques contenant des derives oligonucleotidiques antisens agissant contre le gene de la tumeur de wilms (wt1)
|
US6316652B1
(en)
|
1995-06-06 |
2001-11-13 |
Kosta Steliou |
Drug mitochondrial targeting agents
|
GB9515975D0
(en)
|
1995-08-04 |
1995-10-04 |
Zeneca Ltd |
Chemical compounds
|
US6167301A
(en)
|
1995-08-29 |
2000-12-26 |
Flower; Ronald J. |
Iontophoretic drug delivery device having high-efficiency DC-to-DC energy conversion circuit
|
US5916597A
(en)
|
1995-08-31 |
1999-06-29 |
Alkermes Controlled Therapeutics, Inc. |
Composition and method using solid-phase particles for sustained in vivo release of a biologically active agent
|
US5863904A
(en)
|
1995-09-26 |
1999-01-26 |
The University Of Michigan |
Methods for treating cancers and restenosis with P21
|
GB9601081D0
(en)
|
1995-10-06 |
1996-03-20 |
Cambridge Antibody Tech |
Specific binding members for human transforming growth factor beta;materials and methods
|
US6039975A
(en)
|
1995-10-17 |
2000-03-21 |
Hoffman-La Roche Inc. |
Colon targeted delivery system
|
US6127366A
(en)
|
1995-11-22 |
2000-10-03 |
Merck & Co., Inc. |
Inhibitors of farnesyl-protein transferase
|
EA000710B1
(ru)
|
1995-12-08 |
2000-02-28 |
Жансен Фармасетика Н.В. |
(имидазол-5-ил)метил-2-хинолиноновые производные, ингибирующие фарнезилпротеин-трансферазу
|
US5723125A
(en)
|
1995-12-28 |
1998-03-03 |
Tanox Biosystems, Inc. |
Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide
|
US5958769A
(en)
|
1996-01-18 |
1999-09-28 |
Fred Hutchinson Cancer Research Center |
Compositions and methods for mediating cell cycle progression
|
JP2978435B2
(ja)
|
1996-01-24 |
1999-11-15 |
チッソ株式会社 |
アクリロキシプロピルシランの製造方法
|
US6066738A
(en)
|
1996-01-30 |
2000-05-23 |
Merck & Co., Inc. |
Inhibitors of farnesyl-protein transferase
|
US6090948A
(en)
|
1996-01-30 |
2000-07-18 |
Merck & Co., Inc. |
Inhibitors of farnesyl-protein transferase
|
US5985320A
(en)
|
1996-03-04 |
1999-11-16 |
The Penn State Research Foundation |
Materials and methods for enhancing cellular internalization
|
AU5711196A
(en)
|
1996-03-14 |
1997-10-01 |
Human Genome Sciences, Inc. |
Apoptosis inducing molecule i
|
ATE279947T1
(de)
|
1996-03-18 |
2004-11-15 |
Univ Texas |
Immunglobulinähnliche domäne mit erhöhten halbwertszeiten
|
KR20030096450A
(ko)
|
1996-03-22 |
2003-12-31 |
휴먼 게놈 사이언시즈, 인코포레이티드 |
고사 유도 분자 ⅱ
|
US6080870A
(en)
|
1996-04-03 |
2000-06-27 |
Merck & Co., Inc. |
Biaryl substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
|
US6063930A
(en)
|
1996-04-03 |
2000-05-16 |
Merck & Co., Inc. |
Substituted imidazole compounds useful as farnesyl-protein transferase inhibitors
|
US5883105A
(en)
|
1996-04-03 |
1999-03-16 |
Merck & Co., Inc. |
Inhibitors of farnesyl-protein transferase
|
US5891889A
(en)
|
1996-04-03 |
1999-04-06 |
Merck & Co., Inc. |
Inhibitors of farnesyl-protein transferase
|
US6300501B1
(en)
|
1996-05-22 |
2001-10-09 |
Warner-Lambert Company |
Histidine-(N-benzyl glycinamide) inhibitors of protein farnesyl transferase
|
US5874064A
(en)
|
1996-05-24 |
1999-02-23 |
Massachusetts Institute Of Technology |
Aerodynamically light particles for pulmonary drug delivery
|
US5855913A
(en)
|
1997-01-16 |
1999-01-05 |
Massachusetts Instite Of Technology |
Particles incorporating surfactants for pulmonary drug delivery
|
US5985309A
(en)
|
1996-05-24 |
1999-11-16 |
Massachusetts Institute Of Technology |
Preparation of particles for inhalation
|
TW345603B
(en)
|
1996-05-29 |
1998-11-21 |
Gmundner Fertigteile Gmbh |
A noise control device for tracks
|
US5648239A
(en)
|
1996-06-21 |
1997-07-15 |
Incyte Pharmaceuticals, Inc. |
Human camp-dependent protein kinase inhibitor homolog
|
EP0907649A1
(fr)
|
1996-06-27 |
1999-04-14 |
Pfizer Inc. |
Derives de 2-(2-oxo-ethylidene)-imidazolidin-4-one et leur utilisation comme inhibiteurs de la farnesyl-proteine-transferase
|
CN100389828C
(zh)
|
1996-08-12 |
2008-05-28 |
三菱制药株式会社 |
含Rho激酶抑制剂的药物制剂
|
US5985317A
(en)
|
1996-09-06 |
1999-11-16 |
Theratech, Inc. |
Pressure sensitive adhesive matrix patches for transdermal delivery of salts of pharmaceutical agents
|
US6030982A
(en)
|
1996-09-13 |
2000-02-29 |
Schering Corporationm |
Compounds useful for inhibition of farnesyl protein transferase
|
US5945429A
(en)
|
1996-09-13 |
1999-08-31 |
Schering Corporation |
Compounds useful for inhibition of farnesyl protein transferase
|
US6040305A
(en)
|
1996-09-13 |
2000-03-21 |
Schering Corporation |
Compounds useful for inhibition of farnesyl protein transferase
|
US5885834A
(en)
|
1996-09-30 |
1999-03-23 |
Epstein; Paul M. |
Antisense oligodeoxynucleotide against phosphodiesterase
|
HUP0000116A3
(en)
|
1996-10-01 |
2000-08-28 |
Stanford Res Inst Int |
Taste-masked microcapsule compositions and methods of manufacture
|
US5916771A
(en)
|
1996-10-11 |
1999-06-29 |
Abgenix, Inc. |
Production of a multimeric protein by cell fusion method
|
US6131570A
(en)
|
1998-06-30 |
2000-10-17 |
Aradigm Corporation |
Temperature controlling device for aerosol drug delivery
|
EP1500329B1
(fr)
|
1996-12-03 |
2012-03-21 |
Amgen Fremont Inc. |
Les anticorps humains qui lient en particulier l'alpha de TNF humain
|
US5939439A
(en)
|
1996-12-30 |
1999-08-17 |
Merck & Co., Inc. |
Inhibitors of farnesyl-protein transferase
|
US6093737A
(en)
|
1996-12-30 |
2000-07-25 |
Merck & Co., Inc. |
Inhibitors of farnesyl-protein transferase
|
US6013662A
(en)
|
1996-12-30 |
2000-01-11 |
Rhone-Poulenc Rorer S.A. |
Farnesyl transferase inhibitors, their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments
|
PT954282E
(pt)
|
1997-01-16 |
2005-06-30 |
Massachusetts Inst Technology |
Preparacao de particulas para inalacao
|
AU5772698A
(en)
|
1997-01-29 |
1998-08-18 |
Zeneca Limited |
Inhibitors of farnesyl protein transferase
|
US5860957A
(en)
|
1997-02-07 |
1999-01-19 |
Sarcos, Inc. |
Multipathway electronically-controlled drug delivery system
|
ZA981080B
(en)
|
1997-02-11 |
1998-08-12 |
Warner Lambert Co |
Bicyclic inhibitors of protein farnesyl transferase
|
TW591030B
(en)
|
1997-03-10 |
2004-06-11 |
Janssen Pharmaceutica Nv |
Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with N- or C-linked imidazoles
|
US6120751A
(en)
|
1997-03-21 |
2000-09-19 |
Imarx Pharmaceutical Corp. |
Charged lipids and uses for the same
|
US7227002B1
(en)
|
1997-04-14 |
2007-06-05 |
Micromet Ag |
Human antibodies that bind human 17-A1/EpCAM tumor antigen
|
US6060082A
(en)
|
1997-04-18 |
2000-05-09 |
Massachusetts Institute Of Technology |
Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery
|
US6235883B1
(en)
|
1997-05-05 |
2001-05-22 |
Abgenix, Inc. |
Human monoclonal antibodies to epidermal growth factor receptor
|
US6225322B1
(en)
|
1997-06-17 |
2001-05-01 |
Schering Corporation |
Compounds useful for inhibition of farnesyl protein transferase
|
US6159984A
(en)
|
1997-06-17 |
2000-12-12 |
Schering Corporation |
Farnesyl protein transferase inhibitors
|
US6051582A
(en)
|
1997-06-17 |
2000-04-18 |
Schering Corporation |
Compounds useful for inhibition of farnesyl protein transferase
|
US6228865B1
(en)
|
1997-06-17 |
2001-05-08 |
Schering Corporation |
Compounds useful for inhibition of farnesyl protein transferase
|
US6239140B1
(en)
|
1997-06-17 |
2001-05-29 |
Schering Corporation |
Compounds useful for inhibition of farnesyl protein transferase
|
US6211193B1
(en)
|
1997-06-17 |
2001-04-03 |
Schering Corporation |
Compounds useful for inhibition of farnesyl protein transferase
|
HUP0003194A3
(en)
|
1997-08-15 |
2003-03-28 |
Cephalon Inc West Chester |
Use of tyrosine kinase inhibitor in synergic pharmaceutical composition treating prostate cancer
|
US5948433A
(en)
|
1997-08-21 |
1999-09-07 |
Bertek, Inc. |
Transdermal patch
|
US5989463A
(en)
|
1997-09-24 |
1999-11-23 |
Alkermes Controlled Therapeutics, Inc. |
Methods for fabricating polymer-based controlled release devices
|
US6103723A
(en)
|
1997-10-17 |
2000-08-15 |
Merck & Co., Inc. |
Inhibitors of farnesyl-protein transferase
|
AU9452998A
(en)
|
1997-10-22 |
1999-05-10 |
Zeneca Limited |
Imidazole derivatives and their use as farnesyl protein transferase inhibit ors
|
PT1025088E
(pt)
|
1997-10-22 |
2002-01-30 |
Astrazeneca Ab |
Derivados de imidazole e sua utilizacao como inibidores de farnesil proteino transferase
|
SE512663C2
(sv)
|
1997-10-23 |
2000-04-17 |
Biogram Ab |
Inkapslingsförfarande för aktiv substans i en bionedbrytbar polymer
|
CA2275539A1
(fr)
|
1997-10-28 |
1999-05-06 |
Bando Chemical Industries, Ltd. |
Timbre transdermique et methode de fabrication d'une feuille de substrat connexe
|
KR20010031713A
(ko)
|
1997-11-03 |
2001-04-16 |
벤슨 로버트 에이치. |
맥관형성 및 종양 성장 억제제인 맥관 내피 세포 성장억제제
|
US6124465A
(en)
|
1997-11-25 |
2000-09-26 |
Rhone-Poulenc S.A. |
Farnesyl transferase inhibitors, their preparation, the pharmaceutical compositions which contain them and their use in the preparation of medicaments
|
RU2179975C1
(ru)
|
1997-11-28 |
2002-02-27 |
Эл Джи Кемикал Лтд. |
Производные имидазола, обладающие ингибирующей активностью в отношении фарнезилтрансферазы, способ их получения, промежуточные соединения, фармацевтическая композиция
|
US6054466A
(en)
|
1997-12-04 |
2000-04-25 |
Merck & Co., Inc. |
Inhibitors of farnesyl-protein transferase
|
US6242196B1
(en)
|
1997-12-11 |
2001-06-05 |
Dana-Farber Cancer Institute |
Methods and pharmaceutical compositions for inhibiting tumor cell growth
|
US6335156B1
(en)
|
1997-12-18 |
2002-01-01 |
The Johns Hopkins University School Of Medicine |
14-3-3σ arrests the cell cycle
|
CA2320233C
(fr)
|
1998-02-02 |
2004-07-27 |
Lg Chemical Ltd. |
Inhibiteurs de farnesyl-transferases, ayant une structure piperidine, et procede de preparation correspondant
|
AU2873999A
(en)
|
1998-02-24 |
1999-09-06 |
Sisters Of Providence In Oregon |
Compositions containing an OX-40 receptor binding agent or nucleic acid encoding the same and methods for enhancing antigen-specific immune response
|
ES2214021T3
(es)
|
1998-04-27 |
2004-09-01 |
Warner-Lambert Company Llc |
Derivados funcionalizados de glicinamidas con cadena lateral de alquilo y alquenilo como inhibidores de la farnesil-transferasa.
|
US6048736A
(en)
|
1998-04-29 |
2000-04-11 |
Kosak; Kenneth M. |
Cyclodextrin polymers for carrying and releasing drugs
|
EP1089712B1
(fr)
|
1998-06-24 |
2003-05-02 |
Advanced Inhalation Research, Inc. |
Grandes particules poreuses emises par un inhalateur
|
UA64797C2
(uk)
|
1998-07-06 |
2004-03-15 |
Янссен Фармацевтика Н.В. |
Інгібітори фарнезил білок трансферази як засіб для лікування артропатії
|
US6034053A
(en)
|
1998-07-13 |
2000-03-07 |
Wayne Hughes Institute |
EGF-isoflavone conjugates for the prevention of restenosis
|
US6372747B1
(en)
|
1998-12-18 |
2002-04-16 |
Schering Corporation |
Farnesyl protein transferase inhibitors
|
US6362188B1
(en)
|
1998-12-18 |
2002-03-26 |
Schering Corporation |
Farnesyl protein transferase inhibitors
|
FR2787327B1
(fr)
|
1998-12-21 |
2003-01-17 |
Aventis Pharma Sa |
Compositions contenant des inhibiteurs de farnesyle transferase
|
US6432959B1
(en)
|
1998-12-23 |
2002-08-13 |
Schering Corporation |
Inhibitors of farnesyl-protein transferase
|
EP1140938B1
(fr)
|
1999-01-11 |
2003-08-27 |
Princeton University |
Inhibiteurs de haute affinite pour la validation de cibles, et leurs utilisations
|
US6399633B1
(en)
|
1999-02-01 |
2002-06-04 |
Aventis Pharmaceuticals Inc. |
Use of 4-H-1-benzopryan-4-one derivatives as inhibitors of smooth muscle cell proliferation
|
US6245759B1
(en)
|
1999-03-11 |
2001-06-12 |
Merck & Co., Inc. |
Tyrosine kinase inhibitors
|
US6271359B1
(en)
|
1999-04-14 |
2001-08-07 |
Musc Foundation For Research Development |
Tissue-specific and pathogen-specific toxic agents and ribozymes
|
US6143766A
(en)
|
1999-04-16 |
2000-11-07 |
Warner-Lambert Company |
Benzopyranone and quinolone inhibitors of ras farnesyl transferase
|
US6256533B1
(en)
|
1999-06-09 |
2001-07-03 |
The Procter & Gamble Company |
Apparatus and method for using an intracutaneous microneedle array
|
US6458935B1
(en)
|
1999-06-23 |
2002-10-01 |
Merck & Co., Inc. |
Radiolabeled farnesyl-protein transferase inhibitors
|
AU2161501A
(en)
|
1999-11-29 |
2001-06-25 |
Unilever Plc |
Immobilized single domain antigen-binding molecules
|
US6403581B1
(en)
|
2000-01-19 |
2002-06-11 |
American Cyanamid Company |
Method of inhibition of farnesyl-protein transferase using substituted benz (cd) indol-2-imine and-amine derivatives
|
US6261595B1
(en)
|
2000-02-29 |
2001-07-17 |
Zars, Inc. |
Transdermal drug patch with attached pocket for controlled heating device
|
US20040110226A1
(en)
*
|
2002-03-01 |
2004-06-10 |
Xencor |
Antibody optimization
|
WO2003106498A2
(fr)
|
2002-06-13 |
2003-12-24 |
Crucell Holland, B.V. |
Molecules de liaison agonistes au recepteur ox40 humain
|
US7291331B1
(en)
*
|
2002-09-11 |
2007-11-06 |
La Jolla Institute For Allergy And Immunology |
Methods of treating OX40 medicated recall immune responses
|
WO2005035575A2
(fr)
|
2003-08-22 |
2005-04-21 |
Medimmune, Inc. |
Humanisation d'anticorps
|
JP5848861B2
(ja)
|
2004-04-20 |
2016-01-27 |
ジェンマブ エー/エスGenmab A/S |
Cd20に対するヒトモノクローナル抗体
|
TWI380996B
(zh)
*
|
2004-09-17 |
2013-01-01 |
Hoffmann La Roche |
抗ox40l抗體
|
CN101023102B
(zh)
*
|
2004-09-17 |
2013-05-29 |
霍夫曼-拉罗奇有限公司 |
抗-ox40l抗体
|
TWI461436B
(zh)
|
2005-11-25 |
2014-11-21 |
Kyowa Hakko Kirin Co Ltd |
人類cd134(ox40)之人類單株抗體及其製造及使用方法
|
KR20080080639A
(ko)
|
2005-12-16 |
2008-09-04 |
제넨테크, 인크. |
항-ox40l 항체 및 그의 사용 방법
|
US20100136030A1
(en)
*
|
2007-02-27 |
2010-06-03 |
Lamhamedi-Cherradi Salah-Eddine |
Antagonist ox40 antibodies and their use in the treatment of inflammatory and autoimmune diseases
|
PT2242771E
(pt)
|
2007-12-14 |
2013-08-29 |
Bristol Myers Squibb Co |
Moléculas de ligação ao recetor humano ox40
|
WO2009141239A1
(fr)
*
|
2008-05-20 |
2009-11-26 |
F. Hoffmann-La Roche Ag |
Formulation pharmaceutique comprenant un anticorps contre ox40l, utilisations de celle-ci
|
MA33122B1
(fr)
|
2009-02-17 |
2012-03-01 |
Ucb Pharma Sa |
Molecules d'anticorps ayant une specificite pour ox40 humain
|
LT3241435T
(lt)
|
2009-07-08 |
2021-10-25 |
Kymab Limited |
Gyvūnų modeliai ir terapinės molekulės
|
WO2011073180A1
(fr)
|
2009-12-14 |
2011-06-23 |
Ablynx N.V. |
Anticorps à domaine variable unique dirigés contre ox4ql, produits de recombinaison et utilisation thérapeutique
|
BR112013004266A8
(pt)
*
|
2010-08-23 |
2018-01-02 |
Univ Texas |
anticorpos anti-ox40 e métodos de uso dos mesmos.
|
EP2720719A4
(fr)
*
|
2011-06-15 |
2015-12-09 |
Glaxosmithkline Ip No 2 Ltd |
Procédé de sélection d'indications thérapeutiques
|
ES2670621T3
(es)
|
2011-07-11 |
2018-05-31 |
Glenmark Pharmaceuticals S.A. |
Anticuerpos que se unen a OX40 y sus usos
|
RU2562874C1
(ru)
|
2011-08-23 |
2015-09-10 |
Борд Оф Риджентс, Дзе Юниверсити Оф Техас Систем |
Антитела против ох40 и способы их применения
|
GB201116092D0
(en)
|
2011-09-16 |
2011-11-02 |
Bioceros B V |
Antibodies and uses thereof
|
UA112203C2
(uk)
|
2011-11-11 |
2016-08-10 |
Юсб Фарма С.А. |
Злитий білок біоспецифічного антитіла, який зв'язується з ox40 людини та сироватковим альбуміном людини
|
US9828432B2
(en)
|
2012-02-06 |
2017-11-28 |
Providence Health & Services—Oregon |
Cancer treatment and monitoring methods using OX40 agonists
|
CA2865899A1
(fr)
|
2012-03-02 |
2013-09-06 |
William Redmond |
Bitherapie anticancereuse basee sur l'agoniste ox40/il-2
|
AU2014243816B2
(en)
*
|
2013-03-13 |
2019-01-31 |
Bioasis Technologies Inc. |
Fragments of p97 and uses thereof
|
MD4633B1
(ro)
|
2013-03-18 |
2019-06-30 |
Biocerox Products B.V. |
Anticorpi umanizaţi anti-CD134 (OX40) şi utilizarea acestora
|
GB201403775D0
(en)
|
2014-03-04 |
2014-04-16 |
Kymab Ltd |
Antibodies, uses & methods
|