SG10201605655UA - Substituted annulated pyrimidines and triazines, and use thereof - Google Patents
Substituted annulated pyrimidines and triazines, and use thereofInfo
- Publication number
- SG10201605655UA SG10201605655UA SG10201605655UA SG10201605655UA SG10201605655UA SG 10201605655U A SG10201605655U A SG 10201605655UA SG 10201605655U A SG10201605655U A SG 10201605655UA SG 10201605655U A SG10201605655U A SG 10201605655UA SG 10201605655U A SG10201605655U A SG 10201605655UA
- Authority
- SG
- Singapore
- Prior art keywords
- triazines
- pyrimidines
- substituted annulated
- annulated
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102012200349A DE102012200349A1 (de) | 2012-01-11 | 2012-01-11 | Substituierte annellierte Pyrimidine und Triazine und ihre Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201605655UA true SG10201605655UA (en) | 2016-09-29 |
Family
ID=47559479
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201605655UA SG10201605655UA (en) | 2012-01-11 | 2013-01-10 | Substituted annulated pyrimidines and triazines, and use thereof |
| SG11201403345UA SG11201403345UA (en) | 2012-01-11 | 2013-01-10 | Substituted annulated pyrimidines and triazines, and use thereof |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201403345UA SG11201403345UA (en) | 2012-01-11 | 2013-01-10 | Substituted annulated pyrimidines and triazines, and use thereof |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US20140357637A1 (ru) |
| EP (1) | EP2802592A1 (ru) |
| JP (1) | JP6251183B2 (ru) |
| KR (1) | KR20140114416A (ru) |
| CN (1) | CN104812762B (ru) |
| AP (1) | AP2014007844A0 (ru) |
| AU (1) | AU2013208968A1 (ru) |
| BR (1) | BR112014016971A8 (ru) |
| CA (1) | CA2860855A1 (ru) |
| CL (1) | CL2014001779A1 (ru) |
| CO (1) | CO7000776A2 (ru) |
| CR (1) | CR20140327A (ru) |
| CU (1) | CU20140082A7 (ru) |
| DE (1) | DE102012200349A1 (ru) |
| DO (1) | DOP2014000160A (ru) |
| EA (1) | EA025837B1 (ru) |
| EC (1) | ECSP14008556A (ru) |
| GT (1) | GT201400147A (ru) |
| HK (1) | HK1211585A1 (ru) |
| IL (1) | IL233460A0 (ru) |
| MA (1) | MA35844B1 (ru) |
| MX (1) | MX2014008201A (ru) |
| NZ (1) | NZ626394A (ru) |
| PE (1) | PE20142293A1 (ru) |
| PH (1) | PH12014501595A1 (ru) |
| SG (2) | SG10201605655UA (ru) |
| TN (1) | TN2014000298A1 (ru) |
| WO (1) | WO2013104703A1 (ru) |
| ZA (1) | ZA201405042B (ru) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012004258A1 (de) | 2010-07-09 | 2012-01-12 | Bayer Pharma Aktiengesellschaft | Annellierte pyrimidine und triazine und ihre verwendung zur behandlung bzw. prophylaxe von herz-kreislauf-erkrankungen |
| US9090610B2 (en) * | 2011-04-21 | 2015-07-28 | Bayer Intellectual Property Gmbh | Fluoroalkyl-substituted pyrazolopyridines and use thereof |
| DE102012200349A1 (de) | 2012-01-11 | 2013-07-11 | Bayer Intellectual Property Gmbh | Substituierte annellierte Pyrimidine und Triazine und ihre Verwendung |
| DE102012200360A1 (de) | 2012-01-11 | 2013-07-11 | Bayer Intellectual Property Gmbh | Substituierte Triazine und ihre Verwendung |
| DE102012200352A1 (de) * | 2012-01-11 | 2013-07-11 | Bayer Intellectual Property Gmbh | Substituierte, annellierte Imidazole und Pyrazole und ihre Verwendung |
| ES2644781T3 (es) | 2012-03-06 | 2017-11-30 | Bayer Intellectual Property Gmbh | Azabiciclos sustituidos y su uso |
| PL2927231T3 (pl) | 2012-11-30 | 2018-01-31 | Astellas Pharma Inc | Związki imidazopirydyny |
| JP2016513129A (ja) * | 2013-03-01 | 2016-05-12 | バイエル・ファルマ・アクティエンゲゼルシャフト | ベンジル−置換ピラゾロピリジンおよびその使用 |
| KR20150121007A (ko) | 2013-03-01 | 2015-10-28 | 바이엘 파마 악티엔게젤샤프트 | 트리플루오르메틸-치환된 고리-융합된 피리미딘 및 그의 용도 |
| US9776997B2 (en) | 2013-06-04 | 2017-10-03 | Bayer Pharma Aktiengesellschaft | 3-aryl-substituted imidazo[1,2-A]pyridines and their use |
| JP2016523944A (ja) * | 2013-07-10 | 2016-08-12 | バイエル・ファルマ・アクティエンゲゼルシャフト | ベンジル−１Ｈ−ピラゾロ［３，４−ｂ］ピリジンおよびその使用 |
| WO2015088885A1 (en) | 2013-12-11 | 2015-06-18 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
| JP2016540017A (ja) | 2013-12-11 | 2016-12-22 | アイアンウッド ファーマシューティカルズ インコーポレイテッド | ｓＧＣ刺激物質 |
| WO2015088886A1 (en) | 2013-12-11 | 2015-06-18 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
| EP3094327A1 (en) | 2014-01-13 | 2016-11-23 | Ironwood Pharmaceuticals, Inc. | USE OF sGC STIMULATORS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS |
| CA2939793A1 (en) | 2014-02-19 | 2015-08-27 | Bayer Pharma Aktiengesellschaft | 3-(pyrimidine-2-yl)imidazo[1,2-a]pyridines |
| US9796733B2 (en) | 2014-06-04 | 2017-10-24 | Merck Sharp & Dohme Corp. | Imidazo-pyrazine derivatives useful as soluble guanylate cyclase activators |
| EP3186251A1 (de) | 2014-08-29 | 2017-07-05 | Bayer Pharma Aktiengesellschaft | Substituierte annellierte pyrimidine und ihre verwendung |
| US20170240566A1 (en) | 2014-08-29 | 2017-08-24 | Bayer Pharma Aktiengesellschaft | Amino-substituted annulated pyrimidines and use thereof |
| TW201625635A (zh) | 2014-11-21 | 2016-07-16 | 默沙東藥廠 | 作為可溶性鳥苷酸環化酶活化劑之三唑并吡基衍生物 |
| CA2969268A1 (en) | 2014-12-02 | 2016-06-09 | Bayer Pharma Aktiengesellschaft | Heteroaryl-substituted imidazo[1,2-a]pyridines and their use |
| TN2017000465A1 (en) | 2015-05-06 | 2019-04-12 | Bayer Pharma AG | The use of sgc stimulators, sgc activators, alone and combinations with pde5 inhibitors for the treatment of digital ulcers (du) concomitant to systemic sclerosis (ssc) |
| WO2016191334A1 (en) | 2015-05-27 | 2016-12-01 | Merck Sharp & Dohme Corp. | Imidazo-pyrazinyl derivatives useful as soluble guanylate cyclase activators |
| EP3310782B1 (en) | 2015-05-28 | 2021-12-01 | Merck Sharp & Dohme Corp. | Imidazo-pyrazinyl derivatives useful as soluble guanylate cyclase activators |
| HRP20201932T4 (hr) | 2015-07-23 | 2024-02-16 | Bayer Pharma Aktiengesellschaft | Stimulatori / aktivatori topive gvanilat-ciklaze u kombinaciji s nep-inhibitorom i/ili angiotenzin aii-antagonistom i njihova uporaba |
| KR101753652B1 (ko) * | 2015-10-21 | 2017-07-05 | 한국화학연구원 | N-아릴-1h-피라졸로피리딘-3-아민 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 melk 관련 질환의 예방 또는 치료용 약학적 조성물 |
| AU2016371762A1 (en) | 2015-12-14 | 2018-06-21 | Cyclerion Therapeutics, Inc. | Use of sGC stimulators for the treatment of gastrointestinal sphincter dysfunction |
| WO2017107052A1 (en) | 2015-12-22 | 2017-06-29 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase stimulators |
| WO2017197555A1 (en) | 2016-05-16 | 2017-11-23 | Merck Sharp & Dohme Corp. | Fused pyrazine derivatives useful as soluble guanylate cyclase stimulators |
| EP3458063A4 (en) | 2016-05-18 | 2020-02-26 | Merck Sharp & Dohme Corp. | METHODS OF USING TRIAZOLO-PYRAZINYL-SOLUBLE GUANYLATE CYCLASE ACTIVATORS FOR FIBROTIC DISORDERS |
| KR20230124760A (ko) | 2016-09-02 | 2023-08-25 | 사이클리온 테라퓨틱스, 인크. | 융합된 비시클릭 sGC 자극제 |
| EP3525779B1 (de) | 2016-10-11 | 2024-06-05 | Bayer Pharma Aktiengesellschaft | Kombination enthaltend den sgc stimulator vericuguat und den mineralcorticoid-rezeptor-antagonist finerenone |
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| US20190381039A1 (en) | 2016-12-13 | 2019-12-19 | Cyclerion Therapeutics, Inc. | USE OF sGC STIMULATORS FOR THE TREATMENT OF ESOPHAGEAL MOTILITY DISORDERS |
| ES2924359T3 (es) | 2017-04-11 | 2022-10-06 | Sunshine Lake Pharma Co Ltd | Compuestos de indazol sustituidos con flúor y usos de los mismos |
| CA3100096A1 (en) | 2018-05-15 | 2019-11-21 | Bayer Aktiengesellschaft | 1,3-thiazol-2-yl substituted benzamides for the treatment of diseases associated with nerve fiber sensitization |
| CN108640923A (zh) * | 2018-07-09 | 2018-10-12 | 湖南天地恒制药有限公司 | 一种托法替布关键中间体的制备方法 |
| BR112021000358A2 (pt) | 2018-07-11 | 2021-04-06 | Cyclerion Therapeutics, Inc. | Uso de estimulantes de sgc para o tratamento de distúrbios mitocondriais |
| WO2020164008A1 (en) | 2019-02-13 | 2020-08-20 | Bayer Aktiengesellschaft | Process for the preparation of porous microparticles |
| CN113368240B (zh) * | 2021-06-13 | 2022-08-02 | 重庆医科大学 | 一种二茂铁基金属有机框架纳米粒及其制备方法 |
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| US9090610B2 (en) | 2011-04-21 | 2015-07-28 | Bayer Intellectual Property Gmbh | Fluoroalkyl-substituted pyrazolopyridines and use thereof |
| ES2597034T3 (es) | 2011-05-30 | 2017-01-13 | Astellas Pharma Inc. | Compuesto de imidazopiridina |
| RU2014103960A (ru) | 2011-07-06 | 2015-08-20 | Байер Интеллектуэль Проперти Гмбх | Гетероарилзамещенные пиразолопиридины и их применение в качестве стимуляторов растворимой гуанилатциклазы |
| KR20140074912A (ko) | 2011-09-01 | 2014-06-18 | 에프. 호프만-라 로슈 아게 | 피롤로피라진 키나아제 억제제 |
| BR112014005110A2 (pt) | 2011-09-02 | 2017-04-18 | Bayer Ip Gmbh | pirimidinas aneladas substituídas e utilização das mesmas |
| DE102012200349A1 (de) | 2012-01-11 | 2013-07-11 | Bayer Intellectual Property Gmbh | Substituierte annellierte Pyrimidine und Triazine und ihre Verwendung |
| DE102012200360A1 (de) | 2012-01-11 | 2013-07-11 | Bayer Intellectual Property Gmbh | Substituierte Triazine und ihre Verwendung |
| DE102012200352A1 (de) | 2012-01-11 | 2013-07-11 | Bayer Intellectual Property Gmbh | Substituierte, annellierte Imidazole und Pyrazole und ihre Verwendung |
| ES2644781T3 (es) | 2012-03-06 | 2017-11-30 | Bayer Intellectual Property Gmbh | Azabiciclos sustituidos y su uso |
| KR20150121007A (ko) | 2013-03-01 | 2015-10-28 | 바이엘 파마 악티엔게젤샤프트 | 트리플루오르메틸-치환된 고리-융합된 피리미딘 및 그의 용도 |
| JP2016513129A (ja) | 2013-03-01 | 2016-05-12 | バイエル・ファルマ・アクティエンゲゼルシャフト | ベンジル−置換ピラゾロピリジンおよびその使用 |
| JP2016523944A (ja) | 2013-07-10 | 2016-08-12 | バイエル・ファルマ・アクティエンゲゼルシャフト | ベンジル−１Ｈ−ピラゾロ［３，４−ｂ］ピリジンおよびその使用 |
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2012
- 2012-01-11 DE DE102012200349A patent/DE102012200349A1/de not_active Withdrawn
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2013
- 2013-01-10 KR KR1020147021969A patent/KR20140114416A/ko not_active Application Discontinuation
- 2013-01-10 MX MX2014008201A patent/MX2014008201A/es not_active Application Discontinuation
- 2013-01-10 SG SG10201605655UA patent/SG10201605655UA/en unknown
- 2013-01-10 AU AU2013208968A patent/AU2013208968A1/en not_active Abandoned
- 2013-01-10 EA EA201491339A patent/EA025837B1/ru not_active IP Right Cessation
- 2013-01-10 EP EP13700288.7A patent/EP2802592A1/de not_active Withdrawn
- 2013-01-10 CA CA2860855A patent/CA2860855A1/en not_active Abandoned
- 2013-01-10 PE PE2014001063A patent/PE20142293A1/es not_active Application Discontinuation
- 2013-01-10 US US14/371,046 patent/US20140357637A1/en not_active Abandoned
- 2013-01-10 WO PCT/EP2013/050381 patent/WO2013104703A1/de active Application Filing
- 2013-01-10 BR BR112014016971A patent/BR112014016971A8/pt not_active IP Right Cessation
- 2013-01-10 AP AP2014007844A patent/AP2014007844A0/xx unknown
- 2013-01-10 JP JP2014551609A patent/JP6251183B2/ja not_active Expired - Fee Related
- 2013-01-10 NZ NZ626394A patent/NZ626394A/en not_active IP Right Cessation
- 2013-01-10 CN CN201380013679.1A patent/CN104812762B/zh not_active Expired - Fee Related
- 2013-01-10 SG SG11201403345UA patent/SG11201403345UA/en unknown
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2014
- 2014-06-30 IL IL233460A patent/IL233460A0/en unknown
- 2014-07-03 CL CL2014001779A patent/CL2014001779A1/es unknown
- 2014-07-07 CU CU2014000082A patent/CU20140082A7/es unknown
- 2014-07-07 MA MA37178A patent/MA35844B1/fr unknown
- 2014-07-08 DO DO2014000160A patent/DOP2014000160A/es unknown
- 2014-07-08 CR CR20140327A patent/CR20140327A/es unknown
- 2014-07-08 CO CO14146937A patent/CO7000776A2/es unknown
- 2014-07-09 EC ECIEPI20148556A patent/ECSP14008556A/es unknown
- 2014-07-09 TN TNP2014000298A patent/TN2014000298A1/fr unknown
- 2014-07-10 GT GT201400147A patent/GT201400147A/es unknown
- 2014-07-10 PH PH12014501595A patent/PH12014501595A1/en unknown
- 2014-07-10 ZA ZA2014/05042A patent/ZA201405042B/en unknown
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2015
- 2015-06-12 US US14/738,148 patent/US9505786B2/en not_active Expired - Fee Related
- 2015-12-17 HK HK15112419.1A patent/HK1211585A1/xx unknown
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