HRP20201932T4 - Stimulatori / aktivatori topive gvanilat-ciklaze u kombinaciji s nep-inhibitorom i/ili angiotenzin aii-antagonistom i njihova uporaba - Google Patents
Stimulatori / aktivatori topive gvanilat-ciklaze u kombinaciji s nep-inhibitorom i/ili angiotenzin aii-antagonistom i njihova uporaba Download PDFInfo
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- HRP20201932T4 HRP20201932T4 HRP20201932TT HRP20201932T HRP20201932T4 HR P20201932 T4 HRP20201932 T4 HR P20201932T4 HR P20201932T T HRP20201932T T HR P20201932TT HR P20201932 T HRP20201932 T HR P20201932T HR P20201932 T4 HRP20201932 T4 HR P20201932T4
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- Prior art keywords
- disorders
- combination
- ylmethyl
- solvates
- prophylaxis
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- 102000015427 Angiotensins Human genes 0.000 title 1
- 108010064733 Angiotensins Proteins 0.000 title 1
- 101710095468 Cyclase Proteins 0.000 title 1
- 239000012190 activator Substances 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 238000011321 prophylaxis Methods 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- 238000011282 treatment Methods 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 229940127296 soluble guanylate cyclase stimulator Drugs 0.000 claims 3
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 claims 2
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims 2
- 239000004072 C09CA03 - Valsartan Substances 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- 208000019693 Lung disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000003176 fibrotic effect Effects 0.000 claims 2
- 208000017169 kidney disease Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- SOBHUZYZLFQYFK-UHFFFAOYSA-K trisodium;hydroxy-[[phosphonatomethyl(phosphonomethyl)amino]methyl]phosphinate Chemical compound [Na+].[Na+].[Na+].OP(O)(=O)CN(CP(O)([O-])=O)CP([O-])([O-])=O SOBHUZYZLFQYFK-UHFFFAOYSA-K 0.000 claims 2
- SJSNUMAYCRRIOM-QFIPXVFZSA-N valsartan Chemical compound C1=CC(CN(C(=O)CCCC)[C@@H](C(C)C)C(O)=O)=CC=C1C1=CC=CC=C1C1=NN=N[N]1 SJSNUMAYCRRIOM-QFIPXVFZSA-N 0.000 claims 2
- 229960004699 valsartan Drugs 0.000 claims 2
- BSYNRYMUTXBXSQ-FOQJRBATSA-N 59096-14-9 Chemical compound CC(=O)OC1=CC=CC=C1[14C](O)=O BSYNRYMUTXBXSQ-FOQJRBATSA-N 0.000 claims 1
- 239000005541 ACE inhibitor Substances 0.000 claims 1
- 229940127291 Calcium channel antagonist Drugs 0.000 claims 1
- 229940122434 Calcium sensitizer Drugs 0.000 claims 1
- 241000208011 Digitalis Species 0.000 claims 1
- LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 claims 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 claims 1
- 230000002785 anti-thrombosis Effects 0.000 claims 1
- 229960004676 antithrombotic agent Drugs 0.000 claims 1
- 239000002876 beta blocker Substances 0.000 claims 1
- 229940097320 beta blocking agent Drugs 0.000 claims 1
- -1 calcium antagonists Substances 0.000 claims 1
- LTMHDMANZUZIPE-PUGKRICDSA-N digoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 claims 1
- 229960005156 digoxin Drugs 0.000 claims 1
- LTMHDMANZUZIPE-UHFFFAOYSA-N digoxine Natural products C1C(O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)C(O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O LTMHDMANZUZIPE-UHFFFAOYSA-N 0.000 claims 1
- 239000002934 diuretic Substances 0.000 claims 1
- 229940030606 diuretics Drugs 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims 1
- 150000002823 nitrates Chemical class 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 239000002461 renin inhibitor Substances 0.000 claims 1
- 229940086526 renin-inhibitors Drugs 0.000 claims 1
- PYNXFZCZUAOOQC-UTKZUKDTSA-N sacubitril Chemical compound C1=CC(C[C@H](C[C@@H](C)C(=O)OCC)NC(=O)CCC(O)=O)=CC=C1C1=CC=CC=C1 PYNXFZCZUAOOQC-UTKZUKDTSA-N 0.000 claims 1
- 229960003953 sacubitril Drugs 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (8)
1. Kombinacije naznačene time što sadrže sGC stimulator s formulom
[image]
sakubitril i valsartan i također u svakom slučaju i soli, solvate i solvate njihovih soli.
2. Kombinacije prema patentnom zahtjevu 1 naznačene time što sadrže trinatrijev [3-((1S,3R)-1-bifenil-4-ilmetil-3-etoksikarbonil-1-butilkarbamoil)propionat-(S)-3'-metil-2'-(pentanoil{2"-(tetrazol-5-ilat)bifenil-4'-ilmetil}amino)butirat] hemipentahidrat i također u svakom slučaju i soli, solvate i solvate njihovih soli.
3. Kombinacija prema bilo kojem od zahtjeva 1 ili 2, naznačena time što je za uporabu u postupku za liječenje i/ili profilaksu kardiovaskularnih poremećaja, bubrežnih poremećaja, plućnih poremećaja, kao i za liječenje i/ili profilaksu fibrotičnih poremećaja.
4. Lijek naznačen time što sadrži kombinaciju prema bilo kojem od zahtjeva 1 ili 2, u kombinaciji s inertnim, netoksičnim, farmaceutski prikladnim pomoćnim sredstvom.
5. Lijek koji sadrži kombinaciju prema bilo kojem od zahtjeva 1 ili 2, u kombinaciji s jednim ili više daljnjih aktivnih sastojaka odabranih iz skupine koju čine ACE inhibitori, inhibitori renina, beta blokatori, acetilsalicilna kiselina, diuretici, antagonisti kalcija, statini, derivati digitalisa (digoksin), senzibilizatori kalcija, nitrati i antitrombotici.
6. Lijek koji sadrži kombinaciju prema bilo kojem od zahtjeva 1 ili 2 naznačen time što je za uporabu u postupku za liječenje i/ili profilaksu kardiovaskularnih poremećaja, bubrežnih poremećaja, plućnih poremećaja, kao i za liječenje i/ili profilaksu fibrotičnih poremećaja.
7. Komplet naznačen time što sadrži farmaceutski pripravak koji sadrži sGC stimulator s formulom
[image]
i farmaceutski pripravak koji sadrži valsartan i N-(3-karboksi-1-oksopropil)-(4S)-(p-fenilfenilmetil)-4-amino-2R-metilbutansku kiselinu ili njen ester.
8. Komplet prema patentnom zahtjevu 7 naznačen time što sadrži farmaceutski pripravak koji sadrži sGC stimulator s formulom
[image]
i farmaceutski pripravak koji sadrži trinatrijev [3-((1S,3R)-1-bifenil-4-ilmetil-3-etoksikarbonil-1-butilkarbamoil)propionat-(S)-3'-metil-2'-(pentanoil{2"(tetrazol-5-ilat)bifenil-4'-ilmetil}amino)butirat] hemipentahidrat.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15178141 | 2015-07-23 | ||
EP16739146.5A EP3325013B2 (de) | 2015-07-23 | 2016-07-15 | Stimulatoren und/oder aktivatoren der löslichen guanylatzyklase (sgc) in kombination mit einem inhibitor der neutralen endopeptidase (nep inhibitor) und einem angiotensin aii-antagonisten und ihre verwendung |
PCT/EP2016/066891 WO2017013010A1 (de) | 2015-07-23 | 2016-07-15 | Stimulatoren und/oder aktivatoren der löslichen guanylatzyklase (sgc) in kombination mit einem inhibitor der neutralen endopeptidase (nep inhibitor) und/oder einem angiotensin aii-antagonisten und ihre verwendung |
Publications (2)
Publication Number | Publication Date |
---|---|
HRP20201932T1 HRP20201932T1 (hr) | 2021-02-05 |
HRP20201932T4 true HRP20201932T4 (hr) | 2024-02-16 |
Family
ID=53758071
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20201932TT HRP20201932T4 (hr) | 2015-07-23 | 2016-07-15 | Stimulatori / aktivatori topive gvanilat-ciklaze u kombinaciji s nep-inhibitorom i/ili angiotenzin aii-antagonistom i njihova uporaba |
Country Status (13)
Country | Link |
---|---|
US (2) | US11166932B2 (hr) |
EP (1) | EP3325013B2 (hr) |
JP (1) | JP6849618B2 (hr) |
CN (3) | CN113750102A (hr) |
CA (1) | CA2989740C (hr) |
DK (1) | DK3325013T4 (hr) |
ES (1) | ES2839248T5 (hr) |
FI (1) | FI3325013T4 (hr) |
HR (1) | HRP20201932T4 (hr) |
HU (1) | HUE052337T2 (hr) |
LT (1) | LT3325013T (hr) |
SI (1) | SI3325013T2 (hr) |
WO (1) | WO2017013010A1 (hr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI3325013T2 (sl) | 2015-07-23 | 2023-11-30 | Bayer Pharma Aktiengesellschaft | Stimulatorji/aktivatorji topne gvanilat ciklaze v kombinaciji z zaviralcem NEP in/ali antagonistom angiotenzina II in njihova uporaba |
WO2019022436A2 (ko) * | 2017-07-27 | 2019-01-31 | 에리슨제약(주) | Nep 저해제 및 베타-차단제를 포함하는 약제학적 조성물 |
WO2019081456A1 (en) * | 2017-10-24 | 2019-05-02 | Bayer Aktiengesellschaft | USE OF SGC ACTIVATORS AND STIMULATORS COMPRISING A BETA2 SUBUNIT |
CN112055584A (zh) * | 2018-04-30 | 2020-12-08 | 拜耳公司 | sGC活化剂和sGC刺激剂用于治疗认知障碍的用途 |
WO2021230664A1 (ko) * | 2020-05-12 | 2021-11-18 | 에리슨제약(주) | 사쿠비트릴, 발사르탄 및 네비보롤을 포함하는 심부전 및 허혈성 심질환의 예방 또는 치료용 약제학적 조성물 및 이를 포함하는 약제학적 복합제제 |
KR20210138510A (ko) | 2020-05-12 | 2021-11-19 | 에리슨제약(주) | 사쿠비트릴, 발사르탄 및 네비보롤을 포함하는 심부전 및 허혈성 심질환의 예방 또는 치료용 약제학적 조성물 및 이를 포함하는 약제학적 복합제제 |
CN115317478B (zh) * | 2022-08-26 | 2023-05-02 | 宁波大学 | 沙库巴曲缬沙坦类物质在制备药物成瘾和复吸药物的应用 |
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2016
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- 2016-07-15 JP JP2017567712A patent/JP6849618B2/ja active Active
- 2016-07-15 US US15/746,624 patent/US11166932B2/en active Active
- 2016-07-15 LT LTEP16739146.5T patent/LT3325013T/lt unknown
- 2016-07-15 HU HUE16739146A patent/HUE052337T2/hu unknown
- 2016-07-15 EP EP16739146.5A patent/EP3325013B2/de active Active
- 2016-07-15 CN CN202111173343.4A patent/CN113750102A/zh active Pending
- 2016-07-15 FI FIEP16739146.5T patent/FI3325013T4/fi active
- 2016-07-15 CN CN202111173325.6A patent/CN113712969A/zh active Pending
- 2016-07-15 HR HRP20201932TT patent/HRP20201932T4/hr unknown
- 2016-07-15 CN CN201680043258.7A patent/CN108430510B/zh active Active
- 2016-07-15 WO PCT/EP2016/066891 patent/WO2017013010A1/de active Application Filing
- 2016-07-15 CA CA2989740A patent/CA2989740C/en active Active
- 2016-07-15 DK DK16739146.5T patent/DK3325013T4/da active
- 2016-07-15 ES ES16739146T patent/ES2839248T5/es active Active
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2021
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Also Published As
Publication number | Publication date |
---|---|
SI3325013T1 (sl) | 2020-11-30 |
EP3325013B1 (de) | 2020-09-23 |
SI3325013T2 (sl) | 2023-11-30 |
CN108430510B (zh) | 2021-10-29 |
CA2989740A1 (en) | 2017-01-26 |
LT3325013T (lt) | 2020-11-10 |
EP3325013B2 (de) | 2023-07-19 |
CN113750102A (zh) | 2021-12-07 |
ES2839248T5 (es) | 2024-02-22 |
US20190125709A1 (en) | 2019-05-02 |
CA2989740C (en) | 2023-07-11 |
WO2017013010A1 (de) | 2017-01-26 |
JP2018520151A (ja) | 2018-07-26 |
HUE052337T2 (hu) | 2021-04-28 |
JP6849618B2 (ja) | 2021-03-24 |
CN113712969A (zh) | 2021-11-30 |
CN108430510A (zh) | 2018-08-21 |
US11166932B2 (en) | 2021-11-09 |
DK3325013T4 (da) | 2023-10-16 |
US20220023246A1 (en) | 2022-01-27 |
DK3325013T3 (da) | 2020-12-14 |
ES2839248T3 (es) | 2021-07-05 |
HRP20201932T1 (hr) | 2021-02-05 |
FI3325013T4 (fi) | 2023-10-11 |
EP3325013A1 (de) | 2018-05-30 |
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