MA35844B1 - Pyrimidines et triazines annelées substituées et leur utilisation - Google Patents
Pyrimidines et triazines annelées substituées et leur utilisationInfo
- Publication number
- MA35844B1 MA35844B1 MA37178A MA37178A MA35844B1 MA 35844 B1 MA35844 B1 MA 35844B1 MA 37178 A MA37178 A MA 37178A MA 37178 A MA37178 A MA 37178A MA 35844 B1 MA35844 B1 MA 35844B1
- Authority
- MA
- Morocco
- Prior art keywords
- triazines
- pyrimidines
- substituted
- ringed
- prophylaxis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La présente invention concerne de nouvelles pyrimidines et triazines annelées substituées, leur procédé de fabrication, leur utilisation seules ou en combinaisons pour le traitement et/ou la prophylaxie de maladies, ainsi que leur utilisation pour fabriquer des médicaments destinés au traitement et/ou à la prophylaxie de maladies, notamment au traitement et/ou à la prophylaxie de maladies cardiovasculaires.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102012200349A DE102012200349A1 (de) | 2012-01-11 | 2012-01-11 | Substituierte annellierte Pyrimidine und Triazine und ihre Verwendung |
PCT/EP2013/050381 WO2013104703A1 (fr) | 2012-01-11 | 2013-01-10 | Pyrimidines et triazines annelées substituées et leur utilisation |
Publications (1)
Publication Number | Publication Date |
---|---|
MA35844B1 true MA35844B1 (fr) | 2014-12-01 |
Family
ID=47559479
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA37178A MA35844B1 (fr) | 2012-01-11 | 2014-07-07 | Pyrimidines et triazines annelées substituées et leur utilisation |
Country Status (29)
Country | Link |
---|---|
US (2) | US20140357637A1 (fr) |
EP (1) | EP2802592A1 (fr) |
JP (1) | JP6251183B2 (fr) |
KR (1) | KR20140114416A (fr) |
CN (1) | CN104812762B (fr) |
AP (1) | AP2014007844A0 (fr) |
AU (1) | AU2013208968A1 (fr) |
BR (1) | BR112014016971A8 (fr) |
CA (1) | CA2860855A1 (fr) |
CL (1) | CL2014001779A1 (fr) |
CO (1) | CO7000776A2 (fr) |
CR (1) | CR20140327A (fr) |
CU (1) | CU20140082A7 (fr) |
DE (1) | DE102012200349A1 (fr) |
DO (1) | DOP2014000160A (fr) |
EA (1) | EA025837B1 (fr) |
EC (1) | ECSP14008556A (fr) |
GT (1) | GT201400147A (fr) |
HK (1) | HK1211585A1 (fr) |
IL (1) | IL233460A0 (fr) |
MA (1) | MA35844B1 (fr) |
MX (1) | MX2014008201A (fr) |
NZ (1) | NZ626394A (fr) |
PE (1) | PE20142293A1 (fr) |
PH (1) | PH12014501595A1 (fr) |
SG (2) | SG11201403345UA (fr) |
TN (1) | TN2014000298A1 (fr) |
WO (1) | WO2013104703A1 (fr) |
ZA (1) | ZA201405042B (fr) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
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EA201390060A1 (ru) | 2010-07-09 | 2013-07-30 | Байер Интеллектуэль Проперти Гмбх | Аннелированные пиримидины и триазины и их применение для лечения и/или профилактики сердечно-сосудистых заболеваний |
CN103619845B (zh) * | 2011-04-21 | 2016-08-17 | 拜耳知识产权有限责任公司 | 氟烷基取代的吡唑并吡啶及其用途 |
DE102012200349A1 (de) | 2012-01-11 | 2013-07-11 | Bayer Intellectual Property Gmbh | Substituierte annellierte Pyrimidine und Triazine und ihre Verwendung |
DE102012200360A1 (de) | 2012-01-11 | 2013-07-11 | Bayer Intellectual Property Gmbh | Substituierte Triazine und ihre Verwendung |
DE102012200352A1 (de) * | 2012-01-11 | 2013-07-11 | Bayer Intellectual Property Gmbh | Substituierte, annellierte Imidazole und Pyrazole und ihre Verwendung |
ES2644781T3 (es) | 2012-03-06 | 2017-11-30 | Bayer Intellectual Property Gmbh | Azabiciclos sustituidos y su uso |
BR112015012571B1 (pt) | 2012-11-30 | 2022-05-24 | Astellas Pharma Inc | Compostos de imidazopiridina e usos terapêuticos dos mesmos |
EP2961754B1 (fr) * | 2013-03-01 | 2016-11-16 | Bayer Pharma Aktiengesellschaft | Pyrazolopyridines à substitution benzyle et leur utilisation |
WO2014131760A1 (fr) | 2013-03-01 | 2014-09-04 | Bayer Pharma Aktiengesellschaft | Pyrimidines annelées à subsitution trifluorométhyle et utilisation correspondante |
CA2914100A1 (fr) | 2013-06-04 | 2014-12-11 | Bayer Pharma Aktiengesellschaft | Imidazo[1,2-a]pyridines a substitution 3-aryle et leur utilisation |
AP2016008970A0 (en) * | 2013-07-10 | 2016-01-31 | Bayer Pharma AG | Benzyl-1h-pyrazolo[3,4-b]pyridines and use thereof |
US20160311826A1 (en) | 2013-12-11 | 2016-10-27 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
EP3079700B1 (fr) | 2013-12-11 | 2020-11-25 | Merck Sharp & Dohme Corp. | Activateurs solubles de guanylate cyclase |
US9611278B2 (en) | 2013-12-11 | 2017-04-04 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
WO2015106268A1 (fr) | 2014-01-13 | 2015-07-16 | Ironwood Pharmaceuticals, Inc. | Utilisation de stimulateurs de la sgc pour le traitement de troubles neuromusculaires |
WO2015124544A1 (fr) * | 2014-02-19 | 2015-08-27 | Bayer Pharma Aktiengesellschaft | 3-(pyrimidin-2-yl)imidazo[1,2-a]pyridines |
US9796733B2 (en) | 2014-06-04 | 2017-10-24 | Merck Sharp & Dohme Corp. | Imidazo-pyrazine derivatives useful as soluble guanylate cyclase activators |
CA2959199A1 (fr) | 2014-08-29 | 2016-03-03 | Bayer Pharma Aktiengesellschaft | Pyrimidines annelees amino-substituees et leur utilisation |
EP3186251A1 (fr) | 2014-08-29 | 2017-07-05 | Bayer Pharma Aktiengesellschaft | Pyrimidines condensées substituées et leur utilisation |
TW201625635A (zh) | 2014-11-21 | 2016-07-16 | 默沙東藥廠 | 作為可溶性鳥苷酸環化酶活化劑之三唑并吡基衍生物 |
WO2016087343A1 (fr) | 2014-12-02 | 2016-06-09 | Bayer Pharma Aktiengesellschaft | Imidazo[1,2-a]pyridines à substitution hétéroaryle et leur utilisation |
US20180169095A1 (en) | 2015-05-06 | 2018-06-21 | Bayer Pharma Aktiengesellschaft | The use of sgc stimulators, sgc activators, alone and combinations with pde5 inhibitors for the treatment of digital ulcers (du) concomitant to systemic sclerosis (ssc) |
EP3303342B1 (fr) | 2015-05-27 | 2021-03-17 | Merck Sharp & Dohme Corp. | Dérivés d'imidazo-pyrazinyle utiles à titre d'activateurs de guanylate cyclase solubles |
US10213429B2 (en) | 2015-05-28 | 2019-02-26 | Merck Sharp & Dohme Corp. | Imidazo-pyrazinyl derivatives useful as soluble guanylate cyclase activators |
DK3325013T4 (da) | 2015-07-23 | 2023-10-16 | Bayer Pharma AG | Stimulatorer og/eller aktivatorer af den opløselige guanylatcyklase (sgc) i kombination med en inhibitor af den neutrale endopeptidase (nep inhibitor) og en angiotensin aii-antagonist og deres anvendelse |
KR101753652B1 (ko) * | 2015-10-21 | 2017-07-05 | 한국화학연구원 | N-아릴-1h-피라졸로피리딘-3-아민 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 melk 관련 질환의 예방 또는 치료용 약학적 조성물 |
CN108463224A (zh) | 2015-12-14 | 2018-08-28 | 铁木医药有限公司 | sGC刺激剂用于胃肠功能障碍治疗的应用 |
WO2017107052A1 (fr) | 2015-12-22 | 2017-06-29 | Merck Sharp & Dohme Corp. | Activateurs solubles de guanylate cyclase |
WO2017197555A1 (fr) | 2016-05-16 | 2017-11-23 | Merck Sharp & Dohme Corp. | Dérivés de pyrazine fusionnés utiles en tant que stimulateurs de la guanylate cyclase soluble |
US10925876B2 (en) | 2016-05-18 | 2021-02-23 | Merck Sharp & Dohme Corp. | Methods for using triazolo-pyrazinyl soluble guanylate cyclase activators in fibrotic disorders |
BR112019004468A2 (pt) | 2016-09-02 | 2019-05-28 | Ironwood Pharmaceuticals Inc | estimulantes de sgc |
EP3525779B1 (fr) | 2016-10-11 | 2024-06-05 | Bayer Pharma Aktiengesellschaft | Combinaison contenant le stimulateur sgc vericugat et l'antagoniste des récepteurs minéralcorticoïdes finerenone |
CN109890379A (zh) | 2016-10-11 | 2019-06-14 | 拜耳制药股份公司 | 包含sGC活化剂和盐皮质激素受体拮抗剂的组合产品 |
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EP3820476A1 (fr) | 2018-07-11 | 2021-05-19 | Cyclerion Therapeutics, Inc. | Utilisation de stimulateurs gcs pour le traitement de maladies mitochondriales |
WO2020164008A1 (fr) | 2019-02-13 | 2020-08-20 | Bayer Aktiengesellschaft | Procédé de préparation de microparticules poreuses |
CN113368240B (zh) * | 2021-06-13 | 2022-08-02 | 重庆医科大学 | 一种二茂铁基金属有机框架纳米粒及其制备方法 |
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CN103608347B (zh) | 2011-05-30 | 2016-04-27 | 安斯泰来制药株式会社 | 咪唑并吡啶化合物 |
ES2648810T3 (es) * | 2011-07-06 | 2018-01-08 | Bayer Intellectual Property Gmbh | Pirazolopiridinas sustituidas con heteroarilo y uso de las mismas como estimuladores de la guanilato ciclasa soluble |
JP6096778B2 (ja) | 2011-09-01 | 2017-03-15 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | ピロロピラジンキナーゼ阻害剤 |
AU2012300844B2 (en) | 2011-09-02 | 2017-03-30 | Bayer Intellectual Property Gmbh | Substituted annellated pyrimidine and the use thereof |
DE102012200352A1 (de) | 2012-01-11 | 2013-07-11 | Bayer Intellectual Property Gmbh | Substituierte, annellierte Imidazole und Pyrazole und ihre Verwendung |
DE102012200349A1 (de) | 2012-01-11 | 2013-07-11 | Bayer Intellectual Property Gmbh | Substituierte annellierte Pyrimidine und Triazine und ihre Verwendung |
DE102012200360A1 (de) | 2012-01-11 | 2013-07-11 | Bayer Intellectual Property Gmbh | Substituierte Triazine und ihre Verwendung |
ES2644781T3 (es) | 2012-03-06 | 2017-11-30 | Bayer Intellectual Property Gmbh | Azabiciclos sustituidos y su uso |
WO2014131760A1 (fr) | 2013-03-01 | 2014-09-04 | Bayer Pharma Aktiengesellschaft | Pyrimidines annelées à subsitution trifluorométhyle et utilisation correspondante |
EP2961754B1 (fr) | 2013-03-01 | 2016-11-16 | Bayer Pharma Aktiengesellschaft | Pyrazolopyridines à substitution benzyle et leur utilisation |
AP2016008970A0 (en) | 2013-07-10 | 2016-01-31 | Bayer Pharma AG | Benzyl-1h-pyrazolo[3,4-b]pyridines and use thereof |
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2012
- 2012-01-11 DE DE102012200349A patent/DE102012200349A1/de not_active Withdrawn
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2013
- 2013-01-10 CN CN201380013679.1A patent/CN104812762B/zh not_active Expired - Fee Related
- 2013-01-10 AU AU2013208968A patent/AU2013208968A1/en not_active Abandoned
- 2013-01-10 EA EA201491339A patent/EA025837B1/ru not_active IP Right Cessation
- 2013-01-10 CA CA2860855A patent/CA2860855A1/fr not_active Abandoned
- 2013-01-10 US US14/371,046 patent/US20140357637A1/en not_active Abandoned
- 2013-01-10 KR KR1020147021969A patent/KR20140114416A/ko not_active Application Discontinuation
- 2013-01-10 EP EP13700288.7A patent/EP2802592A1/fr not_active Withdrawn
- 2013-01-10 SG SG11201403345UA patent/SG11201403345UA/en unknown
- 2013-01-10 NZ NZ626394A patent/NZ626394A/en not_active IP Right Cessation
- 2013-01-10 SG SG10201605655UA patent/SG10201605655UA/en unknown
- 2013-01-10 JP JP2014551609A patent/JP6251183B2/ja not_active Expired - Fee Related
- 2013-01-10 PE PE2014001063A patent/PE20142293A1/es not_active Application Discontinuation
- 2013-01-10 BR BR112014016971A patent/BR112014016971A8/pt not_active IP Right Cessation
- 2013-01-10 MX MX2014008201A patent/MX2014008201A/es not_active Application Discontinuation
- 2013-01-10 AP AP2014007844A patent/AP2014007844A0/xx unknown
- 2013-01-10 WO PCT/EP2013/050381 patent/WO2013104703A1/fr active Application Filing
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2014
- 2014-06-30 IL IL233460A patent/IL233460A0/en unknown
- 2014-07-03 CL CL2014001779A patent/CL2014001779A1/es unknown
- 2014-07-07 CU CU2014000082A patent/CU20140082A7/es unknown
- 2014-07-07 MA MA37178A patent/MA35844B1/fr unknown
- 2014-07-08 CR CR20140327A patent/CR20140327A/es unknown
- 2014-07-08 CO CO14146937A patent/CO7000776A2/es unknown
- 2014-07-08 DO DO2014000160A patent/DOP2014000160A/es unknown
- 2014-07-09 EC ECIEPI20148556A patent/ECSP14008556A/es unknown
- 2014-07-09 TN TNP2014000298A patent/TN2014000298A1/fr unknown
- 2014-07-10 ZA ZA2014/05042A patent/ZA201405042B/en unknown
- 2014-07-10 GT GT201400147A patent/GT201400147A/es unknown
- 2014-07-10 PH PH12014501595A patent/PH12014501595A1/en unknown
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2015
- 2015-06-12 US US14/738,148 patent/US9505786B2/en not_active Expired - Fee Related
- 2015-12-17 HK HK15112419.1A patent/HK1211585A1/xx unknown
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