SG10201400329YA - Method of nuclear reprogramming - Google Patents
Method of nuclear reprogrammingInfo
- Publication number
- SG10201400329YA SG10201400329YA SG10201400329YA SG10201400329YA SG10201400329YA SG 10201400329Y A SG10201400329Y A SG 10201400329YA SG 10201400329Y A SG10201400329Y A SG 10201400329YA SG 10201400329Y A SG10201400329Y A SG 10201400329YA SG 10201400329Y A SG10201400329Y A SG 10201400329YA
- Authority
- SG
- Singapore
- Prior art keywords
- nuclear reprogramming
- reprogramming
- nuclear
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J37/00—Discharge tubes with provision for introducing objects or material to be exposed to the discharge, e.g. for the purpose of examination or processing thereof
- H01J37/02—Details
- H01J37/24—Circuit arrangements not adapted to a particular application of the tube and not otherwise provided for
- H01J37/241—High voltage power supply or regulation circuits
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J37/00—Discharge tubes with provision for introducing objects or material to be exposed to the discharge, e.g. for the purpose of examination or processing thereof
- H01J37/32—Gas-filled discharge tubes
- H01J37/32009—Arrangements for generation of plasma specially adapted for examination or treatment of objects, e.g. plasma sources
- H01J37/32073—Corona discharge
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/602—Sox-2
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/603—Oct-3/4
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/604—Klf-4
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/605—Nanog
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/606—Transcription factors c-Myc
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/608—Lin28
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
- C12N2506/1307—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from adult fibroblasts
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
- C12N2506/1346—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells
- C12N2506/1361—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from mesenchymal stem cells from dental pulp or dental follicle stem cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J2237/00—Discharge tubes exposing object to beam, e.g. for analysis treatment, etching, imaging
- H01J2237/03—Mounting, supporting, spacing or insulating electrodes
- H01J2237/038—Insulating
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J2237/00—Discharge tubes exposing object to beam, e.g. for analysis treatment, etching, imaging
- H01J2237/06—Sources
- H01J2237/063—Electron sources
- H01J2237/06375—Arrangement of electrodes
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Developmental Biology & Embryology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Transplantation (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Analytical Chemistry (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Plasma & Fusion (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7150808P | 2008-05-02 | 2008-05-02 | |
US13624608P | 2008-08-21 | 2008-08-21 | |
US13661508P | 2008-09-19 | 2008-09-19 | |
US19336308P | 2008-11-21 | 2008-11-21 |
Publications (1)
Publication Number | Publication Date |
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SG10201400329YA true SG10201400329YA (en) | 2014-05-29 |
Family
ID=41255176
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201400329YA SG10201400329YA (en) | 2008-05-02 | 2009-05-01 | Method of nuclear reprogramming |
Country Status (9)
Country | Link |
---|---|
US (5) | US20100279404A1 (fr) |
EP (1) | EP2268809B1 (fr) |
JP (1) | JP5346925B2 (fr) |
KR (1) | KR101661940B1 (fr) |
CN (1) | CN101855350B (fr) |
CA (1) | CA2695522C (fr) |
ES (1) | ES2722198T3 (fr) |
SG (1) | SG10201400329YA (fr) |
WO (1) | WO2009133971A1 (fr) |
Families Citing this family (46)
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US7682828B2 (en) | 2003-11-26 | 2010-03-23 | Whitehead Institute For Biomedical Research | Methods for reprogramming somatic cells |
ES2933478T3 (es) * | 2005-08-03 | 2023-02-09 | Astellas Inst For Regenerative Medicine | Métodos mejorados de reprogramación de células somáticas animales |
EA014166B1 (ru) | 2005-12-13 | 2010-10-29 | Киото Юниверсити | Ядерный фактор перепрограммирования |
US8129187B2 (en) | 2005-12-13 | 2012-03-06 | Kyoto University | Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2 |
US8278104B2 (en) | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
AU2008231020B2 (en) | 2007-03-23 | 2013-09-05 | Wisconsin Alumni Research Foundation | Somatic cell reprogramming |
US9382515B2 (en) | 2007-04-07 | 2016-07-05 | Whitehead Institute For Biomedical Research | Reprogramming of somatic cells |
US9213999B2 (en) | 2007-06-15 | 2015-12-15 | Kyoto University | Providing iPSCs to a customer |
JP2008307007A (ja) * | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
SG10201400329YA (en) | 2008-05-02 | 2014-05-29 | Univ Kyoto | Method of nuclear reprogramming |
AU2009256202B2 (en) * | 2008-06-04 | 2014-07-03 | FUJIFILM Cellular Dynamics, Inc. | Methods for the production of IPS cells using non-viral approach |
AU2015202237B2 (en) * | 2008-06-13 | 2017-09-28 | Whitehead Institute For Biomedical Research | Programming and reprogramming of cells |
CA2969377C (fr) * | 2008-06-13 | 2019-12-03 | Whitehead Institute For Biomedical Research | Programmation et reprogrammation des cellules |
CN104962583B (zh) | 2008-07-16 | 2019-11-01 | 株式会社爱迪药业 | 使用染色体非整合型病毒载体制造经初始化的细胞的方法 |
JP5562231B2 (ja) * | 2008-07-30 | 2014-07-30 | 国立大学法人京都大学 | 効率的な人工多能性幹細胞の樹立方法 |
AU2009282133B2 (en) | 2008-08-12 | 2015-12-10 | FUJIFILM Cellular Dynamics, Inc. | Methods for the Production of IPS Cells |
WO2010030003A1 (fr) * | 2008-09-12 | 2010-03-18 | 協和発酵キリン株式会社 | Système destiné à réguler l’expression d’une famille de gènes pour une utilisation dans la reprogrammation d’une cellule |
WO2010042490A1 (fr) * | 2008-10-06 | 2010-04-15 | Boston Medical Center Corporation | Système de vecteur lentiviral unique pour dérivation de cellules souches pluripotentes induites (ips) |
DK3450545T3 (da) | 2008-10-24 | 2023-10-02 | Wisconsin Alumni Res Found | Pluripotente stamceller opnået ved ikke-viral omprogrammering |
SG174426A1 (en) | 2009-03-20 | 2011-10-28 | Angioblast Systems Inc | Production of reprogrammed pluripotent cells |
CA2952805C (fr) | 2009-06-05 | 2021-06-01 | Cellular Dynamics International, Inc. | Reprogrammation de lymphocytes t et de cellules hematopoietiques |
US20130071919A1 (en) * | 2010-03-10 | 2013-03-21 | Kyoto University | Method of selecting induced pluripotent stem cell |
CN105176930B (zh) * | 2010-03-31 | 2021-05-04 | 斯克里普斯研究所 | 重编程细胞 |
CA3122219A1 (fr) | 2010-04-16 | 2011-10-20 | The Children's Hospital Corporation | Expression de polypeptide prolongee a partir d'arn synthetiques modifies et utilisations de celle-ci |
US8048675B1 (en) | 2010-05-12 | 2011-11-01 | Ipierian, Inc. | Integration-free human induced pluripotent stem cells from blood |
CA2809515A1 (fr) * | 2010-08-30 | 2012-03-08 | Dnavec Corporation | Composition pour induire une cellule souche pluripotente, et utilisation de cette composition |
WO2012051515A2 (fr) * | 2010-10-14 | 2012-04-19 | University Of Central Florida Research Foundation, Inc. | Cellules souches pluripotentes cardio-induites et procédés d'utilisation pour la réparation et la régénération du myocarde |
EP2647699B1 (fr) * | 2010-12-03 | 2020-04-01 | Kyoto University | Procédé efficace pour l'établissement de cellules souches pluripotentes artificielles |
WO2012098260A1 (fr) | 2011-01-21 | 2012-07-26 | Axiogenesis Ag | Système non viral pour générer des cellules souches pluripotentes induites (ips) |
US9228204B2 (en) | 2011-02-14 | 2016-01-05 | University Of Utah Research Foundation | Constructs for making induced pluripotent stem cells |
JP6189829B2 (ja) | 2011-05-13 | 2017-08-30 | ザ・ユナイテッド・ステイツ・オブ・アメリカ・アズ・リプリゼンティド・バイ・ザ・セクレタリー・フォー・ザ・デパートメント・オブ・ヘルス・アンド・ヒューマン・サービシズ | Zscan4とzscan4依存性遺伝子を利用した体細胞の直接的な再プログラム化 |
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WO2014186766A1 (fr) * | 2013-05-17 | 2014-11-20 | The Broad Institute, Inc. | Cellules reprogrammées et procédés de production et utilisation correspondants |
WO2015006725A2 (fr) * | 2013-07-12 | 2015-01-15 | Cedars-Sinai Medical Center | Génération de cellules souches pluripotentes induites à partir de cellules épithéliales mammaires humaines normales |
WO2015030111A1 (fr) | 2013-08-28 | 2015-03-05 | 国立大学法人岐阜大学 | Procédé de production de cellules souches pluripotentes induites |
WO2015066488A2 (fr) | 2013-11-01 | 2015-05-07 | New England Biolabs, Inc. | Procédé de production de cellules souches pluripotentes induites |
CN108601801A (zh) | 2015-10-05 | 2018-09-28 | 欧瑞3恩公司 | 基于鉴别和改善肝功能障碍来诊断和治疗帕金森病 |
RU2741786C2 (ru) | 2016-05-25 | 2021-01-28 | Энсэрм (Энститю Насьональ Де Ла Санте Э Де Ла Решерш Медикаль) | Способы и композиции для лечения опухолей |
US11572545B2 (en) | 2016-06-16 | 2023-02-07 | Cedars-Sinai Medical Center | Efficient method for reprogramming blood to induced pluripotent stem cells |
US10221395B2 (en) | 2016-06-16 | 2019-03-05 | Cedars-Sinai Medical Center | Efficient method for reprogramming blood to induced pluripotent stem cells |
DK3644728T3 (da) * | 2017-06-28 | 2022-10-31 | Sci Group As | Frysning af biologisk materiale |
US11679148B2 (en) | 2017-11-24 | 2023-06-20 | Institut National De La Santé Et De La Recherche Médicale (Inserm) | Methods and compositions for treating cancers |
CN112703011A (zh) | 2018-08-06 | 2021-04-23 | 国家医疗保健研究所 | 用于治疗癌症的方法和组合物 |
EP4314246A1 (fr) | 2021-04-01 | 2024-02-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Procédés de fabrication d'organoïdes hépatiques, organoïdes hépatiques obtenus à l'aide de ceux-ci, et leurs utilisations |
CN113462638B (zh) * | 2021-06-30 | 2022-10-25 | 呈诺再生医学科技(珠海横琴新区)有限公司 | 一种高效无遗传修饰的iPSC诱导、产业化单克隆挑取平台及应用 |
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CA2695522C (fr) | 2019-01-15 |
US20150072417A1 (en) | 2015-03-12 |
JP5346925B2 (ja) | 2013-11-20 |
KR20110015500A (ko) | 2011-02-16 |
US20200172875A1 (en) | 2020-06-04 |
CA2695522A1 (fr) | 2009-11-05 |
KR101661940B1 (ko) | 2016-10-04 |
EP2268809A4 (fr) | 2013-02-27 |
EP2268809A1 (fr) | 2011-01-05 |
US20130065311A1 (en) | 2013-03-14 |
CN101855350B (zh) | 2014-12-31 |
US20100279404A1 (en) | 2010-11-04 |
CN101855350A (zh) | 2010-10-06 |
EP2268809B1 (fr) | 2019-02-06 |
WO2009133971A1 (fr) | 2009-11-05 |
US20230282445A1 (en) | 2023-09-07 |
US9499797B2 (en) | 2016-11-22 |
ES2722198T3 (es) | 2019-08-08 |
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