CA2346152A1 - Procede pour favoriser l'autorenouvellement et transduction genique amelioree des cellules souches hematopoietiques par des inhibiteurs de desacetylase de l'histone - Google Patents
Procede pour favoriser l'autorenouvellement et transduction genique amelioree des cellules souches hematopoietiques par des inhibiteurs de desacetylase de l'histone Download PDFInfo
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- CA2346152A1 CA2346152A1 CA002346152A CA2346152A CA2346152A1 CA 2346152 A1 CA2346152 A1 CA 2346152A1 CA 002346152 A CA002346152 A CA 002346152A CA 2346152 A CA2346152 A CA 2346152A CA 2346152 A1 CA2346152 A1 CA 2346152A1
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/145—Thrombopoietin [TPO]
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2306—Interleukin-6 (IL-6)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/235—Leukemia inhibitory factor [LIF]
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
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Abstract
L'invention porte sur un procédé visant à favoriser l'autorenouvellement des cellules souches et consistant à exposer une population de cellules souches, notamment les cellules souches hématopoïétiques, à une dose effective d'un inhibiteur de désacétylase de l'histone, notamment la trichostatine ou la chlamydocine. L'invention porte également sur l'utilisation des inhibiteurs de désacétylase de l'histone permettant d'accroître le nombre des cellules souches ayant subi une transduction.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US17363398A | 1998-10-16 | 1998-10-16 | |
US09/173,633 | 1998-10-16 | ||
US13247699P | 1999-05-04 | 1999-05-04 | |
US60/132,476 | 1999-05-04 | ||
PCT/EP1999/007741 WO2000023567A2 (fr) | 1998-10-16 | 1999-10-14 | Procede pour favoriser l'autorenouvellement et transduction genique amelioree des cellules souches hematopoietiques par des inhibiteurs de desacetylase de l'histone |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2346152A1 true CA2346152A1 (fr) | 2000-04-27 |
Family
ID=26830391
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002346152A Abandoned CA2346152A1 (fr) | 1998-10-16 | 1999-10-14 | Procede pour favoriser l'autorenouvellement et transduction genique amelioree des cellules souches hematopoietiques par des inhibiteurs de desacetylase de l'histone |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1129175A2 (fr) |
JP (1) | JP2002527101A (fr) |
AU (1) | AU6339399A (fr) |
CA (1) | CA2346152A1 (fr) |
WO (1) | WO2000023567A2 (fr) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5032669A (en) * | 1990-05-01 | 1991-07-16 | University Of Massachusetts At Amherst | Liquid crystalline polyesters formed by reaction of bis(hydroxyalkoxy) biphenyls with terephthaloyl chloride |
WO2002055017A2 (fr) | 2000-11-21 | 2002-07-18 | Wake Forest University | Methode de traitement de maladies auto-immunes |
DE10162080A1 (de) * | 2001-12-10 | 2003-06-26 | Albrecht Mueller | Verfahren zur Herstellung von Stammzellen mit erhöhtem Entwicklungspotential |
CA2478479A1 (fr) | 2002-03-07 | 2003-09-18 | University Of Delaware | Methodes, compositions et kits visant a ameliorer l'alteration de sequences d'acides nucleiques a l'aide d'oligonucleotides grace a des compositions contenant un inhibiteur d'histone deacetylase, une beta proteine du phage lambda, ou de l'hydroxyuree |
EP1593737B1 (fr) * | 2004-05-05 | 2011-02-02 | Zorica Becker-Kojic | Utilisation d'anticorps contre la glycoprotéine ACA pour l'obtention ou le maintien de cellules souches pluripotentes non-embryonnaires |
US20090130064A1 (en) * | 2004-10-27 | 2009-05-21 | Vera Rogiers | Differentiation of stem cells and stabilization of phenotypical properties of primary cells |
EA200800321A1 (ru) | 2005-07-14 | 2008-06-30 | Такеда Сан Диего, Инк. | Ингибиторы гистондеацетилазы |
US8278104B2 (en) | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
EP2208786B1 (fr) | 2005-12-13 | 2018-08-01 | Kyoto University | Facteur de reprogrammation nucléaire |
US8129187B2 (en) | 2005-12-13 | 2012-03-06 | Kyoto University | Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2 |
JP2008307007A (ja) | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
US9213999B2 (en) | 2007-06-15 | 2015-12-15 | Kyoto University | Providing iPSCs to a customer |
CA2695522C (fr) | 2008-05-02 | 2019-01-15 | Kyoto University | Procede de reprogrammation nucleaire |
JP5010760B2 (ja) | 2010-10-05 | 2012-08-29 | タカラバイオ株式会社 | ウイルスベクターの製造方法 |
DK3269802T3 (da) | 2011-09-30 | 2020-02-03 | Bluebird Bio Inc | Forbindelser til forbedret virustransduktion |
EP2829606A4 (fr) | 2012-03-22 | 2016-02-24 | Takara Bio Inc | Procédé de production de vecteur viral |
WO2013146480A1 (fr) * | 2012-03-29 | 2013-10-03 | タカラバイオ株式会社 | Procédé d'introduction de gène |
JP6551963B2 (ja) * | 2014-05-14 | 2019-07-31 | 国立大学法人京都大学 | 巨核球前駆細胞の製造方法 |
KR102097191B1 (ko) * | 2016-11-10 | 2020-04-06 | 울산대학교 산학협력단 | 히스톤 탈아세틸화 저해제 및 프라이밍 인자를 유효성분으로 포함하는 줄기세포 활성 촉진용 조성물 |
WO2018088821A1 (fr) * | 2016-11-10 | 2018-05-17 | 울산대학교 산학협력단 | Composition favorisant l'activité des cellules souches, comprenant un inhibiteur d'histone désacétylase et un facteur d'amorçage en tant que principes actifs |
WO2021207673A1 (fr) * | 2020-04-09 | 2021-10-14 | The Regents of the University of Colorodo, a body corporate | Compositions, méthodes et utilisations pour production de cellules souches hématopoïétiques (csh) |
WO2021224633A1 (fr) | 2020-05-06 | 2021-11-11 | Orchard Therapeutics (Europe) Limited | Traitement pour les maladies neurodégénératives |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ314644A (en) * | 1993-05-24 | 2000-11-24 | Immunex Corp | Use of flt3-ligands as a growth stimulator of stem cells in the transplantation of tissue |
US6060052A (en) * | 1995-10-30 | 2000-05-09 | Systemix, Inc. | Methods for use of Mpl ligands with primitive human hematopoietic stem cells |
EP0827742A1 (fr) * | 1996-09-04 | 1998-03-11 | Vrije Universiteit Brussel | Utilisation des inhibiteurs de l'histone déacétylase pour le traitement de la fibrose ou de la cirrhose |
-
1999
- 1999-10-14 CA CA002346152A patent/CA2346152A1/fr not_active Abandoned
- 1999-10-14 AU AU63393/99A patent/AU6339399A/en not_active Abandoned
- 1999-10-14 EP EP99950725A patent/EP1129175A2/fr not_active Withdrawn
- 1999-10-14 WO PCT/EP1999/007741 patent/WO2000023567A2/fr not_active Application Discontinuation
- 1999-10-14 JP JP2000577279A patent/JP2002527101A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2002527101A (ja) | 2002-08-27 |
WO2000023567A3 (fr) | 2000-07-27 |
WO2000023567A2 (fr) | 2000-04-27 |
AU6339399A (en) | 2000-05-08 |
EP1129175A2 (fr) | 2001-09-05 |
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