SE9704544D0 - Novel compounds - Google Patents

Novel compounds

Info

Publication number
SE9704544D0
SE9704544D0 SE9704544A SE9704544A SE9704544D0 SE 9704544 D0 SE9704544 D0 SE 9704544D0 SE 9704544 A SE9704544 A SE 9704544A SE 9704544 A SE9704544 A SE 9704544A SE 9704544 D0 SE9704544 D0 SE 9704544D0
Authority
SE
Sweden
Prior art keywords
novel compounds
pharmaceutical compositions
therapy
preparing
preparation
Prior art date
Application number
SE9704544A
Other languages
English (en)
Swedish (sv)
Inventor
Andrew Baxter
Thomas Mcinally
Michael Mortimore
Original Assignee
Astra Pharma Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Pharma Prod filed Critical Astra Pharma Prod
Priority to SE9704544A priority Critical patent/SE9704544D0/xx
Publication of SE9704544D0 publication Critical patent/SE9704544D0/xx
Priority to SK843-2000A priority patent/SK8432000A3/sk
Priority to NZ504447A priority patent/NZ504447A/en
Priority to RU2000117574/04A priority patent/RU2214997C2/ru
Priority to HU0004434A priority patent/HUP0004434A3/hu
Priority to JP2000524258A priority patent/JP2001525392A/ja
Priority to IL13636998A priority patent/IL136369A0/xx
Priority to US09/230,478 priority patent/US6201024B1/en
Priority to IDW20001019A priority patent/ID28003A/id
Priority to CA002312420A priority patent/CA2312420A1/fr
Priority to CN98813491A priority patent/CN1284057A/zh
Priority to TR2000/01605T priority patent/TR200001605T2/xx
Priority to AU17913/99A priority patent/AU744280B2/en
Priority to EP98962751A priority patent/EP1036059B1/fr
Priority to DE69808130T priority patent/DE69808130T2/de
Priority to ES98962751T priority patent/ES2184352T3/es
Priority to AT98962751T priority patent/ATE224360T1/de
Priority to KR1020007006132A priority patent/KR20010032814A/ko
Priority to PT98962751T priority patent/PT1036059E/pt
Priority to EEP200000378A priority patent/EE200000378A/xx
Priority to SI9830276T priority patent/SI1036059T1/xx
Priority to DK98962751T priority patent/DK1036059T3/da
Priority to BR9813390-0A priority patent/BR9813390A/pt
Priority to PCT/SE1998/002188 priority patent/WO1999029661A1/fr
Priority to PL98340906A priority patent/PL340906A1/xx
Priority to NO20002786A priority patent/NO20002786L/no
Priority to US09/745,740 priority patent/US6303659B2/en
Priority to US09/745,346 priority patent/US6258838B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/04—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D203/06—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D203/08—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom
    • C07D203/14—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring nitrogen atom with carbocyclic rings directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C233/65—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SE9704544A 1997-12-05 1997-12-05 Novel compounds SE9704544D0 (sv)

Priority Applications (28)

Application Number Priority Date Filing Date Title
SE9704544A SE9704544D0 (sv) 1997-12-05 1997-12-05 Novel compounds
PL98340906A PL340906A1 (en) 1997-12-05 1998-12-01 Adamantane derivatives
AU17913/99A AU744280B2 (en) 1997-12-05 1998-12-01 Adamantane derivatives
DE69808130T DE69808130T2 (de) 1997-12-05 1998-12-01 Adamantan-derivate
RU2000117574/04A RU2214997C2 (ru) 1997-12-05 1998-12-01 Производные адамантана, способ их получения, фармацевтическая композиция и способ получения фармацевтической композиции
HU0004434A HUP0004434A3 (en) 1997-12-05 1998-12-01 Adamantane derivatives and pharmaceuticals containing them
JP2000524258A JP2001525392A (ja) 1997-12-05 1998-12-01 アダマンタン誘導体
IL13636998A IL136369A0 (en) 1997-12-05 1998-12-01 Adamantane derivatives
US09/230,478 US6201024B1 (en) 1997-12-05 1998-12-01 Adamantane derivatives
IDW20001019A ID28003A (id) 1997-12-05 1998-12-01 Turunan-turunan adamantana
CA002312420A CA2312420A1 (fr) 1997-12-05 1998-12-01 Derives d'adamantane
CN98813491A CN1284057A (zh) 1997-12-05 1998-12-01 金刚烷衍生物
TR2000/01605T TR200001605T2 (tr) 1997-12-05 1998-12-01 Adamantan türevleri.
SK843-2000A SK8432000A3 (en) 1997-12-05 1998-12-01 Adamantane derivatives
EP98962751A EP1036059B1 (fr) 1997-12-05 1998-12-01 Derives d'adamantane
NZ504447A NZ504447A (en) 1997-12-05 1998-12-01 Substituted-N-(tricyclo[3.3.1.1]dec-1-methyl)-benzamides and their use in treating inflammatory, immune or cardiovascular diseases
ES98962751T ES2184352T3 (es) 1997-12-05 1998-12-01 Derivados de adamantano.
AT98962751T ATE224360T1 (de) 1997-12-05 1998-12-01 Adamantan-derivate
KR1020007006132A KR20010032814A (ko) 1997-12-05 1998-12-01 아다만탄 유도체
PT98962751T PT1036059E (pt) 1997-12-05 1998-12-01 Derivados de adamantano
EEP200000378A EE200000378A (et) 1997-12-05 1998-12-01 Adamantaani derivaadid
SI9830276T SI1036059T1 (en) 1997-12-05 1998-12-01 Adamantane derivatives
DK98962751T DK1036059T3 (da) 1997-12-05 1998-12-01 Adamantanderivater
BR9813390-0A BR9813390A (pt) 1997-12-05 1998-12-01 Composto, processo para a preparação do mesmo, e uso do mesmo, composição farmacêutica, processo para a preparação da mesma, e, processo para efetuar a imunossupressão
PCT/SE1998/002188 WO1999029661A1 (fr) 1997-12-05 1998-12-01 Derives d'adamantane
NO20002786A NO20002786L (no) 1997-12-05 2000-05-31 Adamantanderivater
US09/745,740 US6303659B2 (en) 1997-12-05 2000-12-26 Compounds
US09/745,346 US6258838B1 (en) 1997-12-05 2000-12-26 Compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9704544A SE9704544D0 (sv) 1997-12-05 1997-12-05 Novel compounds

Publications (1)

Publication Number Publication Date
SE9704544D0 true SE9704544D0 (sv) 1997-12-05

Family

ID=20409281

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9704544A SE9704544D0 (sv) 1997-12-05 1997-12-05 Novel compounds

Country Status (25)

Country Link
US (3) US6201024B1 (fr)
EP (1) EP1036059B1 (fr)
JP (1) JP2001525392A (fr)
KR (1) KR20010032814A (fr)
CN (1) CN1284057A (fr)
AT (1) ATE224360T1 (fr)
AU (1) AU744280B2 (fr)
BR (1) BR9813390A (fr)
CA (1) CA2312420A1 (fr)
DE (1) DE69808130T2 (fr)
DK (1) DK1036059T3 (fr)
EE (1) EE200000378A (fr)
ES (1) ES2184352T3 (fr)
HU (1) HUP0004434A3 (fr)
ID (1) ID28003A (fr)
IL (1) IL136369A0 (fr)
NO (1) NO20002786L (fr)
NZ (1) NZ504447A (fr)
PL (1) PL340906A1 (fr)
PT (1) PT1036059E (fr)
RU (1) RU2214997C2 (fr)
SE (1) SE9704544D0 (fr)
SK (1) SK8432000A3 (fr)
TR (1) TR200001605T2 (fr)
WO (1) WO1999029661A1 (fr)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002539185A (ja) * 1999-03-16 2002-11-19 グラクソ グループ リミテッド 核内受容体アリール化化合物
SK13422001A3 (sk) 1999-04-09 2002-05-09 Astrazeneca Ab Adamantánové deriváty
SE9904505D0 (sv) * 1999-12-09 1999-12-09 Astra Pharma Prod Novel compounds
TWI258462B (en) * 1999-12-17 2006-07-21 Astrazeneca Ab Adamantane derivative compounds, process for preparing the same and pharmaceutical composition comprising the same
SE9904738D0 (sv) * 1999-12-22 1999-12-22 Astra Pharma Prod Novel compounds
KR20030013433A (ko) 2000-05-31 2003-02-14 아스트라제네카 아베 혈관 손상 활성을 가진 인돌 유도체
GB0013737D0 (en) * 2000-06-07 2000-07-26 Astrazeneca Ab Novel compounds
JP2002330787A (ja) * 2000-10-21 2002-11-19 Astrazeneca Ab 化学物質
US7795468B2 (en) * 2001-01-19 2010-09-14 Chevron U.S.A. Inc. Functionalized higher diamondoids
EP2335700A1 (fr) 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Inhibiteurs de la polymerase du virus hepatitis C avec une structure heterobicylic
SE524952C2 (sv) * 2001-09-02 2004-10-26 Sandvik Ab Duplex rostfri stållegering
SE524951C2 (sv) * 2001-09-02 2004-10-26 Sandvik Ab Användning av en duplex rostfri stållegering
PA8557501A1 (es) 2001-11-12 2003-06-30 Pfizer Prod Inc Benzamida, heteroarilamida y amidas inversas
WO2003042190A1 (fr) 2001-11-12 2003-05-22 Pfizer Products Inc. Derives de n-adamantylalkyle benzamide en tant qu'antagonistes du recepteur p2x7
SE0103836D0 (sv) 2001-11-16 2001-11-16 Astrazeneca Ab Novel compounds
SE0200920D0 (sv) * 2002-03-25 2002-03-25 Astrazeneca Ab Novel compounds
EP1515716A2 (fr) 2002-04-03 2005-03-23 Astrazeneca AB Composes chimiques
US7582309B2 (en) * 2002-11-15 2009-09-01 Etex Corporation Cohesive demineralized bone compositions
PA8591801A1 (es) 2002-12-31 2004-07-26 Pfizer Prod Inc Inhibidores benzamidicos del receptor p2x7.
US7071223B1 (en) 2002-12-31 2006-07-04 Pfizer, Inc. Benzamide inhibitors of the P2X7 receptor
SE0300480D0 (sv) * 2003-02-21 2003-02-21 Astrazeneca Ab Novel compounds
ATE355273T1 (de) * 2003-05-12 2006-03-15 Pfizer Prod Inc Benzamidinhibitoren des p2x7-rezeptors
US20070281931A1 (en) * 2003-05-29 2007-12-06 Nigel Boughton-Smith Pharmaceutical Composition Containing a P2x7 Receptor Antagonist and Methotrexate
EP1633401A1 (fr) * 2003-05-29 2006-03-15 AstraZeneca AB Composition pharmaceutique comprenant un antagoniste des recepteurs p2x7 et un facteur de necrose tumorale alpha
WO2004105797A1 (fr) * 2003-05-29 2004-12-09 Astrazeneca Ab Nouvelle combinaison
GB0312609D0 (en) * 2003-06-02 2003-07-09 Astrazeneca Ab Novel compounds
GB0324498D0 (en) 2003-07-21 2003-11-26 Aventis Pharma Inc Heterocyclic compounds as P2X7 ion channel blockers
SE0302192D0 (sv) * 2003-08-08 2003-08-08 Astrazeneca Ab Novel compounds
SE0302488D0 (sv) * 2003-09-18 2003-09-18 Astrazeneca Ab New combination
KR20120091276A (ko) 2004-02-20 2012-08-17 베링거 인겔하임 인터내셔날 게엠베하 바이러스 폴리머라제 억제제
EP1776352A1 (fr) * 2004-06-29 2007-04-25 Pfizer Products Inc. Procedes permettant de preparer des derives de 5-[4-(2-hydroxy-propyl)-3,5-dioxo-4,5-dihydro-3h-[1,2,4]triazin-2-yl]-benzamides par deprotection des precurseurs proteges par hydroxyle
JP2008504363A (ja) * 2004-06-29 2008-02-14 ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー Ｐ２ｘ７受容体のベンズアミド阻害剤を利用する併用療法
AU2005258924A1 (en) * 2004-06-29 2006-01-12 Pfizer Products Inc. Method for preparing 5-`4-(2-hydroxy-ethyl)-3,5-dioxo-4,5-dihydro-3H-`1,2,4!-triazin-2-YK!benzamide derivatives with P2x7 inhibiting activity by reaction of the derivative unsubstituted in 4-position of the triazine with an oxiran in the presence of a lewis acid
SA05260265A (ar) * 2004-08-30 2005-12-03 استرازينيكا ايه بي مركبات جديدة
US20060063834A1 (en) * 2004-09-09 2006-03-23 Frangioni John V Substituted adamantanes, and methods of making the same
SE0402925D0 (sv) * 2004-11-30 2004-11-30 Astrazeneca Ab Novel Compounds
EP1879881A2 (fr) * 2005-04-14 2008-01-23 Bristol-Myers Squibb Company Inhibiteurs de la 11-beta hydroxysteroide deshydrogenase de type i
EP1893566B1 (fr) * 2005-06-06 2013-02-13 Merck Sharp & Dohme Ltd. Derives de cyclohexanesulfonyle en tant qu inhibiteurs de glyt1 pour traiter la schizophrenie
TWI464148B (zh) 2006-03-16 2014-12-11 Evotec Us Inc 作為ｐ２ｘ7調節劑之雙環雜芳基化合物與其用途
MX2008011919A (es) 2006-03-16 2008-11-28 Renovis Inc Compuestos de bicicloheteroarilo como moduladores de p2x7 y usos de los mismos.
JP5306987B2 (ja) 2006-03-16 2013-10-02 エボテック （ユーエス） インコーポレイテッド Ｐ２ｘ７調節因子としてのビシクロへテロアリール化合物およびその使用
SI2049478T1 (sl) * 2006-07-06 2012-08-31 Glaxo Group Ltd Substituirani N-fenilmetil-5-okso-prolin-2-amidi kot antagonisti receptorja P2X7 in postopki za njihovo uporabo
EA018036B1 (ru) 2006-11-27 2013-05-30 Х. Лундбекк А/С Гетероариламидные производные
US8093265B2 (en) 2007-03-09 2012-01-10 Renovis, Inc. Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
ES2388454T3 (es) 2007-03-22 2012-10-15 Astrazeneca Ab Derivados de quinolina para el tratamiento de enfermedades inflamatorias
GB0705882D0 (en) * 2007-03-27 2007-05-02 Glaxo Group Ltd Novel compounds
WO2008116845A1 (fr) * 2007-03-28 2008-10-02 Glaxo Group Limited Dérivés pipéridone carboxamide comme modulateurs du p2x7
NZ580394A (en) 2007-04-10 2011-10-28 Lundbeck & Co As H Heteroaryl amide analogues as p2x7 antagonists
NZ582057A (en) 2007-07-19 2012-03-30 Lundbeck & Co As H 5-membered heterocyclic amides and related compounds
KR20100093552A (ko) 2007-11-02 2010-08-25 버텍스 파마슈티칼스 인코포레이티드 단백질 키나제 ｃ-세타로서의 [1ｈ-피라졸로[3,4-ｂ]피리딘-4-일]-페닐 또는 -피리딘-2-일 유도체
PE20091036A1 (es) 2007-11-30 2009-08-15 Astrazeneca Ab Derivado de quinolina como antagonista del receptor p2x7
DE602009000550D1 (de) 2008-03-25 2011-02-24 Affectis Pharmaceuticals Ag Neuartige P2X7R-Antagonisten und ihre Verwendung
RU2386616C2 (ru) 2008-04-23 2010-04-20 Общество С Ограниченной Ответственностью "Бинатех" Производные 5-гидрокси-4-аминометил-1-циклогексил (или циклогептил)-3-алкоксикарбонилиндолов, их фармацевтически приемлемые соли, обладающие противовирусной активностью, и способ их получения
BRPI0923488A2 (pt) 2008-12-23 2019-09-24 Hoffmann La Roche amidas de didropiridona como modulares p2x7
KR101381074B1 (ko) * 2008-12-23 2014-04-11 에프. 호프만-라 로슈 아게 Ｐ2ｘ7 조절제로서의 디히드로피리돈 아미드
CN102264701A (zh) 2008-12-23 2011-11-30 霍夫曼-拉罗奇有限公司 作为p2x7调节剂的二氢吡啶酮脲
AU2010237302A1 (en) 2009-04-14 2011-12-01 Affectis Pharmaceuticals Ag Novel P2X7R antagonists and their use
EP2322149A1 (fr) 2009-11-03 2011-05-18 Universidad del Pais Vasco Procédés et compositions de traitement de l'ischémie
CA2799154A1 (fr) 2010-05-12 2011-11-17 Abbvie Inc. Inhibiteurs indazoliques des kinases
CN102858741A (zh) 2010-05-14 2013-01-02 阿费克蒂斯制药股份公司 制备p2x7r拮抗剂的新方法
WO2012110190A1 (fr) 2011-02-17 2012-08-23 Affectis Pharmaceuticals Ag Nouveaux antagonistes p2x7r et leur utilisation
WO2012163792A1 (fr) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Nouveaux antagonistes de p2x7r et leur utilisation
WO2012163456A1 (fr) 2011-05-27 2012-12-06 Affectis Pharmaceuticals Ag Nouveaux antagonistes de p2x7r et leur utilisation
KR101957843B1 (ko) * 2011-10-06 2019-03-14 (주)아모레퍼시픽 신규 아다만탄 유도체 화합물
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
US9775843B2 (en) 2012-10-11 2017-10-03 Grünenthal GmbH Treatment and/or prophylaxis of TSPO mediated diseases and/or disorders
TWI612034B (zh) * 2012-12-12 2018-01-21 愛杜西亞製藥有限公司 作爲ｐ２ｘ７受體拮抗劑之吲哚羧醯胺衍生物
WO2014097140A1 (fr) * 2012-12-18 2014-06-26 Actelion Pharmaceuticals Ltd Dérivés d'indole carboxamide utilisés en tant qu'antagonistes du récepteur p2x7
CA2905242C (fr) 2013-03-15 2016-11-29 Pfizer Inc. Composes indoliques activant l'ampk
KR102529578B1 (ko) 2014-08-29 2023-05-09 (주)아모레퍼시픽 신규 아다만탄 유도체 화합물
WO2016032182A1 (fr) * 2014-08-29 2016-03-03 (주)아모레퍼시픽 Nouveau composé dérivé d'adamantane
WO2020037350A1 (fr) * 2018-08-24 2020-02-27 The University Of Sydney Composés benzamide substitués par adamantanyle et leur utilisation en tant qu'antagonistes du récepteur p2x7

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3464998A (en) 1968-03-04 1969-09-02 Searle & Co Adamantyl esters and amides of pyridinecarboxylic acids
US3732305A (en) * 1970-03-03 1973-05-08 Us Army S-substituted thiosulfuric acid derivatives and preparation thereof
US3789072A (en) 1970-04-22 1974-01-29 Squibb & Sons Inc Carboxamides
CA2015473C (fr) * 1989-04-28 1998-04-14 Iwao Kinoshita Derives de triphenylmethane
CA2091194A1 (fr) * 1992-04-08 1993-10-09 Richard D. Connell Derives 2-oxoethyliques utilises comme immunosuppresseurs
WO1995004720A2 (fr) 1993-08-10 1995-02-16 Black James Foundation Ligands de recepteur de cck et de gastrine
GB9409150D0 (en) 1994-05-09 1994-06-29 Black James Foundation Cck and gastrin receptor ligands

Also Published As

Publication number Publication date
JP2001525392A (ja) 2001-12-11
HUP0004434A3 (en) 2002-12-28
US20010003121A1 (en) 2001-06-07
NZ504447A (en) 2002-04-26
ID28003A (id) 2001-05-03
US6258838B1 (en) 2001-07-10
KR20010032814A (ko) 2001-04-25
NO20002786L (no) 2000-07-31
US6303659B2 (en) 2001-10-16
IL136369A0 (en) 2001-06-14
EP1036059B1 (fr) 2002-09-18
ATE224360T1 (de) 2002-10-15
PL340906A1 (en) 2001-03-12
AU744280B2 (en) 2002-02-21
AU1791399A (en) 1999-06-28
CA2312420A1 (fr) 1999-06-17
NO20002786D0 (no) 2000-05-31
DE69808130T2 (de) 2003-05-28
BR9813390A (pt) 2000-10-03
DE69808130D1 (de) 2002-10-24
EE200000378A (et) 2001-12-17
HUP0004434A2 (hu) 2001-05-28
RU2214997C2 (ru) 2003-10-27
PT1036059E (pt) 2003-02-28
TR200001605T2 (tr) 2000-10-23
CN1284057A (zh) 2001-02-14
SK8432000A3 (en) 2000-12-11
DK1036059T3 (da) 2002-12-02
US6201024B1 (en) 2001-03-13
WO1999029661A1 (fr) 1999-06-17
EP1036059A1 (fr) 2000-09-20
ES2184352T3 (es) 2003-04-01

Similar Documents

Publication Publication Date Title
SE9704545D0 (sv) Novel compounds
SE9704544D0 (sv) Novel compounds
SE9704546D0 (sv) Novel compounds
MY125978A (en) Admantane derivatives
SE9904505D0 (sv) Novel compounds
MX9602683A (es) Compuestos de 6-dimetilaminometil-1-fenil-ciclohexano como substancias farmaceuticamente activas.
AP9801392A0 (en) Concentrated antibody preparation.
EE200000318A (et) Uudsed ühendid
SE9901875D0 (sv) Novel compounds
ATE231872T1 (de) Thiazolopyrimidinderivate
HUP0001508A3 (en) 4-arylmethylene-2-imino-2,3-dihydrothiazole derivatives, their use, process for the preparation thereof and pharmaceutical compositions containing them
GR990100140A (el) Νεες ενωσεις
ZA965752B (en) Triphenylethylenes, process for their production, pharmaceutical preparations that contain these triphenylethylenes as well as their use for the production of pharmaceutical agents.
IL117091A (en) Methylphenyloxazolidinone derivatives pharmaceutical compositions containing the same and processes for the preparation threreof
SE9802937D0 (sv) Novel compounds
ZA9610460B (en) New phenylamidine derivatives, processes for preparing them and their use as pharmaceutical compositions.
EE03996B1 (et) Farmatseutilised kompositsioonid, nende valmistamismeetod ja kasutamine
IL134039A0 (en) Polyhydroxybutylpyrazines, their preparation and medicines containing them
PT83253A (en) Process for preparing p-acylaminobenzamides
SE9803277D0 (sv) Novel compounds
ZA9811804B (en) 11ß-halogen-7Ó-substituted estratrienes, process for the production of pharmaceutical preparations that contain these 11ß-halogen-7Ó-substituted estratrienes as well as their use for the production of pharmaceutical agents.