SE8002904L - Forfarande for framstellning av derivat av omettad 7-acylamido-3-cefem-4-karboxylsyra - Google Patents
Forfarande for framstellning av derivat av omettad 7-acylamido-3-cefem-4-karboxylsyraInfo
- Publication number
- SE8002904L SE8002904L SE8002904A SE8002904A SE8002904L SE 8002904 L SE8002904 L SE 8002904L SE 8002904 A SE8002904 A SE 8002904A SE 8002904 A SE8002904 A SE 8002904A SE 8002904 L SE8002904 L SE 8002904L
- Authority
- SE
- Sweden
- Prior art keywords
- van
- compound
- formula
- coor
- meanings given
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
- C07D501/28—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by an aliphatic carboxylic acid, which is substituted by hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
Claims (3)
1. PATENTKRAVkannetecknat dIrav, a€€ (a) en fdrening med formeln (II) Ferfarande for framstallning av en farening med den allmanna formeln (I) 7 CH2 -S -B S A-S CH2 C-NH 0C 2-S-B(I) vani Z betecknar cyano, karbamoyl eller -COOR, van i R betecknar vate eller (C1-C6)-alkyl; A betecknar en grenad eller ogrenad °matted alifatisk kolvategrupp med 2-6 kolatomer, vilken grupp ar osubstituerad eller substituerad med en eller flera substituenter, som valts ur en grupp, som bestAr av (a) hydroxi; (b) halogen; (c) cyano; (d) -COOR, van i R her angiven bete; (e) -CORIllri R har angiven betyde1- van i B och X baroven angivna betydelser, och E betecknar -NC=O eller -N=C=S eller ett reaktionsbenaget derivat darav, hringas att reagera med en syra med formeln (III) Z-A-S-CH2-COOH van i Z och A barIvan angivn'ydelser, eller med ett reak- se; (f) 111-S02-, van i R betecknar (C1-C6)-alkyl, (g) -N7R2 • vari var och en av 112 och R3, corn kan vara like eller olika, betecknar vate eller (C1-C6)-alkyl, eller bildar P2 och 113 tillsammans med den kv5veatom till vilken de Br bundna en matted eller ondttad heteromonocyklisk 5- eller 6-ring, i silken N-atomen Br den enda hetereatomen eller vilken ring innehAller en annan heteroatom, som valts bland N, S och 0 forutom oven visade N-atomen; (h) -NH-C-NH-C-NH2 och (i) -NH-C-NHR, van i har angiven betydelse, 0 NH0 X betecknar en karboxi- eller f5restrad karboxigrupp; och H betecknar (1) en tetrazolylgrupp, som Br substituerad med (a') 7B2 (C2-C4)-alkyl; (b') (C2-C4)-alkenyl; (c') -CH2CN; (d9 -(CH2)n-N, 3 vari n betecknar 0, 1, 2 eller 3 och 2 och R3 her angivna betydelser; (e') -(CH2)n-COOR, vari n och N har angivna betydelser; (f') -CH=C1P:C0OR, van i R har angiven betydelse; (g.) -(CH2)0-00-NH2, vari n har angiven betydelse; (11') -cH2-CH=NO-CH2COOR, van i R har angiven betydelse; (i') -CH=CH-CONH2; (3') -(C(2)n-S0311, vari n har angiven betydelse; (k') -CH=CH-S03H; eller (2) en tiadiarolylgrupp, corn Br suhstituerad med (a") (C1-C4)-alkyl; (c") cyano; (c") hydroxi; (d") (C1-C4)-alkoxi; (e") -CH2CN; Cl") karbamoyl; (g") -SR, vari R har angiven betydelse; (h") -S0211, vari R bar angiven betydelse; (i") R1-2-NH-, van i R her angiven 7B2 betydelse; (3") -(CH2)0-N'van i n, 112 och 3 har angivna NFL, tionsbenaget derivat darav, eller
2. en fOrening med formeln (IV) Y-CH2 C-N • 0 van i H och X heroven angivna betydelser och Y betecknar halogen, eller ett salt dArav, bringas att reagera med en forening med formeln on Z-A-SH(V) van i Z och A haroven angivna betydelser, eller med ett reek- tionsbenaget derivat &fray, eller
3. en forening med formeln (VI) HS-CH2 C -NH (VI) van i B och X har oven angivna betydelser, eller ett reaktionsbenAget derivat darav, bringas att reagera med en fOrening med formeln (VII) (un Z -A -X'(VII) betydelser, (Cc") -(CH2)n-COOR, vari n och R har angivna betydelser, (1") -CH=CH-COOR, van i R her angiven betydelse; (m") -NH-CONH2; (n") -CH2-CO-NH2; (0") -NH-CH2-COOR, van i R her angiven betydelse; (p") -NH-00-(CH2)-COOR, vari n och N har angivna betydelser; (q") -NH-CH=CH-COON, vari B her angiven betydelse; (r") -CH=CH-CONH2; (s") -(CH2)0-S031-1, vari n har angiven betydelse; (t") -CH=CH-S0211; eller (u") -NH-CO-CH=CH-COOR, vari N her angiven betydelse; liksom farmaceutiskt eller veterinarmedicinskt godtagbare salter darav, vari Z och A har oven angivna betydelser och Y betecknar halogen eller en rest av en aktiv ester av en alkohol, eller (d) en ftSrening med formeln (VIII) C2-0-C-C112 0 Forts. ndsta side Z A S CH2 C NH 0 yari Z, A och X her ovan angivna betydelser, eller ett salt darav, bringas att reagera med en forening med formeln (IX) H -S-8(IX) Vari B har oven angiven betydelse, eller ett reaktionsbenaget derivat dArav, och att cm sA onskas en forening med formeln (I) overVires till ett farmaceutiskt eller veterinArmedicinskt godtagbart salt och/eller att on, s& onskas en fri fdrening erhAlles ur ett salt och/eller att om s& onskas en fOrening med formeln (/) eller ett salt darav overfores till en annan forening med fox-mein (I) eller ett salt darav och/eller att cm sA Onskas en blandning av isomerer uppdelas i enskilda isomerer. 9
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT20173/77A IT1075277B (it) | 1977-02-11 | 1977-02-11 | Derivati insaturi e epossidici dell'acio 7-acilamido-3-cefem-4-carbossilico e procedimento per la loro preparazione |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SE8002904L true SE8002904L (sv) | 1980-04-18 |
Family
ID=11164407
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7709002A SE7709002L (sv) | 1977-02-11 | 1977-08-09 | Omettat derivat av 7-acylamido-3-cefem-4-karboxylsyra och sett att framstella detsamma |
| SE7800292A SE7800292L (sv) | 1977-02-11 | 1978-01-11 | Heteromonocykliska och heterobicykliska derivat av omettade 7-acylamido-3-cefem-4-karboxylsyra samt forfarande for framstellning av dem |
| SE8000110A SE446536B (sv) | 1977-02-11 | 1980-01-08 | Forfarande for framstellning av omettade derivat av 7-acylamido-3-cefem-4-karboxylsyra |
| SE8002904A SE8002904L (sv) | 1977-02-11 | 1980-04-18 | Forfarande for framstellning av derivat av omettad 7-acylamido-3-cefem-4-karboxylsyra |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7709002A SE7709002L (sv) | 1977-02-11 | 1977-08-09 | Omettat derivat av 7-acylamido-3-cefem-4-karboxylsyra och sett att framstella detsamma |
| SE7800292A SE7800292L (sv) | 1977-02-11 | 1978-01-11 | Heteromonocykliska och heterobicykliska derivat av omettade 7-acylamido-3-cefem-4-karboxylsyra samt forfarande for framstellning av dem |
| SE8000110A SE446536B (sv) | 1977-02-11 | 1980-01-08 | Forfarande for framstellning av omettade derivat av 7-acylamido-3-cefem-4-karboxylsyra |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US4154830A (sv) |
| JP (2) | JPS5398991A (sv) |
| AT (2) | AT355206B (sv) |
| AU (2) | AU512934B2 (sv) |
| BE (2) | BE858433A (sv) |
| CA (2) | CA1103237A (sv) |
| CH (3) | CH632513A5 (sv) |
| CS (3) | CS196381B2 (sv) |
| CY (1) | CY1234A (sv) |
| DE (2) | DE2736471A1 (sv) |
| DK (2) | DK155944C (sv) |
| FI (2) | FI65259C (sv) |
| FR (3) | FR2380285A1 (sv) |
| GB (4) | GB1590610A (sv) |
| GR (2) | GR71901B (sv) |
| HK (1) | HK55284A (sv) |
| HU (2) | HU177596B (sv) |
| IL (3) | IL52708A0 (sv) |
| IT (1) | IT1075277B (sv) |
| MY (1) | MY8500446A (sv) |
| NL (2) | NL7708943A (sv) |
| NO (4) | NO152654C (sv) |
| NZ (2) | NZ184889A (sv) |
| PH (1) | PH16946A (sv) |
| SE (4) | SE7709002L (sv) |
| SG (1) | SG9484G (sv) |
| SU (4) | SU845788A3 (sv) |
| YU (1) | YU40307B (sv) |
| ZA (2) | ZA774835B (sv) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1075277B (it) * | 1977-02-11 | 1985-04-22 | Erba Carlo Spa | Derivati insaturi e epossidici dell'acio 7-acilamido-3-cefem-4-carbossilico e procedimento per la loro preparazione |
| JPS5593413A (en) * | 1979-01-11 | 1980-07-15 | Osaka Gas Co Ltd | Lining method for inner surface of pipe |
| US4331666A (en) * | 1979-05-11 | 1982-05-25 | Farmitalia Carlo Erba S.P.A. | 3-[(8-Carboxy-6-tetrazolo[1,5-b]pyridazinyl)-thiomethyl]-7-[2-(2-amino-4-thiazolyl)-2-methoxyimino-acetamido]-3-cephem-4-carboxylic acid |
| US4420477A (en) * | 1979-11-30 | 1983-12-13 | Fujisawa Pharmaceutical Co., Ltd. | Cephem compounds |
| US4405617A (en) * | 1980-02-11 | 1983-09-20 | Fujisawa Pharmaceutical Co., Ltd. | 3-(Propynyltetrazol)thiomethyl-3-cephems |
| GB2076803B (en) * | 1980-05-16 | 1984-02-08 | Erba Farmitalia | Substituted 7-(a-oxy-imino-acetamido)-cephalosporins and process for their preparation |
| GB2186875A (en) * | 1983-10-31 | 1987-08-26 | Fujisawa Pharmaceutical Co | New cephem compounds and processes for preparation thereof |
| DE3689762T2 (de) * | 1985-12-13 | 1994-08-18 | Takeda Chemical Industries Ltd | Antibakterielle Verbindungen, ihre Herstellung und Verwendung. |
| JPH0544294Y2 (sv) * | 1986-06-10 | 1993-11-10 | ||
| US5126349A (en) * | 1990-01-12 | 1992-06-30 | The Dow Chemical Company | Composition and use of substituted 3-thio-2-propynenitriles as an industrial antimicrobial |
| CA2073458A1 (en) * | 1990-01-12 | 1991-07-13 | Connie I. Deford | Composition and use of substituted 3-thio-2-propynenitriles as an industrial antimicrobial |
| US5198445A (en) * | 1990-01-12 | 1993-03-30 | The Dow Chemical Company | Composition and use of substituted 3-thio-2-propynenitriles as industrial antimicrobials |
| US5155119A (en) * | 1992-03-05 | 1992-10-13 | The Dow Chemical Company | 3-(2-pyridinylthio)-N-oxide, 2-halo-2-propenenitrile compounds useful as antimicrobials |
| US5157051A (en) * | 1992-03-05 | 1992-10-20 | The Dow Chemical Company | Composition and use of 3-thiocyano-2-halo-2-propenenitriles as antimicrobial agents |
| US5206227A (en) * | 1992-06-02 | 1993-04-27 | The Dow Chemical Company | Composition and use of phosphonic acid, (2-halo-2-cyanoethenyl)-dialkyl esters as antimicrobials |
| JP3115455B2 (ja) * | 1992-12-18 | 2000-12-04 | 明治製菓株式会社 | 新規セファロスポリン誘導体 |
| SE9802974D0 (sv) | 1998-09-03 | 1998-09-03 | Astra Ab | New crystalline forms |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1075277B (it) * | 1977-02-11 | 1985-04-22 | Erba Carlo Spa | Derivati insaturi e epossidici dell'acio 7-acilamido-3-cefem-4-carbossilico e procedimento per la loro preparazione |
| GB1478055A (en) * | 1973-07-27 | 1977-06-29 | Erba Carlo Spa | Cephalosporin compounds |
| US3883520A (en) * | 1973-08-17 | 1975-05-13 | Smithkline Corp | Substituted mercaptoacetamidocephalosporins |
| FI761035A (sv) * | 1975-04-21 | 1976-10-22 | Erba Carlo Spa | |
| ZA767084B (en) * | 1975-12-16 | 1977-10-26 | Erba Carlo Spa | Thiadiazolyl derivatives of 7-acylamido 3-cephem-4-carboxylic acid and process for their preparation |
| US4057631A (en) * | 1976-09-02 | 1977-11-08 | Smithkline Corporation | 7-(α-Substituted phenylacetamido)-3-(1-carboxymethylthioethyltetrazolyl-5-thiomethyl)-3-cephem-4-carboxylic acids |
| US4079134A (en) * | 1976-09-24 | 1978-03-14 | Smithkline Corporation | 7-Acylamino-3-(5-sulfomethyl-1,3,4-thiadiazol-2-ylthiomethyl)-3-cephem-4-carboxylic acids |
-
1977
- 1977-02-11 IT IT20173/77A patent/IT1075277B/it active
- 1977-08-08 US US05/822,638 patent/US4154830A/en not_active Expired - Lifetime
- 1977-08-08 DK DK353577A patent/DK155944C/da not_active IP Right Cessation
- 1977-08-08 NO NO772779A patent/NO152654C/no unknown
- 1977-08-09 GB GB43324/79A patent/GB1590610A/en not_active Expired
- 1977-08-09 SE SE7709002A patent/SE7709002L/sv not_active Application Discontinuation
- 1977-08-09 GB GB33418/77A patent/GB1582295A/en not_active Expired
- 1977-08-09 CY CY1234A patent/CY1234A/xx unknown
- 1977-08-10 ZA ZA00774835A patent/ZA774835B/xx unknown
- 1977-08-10 FI FI772411A patent/FI65259C/fi not_active IP Right Cessation
- 1977-08-10 NZ NZ184889A patent/NZ184889A/xx unknown
- 1977-08-10 CA CA284,460A patent/CA1103237A/en not_active Expired
- 1977-08-10 HU HU77EA176A patent/HU177596B/hu not_active IP Right Cessation
- 1977-08-11 GR GR54135A patent/GR71901B/el unknown
- 1977-08-11 CH CH984577A patent/CH632513A5/de not_active IP Right Cessation
- 1977-08-11 AT AT585677A patent/AT355206B/de not_active IP Right Cessation
- 1977-08-11 CS CS775327A patent/CS196381B2/cs unknown
- 1977-08-12 IL IL52708A patent/IL52708A0/xx not_active IP Right Cessation
- 1977-08-12 AU AU27865/77A patent/AU512934B2/en not_active Expired
- 1977-08-12 FR FR7724952A patent/FR2380285A1/fr active Granted
- 1977-08-12 DE DE19772736471 patent/DE2736471A1/de active Granted
- 1977-08-12 NL NL7708943A patent/NL7708943A/xx not_active Application Discontinuation
- 1977-08-13 JP JP9742077A patent/JPS5398991A/ja active Granted
- 1977-08-22 SU SU772516753A patent/SU845788A3/ru active
- 1977-09-06 YU YU2109/77A patent/YU40307B/xx unknown
- 1977-09-06 BE BE180695A patent/BE858433A/xx not_active IP Right Cessation
-
1978
- 1978-01-09 NO NO780074A patent/NO780074L/no unknown
- 1978-01-10 DK DK11578A patent/DK11578A/da not_active Application Discontinuation
- 1978-01-11 SE SE7800292A patent/SE7800292L/sv unknown
- 1978-01-11 GB GB1121/78A patent/GB1597261A/en not_active Expired
- 1978-01-11 ZA ZA00780181A patent/ZA78181B/xx unknown
- 1978-01-11 GB GB4691/80A patent/GB1597262A/en not_active Expired
- 1978-01-11 US US05/868,665 patent/US4172892A/en not_active Expired - Lifetime
- 1978-01-12 HU HU78EA182A patent/HU178918B/hu unknown
- 1978-01-13 NL NL7800443A patent/NL7800443A/xx not_active Application Discontinuation
- 1978-01-16 DE DE19782801644 patent/DE2801644A1/de not_active Withdrawn
- 1978-01-16 AU AU32476/78A patent/AU513444B2/en not_active Expired
- 1978-01-17 IL IL53830A patent/IL53830A/xx unknown
- 1978-01-17 NZ NZ186236A patent/NZ186236A/xx unknown
- 1978-01-17 AT AT32778A patent/AT356270B/de not_active IP Right Cessation
- 1978-01-17 CS CS788042A patent/CS199714B2/cs unknown
- 1978-01-17 CS CS78331A patent/CS199713B2/cs unknown
- 1978-01-19 GR GR55208A patent/GR72589B/el unknown
- 1978-01-20 PH PH20693A patent/PH16946A/en unknown
- 1978-01-24 FR FR7801928A patent/FR2384783A1/fr active Granted
- 1978-01-26 JP JP676978A patent/JPS53121788A/ja active Pending
- 1978-02-03 BE BE184877A patent/BE863625A/xx not_active IP Right Cessation
- 1978-02-10 CA CA296,689A patent/CA1108603A/en not_active Expired
- 1978-02-10 FI FI780437A patent/FI780437A/fi not_active Application Discontinuation
- 1978-02-10 SU SU782578100A patent/SU856388A3/ru active
- 1978-02-10 CH CH153278A patent/CH636359A5/de not_active IP Right Cessation
- 1978-07-28 SU SU782640405A patent/SU753361A3/ru active
-
1979
- 1979-04-26 SU SU792759905A patent/SU904524A3/ru active
- 1979-12-14 NO NO794101A patent/NO794101L/no unknown
-
1980
- 1980-01-08 SE SE8000110A patent/SE446536B/sv not_active IP Right Cessation
- 1980-01-24 CH CH58280A patent/CH634330A5/de not_active IP Right Cessation
- 1980-01-31 NO NO800239A patent/NO800239L/no unknown
- 1980-03-05 IL IL59527A patent/IL59527A0/xx unknown
- 1980-03-07 FR FR8005220A patent/FR2445834A1/fr active Granted
- 1980-04-18 SE SE8002904A patent/SE8002904L/sv not_active Application Discontinuation
-
1981
- 1981-08-21 US US06/295,074 patent/US4388314A/en not_active Expired - Fee Related
-
1984
- 1984-02-06 SG SG94/84A patent/SG9484G/en unknown
- 1984-07-19 HK HK552/84A patent/HK55284A/xx unknown
-
1985
- 1985-12-30 MY MY446/85A patent/MY8500446A/xx unknown
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