MX9306421A - Derivados de amidas y procedimiento para su preparacion. - Google Patents
Derivados de amidas y procedimiento para su preparacion.Info
- Publication number
- MX9306421A MX9306421A MX9306421A MX9306421A MX9306421A MX 9306421 A MX9306421 A MX 9306421A MX 9306421 A MX9306421 A MX 9306421A MX 9306421 A MX9306421 A MX 9306421A MX 9306421 A MX9306421 A MX 9306421A
- Authority
- MX
- Mexico
- Prior art keywords
- pct
- formula
- date apr
- amides
- sec
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyridine Compounds (AREA)
Abstract
Se describe un procedimiento para preparar una amida ópticamente activa de la fórmula general (Ver Fórmula); o una sal farmacéuticamente aceptable de la misma, donde X representa -N- o -CH-, R representa un grupo arilo o heteroarilo mono- o bicíclico, R1 es un radical arilo o heteroarilo, R2 es hidrógeno o alquilo inferior, R3 es hidrógeno, un grupo alquilo de 1 a 10 átomos de carbono, cicloalquilo de 3 a 12 átomos de carbono, ciclo-alquil-alquilo inferior, aril o arilalquilo inferior o R2 y R3 junto con el átomo de nitrógeno al cual ambos están unidos, representan un anillo heterocíclico saturado, que puede contener un heteroátomo adicional, el procedimiento comprende condensar un aldehído de la fórmula (Ver Fórmula); (donde R1 y R2 y R3 son como se definen anteriormente) con una amina de la fórmula (Ver Fórmula); (donde X y R son como se definen anteriormente).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929221931A GB9221931D0 (en) | 1992-10-17 | 1992-10-17 | Piperazine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9306421A true MX9306421A (es) | 1994-04-29 |
Family
ID=10723688
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9306421A MX9306421A (es) | 1992-10-17 | 1993-10-15 | Derivados de amidas y procedimiento para su preparacion. |
Country Status (17)
Country | Link |
---|---|
US (1) | US5637701A (es) |
EP (1) | EP0664799B1 (es) |
JP (1) | JP3478827B2 (es) |
KR (1) | KR950703544A (es) |
AT (1) | ATE182144T1 (es) |
AU (1) | AU5152493A (es) |
CA (1) | CA2147155C (es) |
DE (1) | DE69325660T2 (es) |
DK (1) | DK0664799T3 (es) |
ES (1) | ES2133414T3 (es) |
GB (2) | GB9221931D0 (es) |
GR (1) | GR3031123T3 (es) |
MX (1) | MX9306421A (es) |
PH (1) | PH31583A (es) |
TW (1) | TW340844B (es) |
WO (1) | WO1994008983A1 (es) |
ZA (1) | ZA937516B (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5607936A (en) * | 1994-09-30 | 1997-03-04 | Merck & Co., Inc. | Substituted aryl piperazines as neurokinin antagonists |
US5525600A (en) * | 1994-11-28 | 1996-06-11 | American Home Products Corporation | (Thiophen-2-yl)-piperidin or tetrahydropyridin carboxamides |
DE19519245C2 (de) * | 1995-04-14 | 2003-04-30 | Boehringer Ingelheim Kg | Neue Arylglycinamidderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen |
FR2744448B1 (fr) * | 1996-02-02 | 1998-04-24 | Pf Medicament | Nouvelles piperidines derivees d'aryl piperazine, ainsi que leur procede de preparation, les compositions pharmaceutiques et leur utilisation comme medicaments |
FR2757158B1 (fr) * | 1996-12-18 | 1999-04-02 | Lipha | Nouveaux derives d'acide 4-(1-piperazinyl) benzoique, leur procede de preparation et leurs applications therapeutiques |
US6900228B1 (en) | 1998-03-10 | 2005-05-31 | Research Triangle Institute | Opiate compounds, methods of making and methods of use |
US20040072839A1 (en) * | 2002-06-14 | 2004-04-15 | Amedeo Leonardi | 1-Phenylalkylpiperazines |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2776282A (en) * | 1954-05-04 | 1957-01-01 | Searle & Co | Cyclic amides of alpha-toluic acids and derivatives thereof |
GB8909209D0 (en) * | 1989-04-22 | 1989-06-07 | Wyeth John & Brother Ltd | Piperazine derivatives |
PT93824B (pt) * | 1989-04-22 | 1996-09-30 | Wyeth John & Brother Ltd | Processo para a preparacao de derivados de piperazina |
DE69033100T2 (de) * | 1989-04-22 | 2000-01-05 | Wyeth John & Brother Ltd | Piperazin-Derivate |
GB9022820D0 (en) * | 1990-10-19 | 1990-12-05 | Wyeth John & Brother Ltd | Piperazine derivatives |
-
1992
- 1992-10-17 GB GB929221931A patent/GB9221931D0/en active Pending
-
1993
- 1993-10-08 EP EP93922576A patent/EP0664799B1/en not_active Expired - Lifetime
- 1993-10-08 AU AU51524/93A patent/AU5152493A/en not_active Abandoned
- 1993-10-08 KR KR1019950701459A patent/KR950703544A/ko active IP Right Grant
- 1993-10-08 DK DK93922576T patent/DK0664799T3/da active
- 1993-10-08 DE DE69325660T patent/DE69325660T2/de not_active Expired - Fee Related
- 1993-10-08 JP JP50974494A patent/JP3478827B2/ja not_active Expired - Fee Related
- 1993-10-08 GB GB9320819A patent/GB2272436B/en not_active Expired - Fee Related
- 1993-10-08 WO PCT/GB1993/002090 patent/WO1994008983A1/en active IP Right Grant
- 1993-10-08 US US08/411,601 patent/US5637701A/en not_active Expired - Lifetime
- 1993-10-08 ES ES93922576T patent/ES2133414T3/es not_active Expired - Lifetime
- 1993-10-08 CA CA002147155A patent/CA2147155C/en not_active Expired - Fee Related
- 1993-10-08 AT AT93922576T patent/ATE182144T1/de not_active IP Right Cessation
- 1993-10-11 ZA ZA937516A patent/ZA937516B/xx unknown
- 1993-10-15 PH PH47088A patent/PH31583A/en unknown
- 1993-10-15 MX MX9306421A patent/MX9306421A/es not_active IP Right Cessation
- 1993-10-15 TW TW082108553A patent/TW340844B/zh active
-
1999
- 1999-08-31 GR GR990402205T patent/GR3031123T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
GB2272436A (en) | 1994-05-18 |
EP0664799B1 (en) | 1999-07-14 |
GR3031123T3 (en) | 1999-12-31 |
TW340844B (en) | 1998-09-21 |
ZA937516B (en) | 1995-04-21 |
WO1994008983A1 (en) | 1994-04-28 |
JP3478827B2 (ja) | 2003-12-15 |
GB9221931D0 (en) | 1992-12-02 |
GB9320819D0 (en) | 1993-12-01 |
JPH08502738A (ja) | 1996-03-26 |
DK0664799T3 (da) | 1999-11-29 |
EP0664799A1 (en) | 1995-08-02 |
DE69325660T2 (de) | 2000-03-09 |
ES2133414T3 (es) | 1999-09-16 |
CA2147155A1 (en) | 1994-04-28 |
AU5152493A (en) | 1994-05-09 |
GB2272436B (en) | 1997-06-18 |
DE69325660D1 (de) | 1999-08-19 |
CA2147155C (en) | 2005-01-04 |
ATE182144T1 (de) | 1999-07-15 |
PH31583A (en) | 1998-11-03 |
KR950703544A (ko) | 1995-09-20 |
US5637701A (en) | 1997-06-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration | ||
MM | Annulment or lapse due to non-payment of fees |