ES2133414T3 - Derivados de amida. - Google Patents

Derivados de amida.

Info

Publication number
ES2133414T3
ES2133414T3 ES93922576T ES93922576T ES2133414T3 ES 2133414 T3 ES2133414 T3 ES 2133414T3 ES 93922576 T ES93922576 T ES 93922576T ES 93922576 T ES93922576 T ES 93922576T ES 2133414 T3 ES2133414 T3 ES 2133414T3
Authority
ES
Spain
Prior art keywords
pct
formula
date apr
sec
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93922576T
Other languages
English (en)
Inventor
Mark Antony Ashwell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
John Wyeth and Brother Ltd
Original Assignee
John Wyeth and Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by John Wyeth and Brother Ltd filed Critical John Wyeth and Brother Ltd
Application granted granted Critical
Publication of ES2133414T3 publication Critical patent/ES2133414T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyridine Compounds (AREA)

Abstract

SE PRESENTA UNA NUEVA SINTESIS ASIMETRICA PARA LA PREPARACION DE AMIDAS OPTICAMENTE ACTIVAS DE LA FORMULA (A) Y SUS SALES. EN LA FORMULA, X REPRESENTA (A) O (B), R REPRESENTA UN GRUPO ARILO MONO O BICICLICO O HETEROARILO, R ES UN RADICAL ARILO O HETEROARILO Y R2 Y R3 REPRESENTAN LO ESPECIFICADO. LOS PRODUCTOS SON UTILES COMO ANTAGONISTAS DE 5-HT1A. TAMBIEN SE PRESENTAN NUEVOS DIESTERES UTILES COMO INTERMEDIOS EN EL PROCESO.
ES93922576T 1992-10-17 1993-10-08 Derivados de amida. Expired - Lifetime ES2133414T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929221931A GB9221931D0 (en) 1992-10-17 1992-10-17 Piperazine derivatives

Publications (1)

Publication Number Publication Date
ES2133414T3 true ES2133414T3 (es) 1999-09-16

Family

ID=10723688

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93922576T Expired - Lifetime ES2133414T3 (es) 1992-10-17 1993-10-08 Derivados de amida.

Country Status (17)

Country Link
US (1) US5637701A (es)
EP (1) EP0664799B1 (es)
JP (1) JP3478827B2 (es)
KR (1) KR950703544A (es)
AT (1) ATE182144T1 (es)
AU (1) AU5152493A (es)
CA (1) CA2147155C (es)
DE (1) DE69325660T2 (es)
DK (1) DK0664799T3 (es)
ES (1) ES2133414T3 (es)
GB (2) GB9221931D0 (es)
GR (1) GR3031123T3 (es)
MX (1) MX9306421A (es)
PH (1) PH31583A (es)
TW (1) TW340844B (es)
WO (1) WO1994008983A1 (es)
ZA (1) ZA937516B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5607936A (en) * 1994-09-30 1997-03-04 Merck & Co., Inc. Substituted aryl piperazines as neurokinin antagonists
US5525600A (en) * 1994-11-28 1996-06-11 American Home Products Corporation (Thiophen-2-yl)-piperidin or tetrahydropyridin carboxamides
DE19519245C2 (de) * 1995-04-14 2003-04-30 Boehringer Ingelheim Kg Neue Arylglycinamidderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
FR2744448B1 (fr) * 1996-02-02 1998-04-24 Pf Medicament Nouvelles piperidines derivees d'aryl piperazine, ainsi que leur procede de preparation, les compositions pharmaceutiques et leur utilisation comme medicaments
FR2757158B1 (fr) * 1996-12-18 1999-04-02 Lipha Nouveaux derives d'acide 4-(1-piperazinyl) benzoique, leur procede de preparation et leurs applications therapeutiques
US6900228B1 (en) 1998-03-10 2005-05-31 Research Triangle Institute Opiate compounds, methods of making and methods of use
US20040072839A1 (en) * 2002-06-14 2004-04-15 Amedeo Leonardi 1-Phenylalkylpiperazines

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2776282A (en) * 1954-05-04 1957-01-01 Searle & Co Cyclic amides of alpha-toluic acids and derivatives thereof
GB8909209D0 (en) * 1989-04-22 1989-06-07 Wyeth John & Brother Ltd Piperazine derivatives
KR0173310B1 (ko) * 1989-04-22 1999-02-01 폴 에이 리쳐 피페라진 유도체
ATE187718T1 (de) * 1989-04-22 2000-01-15 American Home Prod Tertiäre alkyl funktionalisierte piperazin- derivate
GB9022820D0 (en) * 1990-10-19 1990-12-05 Wyeth John & Brother Ltd Piperazine derivatives

Also Published As

Publication number Publication date
DE69325660T2 (de) 2000-03-09
CA2147155C (en) 2005-01-04
EP0664799B1 (en) 1999-07-14
CA2147155A1 (en) 1994-04-28
GB9320819D0 (en) 1993-12-01
US5637701A (en) 1997-06-10
GB2272436A (en) 1994-05-18
WO1994008983A1 (en) 1994-04-28
DK0664799T3 (da) 1999-11-29
EP0664799A1 (en) 1995-08-02
AU5152493A (en) 1994-05-09
PH31583A (en) 1998-11-03
GB2272436B (en) 1997-06-18
ZA937516B (en) 1995-04-21
JPH08502738A (ja) 1996-03-26
TW340844B (en) 1998-09-21
JP3478827B2 (ja) 2003-12-15
ATE182144T1 (de) 1999-07-15
KR950703544A (ko) 1995-09-20
MX9306421A (es) 1994-04-29
DE69325660D1 (de) 1999-08-19
GR3031123T3 (en) 1999-12-31
GB9221931D0 (en) 1992-12-02

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