SE448543B - /3h/-imidazo/5,1-d/-1,2,3,5-tetrazin-4-onderivat, forfarande for deras framstellning och farmaceutiska kompositioner innehallande desamma - Google Patents

/3h/-imidazo/5,1-d/-1,2,3,5-tetrazin-4-onderivat, forfarande for deras framstellning och farmaceutiska kompositioner innehallande desamma

Info

Publication number
SE448543B
SE448543B SE8204817A SE8204817A SE448543B SE 448543 B SE448543 B SE 448543B SE 8204817 A SE8204817 A SE 8204817A SE 8204817 A SE8204817 A SE 8204817A SE 448543 B SE448543 B SE 448543B
Authority
SE
Sweden
Prior art keywords
carbon atoms
group
groups
general formula
substituted
Prior art date
Application number
SE8204817A
Other languages
English (en)
Swedish (sv)
Other versions
SE8204817D0 (sv
SE8204817L (sv
Inventor
E Lunt
M F G Stevens
R Stone
K R H Woolridge
Original Assignee
May & Baker Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by May & Baker Ltd filed Critical May & Baker Ltd
Publication of SE8204817D0 publication Critical patent/SE8204817D0/xx
Publication of SE8204817L publication Critical patent/SE8204817L/xx
Publication of SE448543B publication Critical patent/SE448543B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
SE8204817A 1981-08-24 1982-08-23 /3h/-imidazo/5,1-d/-1,2,3,5-tetrazin-4-onderivat, forfarande for deras framstellning och farmaceutiska kompositioner innehallande desamma SE448543B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8125791 1981-08-24

Publications (3)

Publication Number Publication Date
SE8204817D0 SE8204817D0 (sv) 1982-08-23
SE8204817L SE8204817L (sv) 1983-02-25
SE448543B true SE448543B (sv) 1987-03-02

Family

ID=10524141

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8204817A SE448543B (sv) 1981-08-24 1982-08-23 /3h/-imidazo/5,1-d/-1,2,3,5-tetrazin-4-onderivat, forfarande for deras framstellning och farmaceutiska kompositioner innehallande desamma

Country Status (29)

Country Link
JP (1) JPS5843975A (Direct)
KR (1) KR890000094B1 (Direct)
AT (1) AT380256B (Direct)
AU (1) AU571430B2 (Direct)
BE (1) BE894175A (Direct)
CA (1) CA1197247A (Direct)
CH (1) CH655114A5 (Direct)
DE (2) DE19975037I2 (Direct)
DK (1) DK161147C (Direct)
ES (1) ES8400438A1 (Direct)
FI (1) FI73434C (Direct)
FR (1) FR2511679A1 (Direct)
GB (1) GB2104522B (Direct)
GE (1) GEP19960641B (Direct)
GR (1) GR76863B (Direct)
HU (1) HU186107B (Direct)
IE (1) IE53408B1 (Direct)
IL (1) IL66606A (Direct)
IT (1) IT1152505B (Direct)
LT (1) LT2436B (Direct)
LU (1) LU84347A1 (Direct)
LV (2) LV5511A3 (Direct)
NL (2) NL192739C (Direct)
NZ (1) NZ201668A (Direct)
OA (1) OA07174A (Direct)
SE (1) SE448543B (Direct)
SU (1) SU1447284A3 (Direct)
UA (1) UA5971A1 (Direct)
ZA (1) ZA826120B (Direct)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260291A (en) * 1981-08-24 1993-11-09 Cancer Research Campaign Technology Limited Tetrazine derivatives
FR2531958B1 (fr) * 1982-08-17 1986-10-31 May & Baker Ltd Nouveaux derive
GB2125402B (en) * 1982-08-17 1985-11-13 May & Baker Ltd New tetrazine derivatives
US4517182A (en) * 1983-05-24 1985-05-14 Warner-Lambert Company 3-(Haloethyl)-4-oxopyrazolo-[5,1-d]-1,2,3,5-tetrazine-8-carboxamide composition
GB8616125D0 (en) * 1986-07-02 1986-08-06 May & Baker Ltd Compositions of matter
AU622330B2 (en) * 1989-06-23 1992-04-02 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds having a nitrogen atom in the bridgehead for use as fungicides
RU2166946C2 (ru) * 1995-09-25 2001-05-20 Санофи-Синтелабо Инк. Состав, содержащий 1,2,4-бензотриазин-3-амин-1,4-диоксид, для парентерального введения и способ лечения с его применением
CA2552095A1 (en) * 2003-12-30 2005-07-14 Chemagis Ltd. Novel crystalline forms of temozolomide
JP5475235B2 (ja) 2005-01-21 2014-04-16 アステックス・セラピューティクス・リミテッド 医薬化合物
AR060635A1 (es) 2006-04-27 2008-07-02 Banyu Pharma Co Ltd Derivados de 1,2-dihidro-3h-pirazolo[3,4-d]pirimidin-3-ona, composiciones farmaceuticas que los comprenden y su uso en el tratamiento del cancer
JP2008081492A (ja) 2006-08-31 2008-04-10 Banyu Pharmaceut Co Ltd オーロラａ選択的阻害作用を有する新規アミノピリジン誘導体
EP2073803B1 (en) 2006-10-12 2018-09-19 Astex Therapeutics Limited Pharmaceutical combinations
WO2008044045A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
JPWO2009054332A1 (ja) 2007-10-23 2011-03-03 萬有製薬株式会社 ピリドン置換ジヒドロピラゾロピリミジノン誘導体
PE20091101A1 (es) * 2007-12-18 2009-07-26 Pharminox Ltd AMIDAS DE ACIDO 3-SUBSTITUIDO-4-OXO-3,4-DIHIDRO-IMIDAZO[5,1-d] [1,2,3,5-TETRACINA-8-CARBOXILICO Y SU EMPLEO
CN102256978A (zh) * 2008-11-24 2011-11-23 利莱恩斯生命科学有限公司 制备四嗪衍生物的工艺
EP2403339B1 (en) 2009-03-06 2017-01-18 Merck Sharp & Dohme Corp. Combination cancer therapy with an akt inhibitor and other anticancer agents
EP2445915B1 (en) 2009-06-23 2016-04-20 Pharminox Limited 3-substituted-8-substituted-3h imidazo[5,1-d][1,2,3,5-tetrazin-4-one compounds and their use
RU2462466C1 (ru) * 2011-06-24 2012-09-27 Автономная Некоммерческая Организация "Научно-Исследовательский Центр Биотехнологии Антибиотиков И Других Биологически Активных Веществ "Биоан" Замещенные азоло[1,2,4,5]тетразины - ингибиторы актинобактериальных серин-треониновых протеинкиназ
US20140271657A1 (en) 2011-10-12 2014-09-18 Children's Medical Center Corporation Combinatorial compositions and methods of treating hemoglobinopathies
SG10201913331VA (en) 2016-03-15 2020-03-30 Oryzon Genomics Sa Combinations of lsd1 inhibitors for use in the treatment of solid tumors
KR101847342B1 (ko) * 2017-05-08 2018-04-11 (주)센텍코리아 웨어러블 체지방 연소량 측정기

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2932305A1 (de) * 1979-08-09 1981-02-26 Basf Ag Azolo- eckige klammer auf 5,1-d eckige klammer zu - eckige klammer auf 1,2,3,5 eckige klammer zu -tetrazin-4-one und verfahren zur herstellung dieser verbindungen

Also Published As

Publication number Publication date
IT8222938A0 (it) 1982-08-23
AT380256B (de) 1986-05-12
GR76863B (Direct) 1984-09-04
IT8222938A1 (it) 1984-02-23
FI73434B (fi) 1987-06-30
HU186107B (en) 1985-06-28
GB2104522B (en) 1985-06-12
ES515176A0 (es) 1983-11-01
DK377882A (da) 1983-02-25
LV5621A3 (lv) 1994-05-10
NL192739B (nl) 1997-09-01
FI822921A0 (fi) 1982-08-23
OA07174A (fr) 1984-04-30
DK161147C (da) 1991-11-18
LU84347A1 (fr) 1983-06-07
FI73434C (fi) 1987-10-09
JPS5843975A (ja) 1983-03-14
DE3231255A1 (de) 1983-03-03
IT1152505B (it) 1987-01-07
DK161147B (da) 1991-06-03
BE894175A (fr) 1983-02-23
DE19975037I2 (de) 2001-06-13
ZA826120B (en) 1983-07-27
FR2511679B1 (Direct) 1985-02-01
DE3231255C2 (Direct) 1992-02-27
LT2436B (lt) 1994-02-15
SU1447284A3 (ru) 1988-12-23
GEP19960641B (en) 1996-11-15
SE8204817D0 (sv) 1982-08-23
NL192739C (nl) 1998-01-06
IE53408B1 (en) 1988-11-09
IL66606A0 (en) 1982-12-31
FI822921L (fi) 1983-02-25
CH655114A5 (fr) 1986-03-27
IL66606A (en) 1987-07-31
GB2104522A (en) 1983-03-09
NL990010I1 (nl) 1999-07-01
ES8400438A1 (es) 1983-11-01
FR2511679A1 (fr) 1983-02-25
IE822026L (en) 1983-02-24
KR840001175A (ko) 1984-03-28
NL990010I2 (nl) 1999-09-01
JPH045029B2 (Direct) 1992-01-30
AU8749382A (en) 1983-03-03
NZ201668A (en) 1985-08-16
ATA319182A (de) 1985-09-15
LV5511A3 (lv) 1994-03-10
AU571430B2 (en) 1988-04-21
UA5971A1 (uk) 1994-12-29
SE8204817L (sv) 1983-02-25
KR890000094B1 (ko) 1989-03-07
CA1197247A (fr) 1985-11-26
NL8203286A (nl) 1983-03-16

Similar Documents

Publication Publication Date Title
US5260291A (en) Tetrazine derivatives
SE448543B (sv) /3h/-imidazo/5,1-d/-1,2,3,5-tetrazin-4-onderivat, forfarande for deras framstellning och farmaceutiska kompositioner innehallande desamma
EP0150255B1 (en) Pyrrolo[1,2-a]imidazole and imidazo[1,2-a]pyridine immunomodulators
SE446186B (sv) Beta-laktamforeningar samt farmaceutiska kompositioner derav
HUP0000720A2 (hu) Imidazo [1,2-a] piridinszármazékok, eljárás előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
US5087625A (en) Pyridodiazepines and their use in the prevention or treatment of HIV infection
IE57675B1 (en) 5-pyrimidinecarboxamides and thiocarboxamides and treatment of leukemia and tumors therewith
SE452884B (sv) Ergolinderivat, forfarande for deras framstellning och farmaceutiska kompositioner der de ingar
JPS6366182A (ja) テトラジン誘導体
GB2125402A (en) New tetrazine derivatives
WO1992015310A1 (de) Verwendung von tricyclischen isoindolinonen als antivirale arzneimittel, sowie neue optisch aktive isoindolinone
US4164579A (en) Hydroxythiazolidine-2-thiones
ZA200300797B (en) Derivatives of variolin B.
US3879390A (en) 2-pyridazinylisoindolin-1-one derivatives
EP0415303B1 (en) Pyrido [2,3-b][1,5]benzoxazepin (and thiazepin)-5(6H)-ones and -thiones and their use in the prevention or treatment of HIV infection
US4560758A (en) Process for preparing pyrrolo[1,2-a]imidazoles and imidazo[1,2-a]pyridines
US4603206A (en) Preparation of certain pyrrolo[1,2-a]imidazoles and imidazo[1,2-a]pyridines
US4551535A (en) Process for preparing novel 7-thioester derivatives of 3H pyrrolo [1,2-a]-imidazole and 8-thioester derivatives of imidazo [1,2-a] pyridine
HU189321B (en) Process for producing new condensed tetrazine derivatives
JPS63500031A (ja) オキソジアジン化合物
Chaimbault et al. Synthesis and Preliminary Pharmacological Evaluation of New 6‐cyano‐2, 3‐dihydro‐5H‐oxazolo [3, 2‐a] pyrimidin‐5‐ones and 2‐ethyl (methylenecyanoacetate)‐2‐iminooxazolidines
CA2103457A1 (en) 1,2-dihydropyrido(3,4-b)pyrazines as fungicides
JPS59210093A (ja) ピリドピリミジン誘導体
GB2151623A (en) New pyrazolopyridine derivatives
JPH05194534A (ja) チアゾロピリミジン誘導体

Legal Events

Date Code Title Description
NAL Patent in force

Ref document number: 8204817-4

Format of ref document f/p: F

SPCF Application for supplementary protection certificate filed

Free format text: 9990019, 990126

SPCG Supplementary protection certificate granted

Free format text: 9990019, 990126, EXPIRES: 20070823

NUG Patent has lapsed

Ref document number: 8204817-4

Format of ref document f/p: F