SE447256B - 2-fenoxialkyl-1,2,4-triazol-3-oner, deras framstellning och farmaceutisk komposition derav - Google Patents
2-fenoxialkyl-1,2,4-triazol-3-oner, deras framstellning och farmaceutisk komposition deravInfo
- Publication number
- SE447256B SE447256B SE8201631A SE8201631A SE447256B SE 447256 B SE447256 B SE 447256B SE 8201631 A SE8201631 A SE 8201631A SE 8201631 A SE8201631 A SE 8201631A SE 447256 B SE447256 B SE 447256B
- Authority
- SE
- Sweden
- Prior art keywords
- formula
- chlorophenyl
- triazol
- ethyl
- propyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/067—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/244,464 US4338317A (en) | 1981-03-16 | 1981-03-16 | Phenoxyethyl-1,2,4,-triazol-3-one antidepressants |
Publications (2)
Publication Number | Publication Date |
---|---|
SE8201631L SE8201631L (sv) | 1982-09-17 |
SE447256B true SE447256B (sv) | 1986-11-03 |
Family
ID=22922879
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE8201631A SE447256B (sv) | 1981-03-16 | 1982-03-15 | 2-fenoxialkyl-1,2,4-triazol-3-oner, deras framstellning och farmaceutisk komposition derav |
Country Status (26)
Country | Link |
---|---|
US (1) | US4338317A (fr) |
JP (1) | JPS57159774A (fr) |
KR (1) | KR880001374B1 (fr) |
AT (1) | AT384022B (fr) |
BE (1) | BE892503A (fr) |
CA (1) | CA1198436A (fr) |
CH (1) | CH649539A5 (fr) |
CY (1) | CY1373A (fr) |
DE (1) | DE3209557A1 (fr) |
DK (1) | DK158728C (fr) |
ES (1) | ES8305756A1 (fr) |
FI (1) | FI73670C (fr) |
FR (1) | FR2501690B1 (fr) |
GB (1) | GB2096137B (fr) |
GR (1) | GR76076B (fr) |
HK (1) | HK4788A (fr) |
IE (1) | IE52788B1 (fr) |
IT (1) | IT1148137B (fr) |
KE (1) | KE3711A (fr) |
LU (1) | LU84011A1 (fr) |
MX (1) | MX9203176A (fr) |
NL (2) | NL190757C (fr) |
SE (1) | SE447256B (fr) |
SG (1) | SG30287G (fr) |
YU (1) | YU43256B (fr) |
ZA (1) | ZA821359B (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5399693A (en) * | 1984-04-17 | 1995-03-21 | British Technology Group Limited | Substituted piperazine-2-carboxylic acids and derivatives thereof |
Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4487773A (en) * | 1981-03-16 | 1984-12-11 | Mead Johnson & Company | 1,2,4-Triazol-3-one antidepressants |
US4386091A (en) * | 1982-02-24 | 1983-05-31 | Mead Johnson & Company | 2-Phenoxyalkyl-1,2,4-triazol-3-one antidepressants |
US4575555A (en) * | 1983-06-29 | 1986-03-11 | Mead Johnson & Company | 4-(3-Chlorophenyl)-1,2,3,6-tetrahydropyridine derivative |
AT388555B (de) * | 1983-06-29 | 1989-07-25 | Bristol Myers Co | Verfahren zur herstellung von neuen 1,2,4-triazol-3-on-derivaten |
US4613600A (en) * | 1983-09-30 | 1986-09-23 | Mead Johnson & Company | Antidepressant 1,2,4-triazolone compounds |
YU44721B (en) * | 1983-11-30 | 1990-12-31 | Bristol Myers Co | Process for obtaining 4-(2-phenoxyethyl)-1,2,4-triazolone |
US4784998A (en) * | 1987-04-06 | 1988-11-15 | Bristol-Myers Company | 1,3,4-oxadiazole pyschotropic compounds |
US5116852A (en) * | 1990-12-03 | 1992-05-26 | Bristol-Myers Squibb Co. | Treatment of sleep disorders |
US5266571A (en) * | 1992-01-09 | 1993-11-30 | Amer Moh Samir | Treatment of hemorrhoids with 5-HT2 antagonists |
US5256664A (en) * | 1992-04-28 | 1993-10-26 | Bristol-Myers Squibb Company | Antidepressant 3-halophenylpiperazinylpropyl derivatives of substituted triazolones and triazoldiones |
IT1256387B (it) * | 1992-11-13 | 1995-12-04 | Acraf | Procedimento per preparare triazoloni |
CA2160423A1 (fr) * | 1994-11-02 | 1996-05-03 | Hemant N. Joshi | Sels de nefazodone a taux de dissolution ameliores |
AU7025396A (en) | 1995-10-17 | 1997-05-01 | Bristol-Myers Squibb Company | Nefazodone: treatment of panic attack |
CA2182241C (fr) * | 1996-07-29 | 2002-09-17 | Bo Lei | Methodes pour la preparation de nefazodone |
WO1998004261A1 (fr) * | 1996-07-31 | 1998-02-05 | Bristol-Myers Squibb Company | Utilisation de la nefazodone dans la prophylaxie de la migraine |
US5852020A (en) * | 1996-11-22 | 1998-12-22 | Bristol-Myers Squibb Company | Nefazodone: use in treating post traumatic stress disorder |
US5735873A (en) * | 1996-12-19 | 1998-04-07 | Maclean; David S. | Surgical tool handle |
US5917050A (en) * | 1998-02-11 | 1999-06-29 | Bayer Corporation | Process for preparing alkoxytriazolinones |
ES2152860B1 (es) * | 1998-10-23 | 2001-08-16 | Finaf 92 Sa | Forma cristalina de la nefazodona y procedimiento para su preparacion. |
US6706282B1 (en) | 1998-11-02 | 2004-03-16 | Evangeline Cruz | Controlled delivery of phenoxyethyl-substituted 1,2,4-triazolones |
US6469008B2 (en) | 1999-04-09 | 2002-10-22 | Sepracor Inc. | (R)-hydroxynefazodone antipsychotic therapy |
DE60028955T2 (de) * | 1999-04-09 | 2007-07-05 | Sepracor Inc., Marlborough | R-hydroxynefazodon |
US6586437B2 (en) | 1999-04-09 | 2003-07-01 | Sepracor Inc. | (S)-hydroxynefazodone antipsychotic therapy |
US6465469B1 (en) | 1999-04-09 | 2002-10-15 | Sepracor Inc. | S-hydroxynefazodone |
CA2356450C (fr) | 2001-09-10 | 2003-11-25 | Brantford Chemicals Inc. | Synthese amelioree de chlorhydrate de nefazodone |
WO2003099265A2 (fr) * | 2002-05-24 | 2003-12-04 | Coester Carl-Fr | Combinaison d'agents actifs pharmaceutiques et utilisation |
GB0306604D0 (en) * | 2003-03-21 | 2003-04-30 | Curidium Ltd | Second medical use |
CN1780818A (zh) * | 2003-04-30 | 2006-05-31 | Fmc有限公司 | 苯基取代的环状衍生物 |
US7671072B2 (en) * | 2003-11-26 | 2010-03-02 | Pfizer Inc. | Aminopyrazole derivatives as GSK-3 inhibitors |
CA2567249A1 (fr) * | 2004-04-19 | 2006-10-05 | Jds Pharmaceuticals, Llc | Combinaisons de lithium et utilisations associees |
AR049382A1 (es) * | 2004-05-18 | 2006-07-26 | Fmc Corp | Derivados de la urea ciclica substituida |
EP2317316A3 (fr) | 2005-07-08 | 2011-06-15 | Braincells, Inc. | Procédés permettant d'identifier l'agent et les conditions qui modulent la neurogénèse |
EP1940389A2 (fr) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation de la neurogenese par inhibition de la pde |
CA2625210A1 (fr) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Modulation de la neurogenese dont la mediation est assuree par recepteur gaba |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
MX2008014320A (es) | 2006-05-09 | 2009-03-25 | Braincells Inc | Neurogenesis mediada por el receptor de 5-hidroxitriptamina. |
AU2007249399A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
US7858611B2 (en) * | 2006-05-09 | 2010-12-28 | Braincells Inc. | Neurogenesis by modulating angiotensin |
MX2009002496A (es) | 2006-09-08 | 2009-07-10 | Braincells Inc | Combinaciones que contienen un derivado de 4-acilaminopiridina. |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
WO2008083204A2 (fr) * | 2006-12-28 | 2008-07-10 | Braincells, Inc. | Modulation de la neurogenèse par des ligands mélatoninergiques |
EP2125017A2 (fr) * | 2007-01-11 | 2009-12-02 | Braincells, Inc. | Modulation de la neurogenèse en utilisant du modafinil |
CN101827828B (zh) * | 2007-08-07 | 2013-02-27 | 普罗萨里克斯有限公司 | 作为5-羟色胺能调节剂的1,2,4-三唑衍生物 |
WO2009111031A2 (fr) | 2008-03-04 | 2009-09-11 | Intra-Cellular Therapies, Inc. | Procédés de traitement de symptômes vasomoteurs |
WO2009128058A1 (fr) | 2008-04-18 | 2009-10-22 | UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN et al | Produits psycho-pharmaceutiques |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
TWI368512B (en) * | 2009-04-30 | 2012-07-21 | Univ Kaohsiung Medical | Pharmaceutical compositions comprising chlorophenyl piperazine derived compounds and use of the compounds in producing medicaments |
WO2012072665A1 (fr) | 2010-11-30 | 2012-06-07 | Pharmaneuroboost N.V. | Compositions comprenant de la pipampérone et des antagonistes/inhibiteurs de la recapture de la sérotonine |
CN104402842A (zh) * | 2014-11-19 | 2015-03-11 | 苏州乔纳森新材料科技有限公司 | 一种哌嗪类药物中间体的合成方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1066857B (it) * | 1965-12-15 | 1985-03-12 | Acraf | Derivati della s ipiazolo 4.3 a piridina e processi per la loro preparazione |
IT1052119B (it) * | 1972-10-16 | 1981-06-20 | Sigma Tau Ind Farmaceuti | Derivati del triazolinone e procedimento per la loro preparazione |
-
1981
- 1981-03-16 US US06/244,464 patent/US4338317A/en not_active Expired - Lifetime
-
1982
- 1982-03-02 ZA ZA821359A patent/ZA821359B/xx unknown
- 1982-03-08 CA CA000397793A patent/CA1198436A/fr not_active Expired
- 1982-03-09 GR GR67529A patent/GR76076B/el unknown
- 1982-03-11 YU YU525/82A patent/YU43256B/xx unknown
- 1982-03-11 NL NL8201021A patent/NL190757C/xx not_active IP Right Cessation
- 1982-03-12 FI FI820856A patent/FI73670C/fi not_active IP Right Cessation
- 1982-03-12 IT IT47978/82A patent/IT1148137B/it active Protection Beyond IP Right Term
- 1982-03-12 DK DK112582A patent/DK158728C/da not_active IP Right Cessation
- 1982-03-15 CY CY137382A patent/CY1373A/xx unknown
- 1982-03-15 BE BE0/207574A patent/BE892503A/fr not_active IP Right Cessation
- 1982-03-15 CH CH1615/82A patent/CH649539A5/de not_active IP Right Cessation
- 1982-03-15 LU LU84011A patent/LU84011A1/fr unknown
- 1982-03-15 ES ES510449A patent/ES8305756A1/es not_active Expired
- 1982-03-15 SE SE8201631A patent/SE447256B/sv not_active IP Right Cessation
- 1982-03-15 GB GB8207539A patent/GB2096137B/en not_active Expired
- 1982-03-15 IE IE589/82A patent/IE52788B1/en active Protection Beyond IP Right Term
- 1982-03-15 FR FR8204325A patent/FR2501690B1/fr not_active Expired
- 1982-03-16 KR KR8201129A patent/KR880001374B1/ko active
- 1982-03-16 JP JP57040315A patent/JPS57159774A/ja active Granted
- 1982-03-16 AT AT0104582A patent/AT384022B/de not_active IP Right Cessation
- 1982-03-16 DE DE19823209557 patent/DE3209557A1/de active Granted
-
1987
- 1987-03-27 SG SG302/87A patent/SG30287G/en unknown
- 1987-03-31 KE KE3711A patent/KE3711A/xx unknown
-
1988
- 1988-01-21 HK HK47/88A patent/HK4788A/xx not_active IP Right Cessation
-
1992
- 1992-06-23 MX MX9203176A patent/MX9203176A/es unknown
-
1997
- 1997-03-17 NL NL970014C patent/NL970014I2/nl unknown
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5399693A (en) * | 1984-04-17 | 1995-03-21 | British Technology Group Limited | Substituted piperazine-2-carboxylic acids and derivatives thereof |
US5595983A (en) * | 1984-04-17 | 1997-01-21 | British Technology Group Limited | Substituted piperazine 2-carboxylic acids useful in the treatment of central nervous system disorders |
Also Published As
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