BE892503A - 2-phenoxyalkyl-1,2,4-triazol-3-ones antidepressives - Google Patents

2-phenoxyalkyl-1,2,4-triazol-3-ones antidepressives

Info

Publication number
BE892503A
BE892503A BE0/207574A BE207574A BE892503A BE 892503 A BE892503 A BE 892503A BE 0/207574 A BE0/207574 A BE 0/207574A BE 207574 A BE207574 A BE 207574A BE 892503 A BE892503 A BE 892503A
Authority
BE
Belgium
Prior art keywords
antidepressive
phenoxyalkyl
triazol
ones
ones antidepressive
Prior art date
Application number
BE0/207574A
Other languages
English (en)
Inventor
D L Temple Jr
W G Lobeck Jr
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22922879&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BE892503(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of BE892503A publication Critical patent/BE892503A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/067—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BE0/207574A 1981-03-16 1982-03-15 2-phenoxyalkyl-1,2,4-triazol-3-ones antidepressives BE892503A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/244,464 US4338317A (en) 1981-03-16 1981-03-16 Phenoxyethyl-1,2,4,-triazol-3-one antidepressants

Publications (1)

Publication Number Publication Date
BE892503A true BE892503A (fr) 1982-09-15

Family

ID=22922879

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/207574A BE892503A (fr) 1981-03-16 1982-03-15 2-phenoxyalkyl-1,2,4-triazol-3-ones antidepressives

Country Status (26)

Country Link
US (1) US4338317A (fr)
JP (1) JPS57159774A (fr)
KR (1) KR880001374B1 (fr)
AT (1) AT384022B (fr)
BE (1) BE892503A (fr)
CA (1) CA1198436A (fr)
CH (1) CH649539A5 (fr)
CY (1) CY1373A (fr)
DE (1) DE3209557A1 (fr)
DK (1) DK158728C (fr)
ES (1) ES510449A0 (fr)
FI (1) FI73670C (fr)
FR (1) FR2501690B1 (fr)
GB (1) GB2096137B (fr)
GR (1) GR76076B (fr)
HK (1) HK4788A (fr)
IE (1) IE52788B1 (fr)
IT (1) IT1148137B (fr)
KE (1) KE3711A (fr)
LU (1) LU84011A1 (fr)
MX (1) MX9203176A (fr)
NL (2) NL190757C (fr)
SE (1) SE447256B (fr)
SG (1) SG30287G (fr)
YU (1) YU43256B (fr)
ZA (1) ZA821359B (fr)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4487773A (en) * 1981-03-16 1984-12-11 Mead Johnson & Company 1,2,4-Triazol-3-one antidepressants
US4386091A (en) * 1982-02-24 1983-05-31 Mead Johnson & Company 2-Phenoxyalkyl-1,2,4-triazol-3-one antidepressants
US4575555A (en) * 1983-06-29 1986-03-11 Mead Johnson & Company 4-(3-Chlorophenyl)-1,2,3,6-tetrahydropyridine derivative
AT388555B (de) * 1983-06-29 1989-07-25 Bristol Myers Co Verfahren zur herstellung von neuen 1,2,4-triazol-3-on-derivaten
US4613600A (en) * 1983-09-30 1986-09-23 Mead Johnson & Company Antidepressant 1,2,4-triazolone compounds
YU44721B (en) * 1983-11-30 1990-12-31 Bristol Myers Co Process for obtaining 4-(2-phenoxyethyl)-1,2,4-triazolone
CA1248531A (fr) * 1984-04-17 1989-01-10 Jeffrey C. Watkins Derives de substitution en 4 d'acides piperazine-2- carboxyliques
US4784998A (en) * 1987-04-06 1988-11-15 Bristol-Myers Company 1,3,4-oxadiazole pyschotropic compounds
US5116852A (en) * 1990-12-03 1992-05-26 Bristol-Myers Squibb Co. Treatment of sleep disorders
US5266571A (en) * 1992-01-09 1993-11-30 Amer Moh Samir Treatment of hemorrhoids with 5-HT2 antagonists
US5256664A (en) * 1992-04-28 1993-10-26 Bristol-Myers Squibb Company Antidepressant 3-halophenylpiperazinylpropyl derivatives of substituted triazolones and triazoldiones
IT1256387B (it) * 1992-11-13 1995-12-04 Acraf Procedimento per preparare triazoloni
CA2160423A1 (fr) * 1994-11-02 1996-05-03 Hemant N. Joshi Sels de nefazodone a taux de dissolution ameliores
AU7025396A (en) 1995-10-17 1997-05-01 Bristol-Myers Squibb Company Nefazodone: treatment of panic attack
CA2182241C (fr) * 1996-07-29 2002-09-17 Bo Lei Methodes pour la preparation de nefazodone
AU2452397A (en) * 1996-07-31 1998-02-20 Bristol-Myers Squibb Company Nefazodone: use in migraine prophylaxis
US5852020A (en) * 1996-11-22 1998-12-22 Bristol-Myers Squibb Company Nefazodone: use in treating post traumatic stress disorder
US5735873A (en) * 1996-12-19 1998-04-07 Maclean; David S. Surgical tool handle
US5917050A (en) * 1998-02-11 1999-06-29 Bayer Corporation Process for preparing alkoxytriazolinones
ES2152860B1 (es) * 1998-10-23 2001-08-16 Finaf 92 Sa Forma cristalina de la nefazodona y procedimiento para su preparacion.
US6706282B1 (en) 1998-11-02 2004-03-16 Evangeline Cruz Controlled delivery of phenoxyethyl-substituted 1,2,4-triazolones
ES2262515T3 (es) 1999-04-09 2006-12-01 Sepracor Inc. R-hidroxinefazodona.
JP2002541192A (ja) 1999-04-09 2002-12-03 セプラコール， インク． Ｓ−ヒドロキシネファゾドン
US6586437B2 (en) 1999-04-09 2003-07-01 Sepracor Inc. (S)-hydroxynefazodone antipsychotic therapy
US6469008B2 (en) 1999-04-09 2002-10-22 Sepracor Inc. (R)-hydroxynefazodone antipsychotic therapy
CA2356450C (fr) 2001-09-10 2003-11-25 Brantford Chemicals Inc. Synthese amelioree de chlorhydrate de nefazodone
ATE460933T1 (de) * 2002-05-24 2010-04-15 Carl-Fr Coester Pharmazeutische wirkstoffkombination sowie deren verwendung
GB0306604D0 (en) * 2003-03-21 2003-04-30 Curidium Ltd Second medical use
UA82875C2 (en) * 2003-04-30 2008-05-26 Insecticidal (dihalopropenyl) phenylalkyl substituted dihydrobenzofuran and dihydrobenzopyran derivatives and method for controlling insects
ES2347152T3 (es) * 2003-11-26 2010-10-26 Pfizer Products Inc. Derivados de aminopirazol como inhibidores de gsk-3.
CA2567249A1 (fr) * 2004-04-19 2006-10-05 Jds Pharmaceuticals, Llc Combinaisons de lithium et utilisations associees
AR049382A1 (es) * 2004-05-18 2006-07-26 Fmc Corp Derivados de la urea ciclica substituida
NZ565683A (en) 2005-07-08 2011-04-29 Braincells Inc Methods for identifying agents and conditions that modulate neurogenesis in human neural cells
EP1940389A2 (fr) 2005-10-21 2008-07-09 Braincells, Inc. Modulation de la neurogenese par inhibition de la pde
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US7858611B2 (en) * 2006-05-09 2010-12-28 Braincells Inc. Neurogenesis by modulating angiotensin
MX2008014320A (es) 2006-05-09 2009-03-25 Braincells Inc Neurogenesis mediada por el receptor de 5-hidroxitriptamina.
EP2021000A2 (fr) 2006-05-09 2009-02-11 Braincells, Inc. Neurogenèse par modulation de l'angiotensine
EP2068872A1 (fr) 2006-09-08 2009-06-17 Braincells, Inc. Combinaisons contenant un dérivé de 4-acylaminopyridine
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2008083204A2 (fr) * 2006-12-28 2008-07-10 Braincells, Inc. Modulation de la neurogenèse par des ligands mélatoninergiques
CA2675132A1 (fr) * 2007-01-11 2008-07-17 Braincells, Inc. Modulation de la neurogenese en utilisant du modafinil
WO2009019472A1 (fr) * 2007-08-07 2009-02-12 Prosarix Limited Nouveaux modulateurs sérotonergiques
US9339500B2 (en) 2008-03-04 2016-05-17 Intra-Cellular Therapies, Inc. Methods of treating vasomotor symptoms
WO2009128058A1 (fr) 2008-04-18 2009-10-22 UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN et al Produits psycho-pharmaceutiques
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
TWI368512B (en) * 2009-04-30 2012-07-21 Univ Kaohsiung Medical Pharmaceutical compositions comprising chlorophenyl piperazine derived compounds and use of the compounds in producing medicaments
WO2012072665A1 (fr) 2010-11-30 2012-06-07 Pharmaneuroboost N.V. Compositions comprenant de la pipampérone et des antagonistes/inhibiteurs de la recapture de la sérotonine
CN104402842A (zh) * 2014-11-19 2015-03-11 苏州乔纳森新材料科技有限公司 一种哌嗪类药物中间体的合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1066857B (it) * 1965-12-15 1985-03-12 Acraf Derivati della s ipiazolo 4.3 a piridina e processi per la loro preparazione
IT1052119B (it) * 1972-10-16 1981-06-20 Sigma Tau Ind Farmaceuti Derivati del triazolinone e procedimento per la loro preparazione

Also Published As

Publication number Publication date
SE8201631L (sv) 1982-09-17
FI73670B (fi) 1987-07-31
IT1148137B (it) 1986-11-26
DK112582A (da) 1982-09-17
JPH0237353B2 (fr) 1990-08-23
FR2501690A1 (fr) 1982-09-17
KR830009089A (ko) 1983-12-17
NL8201021A (nl) 1982-10-18
GB2096137A (en) 1982-10-13
SE447256B (sv) 1986-11-03
ES8305756A1 (es) 1983-04-16
FR2501690B1 (fr) 1985-07-05
CA1198436A (fr) 1985-12-24
FI820856L (fi) 1982-09-17
KR880001374B1 (ko) 1988-07-29
NL970014I1 (nl) 1997-06-02
SG30287G (en) 1987-07-17
US4338317A (en) 1982-07-06
NL190757B (nl) 1994-03-01
LU84011A1 (fr) 1983-02-22
KE3711A (en) 1987-04-30
ATA104582A (de) 1987-02-15
IT8247978A0 (it) 1982-03-12
NL190757C (nl) 1994-08-01
GB2096137B (en) 1985-01-03
AU555888B2 (en) 1986-10-16
DK158728C (da) 1990-12-03
NL970014I2 (nl) 1997-09-01
IE52788B1 (en) 1988-03-02
JPS57159774A (en) 1982-10-01
AU8117082A (en) 1982-09-23
DE3209557A1 (de) 1982-12-09
YU52582A (en) 1985-06-30
ZA821359B (en) 1983-01-26
CY1373A (en) 1987-08-07
CH649539A5 (de) 1985-05-31
ES510449A0 (es) 1983-04-16
FI73670C (fi) 1987-11-09
HK4788A (en) 1988-01-29
YU43256B (en) 1989-06-30
AT384022B (de) 1987-09-25
IE820589L (en) 1982-09-16
DE3209557C2 (fr) 1993-07-15
MX9203176A (es) 1992-07-01
DK158728B (da) 1990-07-09
GR76076B (fr) 1984-08-03

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Legal Events

Date Code Title Description
CCPV Grant of a supplementary protection certificate

Free format text: 2000C/007, EXPIRES: 20070315

RE20 Patent expired

Owner name: BRISTOL-MYERS CY

Effective date: 20020315

CCRE Expiry of a supplementary protection certificate

Spc suppl protection certif: 2000C/007

Extension date: 20070315

Effective date: 20070315