FR2501690B1 - Derives heterocycliques du type 1,2,4-triazole, leur preparation et leur application pharmacologique - Google Patents

Derives heterocycliques du type 1,2,4-triazole, leur preparation et leur application pharmacologique

Info

Publication number
FR2501690B1
FR2501690B1 FR8204325A FR8204325A FR2501690B1 FR 2501690 B1 FR2501690 B1 FR 2501690B1 FR 8204325 A FR8204325 A FR 8204325A FR 8204325 A FR8204325 A FR 8204325A FR 2501690 B1 FR2501690 B1 FR 2501690B1
Authority
FR
France
Prior art keywords
preparation
heterocyclic derivatives
triazole type
pharmacological application
pharmacological
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8204325A
Other languages
English (en)
Other versions
FR2501690A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22922879&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FR2501690(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of FR2501690A1 publication Critical patent/FR2501690A1/fr
Application granted granted Critical
Publication of FR2501690B1 publication Critical patent/FR2501690B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/067—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR8204325A 1981-03-16 1982-03-15 Derives heterocycliques du type 1,2,4-triazole, leur preparation et leur application pharmacologique Expired FR2501690B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/244,464 US4338317A (en) 1981-03-16 1981-03-16 Phenoxyethyl-1,2,4,-triazol-3-one antidepressants

Publications (2)

Publication Number Publication Date
FR2501690A1 FR2501690A1 (fr) 1982-09-17
FR2501690B1 true FR2501690B1 (fr) 1985-07-05

Family

ID=22922879

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8204325A Expired FR2501690B1 (fr) 1981-03-16 1982-03-15 Derives heterocycliques du type 1,2,4-triazole, leur preparation et leur application pharmacologique

Country Status (26)

Country Link
US (1) US4338317A (fr)
JP (1) JPS57159774A (fr)
KR (1) KR880001374B1 (fr)
AT (1) AT384022B (fr)
BE (1) BE892503A (fr)
CA (1) CA1198436A (fr)
CH (1) CH649539A5 (fr)
CY (1) CY1373A (fr)
DE (1) DE3209557A1 (fr)
DK (1) DK158728C (fr)
ES (1) ES8305756A1 (fr)
FI (1) FI73670C (fr)
FR (1) FR2501690B1 (fr)
GB (1) GB2096137B (fr)
GR (1) GR76076B (fr)
HK (1) HK4788A (fr)
IE (1) IE52788B1 (fr)
IT (1) IT1148137B (fr)
KE (1) KE3711A (fr)
LU (1) LU84011A1 (fr)
MX (1) MX9203176A (fr)
NL (2) NL190757C (fr)
SE (1) SE447256B (fr)
SG (1) SG30287G (fr)
YU (1) YU43256B (fr)
ZA (1) ZA821359B (fr)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4487773A (en) * 1981-03-16 1984-12-11 Mead Johnson & Company 1,2,4-Triazol-3-one antidepressants
US4386091A (en) * 1982-02-24 1983-05-31 Mead Johnson & Company 2-Phenoxyalkyl-1,2,4-triazol-3-one antidepressants
AT388555B (de) * 1983-06-29 1989-07-25 Bristol Myers Co Verfahren zur herstellung von neuen 1,2,4-triazol-3-on-derivaten
US4575555A (en) * 1983-06-29 1986-03-11 Mead Johnson & Company 4-(3-Chlorophenyl)-1,2,3,6-tetrahydropyridine derivative
US4613600A (en) * 1983-09-30 1986-09-23 Mead Johnson & Company Antidepressant 1,2,4-triazolone compounds
YU44721B (en) * 1983-11-30 1990-12-31 Bristol Myers Co Process for obtaining 4-(2-phenoxyethyl)-1,2,4-triazolone
CA1248531A (fr) * 1984-04-17 1989-01-10 Jeffrey C. Watkins Derives de substitution en 4 d'acides piperazine-2- carboxyliques
US4784998A (en) * 1987-04-06 1988-11-15 Bristol-Myers Company 1,3,4-oxadiazole pyschotropic compounds
US5116852A (en) * 1990-12-03 1992-05-26 Bristol-Myers Squibb Co. Treatment of sleep disorders
US5266571A (en) * 1992-01-09 1993-11-30 Amer Moh Samir Treatment of hemorrhoids with 5-HT2 antagonists
US5256664A (en) * 1992-04-28 1993-10-26 Bristol-Myers Squibb Company Antidepressant 3-halophenylpiperazinylpropyl derivatives of substituted triazolones and triazoldiones
IT1256387B (it) * 1992-11-13 1995-12-04 Acraf Procedimento per preparare triazoloni
CA2160423A1 (fr) * 1994-11-02 1996-05-03 Hemant N. Joshi Sels de nefazodone a taux de dissolution ameliores
AU7025396A (en) 1995-10-17 1997-05-01 Bristol-Myers Squibb Company Nefazodone: treatment of panic attack
CA2182241C (fr) * 1996-07-29 2002-09-17 Bo Lei Methodes pour la preparation de nefazodone
US5854248A (en) * 1996-07-31 1998-12-29 Bristol-Myers Squibb Company Nefazodone: use in migraine prophylaxis
US5852020A (en) * 1996-11-22 1998-12-22 Bristol-Myers Squibb Company Nefazodone: use in treating post traumatic stress disorder
US5735873A (en) * 1996-12-19 1998-04-07 Maclean; David S. Surgical tool handle
US5917050A (en) * 1998-02-11 1999-06-29 Bayer Corporation Process for preparing alkoxytriazolinones
ES2152860B1 (es) * 1998-10-23 2001-08-16 Finaf 92 Sa Forma cristalina de la nefazodona y procedimiento para su preparacion.
US6706282B1 (en) 1998-11-02 2004-03-16 Evangeline Cruz Controlled delivery of phenoxyethyl-substituted 1,2,4-triazolones
US6469008B2 (en) 1999-04-09 2002-10-22 Sepracor Inc. (R)-hydroxynefazodone antipsychotic therapy
AU4215400A (en) * 1999-04-09 2000-11-14 Sepracor, Inc. S-hydroxynefazodone
US6586437B2 (en) 1999-04-09 2003-07-01 Sepracor Inc. (S)-hydroxynefazodone antipsychotic therapy
CA2369732A1 (fr) 1999-04-09 2000-10-19 Sepracor Inc. Hydroxy-nefazodone r
CA2356450C (fr) 2001-09-10 2003-11-25 Brantford Chemicals Inc. Synthese amelioree de chlorhydrate de nefazodone
US20050256131A1 (en) * 2002-05-24 2005-11-17 Carl-Fr Coester Pharmaceutical active substance combination and the use thereof
GB0306604D0 (en) * 2003-03-21 2003-04-30 Curidium Ltd Second medical use
CA2523191A1 (fr) * 2003-04-30 2004-11-18 Fmc Corporation Derives cycliques a substitution phenyle
ATE473967T1 (de) * 2003-11-26 2010-07-15 Pfizer Prod Inc Aminopyrazolderivate als gsk-3-inhibitoren
EP1737473A4 (fr) * 2004-04-19 2009-08-26 Noven Therapeutics Llc Combinaisons de lithium et utilisations associees
TW200612961A (en) * 2004-05-18 2006-05-01 Fmc Corp Substituted cyclic urea derivatives
EP1904843A2 (fr) * 2005-07-08 2008-04-02 Braincells, Inc. Methodes destinees a identifier des agents et des conditions modulant la neurogenese
US7985756B2 (en) 2005-10-21 2011-07-26 Braincells Inc. Modulation of neurogenesis by PDE inhibition
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
JP2009536669A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド アンジオテンシン調節による神経新生
MX2008014320A (es) 2006-05-09 2009-03-25 Braincells Inc Neurogenesis mediada por el receptor de 5-hidroxitriptamina.
US7858611B2 (en) * 2006-05-09 2010-12-28 Braincells Inc. Neurogenesis by modulating angiotensin
AU2007292848A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US20080167363A1 (en) * 2006-12-28 2008-07-10 Braincells, Inc Modulation of Neurogenesis By Melatoninergic Agents
CA2675132A1 (fr) * 2007-01-11 2008-07-17 Braincells, Inc. Modulation de la neurogenese en utilisant du modafinil
GB2454290B (en) * 2007-08-07 2009-09-30 Prosarix Ltd Novel serotonergic modulators
WO2009111031A2 (fr) 2008-03-04 2009-09-11 Intra-Cellular Therapies, Inc. Procédés de traitement de symptômes vasomoteurs
EP2288345B1 (fr) 2008-04-18 2015-06-10 University College Dublin National University Of Ireland, Dublin Produits psycho-pharmaceutiques
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
TWI368512B (en) * 2009-04-30 2012-07-21 Univ Kaohsiung Medical Pharmaceutical compositions comprising chlorophenyl piperazine derived compounds and use of the compounds in producing medicaments
WO2012072665A1 (fr) 2010-11-30 2012-06-07 Pharmaneuroboost N.V. Compositions comprenant de la pipampérone et des antagonistes/inhibiteurs de la recapture de la sérotonine
CN104402842A (zh) * 2014-11-19 2015-03-11 苏州乔纳森新材料科技有限公司 一种哌嗪类药物中间体的合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1066857B (it) * 1965-12-15 1985-03-12 Acraf Derivati della s ipiazolo 4.3 a piridina e processi per la loro preparazione
IT1052119B (it) * 1972-10-16 1981-06-20 Sigma Tau Ind Farmaceuti Derivati del triazolinone e procedimento per la loro preparazione

Also Published As

Publication number Publication date
SE8201631L (sv) 1982-09-17
DK158728B (da) 1990-07-09
IE52788B1 (en) 1988-03-02
HK4788A (en) 1988-01-29
IE820589L (en) 1982-09-16
NL970014I1 (nl) 1997-06-02
MX9203176A (es) 1992-07-01
FI73670B (fi) 1987-07-31
ZA821359B (en) 1983-01-26
DE3209557C2 (fr) 1993-07-15
FR2501690A1 (fr) 1982-09-17
AT384022B (de) 1987-09-25
ES510449A0 (es) 1983-04-16
US4338317A (en) 1982-07-06
YU52582A (en) 1985-06-30
DK158728C (da) 1990-12-03
KR830009089A (ko) 1983-12-17
NL970014I2 (nl) 1997-09-01
CH649539A5 (de) 1985-05-31
NL190757C (nl) 1994-08-01
DK112582A (da) 1982-09-17
NL190757B (nl) 1994-03-01
LU84011A1 (fr) 1983-02-22
AU8117082A (en) 1982-09-23
GB2096137A (en) 1982-10-13
KE3711A (en) 1987-04-30
JPS57159774A (en) 1982-10-01
SG30287G (en) 1987-07-17
DE3209557A1 (de) 1982-12-09
GB2096137B (en) 1985-01-03
FI820856L (fi) 1982-09-17
GR76076B (fr) 1984-08-03
BE892503A (fr) 1982-09-15
IT1148137B (it) 1986-11-26
IT8247978A0 (it) 1982-03-12
YU43256B (en) 1989-06-30
KR880001374B1 (ko) 1988-07-29
ATA104582A (de) 1987-02-15
JPH0237353B2 (fr) 1990-08-23
NL8201021A (nl) 1982-10-18
ES8305756A1 (es) 1983-04-16
SE447256B (sv) 1986-11-03
CA1198436A (fr) 1985-12-24
AU555888B2 (en) 1986-10-16
FI73670C (fi) 1987-11-09
CY1373A (en) 1987-08-07

Similar Documents

Publication Publication Date Title
FR2501690B1 (fr) Derives heterocycliques du type 1,2,4-triazole, leur preparation et leur application pharmacologique
NO844845L (no) Derivater av 2,2`-iminobisetanol
MC1355A1 (fr) Derives d'imidazodiazepine
ES512259A0 (es) "procedimiento para la preparacion de nuevos derivados piperidinicos piperacinicos y homopiperacinicos".
FI814208L (fi) Foerfarande foer framstaellning av loesliga cellulosaderivater
FR2498188B1 (fr) Nouveaux derives de l'indole, leur preparation et leur application comme medicaments
FR2552759B1 (fr) Composes de la 1,2,4-triazolone et leur application pharmacologique
BE875846A (fr) Derives heterocycliques et leur preparation
BE873766A (fr) Derives de la 2-pyrrolidone et leur preparation
MC1478A1 (fr) Nouveaux derives de l'imidazoquinazoline
PT74710A (fr) Nouveaux derives d'aminoethoxy-4 isopropyl-5 methyl-2-phenol
DK121282A (da) Heterocykliske derivater
BE894368A (fr) Derives de cyclopentadiene, leur preparation et leur utilisation
BE853949A (fr) Nouveaux derives de l'indazolyl-(4)-oxy-propanol-amine, leur preparation et utilisation
FR2512819B1 (fr) Derives de macbecine et leur preparation
IT8025285A0 (it) Derivati di prostagliandina e prostaciclina ad attivita'farmacologica.
BE875592A (fr) Derives de pyrrolidinecarboxaldehyde et de piperidinecarboxaldehyde et leur preparation
FR2346337A1 (fr) Derives d'uracil, leur procede de preparation et leur application pharmacologique
FR2510117B1 (fr) Nouveaux derives d'hydrazonocephem et leur application pharmacologique
FR2528045B1 (fr) Derives triazolyles et leur application fongicide
NO157654C (no) Fremgangsmaate for fremstilling av 5,6,7,7a-tetrahydro-4h-thieno-(3,2-c)-pyridin-on-derivater.
BE890853A (fr) Nouveaux derives de l'apramycine
FR2497800B1 (fr) Nouveaux derives de nitrosouree
BE857512A (fr) Nouveaux derives de l'imidazole
BE863083A (fr) Nouveaux derives de l'isoquinoleine, leur preparation et les compositions qui les contiennent