SE444268B - Sett att framstella ett fast porost material for kromatografiskt bruk samt anvendning av materialet for isolering eller rening av biologiska makromolekyler - Google Patents
Sett att framstella ett fast porost material for kromatografiskt bruk samt anvendning av materialet for isolering eller rening av biologiska makromolekylerInfo
- Publication number
- SE444268B SE444268B SE7809789A SE7809789A SE444268B SE 444268 B SE444268 B SE 444268B SE 7809789 A SE7809789 A SE 7809789A SE 7809789 A SE7809789 A SE 7809789A SE 444268 B SE444268 B SE 444268B
- Authority
- SE
- Sweden
- Prior art keywords
- polysaccharide
- modified
- cholera
- alkyl group
- cellulose
- Prior art date
Links
- 239000000463 material Substances 0.000 title claims description 22
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- 238000004140 cleaning Methods 0.000 title 1
- 238000000034 method Methods 0.000 claims description 41
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- 239000005017 polysaccharide Substances 0.000 claims description 31
- 108090000623 proteins and genes Proteins 0.000 claims description 26
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- 229920002678 cellulose Polymers 0.000 claims description 19
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- 102000004169 proteins and genes Human genes 0.000 claims description 19
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- 238000000576 coating method Methods 0.000 claims description 16
- 239000000047 product Substances 0.000 claims description 14
- 239000011248 coating agent Substances 0.000 claims description 13
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- 125000000217 alkyl group Chemical group 0.000 claims description 11
- 229920002307 Dextran Polymers 0.000 claims description 10
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- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims description 4
- 239000012279 sodium borohydride Substances 0.000 claims description 4
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- 230000001580 bacterial effect Effects 0.000 claims description 3
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- 238000004132 cross linking Methods 0.000 claims description 3
- SHKUUQIDMUMQQK-UHFFFAOYSA-N 2-[4-(oxiran-2-ylmethoxy)butoxymethyl]oxirane Chemical group C1OC1COCCCCOCC1CO1 SHKUUQIDMUMQQK-UHFFFAOYSA-N 0.000 claims description 2
- 239000005995 Aluminium silicate Substances 0.000 claims description 2
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 claims description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 2
- 230000009471 action Effects 0.000 claims description 2
- 235000012211 aluminium silicate Nutrition 0.000 claims description 2
- 239000003431 cross linking reagent Substances 0.000 claims description 2
- 239000007857 degradation product Substances 0.000 claims description 2
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- 150000003944 halohydrins Chemical class 0.000 claims description 2
- 125000001183 hydrocarbyl group Chemical group 0.000 claims description 2
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims description 2
- 238000002955 isolation Methods 0.000 claims description 2
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 claims description 2
- 239000000395 magnesium oxide Substances 0.000 claims description 2
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 claims description 2
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 229910044991 metal oxide Inorganic materials 0.000 claims description 2
- 150000004706 metal oxides Chemical group 0.000 claims description 2
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- 230000003612 virological effect Effects 0.000 claims description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 229910000831 Steel Inorganic materials 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims 1
- 239000003638 chemical reducing agent Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 150000004678 hydrides Chemical class 0.000 claims 1
- 125000001841 imino group Chemical group [H]N=* 0.000 claims 1
- 150000002924 oxiranes Chemical class 0.000 claims 1
- 150000003141 primary amines Chemical class 0.000 claims 1
- 150000004760 silicates Chemical class 0.000 claims 1
- 239000010959 steel Substances 0.000 claims 1
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- 239000000243 solution Substances 0.000 description 24
- 108010049048 Cholera Toxin Proteins 0.000 description 21
- 102000009016 Cholera Toxin Human genes 0.000 description 20
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- 125000002091 cationic group Chemical group 0.000 description 7
- 239000003446 ligand Substances 0.000 description 7
- 238000002360 preparation method Methods 0.000 description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
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- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 4
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- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 3
- SQVRNKJHWKZAKO-PFQGKNLYSA-N N-acetyl-beta-neuraminic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-PFQGKNLYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000003776 cleavage reaction Methods 0.000 description 3
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- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 description 2
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- 239000008363 phosphate buffer Substances 0.000 description 2
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- YMDNODNLFSHHCV-UHFFFAOYSA-N 2-chloro-n,n-diethylethanamine Chemical compound CCN(CC)CCCl YMDNODNLFSHHCV-UHFFFAOYSA-N 0.000 description 1
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- 101710146739 Enterotoxin Proteins 0.000 description 1
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- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 1
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- 230000004913 activation Effects 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
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- 238000005349 anion exchange Methods 0.000 description 1
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- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 1
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- QPJBWNIQKHGLAU-IQZHVAEDSA-N ganglioside GM1 Chemical compound O[C@@H]1[C@@H](O)[C@H](OC[C@H](NC(=O)CCCCCCCCCCCCCCCCC)[C@H](O)\C=C\CCCCCCCCCCCCC)O[C@H](CO)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@]2(O[C@H]([C@H](NC(C)=O)[C@@H](O)C2)[C@H](O)[C@H](O)CO)C(O)=O)[C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O3)O)[C@@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](CO)O1 QPJBWNIQKHGLAU-IQZHVAEDSA-N 0.000 description 1
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- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
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- 244000005700 microbiome Species 0.000 description 1
- UDGSVBYJWHOHNN-UHFFFAOYSA-N n',n'-diethylethane-1,2-diamine Chemical compound CCN(CC)CCN UDGSVBYJWHOHNN-UHFFFAOYSA-N 0.000 description 1
- QOHMWDJIBGVPIF-UHFFFAOYSA-N n',n'-diethylpropane-1,3-diamine Chemical compound CCN(CC)CCCN QOHMWDJIBGVPIF-UHFFFAOYSA-N 0.000 description 1
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
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- ZNNZYHKDIALBAK-UHFFFAOYSA-M potassium thiocyanate Chemical compound [K+].[S-]C#N ZNNZYHKDIALBAK-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
-
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Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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FR7728163A FR2403098A1 (fr) | 1977-09-19 | 1977-09-19 | Nouveau materiau capable de fixer de facon reversible des macromolecules biologiques, sa preparation et son application |
Publications (2)
Publication Number | Publication Date |
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SE7809789L SE7809789L (sv) | 1979-03-20 |
SE444268B true SE444268B (sv) | 1986-04-07 |
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Application Number | Title | Priority Date | Filing Date |
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SE7809789A SE444268B (sv) | 1977-09-19 | 1978-09-18 | Sett att framstella ett fast porost material for kromatografiskt bruk samt anvendning av materialet for isolering eller rening av biologiska makromolekyler |
Country Status (12)
Country | Link |
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US (1) | US4308254A (fr) |
JP (1) | JPS5839576B2 (fr) |
BE (1) | BE870565A (fr) |
CH (1) | CH642862A5 (fr) |
DE (1) | DE2840503C2 (fr) |
DK (1) | DK411478A (fr) |
FR (1) | FR2403098A1 (fr) |
GB (1) | GB2006642B (fr) |
IT (1) | IT1174426B (fr) |
NL (1) | NL7809486A (fr) |
NO (1) | NO783154L (fr) |
SE (1) | SE444268B (fr) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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WO1992018237A1 (fr) * | 1991-04-17 | 1992-10-29 | Pharmacia Lkb Biotechnology Ab | Procedes et moyens destines a un traitement en aval |
US6706188B2 (en) | 1993-05-03 | 2004-03-16 | Amersham Biociences Ab | Process and means for down stream processing |
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FR2478104B1 (fr) * | 1980-03-17 | 1986-08-08 | Merieux Inst | Nouveaux derives de gangliosides, leur preparation et leur application |
DE3264713D1 (en) * | 1981-02-26 | 1985-08-22 | Unilever Plc | A process and apparatus for the recovery of immunoglobulines |
FR2502786B1 (fr) * | 1981-03-24 | 1985-06-21 | Stallergenes Laboratoire | Procede de fixation d'antigenes et d'anticorps sur support de polysaccharides, et utilisation du produit ainsi obtenu pour les dosages immunologiques |
US4356170A (en) * | 1981-05-27 | 1982-10-26 | Canadian Patents & Development Ltd. | Immunogenic polysaccharide-protein conjugates |
JPS58129259A (ja) * | 1982-01-26 | 1983-08-02 | Sekisui Chem Co Ltd | 免疫化学的測定試薬 |
JPS5942452A (ja) * | 1982-09-02 | 1984-03-09 | Sekisui Chem Co Ltd | 免疫化学的測定試薬用担体の製造方法 |
FR2543448A1 (fr) * | 1983-04-01 | 1984-10-05 | Rhone Poulenc Spec Chim | Procede de fractionnement du plasma |
US4507472A (en) * | 1983-06-14 | 1985-03-26 | Usher Thomas C | Manufacture of diethylaminoethyl dextrans |
US5192444A (en) * | 1984-04-02 | 1993-03-09 | Daicel Chemical Industries, Ltd. | Separating with an agent comprising an aliphatic ester of a polysaccharide |
US5268098A (en) * | 1984-04-02 | 1993-12-07 | Daicel Chemical Industries, Ltd. | Separation agent comprising aliphatic or aromatic ester of polysaccharide |
JPS60226832A (ja) * | 1984-04-02 | 1985-11-12 | Daicel Chem Ind Ltd | 多糖の脂肪族エステルを含む分離剤 |
EP0164889A3 (fr) * | 1984-05-07 | 1986-12-17 | HSC Research Development Corporation | Supports polymères traités en surface |
GB8415666D0 (en) * | 1984-06-20 | 1984-07-25 | Berezenko S | Support material for immobilisation of ligands |
AU571979B2 (en) * | 1984-07-06 | 1988-04-28 | Ciba-Geigy Ag | Ionically modified polysaccharides |
DE3519011A1 (de) * | 1985-05-25 | 1986-11-27 | Behringwerke Ag, 3550 Marburg | Verfahren zur herstellung eines materials zur affinitaetschromatographie |
JPS62186940A (ja) * | 1986-02-10 | 1987-08-15 | Kanegafuchi Chem Ind Co Ltd | リポ蛋白用吸着体 |
FR2597605B1 (fr) * | 1986-04-16 | 1989-06-23 | Merieux Inst | Nouveau materiau pour chromatographie d'affinite et son application a la separation et a la purification des antigenes proteiques des bacteries du genre bordetella |
JP2606213B2 (ja) * | 1986-04-22 | 1997-04-30 | 味の素株式会社 | 修飾された微生物産生セルロースのゲルおよび動物細胞膜との複合体 |
DE3627063A1 (de) * | 1986-08-09 | 1988-02-11 | Diagen Inst Molekularbio | Verfahren zur abtrennung und reinigung von biopolymeren durch affinitaetschromatographie |
FR2616628B1 (fr) * | 1987-06-19 | 1989-09-29 | Entremont Sa | Procede pour extraire des proteines du lactoserum par adsorption et elution |
US5041079A (en) * | 1987-12-04 | 1991-08-20 | Kuraray Co., Ltd. | Method for removing human immunodeficiency virus and/or its related compounds |
IT1235011B (it) * | 1988-07-26 | 1992-06-16 | Fidia Farmaceutici | Sintesi di derivati di glicosfingolipidi ed in particolare di gangliosidi utilizzabili per la preparazione di immunoadsorbenti ed adsorbenti per affinita' impiegabili per la purificazione di anticorpi e di tossine specifiche, e per uso diagnostico |
FR2635019B1 (fr) * | 1988-08-02 | 1992-06-12 | Centre Nat Rech Scient | Materiau capable de fixer les substances biologiques, et ses applications notamment comme support de chromatographie d'affinite |
US5153166A (en) * | 1988-08-18 | 1992-10-06 | Trustees Of At Biochem | Chromatographic stationary supports |
DE3840044A1 (de) * | 1988-11-27 | 1990-06-07 | Behringwerke Ag | Glykosphingolipide mit kopplungsfaehiger gruppe im sphingoidanteil, ihre herstellung und verwendung |
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-
1977
- 1977-09-19 FR FR7728163A patent/FR2403098A1/fr active Granted
-
1978
- 1978-09-18 NO NO783154A patent/NO783154L/no unknown
- 1978-09-18 DE DE2840503A patent/DE2840503C2/de not_active Expired
- 1978-09-18 BE BE190556A patent/BE870565A/fr not_active IP Right Cessation
- 1978-09-18 GB GB7837185A patent/GB2006642B/en not_active Expired
- 1978-09-18 IT IT27802/78A patent/IT1174426B/it active
- 1978-09-18 NL NL7809486A patent/NL7809486A/xx not_active Application Discontinuation
- 1978-09-18 CH CH970078A patent/CH642862A5/fr not_active IP Right Cessation
- 1978-09-18 SE SE7809789A patent/SE444268B/sv not_active IP Right Cessation
- 1978-09-18 DK DK411478A patent/DK411478A/da unknown
- 1978-09-19 JP JP53115046A patent/JPS5839576B2/ja not_active Expired
- 1978-09-19 US US05/944,121 patent/US4308254A/en not_active Expired - Lifetime
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1992018237A1 (fr) * | 1991-04-17 | 1992-10-29 | Pharmacia Lkb Biotechnology Ab | Procedes et moyens destines a un traitement en aval |
US5522993A (en) * | 1991-04-17 | 1996-06-04 | Pharmacia Biotech Ab | Process and means for down stream processing |
US6325937B1 (en) | 1991-04-17 | 2001-12-04 | Amersham Pharmacia Biotech Ab | Process and means for down stream processing |
US6398963B1 (en) | 1991-04-17 | 2002-06-04 | Amersham Pharmacia Biotech Aktiebolag | Process and means for down stream processing |
US6706188B2 (en) | 1993-05-03 | 2004-03-16 | Amersham Biociences Ab | Process and means for down stream processing |
Also Published As
Publication number | Publication date |
---|---|
IT1174426B (it) | 1987-07-01 |
DK411478A (da) | 1979-03-20 |
NO783154L (no) | 1979-03-20 |
IT7827802A0 (it) | 1978-09-18 |
FR2403098B1 (fr) | 1980-06-13 |
NL7809486A (nl) | 1979-03-21 |
GB2006642B (en) | 1982-04-15 |
DE2840503C2 (de) | 1984-11-22 |
SE7809789L (sv) | 1979-03-20 |
JPS5463894A (en) | 1979-05-23 |
CH642862A5 (fr) | 1984-05-15 |
US4308254A (en) | 1981-12-29 |
FR2403098A1 (fr) | 1979-04-13 |
DE2840503A1 (de) | 1979-03-29 |
BE870565A (fr) | 1979-03-19 |
GB2006642A (en) | 1979-05-10 |
JPS5839576B2 (ja) | 1983-08-31 |
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