SE0400501D0 - Antibody purification - Google Patents
Antibody purificationInfo
- Publication number
- SE0400501D0 SE0400501D0 SE0400501A SE0400501A SE0400501D0 SE 0400501 D0 SE0400501 D0 SE 0400501D0 SE 0400501 A SE0400501 A SE 0400501A SE 0400501 A SE0400501 A SE 0400501A SE 0400501 D0 SE0400501 D0 SE 0400501D0
- Authority
- SE
- Sweden
- Prior art keywords
- cation
- aromatic
- solution
- modal
- exchanging group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3804—Affinity chromatography
- B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3847—Multimodal interactions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/04—Processes using organic exchangers
- B01J39/07—Processes using organic exchangers in the weakly acidic form
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/26—Cation exchangers for chromatographic processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J47/00—Ion-exchange processes in general; Apparatus therefor
- B01J47/014—Ion-exchange processes in general; Apparatus therefor in which the adsorbent properties of the ion-exchanger are involved, e.g. recovery of proteins or other high-molecular compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/361—Ion-exchange
- B01D15/362—Cation-exchange
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Priority Applications (23)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0400501A SE0400501D0 (sv) | 2004-02-27 | 2004-02-27 | Antibody purification |
NZ548127A NZ548127A (en) | 2004-02-27 | 2005-02-24 | Method for antibody purification |
DE602005016220T DE602005016220D1 (de) | 2004-02-27 | 2005-02-24 | Aufreinigung von antikörpern |
KR1020067017115A KR101149969B1 (ko) | 2004-02-27 | 2005-02-24 | 항체 정제 |
CN2005800062670A CN1926146B (zh) | 2004-02-27 | 2005-02-24 | 抗体纯化 |
US10/589,718 US7385040B2 (en) | 2004-02-27 | 2005-02-24 | Antibody purification |
AT05722174T ATE440858T1 (de) | 2004-02-27 | 2005-02-24 | Aufreinigung von antikírpern |
CA2552823A CA2552823C (en) | 2004-02-27 | 2005-02-24 | Antibody purification |
EP05722174A EP1718668B1 (de) | 2004-02-27 | 2005-02-24 | Aufreinigung von antikörpern |
JP2007500724A JP4776615B2 (ja) | 2004-02-27 | 2005-02-24 | 抗体精製 |
PCT/SE2005/000292 WO2005082926A1 (en) | 2004-02-27 | 2005-02-24 | Antibody purification |
AU2005217348A AU2005217348B2 (en) | 2004-02-27 | 2005-02-24 | Antibody purification |
JP2007500725A JP4848356B2 (ja) | 2004-02-27 | 2005-02-25 | 抗体精製法 |
CN200580006276XA CN1925898B (zh) | 2004-02-27 | 2005-02-25 | 纯化抗体的工艺 |
AU2005216847A AU2005216847B2 (en) | 2004-02-27 | 2005-02-25 | A process for the purification of antibodies |
PCT/SE2005/000293 WO2005082483A1 (en) | 2004-02-27 | 2005-02-25 | A process for the purification of antibodies |
NZ548126A NZ548126A (en) | 2004-02-27 | 2005-02-25 | A process for the purification of antibodies involving addition of a second resin |
CA2552639A CA2552639C (en) | 2004-02-27 | 2005-02-25 | A process for the purification of antibodies |
EP05722175A EP1718386A1 (de) | 2004-02-27 | 2005-02-25 | Verfahren zur reinigung von antikörpern |
US10/589,717 US7750129B2 (en) | 2004-02-27 | 2005-02-25 | Process for the purification of antibodies |
KR1020067017113A KR101150050B1 (ko) | 2004-02-27 | 2005-02-25 | 항체 정제 방법 |
IL176635A IL176635A (en) | 2004-02-27 | 2006-06-29 | Method of purification of antibodies from one or more contaminants by chromatography and a system for such purification |
IL176745A IL176745A (en) | 2004-02-27 | 2006-07-06 | Process for the purification of antibodies |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0400501A SE0400501D0 (sv) | 2004-02-27 | 2004-02-27 | Antibody purification |
Publications (1)
Publication Number | Publication Date |
---|---|
SE0400501D0 true SE0400501D0 (sv) | 2004-02-27 |
Family
ID=32067281
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE0400501A SE0400501D0 (sv) | 2004-02-27 | 2004-02-27 | Antibody purification |
Country Status (13)
Country | Link |
---|---|
US (1) | US7385040B2 (de) |
EP (1) | EP1718668B1 (de) |
JP (1) | JP4776615B2 (de) |
KR (1) | KR101149969B1 (de) |
CN (2) | CN1926146B (de) |
AT (1) | ATE440858T1 (de) |
AU (1) | AU2005217348B2 (de) |
CA (1) | CA2552823C (de) |
DE (1) | DE602005016220D1 (de) |
IL (1) | IL176635A (de) |
NZ (1) | NZ548127A (de) |
SE (1) | SE0400501D0 (de) |
WO (1) | WO2005082926A1 (de) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20160279239A1 (en) | 2011-05-02 | 2016-09-29 | Immunomedics, Inc. | Subcutaneous administration of anti-cd74 antibody for systemic lupus erythematosus and autoimmune disease |
US20160355591A1 (en) | 2011-05-02 | 2016-12-08 | Immunomedics, Inc. | Subcutaneous anti-hla-dr monoclonal antibody for treatment of hematologic malignancies |
US7589183B2 (en) * | 2006-11-28 | 2009-09-15 | Bio-Rad Laboratories, Inc. | Prevention of leaching of ligands from affinity-based purification systems |
US7999085B2 (en) * | 2007-01-09 | 2011-08-16 | Bio-Rad Laboratories, Inc. | Enhanced capacity and purification of protein by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers |
US7691980B2 (en) | 2007-01-09 | 2010-04-06 | Bio-Rad Laboratories, Inc. | Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers |
US8092683B2 (en) * | 2007-01-10 | 2012-01-10 | Ge Healthcare Bio-Sciences Ab | Multi-modal ion exchange chromatography resins |
ES2616982T3 (es) | 2007-03-28 | 2017-06-15 | Patheon Holdings I B.V. | Columna de lecho expandido y cromatografía desechable |
US9493548B2 (en) * | 2007-06-01 | 2016-11-15 | Hoffmann-La Roche Inc. | Immunoglobulin purification |
US9433922B2 (en) * | 2007-08-14 | 2016-09-06 | Emd Millipore Corporation | Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same |
EP2027875A1 (de) * | 2007-08-23 | 2009-02-25 | Octapharma AG | Verfahren zur Isolierung und Reinigung eines prionenproteinfreien Target-Proteins |
EP2719705B1 (de) | 2007-10-26 | 2020-07-29 | Asahi Kasei Kabushiki Kaisha | Verfahren zur aufreinigung von proteinen |
US8158405B2 (en) * | 2008-06-30 | 2012-04-17 | General Electric Company | Process for concentrating and processing fluid samples |
US8546127B2 (en) * | 2008-06-30 | 2013-10-01 | General Electric Company | Bacteria/RNA extraction device |
US8753868B2 (en) | 2008-08-04 | 2014-06-17 | General Electric Company | Method and system for selective isolation of target biological molecules in a general purpose system |
US20100051554A1 (en) * | 2008-08-28 | 2010-03-04 | Dong June Ahn | Molecular basket coated micro particles |
EP2360183B1 (de) * | 2008-12-19 | 2016-07-27 | Takeda Pharmaceutical Company Limited | Antikörperreinigungsverfahren mittels "mixed-mode" chromatography unter verwendung einer arginine-haltigen beladungslösung |
CN101797493B (zh) * | 2009-02-06 | 2014-05-21 | 上海抗体药物国家工程研究中心有限公司 | 一种在反应釜中制备亲和层析介质的方法 |
DE102009057993A1 (de) | 2009-06-13 | 2011-01-20 | Sartorius Stedim Biotech Gmbh | Polysaccharidmatrix mit aufgepfropftem Polymer, Verfahren zu ihrer Herstellung und Verwendung |
JPWO2011001963A1 (ja) * | 2009-07-03 | 2012-12-13 | 旭化成ケミカルズ株式会社 | 多孔質基材に固定されたグラフト鎖に結合しているアミノ基及びアルキル基を有する多孔膜を用いた抗体の精製方法 |
WO2011049798A1 (en) * | 2009-10-20 | 2011-04-28 | Merck Sharp & Dohme Corp. | Use of mixed mode chromatography for the capture and purification of basic antibody products |
US8277649B2 (en) * | 2009-12-14 | 2012-10-02 | General Electric Company | Membranes and associated methods for purification of antibodies |
US20130178608A1 (en) * | 2009-12-29 | 2013-07-11 | Samir Kulkarni | Protein purification by ion exchange |
KR101152036B1 (ko) | 2010-04-27 | 2012-06-08 | (주)셀트리온 | 컬럼 순환 및 시료 연속주입법을 이용한 단백질 a 크로마토그래피 정제 방법 |
KR101871683B1 (ko) | 2010-07-30 | 2018-06-27 | 이엠디 밀리포어 코포레이션 | 크로마토그래피 매질 및 방법 |
JP6024025B2 (ja) | 2011-05-02 | 2016-11-09 | イミューノメディクス、インコーポレイテッドImmunomedics, Inc. | 少容量投与用のアロタイプ選択抗体の限外濾過濃縮 |
US9783570B2 (en) | 2011-07-01 | 2017-10-10 | Hoffmann-La Roche Inc. | Method for separation of monomeric polypeptides from aggregated polypeptides |
CN103906762A (zh) * | 2011-10-26 | 2014-07-02 | 生物辐射实验室股份有限公司 | 在混合式层析中去除杀病毒剂 |
GB201202762D0 (en) | 2012-02-17 | 2012-04-04 | Autology Health Ltd | High efficiency cell capture |
CN103506079B (zh) * | 2012-06-19 | 2016-04-06 | 汪志友 | 一种用于分离纯化抗体的介质及其制备方法 |
US9890191B2 (en) | 2012-09-03 | 2018-02-13 | Kaneka Corporation | Mixed-mode antibody affinity separation matrix and purification method using the same, and the target molecules |
RU2015114330A (ru) | 2012-09-17 | 2016-11-10 | У.Р. Грейс Энд Ко.-Конн. | Хроматографические среды и устройства |
CN104797332B (zh) | 2012-11-13 | 2018-05-29 | 通用电气医疗集团生物工艺研发股份公司 | 多元阴离子交换基质 |
JP6639236B2 (ja) | 2013-02-26 | 2020-02-05 | ナトリックス セパレイションズ インコーポレーテッド | 混合モードクロマトグラフィー膜 |
TWI596107B (zh) | 2013-06-25 | 2017-08-21 | 卡地拉保健有限公司 | 單株抗體之新穎純化方法 |
WO2015041218A1 (ja) * | 2013-09-17 | 2015-03-26 | 株式会社カネカ | 新規抗体精製方法及びそれから得られる抗体(Novel Antibody Purification Method and Antibody obtained therefrom)、並びに陽イオン交換基を用いた新規抗体精製法及びそれから得られる抗体(Novel Antibody Purification method using Cation Exchanger and Antibody obtained therefrom) |
CN105793301A (zh) * | 2013-11-17 | 2016-07-20 | 纽波庭塔克有限公司 | 制备层析材料的方法 |
WO2015109068A1 (en) | 2014-01-16 | 2015-07-23 | W. R. Grace & Co.-Conn. | Affinity chromatography media and chromatography devices |
PL3137209T3 (pl) | 2014-05-02 | 2023-01-02 | W.R. Grace & Co. - Conn. | Funkcjonalizowany materiał nośnikowy i sposoby wytwarzania oraz stosowania funkcjonalizowanego materiału nośnikowego |
DE102014010353A1 (de) | 2014-07-10 | 2016-01-14 | Sartorius Stedim Biotech Gmbh | Vorrichtung, Verwendung dieser Vorrichtung und Verfahren für die Stofftrennung mit verbesserter Ausnutzung der Kapazität chromatographischer Medien |
WO2016013609A1 (ja) | 2014-07-25 | 2016-01-28 | 旭化成メディカル株式会社 | 陽イオン交換クロマトグラフィー担体及びその使用方法 |
PL3215528T3 (pl) | 2014-11-06 | 2020-01-31 | F.Hoffmann-La Roche Ag | Warianty regionu Fc ze zmodyfikowanym wiązaniem FcRn i sposoby stosowania |
KR102162753B1 (ko) | 2014-12-08 | 2020-10-07 | 이엠디 밀리포어 코포레이션 | 혼합층 이온 교환 흡착제 |
SG10201911134QA (en) | 2015-06-05 | 2020-01-30 | Grace W R & Co | Adsorbent bioprocessing clarification agents and methods of making and using the same |
JP2019070528A (ja) * | 2016-02-26 | 2019-05-09 | Jsr株式会社 | 多孔質担体、アフィニティクロマトグラフィー用多孔質担体、標的物の精製方法、及び抗体 |
US11135581B2 (en) | 2016-04-29 | 2021-10-05 | Creoptix Sa | Methods and assemblies for molecule recovery |
JP2019529350A (ja) | 2016-08-16 | 2019-10-17 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | 混合物から個々の抗体を定量する方法 |
HUE059631T2 (hu) | 2016-10-25 | 2022-12-28 | Regeneron Pharma | Eljárások és összeállítások kromatográfiás adatelemzéshez |
WO2018187074A1 (en) | 2017-04-03 | 2018-10-11 | Immunomedics, Inc. | Subcutaneous administration of antibody-drug conjugates for cancer therapy |
EP3762120A4 (de) * | 2018-03-08 | 2021-09-01 | Bio-Rad Laboratories, Inc. | Anionisches harz für hydrophobe mischmodus-austausch-chromatografie |
CN111902720A (zh) | 2018-03-21 | 2020-11-06 | 沃特世科技公司 | 基于非抗体高亲和力的样品制备、吸附剂、装置和方法 |
WO2020004583A1 (ja) * | 2018-06-29 | 2020-01-02 | 三菱ケミカル株式会社 | ポリペプチドの分離方法、ポリペプチドの製造方法及びポリペプチドの精製装置 |
TW202005694A (zh) | 2018-07-02 | 2020-02-01 | 美商里珍納龍藥品有限公司 | 自混合物製備多肽之系統及方法 |
US11896969B2 (en) | 2019-09-05 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Anionic exchange-hydrophobic mixed mode chromatography resins |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE462046C (sv) | 1982-08-23 | 1998-04-27 | Pharmacia Biotech Ab | Hybrid-DNA-vektor innehållande DNA-sekvens från Staphylococcus aureus, förfarande för dess framställning och bakterie innehållande densamma |
US5151350A (en) | 1982-10-27 | 1992-09-29 | Repligen Corporation | Cloned genes encoding recombinant protein a |
US4983722A (en) | 1988-06-08 | 1991-01-08 | Miles Inc. | Removal of protein A from antibody preparations |
US5429746A (en) | 1994-02-22 | 1995-07-04 | Smith Kline Beecham Corporation | Antibody purification |
US6117996A (en) * | 1995-09-20 | 2000-09-12 | Novo Nordisk A/S | Triazine based ligands and use thereof |
GB9519197D0 (en) * | 1995-09-20 | 1995-11-22 | Affinity Chromatography Ltd | Novel affinity ligands and their use |
EP0921855B1 (de) * | 1996-08-30 | 2003-11-19 | Upfront Chromatography A/S | Isolierung von immunglobulinen |
SE0002688D0 (sv) * | 2000-07-17 | 2000-07-17 | Amersham Pharm Biotech Ab | Adsorption method and ligands |
JP2004532182A (ja) * | 2000-12-31 | 2004-10-21 | アメルシャム・バイオサイエンシーズ・アクチボラグ | 低濃度の塩を含有する組成物の製造方法 |
JP2004517310A (ja) * | 2001-01-05 | 2004-06-10 | プロ・ケム インク | 精製器具及び方法 |
SE0103084D0 (sv) | 2001-09-14 | 2001-09-14 | Amersham Pharm Biotech Ab | Generation of ion exchange media |
DE10155984A1 (de) | 2001-11-15 | 2003-05-28 | Boehringer Ingelheim Pharma | Verfahren zur Reduktion des Liganden-leakage von Affinitätschromatographie-Matrices |
EP2048154B2 (de) | 2002-02-05 | 2015-06-03 | Genentech, Inc. | Proteinreinigung |
DK1601697T3 (da) | 2003-02-28 | 2007-10-01 | Lonza Biologics Plc | Oprensning af antistof ved protein A- og ionbytningskromatografi |
-
2004
- 2004-02-27 SE SE0400501A patent/SE0400501D0/xx unknown
-
2005
- 2005-02-24 US US10/589,718 patent/US7385040B2/en active Active
- 2005-02-24 DE DE602005016220T patent/DE602005016220D1/de active Active
- 2005-02-24 AU AU2005217348A patent/AU2005217348B2/en active Active
- 2005-02-24 AT AT05722174T patent/ATE440858T1/de not_active IP Right Cessation
- 2005-02-24 EP EP05722174A patent/EP1718668B1/de active Active
- 2005-02-24 CA CA2552823A patent/CA2552823C/en active Active
- 2005-02-24 NZ NZ548127A patent/NZ548127A/en not_active IP Right Cessation
- 2005-02-24 CN CN2005800062670A patent/CN1926146B/zh active Active
- 2005-02-24 JP JP2007500724A patent/JP4776615B2/ja active Active
- 2005-02-24 WO PCT/SE2005/000292 patent/WO2005082926A1/en active Application Filing
- 2005-02-24 KR KR1020067017115A patent/KR101149969B1/ko active IP Right Grant
- 2005-02-25 CN CN200580006276XA patent/CN1925898B/zh active Active
-
2006
- 2006-06-29 IL IL176635A patent/IL176635A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US7385040B2 (en) | 2008-06-10 |
KR101149969B1 (ko) | 2012-07-05 |
EP1718668A1 (de) | 2006-11-08 |
IL176635A0 (en) | 2006-10-31 |
US20070112178A1 (en) | 2007-05-17 |
JP2008505851A (ja) | 2008-02-28 |
ATE440858T1 (de) | 2009-09-15 |
CN1925898B (zh) | 2010-09-01 |
CN1926146A (zh) | 2007-03-07 |
CN1925898A (zh) | 2007-03-07 |
JP4776615B2 (ja) | 2011-09-21 |
CN1926146B (zh) | 2010-06-16 |
NZ548127A (en) | 2009-09-25 |
CA2552823C (en) | 2013-11-19 |
CA2552823A1 (en) | 2005-09-09 |
WO2005082926A1 (en) | 2005-09-09 |
KR20070001969A (ko) | 2007-01-04 |
AU2005217348A1 (en) | 2005-09-09 |
AU2005217348B2 (en) | 2011-03-31 |
IL176635A (en) | 2011-07-31 |
DE602005016220D1 (de) | 2009-10-08 |
EP1718668B1 (de) | 2009-08-26 |
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