SE0104334D0 - Therapeutic agents - Google Patents

Therapeutic agents

Info

Publication number
SE0104334D0
SE0104334D0 SE0104334A SE0104334A SE0104334D0 SE 0104334 D0 SE0104334 D0 SE 0104334D0 SE 0104334 A SE0104334 A SE 0104334A SE 0104334 A SE0104334 A SE 0104334A SE 0104334 D0 SE0104334 D0 SE 0104334D0
Authority
SE
Sweden
Prior art keywords
therapeutic agents
dyslipidemias
enantiomer
prodrugs
solvates
Prior art date
Application number
SE0104334A
Other languages
English (en)
Swedish (sv)
Inventor
Lanna Li
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Priority to SE0104334A priority Critical patent/SE0104334D0/xx
Publication of SE0104334D0 publication Critical patent/SE0104334D0/xx
Priority to EP02788145A priority patent/EP1458672B1/en
Priority to NZ533274A priority patent/NZ533274A/en
Priority to US10/499,378 priority patent/US7256307B2/en
Priority to PL02370673A priority patent/PL370673A1/xx
Priority to CA002469302A priority patent/CA2469302A1/en
Priority to MXPA04006004A priority patent/MXPA04006004A/es
Priority to HU0402133A priority patent/HUP0402133A3/hu
Priority to KR10-2004-7009517A priority patent/KR20040074094A/ko
Priority to PCT/GB2002/005738 priority patent/WO2003051821A1/en
Priority to MXPA04006003A priority patent/MXPA04006003A/es
Priority to SI200230424T priority patent/SI1458673T1/sl
Priority to ES02804964T priority patent/ES2271381T3/es
Priority to ES02788145T priority patent/ES2286310T3/es
Priority to AU2002352427A priority patent/AU2002352427A1/en
Priority to HU0402022A priority patent/HUP0402022A3/hu
Priority to IL16233102A priority patent/IL162331A0/xx
Priority to DE60220441T priority patent/DE60220441T2/de
Priority to KR10-2004-7009501A priority patent/KR20040074092A/ko
Priority to AU2002366315A priority patent/AU2002366315A1/en
Priority to UA20040604246A priority patent/UA77460C2/uk
Priority to PCT/GB2002/005744 priority patent/WO2003051822A1/en
Priority to AT02788145T priority patent/ATE363466T1/de
Priority to JP2003552710A priority patent/JP3820249B2/ja
Priority to BR0214988-5A priority patent/BR0214988A/pt
Priority to EP02804964A priority patent/EP1458673B1/en
Priority to BR0214986-9A priority patent/BR0214986A/pt
Priority to DE60214594T priority patent/DE60214594T2/de
Priority to CNB2006100071731A priority patent/CN100406427C/zh
Priority to UA20040604245A priority patent/UA77987C2/uk
Priority to MYPI20024740A priority patent/MY132565A/en
Priority to CA002470491A priority patent/CA2470491A1/en
Priority to PT02804964T priority patent/PT1458673E/pt
Priority to RU2004116918/04A priority patent/RU2300517C2/ru
Priority to DK02788145T priority patent/DK1458672T3/da
Priority to PT02788145T priority patent/PT1458672E/pt
Priority to SI200230570T priority patent/SI1458672T1/sl
Priority to PL02370672A priority patent/PL370672A1/xx
Priority to RU2004116917/04A priority patent/RU2303031C2/ru
Priority to IL16233002A priority patent/IL162330A0/xx
Priority to CNA028281551A priority patent/CN1620423A/zh
Priority to CNB028281233A priority patent/CN1293044C/zh
Priority to AT02804964T priority patent/ATE338743T1/de
Priority to TW091136518A priority patent/TWI253444B/zh
Priority to US10/499,261 priority patent/US7514471B2/en
Priority to HK05101304.4A priority patent/HK1068870B/en
Priority to JP2003552709A priority patent/JP3784804B2/ja
Priority to HK05100831.8A priority patent/HK1068604B/en
Priority to TW091136519A priority patent/TWI255807B/zh
Priority to NZ533276A priority patent/NZ533276A/en
Priority to DK02804964T priority patent/DK1458673T3/da
Priority to ARP020105002A priority patent/AR038045A1/es
Priority to ARP020105004A priority patent/AR038047A1/es
Priority to IL162330A priority patent/IL162330A/en
Priority to ZA200404658A priority patent/ZA200404658B/en
Priority to ZA200404657A priority patent/ZA200404657B/en
Priority to IS7309A priority patent/IS7309A/is
Priority to IS7313A priority patent/IS7313A/is
Priority to NO20043023A priority patent/NO20043023L/no
Priority to NO20043164A priority patent/NO20043164L/no
Priority to US11/026,806 priority patent/US7488844B2/en
Priority to JP2005235794A priority patent/JP2005336209A/ja
Priority to JP2006123399A priority patent/JP2006298924A/ja
Priority to CY20061101743T priority patent/CY1106276T1/el
Priority to CY20071101028T priority patent/CY1106784T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
    • C07C235/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SE0104334A 2001-12-19 2001-12-19 Therapeutic agents SE0104334D0 (sv)

Priority Applications (65)

Application Number Priority Date Filing Date Title
SE0104334A SE0104334D0 (sv) 2001-12-19 2001-12-19 Therapeutic agents
EP02788145A EP1458672B1 (en) 2001-12-19 2002-12-18 Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor alpha(ppar)
NZ533274A NZ533274A (en) 2001-12-19 2002-12-18 Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor alpha (PPAR)
US10/499,378 US7256307B2 (en) 2001-12-19 2002-12-18 Substituted phenypropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor α(PPAR)
PL02370673A PL370673A1 (en) 2001-12-19 2002-12-18 Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor alpha (ppar)
CA002469302A CA2469302A1 (en) 2001-12-19 2002-12-18 Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor alpha (ppar)
MXPA04006004A MXPA04006004A (es) 2001-12-19 2002-12-18 Derivados del acido fenilpropionico substituidos como agonistas al receptor alfa activado-proliferativo de peroxisoma (ppar) humano.
HU0402133A HUP0402133A3 (en) 2001-12-19 2002-12-18 Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor alpha (ppar), process for their preparation and pharmaceutical compositions containing them
KR10-2004-7009517A KR20040074094A (ko) 2001-12-19 2002-12-18 인간 과산화소체 증식인자 활성화 수용체알파(ｐｐａｒ)에 대한 작용제로서의 치환된페닐프로피온산 유도체
PCT/GB2002/005738 WO2003051821A1 (en) 2001-12-19 2002-12-18 Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor alpha (ppar)
MXPA04006003A MXPA04006003A (es) 2001-12-19 2002-12-18 Derivados del acido fenilpropionico substituidos como agonistas al receptor alfa activado-proliferativo de peroxisoma (ppar) humano.
SI200230424T SI1458673T1 (sl) 2001-12-19 2002-12-18 Substituirani derivati fenilpropionske kisline kot agonisti za humani peroksizomsko proliferatorsko aktivirani receptor ALFA (PPAR)
ES02804964T ES2271381T3 (es) 2001-12-19 2002-12-18 Derivados de acido fenilpropionico sustituido como agonistas del receptor alfa activado por proliferador de peroxisoma (ppar) humano.
ES02788145T ES2286310T3 (es) 2001-12-19 2002-12-18 Derivados del acido fenilpropionico sustituido como agonistas del receptor alfa activado por proliferador de peroxisoma (ppar) humano.
AU2002352427A AU2002352427A1 (en) 2001-12-19 2002-12-18 Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor alpha (ppar)
HU0402022A HUP0402022A3 (en) 2001-12-19 2002-12-18 Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor alpha (ppar) and pharmaceutical compositions containing them
IL16233102A IL162331A0 (en) 2001-12-19 2002-12-18 Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor alpha (ppar)
DE60220441T DE60220441T2 (de) 2001-12-19 2002-12-18 Substituierte phenylpropionsäurederivate als agonisten des menschlichen peroxisom-proliferator-aktiverten rezeptors alpha(ppar)
KR10-2004-7009501A KR20040074092A (ko) 2001-12-19 2002-12-18 인간 과산화소체 증식인자 활성화 수용체알파(ｐｐａｒ)에 대한 작용제로서의 치환된페닐프로피온산 유도체
AU2002366315A AU2002366315A1 (en) 2001-12-19 2002-12-18 Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator activated receptor alpha (PPAR)
UA20040604246A UA77460C2 (en) 2001-12-19 2002-12-18 Substituted derivatives of phenylpropionic acid as agonists of alpha-receptor activated by peroxysome proliferator, method of preparation, pharmaceutical composition, intermediate (variants)
PCT/GB2002/005744 WO2003051822A1 (en) 2001-12-19 2002-12-18 Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor alpha (ppar)
AT02788145T ATE363466T1 (de) 2001-12-19 2002-12-18 Substituierte phenylpropionsäurederivate als agonisten des menschlichen peroxisom-proliferator-aktiverten rezeptors alpha(ppar)
JP2003552710A JP3820249B2 (ja) 2001-12-19 2002-12-18 ヒトペルオキソーム増殖因子活性化受容体α（ＰＰＡＲ）のアゴニストである置換フェニルプロピオン酸誘導体
BR0214988-5A BR0214988A (pt) 2001-12-19 2002-12-18 S-enanciÈmero de um composto, composto, formulação farmacêutica, método de tratamento ou prevenção de distúrbios de lipìdeo, uso de um composto, método de tratamento ou prevenção de diabetes tipo 2, processo para a preparação de um composto, e, composição farmacêutica
EP02804964A EP1458673B1 (en) 2001-12-19 2002-12-18 Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor alpha (ppar)
BR0214986-9A BR0214986A (pt) 2001-12-19 2002-12-18 S-enanciÈmero de um composto, composto, formulação farmacêutica, método de tratamento ou prevenção de distúrbios de lipìdeo, uso de um composto, método de tratamento ou prevenção de diabetes tipo 2, processo para a preparação de um composto, e, composição farmacêutica
DE60214594T DE60214594T2 (de) 2001-12-19 2002-12-18 Substituierte phenylpropionsäurederivate als agonisten für den humanen peroxisomproliferatoraktivierten rezeptor alpha (ppar)
CNB2006100071731A CN100406427C (zh) 2001-12-19 2002-12-18 作为人过氧化物酶体增殖物激活受体α(PPAR)激动剂的取代苯基丙酸衍生物
UA20040604245A UA77987C2 (en) 2001-12-19 2002-12-18 Substituted derivatives of phenylpropionic acid as agonists of peroxisome proliferators activated alpha receptor, method for synthesis, pharmaceutical composition, intermediate (variants)
MYPI20024740A MY132565A (en) 2001-12-19 2002-12-18 Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor alpha (ppar)
CA002470491A CA2470491A1 (en) 2001-12-19 2002-12-18 Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor alpha (ppar)
PT02804964T PT1458673E (pt) 2001-12-19 2002-12-18 Derivados substituídos do ácido fenilpropiónico como agonistas do receptor alfa activado por proliferador de peroxissoma (ppar) humano
RU2004116918/04A RU2300517C2 (ru) 2001-12-19 2002-12-18 ПРОИЗВОДНЫЕ ЗАМЕЩЕННОЙ ФЕНИЛПРОПИОНОВОЙ КИСЛОТЫ КАК АГОНИСТЫ АКТИВИРУЕМОГО ПРОЛИФЕРАТОРОМ ПЕРОКСИСОМ АЛЬФА-РЕЦЕПТОРА ЧЕЛОВЕКА (PPARα), СПОСОБ И ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ ДЛЯ ИХ ПОЛУЧЕНИЯ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ИХ ОСНОВЕ, ИХ ПРИМЕНЕНИЕ И СПОСОБЫ ЛЕЧЕНИЯ ДИСЛИПИДЕМИИ И ДИАБЕТА 2 ТИПА
DK02788145T DK1458672T3 (da) 2001-12-19 2002-12-18 Substituerede phenylpropionsyrederivater som antagonister af human peroxisomproliferatoraktiveret receptor alfa (PPAR)
PT02788145T PT1458672E (pt) 2001-12-19 2002-12-18 Derivados do ácido fenilpropiónico substituído como agonistas para o receptor alfa activado por proliferador de perixissoma humano ( ppar )
SI200230570T SI1458672T1 (sl) 2001-12-19 2002-12-18 Substituirani derivati fenilpropionske kisline kot agonisti humanega alfa-receptorja, aktivnega s peroksisomskim proliferatorjem (PPAR)
PL02370672A PL370672A1 (en) 2001-12-19 2002-12-18 Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor alpha (ppar)
RU2004116917/04A RU2303031C2 (ru) 2001-12-19 2002-12-18 ПРОИЗВОДНЫЕ ЗАМЕЩЕННОЙ ФЕНИЛПРОПИОНОВОЙ КИСЛОТЫ КАК АГОНИСТЫ АКТИВИРУЕМОГО ПРОЛИФЕРАТОРОМ ПЕРОКСИСОМ АЛЬФА- РЕЦЕПТОРА ЧЕЛОВЕКА (PRARα) СПОСОБ И ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ ДЛЯ ИХ ПОЛУЧЕНИЯ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ИХ ОСНОВЕ, ИХ ПРИМЕНЕНИЕ И СПОСОБЫ ЛЕЧЕНИЯ ДИСЛИПИДЕМИИ ДИАБЕТА 2 ТИПА
IL16233002A IL162330A0 (en) 2001-12-19 2002-12-18 Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor alpha (ppar)
CNA028281551A CN1620423A (zh) 2001-12-19 2002-12-18 作为人过氧化物酶体增殖物激活受体α(PPAR)激动剂的取代苯基丙酸衍生物
CNB028281233A CN1293044C (zh) 2001-12-19 2002-12-18 作为人过氧化物酶体增殖物激活受体α(PPAR)激动剂的取代苯基丙酸衍生物
AT02804964T ATE338743T1 (de) 2001-12-19 2002-12-18 Substituierte phenylpropionsäurederivate als agonisten für den humanen peroxisomproliferatoraktivierten rezeptor alpha (ppar)
TW091136518A TWI253444B (en) 2001-12-19 2002-12-18 Therapeutic agents
US10/499,261 US7514471B2 (en) 2001-12-19 2002-12-18 Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor α (PPAR)
HK05101304.4A HK1068870B (en) 2001-12-19 2002-12-18 Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor alpha (ppar)
JP2003552709A JP3784804B2 (ja) 2001-12-19 2002-12-18 ヒトのペルオキシソーム増殖因子活性化受容体α（ＰＰＡＲ）に対するアゴニストとしての置換フェニルプロピオン酸誘導体
HK05100831.8A HK1068604B (en) 2001-12-19 2002-12-18 Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor alpha (ppar)
TW091136519A TWI255807B (en) 2001-12-19 2002-12-18 Therapeutic agents
NZ533276A NZ533276A (en) 2001-12-19 2002-12-18 Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor alpha (PPAR)
DK02804964T DK1458673T3 (da) 2001-12-19 2002-12-18 Substituerede phenylpropionsyrederivater som agonister for human peroxisomproliferatoraktiveret receptor alfa (PRAR)
ARP020105002A AR038045A1 (es) 2001-12-19 2002-12-19 Agentes terapeuticos
ARP020105004A AR038047A1 (es) 2001-12-19 2002-12-19 Agentes terapeuticos
IL162330A IL162330A (en) 2001-12-19 2004-06-03 Substituted phenylpropionic acid derivatives, process for their preparation, pharmaceutical compositions containing them and use thereof in the manufacture of medicaments for the treatment of lipid disorders (dyslipidemias), whether or not associated with insulin resistance
ZA200404658A ZA200404658B (en) 2001-12-19 2004-06-11 Substituted phenylpropionic acid derivatives as aginist to human peroxisome proliferator-activated receptor alpha (PPAR).
ZA200404657A ZA200404657B (en) 2001-12-19 2004-06-11 Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor alpha (PPAR).
IS7309A IS7309A (is) 2001-12-19 2004-06-14 Útskiptar fenýlprópíónsýruafleiður sem gerandefnioxunarkorns fjölgunarvirkjaðs alfaviðtaka í manni(ppar)
IS7313A IS7313A (is) 2001-12-19 2004-06-15 Útskiptar fenýlprópíónsýruafleiður sem gerandefnioxunarkorns fjölgunarvirkjaðs alfaviðtaka í manni(ppar)
NO20043023A NO20043023L (no) 2001-12-19 2004-07-15 Substituerte fenylpropionsyre-derivater som agonister mot human proliferator-aktivert reseptor alfa (PPAR)
NO20043164A NO20043164L (no) 2001-12-19 2004-07-16 Substituerte fenylpropionsyre-derivater som agonister mot human peroksisom-proliferator-aktivert reseptor alfa (PPAR)
US11/026,806 US7488844B2 (en) 2001-12-19 2004-12-30 Therapeutic agents
JP2005235794A JP2005336209A (ja) 2001-12-19 2005-08-16 ヒトのペルオキシソーム増殖因子活性化受容体α（ＰＰＡＲ）に対するアゴニストとしての置換フェニルプロピオン酸誘導体
JP2006123399A JP2006298924A (ja) 2001-12-19 2006-04-27 置換フェニルプロピオン酸誘導体を含む医薬組成物
CY20061101743T CY1106276T1 (el) 2001-12-19 2006-12-05 Παραγωγα υποκατεστημενου φαινυλπροπιονικου οξεος ως ανταγωνιστες σε υποδοχεις αλφα που ενepγοποιουνται απο παραγοντες που επαγουν τον πολλαπλασιασμο των ανθρωπινων υπepοξεισωματων (ppar)
CY20071101028T CY1106784T1 (el) 2001-12-19 2007-08-01 Υποκατεστημενα παραγωγα φαινυλ προπιονικου οξεος ως συναγωνιστες του ανθρωπινου υπεροξυσωματικου πολλαπλασιαστη - ενεργοποιημενου υποδοχεα αλφα (ppar)

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CN100406427C (zh) 2008-07-30
PT1458673E (pt) 2006-12-29
PL370672A1 (en) 2005-05-30
UA77987C2 (en) 2007-02-15
BR0214986A (pt) 2004-12-14
AR038047A1 (es) 2004-12-22
HUP0402133A2 (hu) 2005-02-28
KR20040074092A (ko) 2004-08-21
AR038045A1 (es) 2004-12-22
EP1458673B1 (en) 2006-09-06
CY1106276T1 (el) 2011-10-12
TW200410918A (en) 2004-07-01
AU2002352427A1 (en) 2003-06-30
DE60214594D1 (de) 2006-10-19
RU2300517C2 (ru) 2007-06-10
TWI253444B (en) 2006-04-21
CN1293044C (zh) 2007-01-03
DK1458673T3 (da) 2006-12-11
IL162330A0 (en) 2005-11-20
PT1458672E (pt) 2007-07-18
EP1458673A1 (en) 2004-09-22
RU2303031C2 (ru) 2007-07-20
EP1458672A1 (en) 2004-09-22
MXPA04006003A (es) 2004-09-27
JP2005526011A (ja) 2005-09-02
TW200410925A (en) 2004-07-01
RU2004116918A (ru) 2005-11-10
CA2470491A1 (en) 2003-06-26
WO2003051822A1 (en) 2003-06-26
US20050113362A1 (en) 2005-05-26
JP2005336209A (ja) 2005-12-08
SI1458673T1 (sl) 2007-02-28
ATE338743T1 (de) 2006-09-15
UA77460C2 (en) 2006-12-15
PL370673A1 (en) 2005-05-30
HK1068870A1 (en) 2005-05-06
DE60220441D1 (de) 2007-07-12
HK1068604A1 (en) 2005-04-29
KR20040074094A (ko) 2004-08-21
JP3820249B2 (ja) 2006-09-13
IL162331A0 (en) 2005-11-20
IL162330A (en) 2009-06-15
DE60220441T2 (de) 2008-01-24
ES2286310T3 (es) 2007-12-01
HUP0402133A3 (en) 2010-07-28
CN1896045A (zh) 2007-01-17
BR0214988A (pt) 2004-12-14
CA2469302A1 (en) 2003-06-26
MY132565A (en) 2007-10-31
AU2002366315A1 (en) 2003-06-30
CN1620422A (zh) 2005-05-25
NZ533274A (en) 2005-12-23
JP3784804B2 (ja) 2006-06-14
NZ533276A (en) 2006-04-28
US20050171204A1 (en) 2005-08-04
CY1106784T1 (el) 2012-05-23
EP1458672B1 (en) 2007-05-30
WO2003051821A1 (en) 2003-06-26
ES2271381T3 (es) 2007-04-16
IS7313A (is) 2004-06-15
DE60214594T2 (de) 2007-09-13
DK1458672T3 (da) 2007-09-17

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