DK1458673T3 - Substituerede phenylpropionsyrederivater som agonister for human peroxisomproliferatoraktiveret receptor alfa (PRAR) - Google Patents
Substituerede phenylpropionsyrederivater som agonister for human peroxisomproliferatoraktiveret receptor alfa (PRAR)Info
- Publication number
- DK1458673T3 DK1458673T3 DK02804964T DK02804964T DK1458673T3 DK 1458673 T3 DK1458673 T3 DK 1458673T3 DK 02804964 T DK02804964 T DK 02804964T DK 02804964 T DK02804964 T DK 02804964T DK 1458673 T3 DK1458673 T3 DK 1458673T3
- Authority
- DK
- Denmark
- Prior art keywords
- prar
- agonists
- acid derivatives
- activated receptor
- receptor alpha
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
- C07C235/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Reproductive Health (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Pregnancy & Childbirth (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Gynecology & Obstetrics (AREA)
- Psychology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0104334A SE0104334D0 (sv) | 2001-12-19 | 2001-12-19 | Therapeutic agents |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1458673T3 true DK1458673T3 (da) | 2006-12-11 |
Family
ID=20286433
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK02804964T DK1458673T3 (da) | 2001-12-19 | 2002-12-18 | Substituerede phenylpropionsyrederivater som agonister for human peroxisomproliferatoraktiveret receptor alfa (PRAR) |
DK02788145T DK1458672T3 (da) | 2001-12-19 | 2002-12-18 | Substituerede phenylpropionsyrederivater som antagonister af human peroxisomproliferatoraktiveret receptor alfa (PPAR) |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK02788145T DK1458672T3 (da) | 2001-12-19 | 2002-12-18 | Substituerede phenylpropionsyrederivater som antagonister af human peroxisomproliferatoraktiveret receptor alfa (PPAR) |
Country Status (31)
Country | Link |
---|---|
US (2) | US7514471B2 (da) |
EP (2) | EP1458672B1 (da) |
JP (4) | JP3820249B2 (da) |
KR (2) | KR20040074092A (da) |
CN (3) | CN1620423A (da) |
AR (2) | AR038047A1 (da) |
AT (2) | ATE338743T1 (da) |
AU (2) | AU2002366315A1 (da) |
BR (2) | BR0214986A (da) |
CA (2) | CA2470491A1 (da) |
CY (2) | CY1106276T1 (da) |
DE (2) | DE60214594T2 (da) |
DK (2) | DK1458673T3 (da) |
ES (2) | ES2271381T3 (da) |
HK (2) | HK1068604A1 (da) |
HU (2) | HUP0402133A3 (da) |
IL (3) | IL162331A0 (da) |
IS (2) | IS7309A (da) |
MX (2) | MXPA04006004A (da) |
MY (1) | MY132565A (da) |
NO (2) | NO20043023L (da) |
NZ (2) | NZ533276A (da) |
PL (2) | PL370673A1 (da) |
PT (2) | PT1458672E (da) |
RU (2) | RU2303031C2 (da) |
SE (1) | SE0104334D0 (da) |
SI (2) | SI1458672T1 (da) |
TW (2) | TWI255807B (da) |
UA (2) | UA77987C2 (da) |
WO (2) | WO2003051822A1 (da) |
ZA (2) | ZA200404657B (da) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4834224B2 (ja) | 1999-03-05 | 2011-12-14 | デューク ユニバーシティ | C16不飽和fp−選択的プロスタグランジン類縁体 |
US20020013294A1 (en) | 2000-03-31 | 2002-01-31 | Delong Mitchell Anthony | Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives |
US20020172693A1 (en) | 2000-03-31 | 2002-11-21 | Delong Michell Anthony | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
GB0229931D0 (en) * | 2002-12-21 | 2003-01-29 | Astrazeneca Ab | Therapeutic agents |
GB0314079D0 (en) * | 2003-06-18 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
SE0104334D0 (sv) * | 2001-12-19 | 2001-12-19 | Astrazeneca Ab | Therapeutic agents |
SE0104333D0 (sv) | 2001-12-19 | 2001-12-19 | Astrazeneca Ab | Therapeutic agents |
GB0209467D0 (en) | 2002-04-25 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
EP1517882A1 (en) | 2002-06-19 | 2005-03-30 | Eli Lilly And Company | Amide linker peroxisome proliferator activated receptor modulators |
DE60319084T2 (de) | 2002-06-20 | 2009-01-29 | Astrazeneca Ab | Ortho-substituierte benzoesäurederivate zur behandlung von insulinresistenz |
FR2848452B1 (fr) * | 2002-12-12 | 2007-04-06 | Aventis Pharma Sa | Application des inhibiteurs de recapture intestinale des acides biliaires pour la prevention et le traitement de la maladie d'alzheimer |
ES2295816T3 (es) | 2003-01-14 | 2008-04-16 | Arena Pharmaceuticals, Inc. | Derivados arilo y heteroarilo 1,2,3-trisustituidos como moduladores del metabolismo, y profilaxis y tratamiento de transtornos relacionados con los mismos, tales como la diabetes y la hiperglucemia. |
GB0304194D0 (en) | 2003-02-25 | 2003-03-26 | Astrazeneca Ab | Chemical compounds |
GB0314134D0 (en) * | 2003-06-18 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
GB0314129D0 (en) * | 2003-06-18 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
GB0314136D0 (en) * | 2003-06-18 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
EP2287165A3 (en) | 2003-07-14 | 2011-06-22 | Arena Pharmaceuticals, Inc. | Fused-aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto |
WO2005053683A1 (en) * | 2003-11-26 | 2005-06-16 | Duke University | A method of preventing or treating glaucoma |
US7321056B2 (en) * | 2003-12-15 | 2008-01-22 | Eli Lilly And Company | Selective peroxisome proliferator activated receptor modulators |
EP1780210A4 (en) * | 2004-08-11 | 2009-06-10 | Kyorin Seiyaku Kk | NEW CYCLIC AMINOBENOIC ACID DERIVATIVE |
SE0403072D0 (sv) * | 2004-12-16 | 2004-12-16 | Astrazeneca Ab | Pharmaceutically useful salts of carboxylic acid derivates |
CA2610354C (en) | 2005-05-31 | 2011-03-29 | Pfizer Inc. | Substituted aryloxy-n-bicyclomethyl acetamide compounds as vr1 antagonists |
WO2007004957A1 (en) * | 2005-07-05 | 2007-01-11 | Astrazeneca Ab | Novel crystalline form |
AR055073A1 (es) * | 2005-07-11 | 2007-08-01 | Astrazeneca Ab | Agentes terapeuticos |
TWI331523B (en) * | 2005-12-08 | 2010-10-11 | Nat Health Research Institutes | Vinylsulfonate compounds |
CN101054372B (zh) * | 2006-04-11 | 2010-10-13 | 中国科学院上海药物研究所 | 嘧啶取代苯丙酸衍生化合物、其制法和在治疗多囊肾疾病中的用途 |
KR100847780B1 (ko) * | 2006-10-26 | 2008-07-23 | 재단법인서울대학교산학협력재단 | 2-에톡시프로피온산 유도체 또는 이의 약학적으로허용가능한 염, 이의 제조방법 및 이를 유효성분으로함유하는 당뇨병 예방 및 치료제 |
RU2361581C2 (ru) | 2007-09-14 | 2009-07-20 | Закрытое Акционерное Общество "Мастерклон" | Фармацевтическая композиция, обладающая противодиабетической, гиполипидемической, гипогликемической и гипохолестеринемической активностью, способ ее получения и способы лечения указанных заболеваний |
US20110293549A1 (en) | 2009-02-03 | 2011-12-01 | Athena Cosmetics, Inc. | Composition, method and kit for enhancing hair |
CN103539791B (zh) | 2010-09-22 | 2017-01-11 | 艾尼纳制药公司 | Gpr119 受体调节剂和对与其相关的障碍的治疗 |
AU2011326871B2 (en) | 2010-11-08 | 2015-02-12 | Albireo Ab | IBAT inhibitors for the treatment of liver diseases |
JO3301B1 (ar) * | 2013-04-26 | 2018-09-16 | Albireo Ab | تعديلات بلورية على إيلوبيكسيبات |
WO2015199147A1 (ja) | 2014-06-25 | 2015-12-30 | 味の素株式会社 | 固形製剤及びその着色防止又は着色低減方法 |
EP3012252A1 (en) | 2014-10-24 | 2016-04-27 | Ferring BV | Crystal modifications of elobixibat |
CN107405332A (zh) | 2015-01-06 | 2017-11-28 | 艾尼纳制药公司 | 治疗与s1p1受体有关的病症的方法 |
US10301262B2 (en) | 2015-06-22 | 2019-05-28 | Arena Pharmaceuticals, Inc. | Crystalline L-arginine salt of (R)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta [b]indol-3-yl)acetic acid(Compund1) for use in SIPI receptor-associated disorders |
US10786529B2 (en) | 2016-02-09 | 2020-09-29 | Albireo Ab | Oral cholestyramine formulation and use thereof |
US10441604B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Cholestyramine pellets and methods for preparation thereof |
US10441605B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Oral cholestyramine formulation and use thereof |
EP3582772A1 (en) | 2017-02-16 | 2019-12-25 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of primary biliary cholangitis |
CN111032019B (zh) | 2017-08-09 | 2022-07-05 | 阿尔比里奥公司 | 考来烯胺颗粒、口服考来烯胺制剂及其用途 |
US10793534B2 (en) | 2018-06-05 | 2020-10-06 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
CN112449637B (zh) | 2018-06-05 | 2024-03-19 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
US11801226B2 (en) | 2018-06-20 | 2023-10-31 | Albireo Ab | Pharmaceutical formulation of odevixibat |
MX2020013774A (es) | 2018-06-20 | 2021-03-02 | Albireo Ab | Modificaciones de cristales de odevixibat. |
US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
US11549878B2 (en) | 2018-08-09 | 2023-01-10 | Albireo Ab | In vitro method for determining the adsorbing capacity of an insoluble adsorbant |
US10722457B2 (en) | 2018-08-09 | 2020-07-28 | Albireo Ab | Oral cholestyramine formulation and use thereof |
US10941127B2 (en) | 2019-02-06 | 2021-03-09 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
US10975045B2 (en) | 2019-02-06 | 2021-04-13 | Aibireo AB | Benzothiazepine compounds and their use as bile acid modulators |
CA3158276A1 (en) | 2019-12-04 | 2021-06-10 | Per-Goran Gillberg | Benzothia(di)azepine compounds and their use as bile acid modulators |
US11014898B1 (en) | 2020-12-04 | 2021-05-25 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
BR112022010505A2 (pt) | 2019-12-04 | 2022-09-06 | Albireo Ab | Compostos de benzotia(di)azepina e seu uso como moduladores do ácido biliar |
EP4069247A1 (en) | 2019-12-04 | 2022-10-12 | Albireo AB | Benzothiadiazepine compounds and their use as bile acid modulators |
EP4069361B1 (en) | 2019-12-04 | 2024-01-03 | Albireo AB | Benzothia(di)azepine compounds and their use as bile acid modulators |
CN116157389A (zh) | 2020-08-03 | 2023-05-23 | 阿尔比里奥公司 | 苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 |
CA3196488A1 (en) | 2020-11-12 | 2022-05-19 | Albireo Ab | Odevixibat for treating progressive familial intrahepatic cholestasis (pfic) |
AU2021390172A1 (en) | 2020-12-04 | 2023-06-22 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
WO2023039276A1 (en) * | 2021-09-13 | 2023-03-16 | Curtails Llc | Use of ibat inhibitors and antimicrobials for the treatment of diseases |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE266121C (da) | ||||
BE489216A (da) | 1948-06-05 | 1900-01-01 | ||
US2928840A (en) * | 1958-11-26 | 1960-03-15 | Us Vitamin Pharm Corp | 3-(o-substituted phenyl) oxazolidinediones and process therefor |
GB1081471A (en) | 1963-09-13 | 1967-08-31 | Stauffer Chemical Co | Glycol amide derivatives and use thereof in controlling weed growth |
US3244398A (en) * | 1963-10-28 | 1966-04-05 | Scaramucci Domer | Composite seat ball valve |
AT307640B (de) | 1970-06-18 | 1973-05-25 | Richter Gedeon Vegyeszet | Verfahren zur Herstellung von neuen 17-Aza-steroiden und deren Salzen |
BE792364A (fr) | 1971-12-06 | 1973-06-06 | Basf Ag | Derives de substitution du sulfonylglycolanilide |
DE2349256C2 (de) | 1973-10-01 | 1985-08-01 | Basf Ag, 6700 Ludwigshafen | 0-Alkylsulfonyl-glykolsäureanilide und diese enthaltende Herbizide |
DE2828222A1 (de) | 1978-06-28 | 1980-01-10 | Bayer Ag | Gegenmittel zum schutz von kulturpflanzen vor schaedigungen durch herbizide |
US4735959A (en) * | 1981-01-10 | 1988-04-05 | Dr. Karl Thomae Gmbh | Carboxylic acid amides and pharmaceutical compositions containing them |
US5216167A (en) * | 1983-12-30 | 1993-06-01 | Dr. Karl Thomae Gmbh | Phenylacetic acid benzylamides |
US5312924A (en) * | 1983-12-30 | 1994-05-17 | Dr. Karl Thomae Gmbh | Phenylacetic acid benzylamides |
US5210208A (en) * | 1990-09-24 | 1993-05-11 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Disubstituted aryl compounds exhibiting selective leukotriene b4 antagonist activity |
US5958792A (en) | 1995-06-07 | 1999-09-28 | Chiron Corporation | Combinatorial libraries of substrate-bound cyclic organic compounds |
AU749132B2 (en) | 1997-08-28 | 2002-06-20 | Biovitrum Ab | Inhibitors of protein tyrosine phosphatase |
US6410585B1 (en) * | 1997-08-28 | 2002-06-25 | Scott D. Larsen | Inhibitors of protein tyrosine phosphatase |
US6576766B1 (en) | 1997-11-12 | 2003-06-10 | Ariad Pharmaceuticals, Inc. | Signal transduction inhibitors, compositions containing them |
SE9801992D0 (sv) * | 1998-06-04 | 1998-06-04 | Astra Ab | New 3-aryl-2-hydroxypropionic acid derivative I |
CZ20013593A3 (cs) | 1999-04-06 | 2002-03-13 | Sankyo Company, Limited | Alfa-Substituované deriváty karboxylových kyselin |
AU3670900A (en) * | 1999-04-08 | 2000-11-14 | Sankyo Company Limited | Substituted fused imidazole derivatives |
AU4139600A (en) | 1999-04-14 | 2000-11-14 | University Of British Columbia, The | 1,3-dipolar cycloadditions to polypyrrolic macrocycles |
WO2000063196A1 (en) | 1999-04-20 | 2000-10-26 | Novo Nordisk A/S | New compounds, their preparation and use |
CZ20013833A3 (cs) | 1999-04-28 | 2002-02-13 | Aventis Pharma Deutschland Gmbh | Deriváty kyselin se dvěma arylovými zbytky jako ligandy receptorů PPAR a farmaceutické prostředky, které je obsahují |
JP4618845B2 (ja) * | 1999-06-09 | 2011-01-26 | 杏林製薬株式会社 | ヒトペルオキシゾーム増殖薬活性化受容体(PPAR)αアゴニストとしての置換フェニルプロピオン酸誘導体 |
TWI262185B (en) * | 1999-10-01 | 2006-09-21 | Eisai Co Ltd | Carboxylic acid derivatives having anti-hyperglycemia and anti-hyperlipemia action, and pharmaceutical composition containing the derivatives |
JP2001261612A (ja) * | 2000-03-22 | 2001-09-26 | Mitsui Chemicals Inc | カテコールプロピオン酸誘導体およびそれを有効成分として含有する核内レセプター作動薬 |
WO2002044127A1 (fr) * | 2000-11-29 | 2002-06-06 | Kyorin Pharmaceutical Co., Ltd. | Dérivés d'acide carboxylique substitué |
AU2002222550A1 (en) | 2000-11-29 | 2002-06-11 | Kyorin Pharmaceutical Co. Ltd. | Substituted carboxylic acid derivatives |
BR0207285A (pt) | 2001-02-15 | 2004-02-10 | Pfizer Producs Inc | Agonistas de ppar |
WO2002083616A1 (fr) * | 2001-04-10 | 2002-10-24 | Sankyo Company, Limited | DERIVE D'ACIDE GRAS φomega;-ARYLE α-SUBSTITUE |
GB0229931D0 (en) | 2002-12-21 | 2003-01-29 | Astrazeneca Ab | Therapeutic agents |
GB0314079D0 (en) * | 2003-06-18 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
SE0104334D0 (sv) * | 2001-12-19 | 2001-12-19 | Astrazeneca Ab | Therapeutic agents |
EP1517882A1 (en) * | 2002-06-19 | 2005-03-30 | Eli Lilly And Company | Amide linker peroxisome proliferator activated receptor modulators |
GB0314136D0 (en) * | 2003-06-18 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
GB0314134D0 (en) * | 2003-06-18 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
GB0314129D0 (en) * | 2003-06-18 | 2003-07-23 | Astrazeneca Ab | Therapeutic agents |
-
2001
- 2001-12-19 SE SE0104334A patent/SE0104334D0/xx unknown
-
2002
- 2002-12-18 AT AT02804964T patent/ATE338743T1/de not_active IP Right Cessation
- 2002-12-18 PL PL02370673A patent/PL370673A1/xx not_active Application Discontinuation
- 2002-12-18 AT AT02788145T patent/ATE363466T1/de not_active IP Right Cessation
- 2002-12-18 MY MYPI20024740A patent/MY132565A/en unknown
- 2002-12-18 TW TW091136519A patent/TWI255807B/zh not_active IP Right Cessation
- 2002-12-18 BR BR0214986-9A patent/BR0214986A/pt not_active IP Right Cessation
- 2002-12-18 UA UA20040604245A patent/UA77987C2/uk unknown
- 2002-12-18 KR KR10-2004-7009501A patent/KR20040074092A/ko not_active Application Discontinuation
- 2002-12-18 CA CA002470491A patent/CA2470491A1/en not_active Abandoned
- 2002-12-18 UA UA20040604246A patent/UA77460C2/uk unknown
- 2002-12-18 PT PT02788145T patent/PT1458672E/pt unknown
- 2002-12-18 DK DK02804964T patent/DK1458673T3/da active
- 2002-12-18 ES ES02804964T patent/ES2271381T3/es not_active Expired - Lifetime
- 2002-12-18 SI SI200230570T patent/SI1458672T1/sl unknown
- 2002-12-18 RU RU2004116917/04A patent/RU2303031C2/ru not_active IP Right Cessation
- 2002-12-18 IL IL16233102A patent/IL162331A0/xx unknown
- 2002-12-18 SI SI200230424T patent/SI1458673T1/sl unknown
- 2002-12-18 JP JP2003552710A patent/JP3820249B2/ja not_active Expired - Lifetime
- 2002-12-18 BR BR0214988-5A patent/BR0214988A/pt not_active IP Right Cessation
- 2002-12-18 CN CNA028281551A patent/CN1620423A/zh active Pending
- 2002-12-18 TW TW091136518A patent/TWI253444B/zh not_active IP Right Cessation
- 2002-12-18 PT PT02804964T patent/PT1458673E/pt unknown
- 2002-12-18 MX MXPA04006004A patent/MXPA04006004A/es active IP Right Grant
- 2002-12-18 DE DE60214594T patent/DE60214594T2/de not_active Expired - Lifetime
- 2002-12-18 IL IL16233002A patent/IL162330A0/xx unknown
- 2002-12-18 MX MXPA04006003A patent/MXPA04006003A/es active IP Right Grant
- 2002-12-18 AU AU2002366315A patent/AU2002366315A1/en not_active Abandoned
- 2002-12-18 NZ NZ533276A patent/NZ533276A/en unknown
- 2002-12-18 JP JP2003552709A patent/JP3784804B2/ja not_active Expired - Fee Related
- 2002-12-18 WO PCT/GB2002/005744 patent/WO2003051822A1/en active IP Right Grant
- 2002-12-18 DE DE60220441T patent/DE60220441T2/de not_active Expired - Fee Related
- 2002-12-18 ES ES02788145T patent/ES2286310T3/es not_active Expired - Lifetime
- 2002-12-18 CN CNB2006100071731A patent/CN100406427C/zh not_active Expired - Fee Related
- 2002-12-18 PL PL02370672A patent/PL370672A1/xx not_active Application Discontinuation
- 2002-12-18 NZ NZ533274A patent/NZ533274A/en unknown
- 2002-12-18 HU HU0402133A patent/HUP0402133A3/hu unknown
- 2002-12-18 HU HU0402022A patent/HUP0402022A3/hu unknown
- 2002-12-18 EP EP02788145A patent/EP1458672B1/en not_active Expired - Lifetime
- 2002-12-18 CA CA002469302A patent/CA2469302A1/en not_active Abandoned
- 2002-12-18 CN CNB028281233A patent/CN1293044C/zh not_active Expired - Fee Related
- 2002-12-18 EP EP02804964A patent/EP1458673B1/en not_active Expired - Lifetime
- 2002-12-18 WO PCT/GB2002/005738 patent/WO2003051821A1/en active IP Right Grant
- 2002-12-18 KR KR10-2004-7009517A patent/KR20040074094A/ko not_active Application Discontinuation
- 2002-12-18 RU RU2004116918/04A patent/RU2300517C2/ru not_active IP Right Cessation
- 2002-12-18 US US10/499,261 patent/US7514471B2/en not_active Expired - Fee Related
- 2002-12-18 US US10/499,378 patent/US7256307B2/en not_active Expired - Fee Related
- 2002-12-18 AU AU2002352427A patent/AU2002352427A1/en not_active Abandoned
- 2002-12-18 DK DK02788145T patent/DK1458672T3/da active
- 2002-12-19 AR ARP020105004A patent/AR038047A1/es not_active Application Discontinuation
- 2002-12-19 AR ARP020105002A patent/AR038045A1/es unknown
-
2004
- 2004-06-03 IL IL162330A patent/IL162330A/en not_active IP Right Cessation
- 2004-06-11 ZA ZA200404657A patent/ZA200404657B/en unknown
- 2004-06-11 ZA ZA200404658A patent/ZA200404658B/en unknown
- 2004-06-14 IS IS7309A patent/IS7309A/is unknown
- 2004-06-15 IS IS7313A patent/IS7313A/is unknown
- 2004-07-15 NO NO20043023A patent/NO20043023L/no not_active Application Discontinuation
- 2004-07-16 NO NO20043164A patent/NO20043164L/no not_active Application Discontinuation
-
2005
- 2005-02-01 HK HK05100831A patent/HK1068604A1/xx not_active IP Right Cessation
- 2005-02-16 HK HK05101304A patent/HK1068870A1/xx not_active IP Right Cessation
- 2005-08-16 JP JP2005235794A patent/JP2005336209A/ja active Pending
-
2006
- 2006-04-27 JP JP2006123399A patent/JP2006298924A/ja active Pending
- 2006-12-05 CY CY20061101743T patent/CY1106276T1/el unknown
-
2007
- 2007-08-01 CY CY20071101028T patent/CY1106784T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1458673T3 (da) | Substituerede phenylpropionsyrederivater som agonister for human peroxisomproliferatoraktiveret receptor alfa (PRAR) | |
ATE386026T1 (de) | Peroxisom proliferator aktivierten rezeptor alpha agonisten | |
NO20034986L (no) | Furan og tiofenderivater som aktiverer human peroksisom proliferator aktiverte reseptorer | |
DK1073432T3 (da) | Anvendelse af D serin eller D alanin til behandling af skizofreni | |
NO20030550D0 (no) | 17<beta>-karbotioat 17<alfa>-arylkarbonyloksyandrostanderivat som anti-inflammatoriske midler | |
DK1102762T3 (da) | 2-substituerede-1-piperidylbenzimidazolforbindelser som ORL1-receptoragonister | |
DK1349843T3 (da) | Thiazol- og oxazolderivater som aktivatorer af human peroxisom profilerator-aktiverede receptorer | |
CL2011001971A1 (es) | Uso de compuestos derivados del estereoisomero (-) del acido 3-trihalometilfenoxi) (4-halofenil)acetico para el tratamiento de la hiperuricemia. (divisional sol. 1444-00). | |
NO934800L (no) | Anvendelse av tetrahydrokarbazonderivater som 5HT1-reseptoragonister | |
HUP0201654A2 (en) | Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor (ppar) alpha, their preparation and pharmaceutical composition containing the same | |
IS6811A (is) | Lyfjafræðilegar samsetningar NMDA viðtakagerandefna | |
NO20042737L (no) | Peroksisomproliferatoraktiverte receptoragonister | |
NO20030213D0 (no) | Anvendelse av D2/D3 reseptor-agonister for behandling av fibromyalgi | |
BR0206595A (pt) | Composto, composição farmacêutica, e uso de um composto | |
NO992470L (no) | 2-amidazolinyl-amino-indolforbindelser anvendelige som <alfa>-2-adreno-reseptoragonister | |
NO20020176D0 (no) | Sykliske peptidderivater som inhibitorer for intergrin <alfa>v<beta>6 | |
ATE362367T1 (de) | Phenoxyessigsäure-derivate als peroxisom- proliferator-aktivierte rezeptor (ppar) dual- agonisten | |
DK1537091T3 (da) | Hidtil ukendte 2-arylthiazolforbindelser som PPAR alpha- og PPAR gamma-agonister | |
NO20035209D0 (no) | Oksazol/Tiazol-derivataktivatorer av HPPAR-alfa reseptoren | |
DE60142038D1 (de) | Aktivatoren des peroxisome proliferator-activated rezeptors | |
NO995030D0 (no) | 5-(2-imidazolinylamino)benzimidazolforbindelser nyttige som <alfa>-2-adrenoseptoragonister | |
NO20032582D0 (no) | 1,2,4-oksadiazolderivater som HPPAR alfa agonister | |
SE0103476D0 (sv) | New use | |
IT247792Y1 (it) | Struttura di pinza ad uso chirurgico | |
AR038306A1 (es) | Composicion farmaceutica dispersable oralmente de 2-({2-metoxi-2-[(3-trifluorometil)fenil]etil}amino)etil-4-(2-{[2-(9h-fluoren-9-il)acetil]amino}etil)benzoato |