SA518391033B1 - مركبات أمينو ترايازول به استبدال مفيدة باعتبارها مثبطات إنزيم كيتيناز بشري - Google Patents

مركبات أمينو ترايازول به استبدال مفيدة باعتبارها مثبطات إنزيم كيتيناز بشري Download PDF

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Publication number
SA518391033B1
SA518391033B1 SA518391033A SA518391033A SA518391033B1 SA 518391033 B1 SA518391033 B1 SA 518391033B1 SA 518391033 A SA518391033 A SA 518391033A SA 518391033 A SA518391033 A SA 518391033A SA 518391033 B1 SA518391033 B1 SA 518391033B1
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SA
Saudi Arabia
Prior art keywords
alkyl
aryl
compound
heterocyclic
alkoxy
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SA518391033A
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Arabic (ar)
English (en)
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بلوتا الزبيتا
جاسيك بي. اولكزاك،
سيلويا اوليجنيكزاك،
اغنيسزكا بارتوسزيويكز،
بارتلوميج بوريك
ميشيل سي بيوتروويكز
آدم أيه جوليبيوسكي
ووجكيتش جيه. سزيستكووسكي،
روبرت كوراليوسكي،
ميشيل ال. كوو-السكي،
مارزينا مازور،
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أونكوارندي ثيرابيوتكس أس.أيه
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Publication of SA518391033B1 publication Critical patent/SA518391033B1/ar

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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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SA518391033A 2015-09-04 2018-02-28 مركبات أمينو ترايازول به استبدال مفيدة باعتبارها مثبطات إنزيم كيتيناز بشري SA518391033B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562214299P 2015-09-04 2015-09-04
PL415078A PL415078A1 (pl) 2015-09-04 2015-12-04 Podstawione aminotriazole przydatne jako inhibitory kwaśnej chitynazy ssaków

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SA518391033B1 true SA518391033B1 (ar) 2022-10-17

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EP (1) EP3344616B1 (fr)
JP (2) JP6859325B2 (fr)
KR (1) KR102699408B1 (fr)
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TWI633087B (zh) 2012-06-13 2018-08-21 赫孚孟拉羅股份公司 新穎二氮雜螺環烷及氮雜螺環烷
SI2900669T1 (sl) 2012-09-25 2019-12-31 F. Hoffmann-La Roche Ag Derivati heksahidropirolo(3,4-C)pirola in sorodne spojine kot zaviralci avtotaksina (ATX) in kot zaviralci tvorbe lizofosfatidne kisline (LPA) za zdravljenje npr. bolezni ledvic
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