CO2018003484A2 - Amino triazoles sustituidos útiles como inhibidores de la quitinasa humana - Google Patents

Amino triazoles sustituidos útiles como inhibidores de la quitinasa humana

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Publication number
CO2018003484A2
CO2018003484A2 CONC2018/0003484A CO2018003484A CO2018003484A2 CO 2018003484 A2 CO2018003484 A2 CO 2018003484A2 CO 2018003484 A CO2018003484 A CO 2018003484A CO 2018003484 A2 CO2018003484 A2 CO 2018003484A2
Authority
CO
Colombia
Prior art keywords
diseases
inhibitors
amino substituted
substituted triazoles
human chitinase
Prior art date
Application number
CONC2018/0003484A
Other languages
English (en)
Inventor
Marzena Mazur
Robert Koralewski
Bartlomiej Borek
Sylwia Olejniczak
Wojciech J Czestkowski
Michal C Piotrowicz
Jacek P Olczak
Adam A Golebiowski
Agnieszka Bartoszewicz
Elzbieta Pluta
Michal L Kowalski
Original Assignee
Oncoarendi Therapeutics Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncoarendi Therapeutics Sa filed Critical Oncoarendi Therapeutics Sa
Publication of CO2018003484A2 publication Critical patent/CO2018003484A2/es

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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Abstract

Se describen compuesto de amino triazol sustituidos con un anillo de piperidinilo que en sí mismo está sustituido con un anillo heterocíclico. Estos compuestos son inhibidores de la quitinasa de mamífero ácida y quitotriosidasa. También se describen métodos para usar los compuestos para el tratamiento de reacciones asmáticas provocadas por alérgenos, así como enfermedades inflamatorias agudas y crónicas, enfermedades autoinmunes, enfermedades dentales, enfermedades neurológicas, enfermedades metabólicas, enfermedades hepáticas, síndrome de ovario poliquístico, endometriosis y cáncer.
CONC2018/0003484A 2015-09-04 2018-03-29 Amino triazoles sustituidos útiles como inhibidores de la quitinasa humana CO2018003484A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562214299P 2015-09-04 2015-09-04
PL415078A PL415078A1 (pl) 2015-09-04 2015-12-04 Podstawione aminotriazole przydatne jako inhibitory kwaśnej chitynazy ssaków
PCT/IB2016/055269 WO2017037670A1 (en) 2015-09-04 2016-09-02 Substituted amino triazoles useful as human chitinase inhibitors

Publications (1)

Publication Number Publication Date
CO2018003484A2 true CO2018003484A2 (es) 2018-07-10

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CA2872213A1 (en) 2012-06-13 2013-12-19 F. Hoffmann-La Roche Ag New diazaspirocycloalkane and azaspirocycloalkane
UA116547C2 (uk) 2012-09-25 2018-04-10 Ф. Хоффманн-Ля Рош Аг Біциклічні похідні
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
CN105764905B (zh) 2013-11-26 2019-06-07 豪夫迈·罗氏有限公司 新的八氢-环丁二烯并[1，2-c；3，4-c’]二吡咯-2基
HUE046820T2 (hu) 2014-03-26 2020-03-30 Hoffmann La Roche Biciklusos vegyületek autotaxin (ATX) és lizofoszfatidsav (LPA) termelésgátlókként
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