RU94031208A - Фармацевтическая композиция, связанное циклическое соединение и способ его получения - Google Patents
Фармацевтическая композиция, связанное циклическое соединение и способ его полученияInfo
- Publication number
- RU94031208A RU94031208A RU94031208/14A RU94031208A RU94031208A RU 94031208 A RU94031208 A RU 94031208A RU 94031208/14 A RU94031208/14 A RU 94031208/14A RU 94031208 A RU94031208 A RU 94031208A RU 94031208 A RU94031208 A RU 94031208A
- Authority
- RU
- Russia
- Prior art keywords
- nitrogen atoms
- pharmaceutical composition
- synthesis
- ones
- cyclic compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
- Liquid Crystal Substances (AREA)
- Steroid Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Abstract
Описываются связанные циклические соединения формулы Z - R - А - R'- у, в которой Z и У являются идентичными циклическими полиаминовыми фрагментами, содержащими в кольце 9 - 20 членов и 3 - 6 аминовых атомов азота, разделенных друг от друга двумя или более атомами углерода; А - ароматический или гетероароматический фрагмент, отличные от хинолина; R и R' - метиленовая группа, присоединенная к атомам азота в Z и У, при этом в иных случаях новые атомы азота вляются незамещенными, и их кислотно-аддитивные соли и комплексы с металлами, способ их получения и фармацевтическая композиция. Данные соединения проявляют анти-ВИЧ активность и могут быть полезны для лечения СПИД'а и других вирусных, в частности ретровирусных инфекций.
Claims (1)
- Описываются связанные циклические соединения формулы Z - R - А - R'- у, в которой Z и У являются идентичными циклическими полиаминовыми фрагментами, содержащими в кольце 9 - 20 членов и 3 - 6 аминовых атомов азота, разделенных друг от друга двумя или более атомами углерода; А - ароматический или гетероароматический фрагмент, отличные от хинолина; R и R' - метиленовая группа, присоединенная к атомам азота в Z и У, при этом в иных случаях новые атомы азота вляются незамещенными, и их кислотно-аддитивные соли и комплексы с металлами, способ их получения и фармацевтическая композиция. Данные соединения проявляют анти-ВИЧ активность и могут быть полезны для лечения СПИД'а и других вирусных, в частности ретровирусных инфекций.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB919126677A GB9126677D0 (en) | 1991-12-16 | 1991-12-16 | Improvements in chemical compounds |
GB9126677.5 | 1991-12-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
RU94031208A true RU94031208A (ru) | 1996-09-10 |
Family
ID=10706343
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU94031208/14A RU94031208A (ru) | 1991-12-16 | 1992-12-16 | Фармацевтическая композиция, связанное циклическое соединение и способ его получения |
Country Status (26)
Country | Link |
---|---|
US (2) | USRE42152E1 (ru) |
EP (2) | EP0619813B1 (ru) |
JP (1) | JP3375961B2 (ru) |
KR (1) | KR100286235B1 (ru) |
AT (1) | ATE273964T1 (ru) |
AU (1) | AU661086B2 (ru) |
CA (1) | CA2125978C (ru) |
CZ (1) | CZ286928B6 (ru) |
DE (2) | DE69233401T2 (ru) |
DK (1) | DK0619813T3 (ru) |
ES (1) | ES2224096T3 (ru) |
FI (1) | FI942849A (ru) |
GB (1) | GB9126677D0 (ru) |
HK (2) | HK1014368A1 (ru) |
HU (1) | HU224013B1 (ru) |
IL (1) | IL103984A (ru) |
MX (1) | MX9207316A (ru) |
MY (1) | MY110897A (ru) |
NL (1) | NL300425I1 (ru) |
NO (2) | NO305984B1 (ru) |
NZ (1) | NZ246179A (ru) |
PL (1) | PL173643B1 (ru) |
PT (1) | PT619813E (ru) |
RU (1) | RU94031208A (ru) |
WO (1) | WO1993012096A1 (ru) |
ZA (1) | ZA929632B (ru) |
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US5606053A (en) * | 1995-05-02 | 1997-02-25 | Johnson Matthey Plc | Process for preparing 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane |
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US20220031633A1 (en) | 2020-07-28 | 2022-02-03 | Yale University | Poly(amine-co-ester) polymeric particles for selective pulmonary delivery |
WO2022197776A1 (en) | 2021-03-16 | 2022-09-22 | Magenta Therapeutics, Inc. | Dosing regimens for hematopoietic stem cell mobilization for stem cell transplants in multiple myeloma patients |
US20230104658A1 (en) | 2021-10-01 | 2023-04-06 | Janssen Pharmaceutica Nv | Methods of increasing progenitor cell production |
WO2023108076A1 (en) | 2021-12-08 | 2023-06-15 | Yale University | Surface conjugation to poly(amine-co-ester) nanoparticles for targeting to cells and tissues |
WO2023159189A1 (en) | 2022-02-18 | 2023-08-24 | Yale University | Branched poly(amine-co-ester) polymers for more efficient nucleic expression |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
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US4994560A (en) * | 1987-06-24 | 1991-02-19 | The Dow Chemical Company | Functionalized polyamine chelants and radioactive rhodium complexes thereof for conjugation to antibodies |
DE3728525A1 (de) | 1987-08-24 | 1989-03-16 | Schering Ag | Mehrkernige substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel |
US5047572A (en) * | 1988-11-18 | 1991-09-10 | Ici Americas Inc. | Trisubstituted benzoic acid intermediates |
FR2644453A1 (fr) | 1989-03-20 | 1990-09-21 | Centre Nat Rech Scient | Procede de preparation de tetramines cycliques monofonctionnalisees |
SG49726A1 (en) * | 1989-10-23 | 1998-06-15 | Nycomed Salutar Inc | Compounds |
US5021409A (en) * | 1989-12-21 | 1991-06-04 | Johnson Matthey Plc | Antiviral cyclic polyamines |
FR2672051B1 (fr) * | 1991-01-24 | 1993-05-21 | Guerbet Sa | Nouveaux ligands macrocycliques azotes, procede de preparation, complexes polymetalliques, composition de diagnostic et therapeutique. |
GB9105489D0 (en) | 1991-03-15 | 1991-05-01 | Johnson Matthey Plc | Improvements in chemical compounds |
GB9126677D0 (en) | 1991-12-16 | 1992-02-12 | Johnson Matthey Plc | Improvements in chemical compounds |
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1991
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1992
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- 1992-12-16 WO PCT/GB1992/002334 patent/WO1993012096A1/en active IP Right Grant
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- 1992-12-16 MX MX9207316A patent/MX9207316A/es unknown
- 1992-12-16 EP EP93900285A patent/EP0619813B1/en not_active Revoked
- 1992-12-16 PT PT93900285T patent/PT619813E/pt unknown
- 1992-12-16 CZ CZ19941188A patent/CZ286928B6/cs not_active IP Right Cessation
- 1992-12-16 EP EP02001112A patent/EP1223166A1/en not_active Withdrawn
- 1992-12-16 JP JP51074593A patent/JP3375961B2/ja not_active Expired - Lifetime
- 1992-12-16 US US08/244,863 patent/US5583131A/en not_active Ceased
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- 1992-12-16 DE DE69233401T patent/DE69233401T2/de not_active Expired - Lifetime
- 1992-12-16 DE DE122010000001C patent/DE122010000001I1/de active Pending
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- 1992-12-16 DK DK93900285T patent/DK0619813T3/da active
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1994
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1998
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2009
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