NO2010001I1 - 1,1'-[1,4-fenylenbis(metylen)]-bis-1,4,8,11-tetraazacyclotetradecan - Google Patents

1,1'-[1,4-fenylenbis(metylen)]-bis-1,4,8,11-tetraazacyclotetradecan

Info

Publication number
NO2010001I1
NO2010001I1 NO2010001C NO2010001C NO2010001I1 NO 2010001 I1 NO2010001 I1 NO 2010001I1 NO 2010001 C NO2010001 C NO 2010001C NO 2010001 C NO2010001 C NO 2010001C NO 2010001 I1 NO2010001 I1 NO 2010001I1
Authority
NO
Norway
Prior art keywords
atoms
contg
esp
tetraazacyclotetradecan
phenylenebis
Prior art date
Application number
NO2010001C
Other languages
English (en)
Other versions
NO2010001I2 (no
Original Assignee
Genzyme Global Sarl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10706343&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO2010001(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genzyme Global Sarl filed Critical Genzyme Global Sarl
Publication of NO2010001I1 publication Critical patent/NO2010001I1/no
Publication of NO2010001I2 publication Critical patent/NO2010001I2/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D257/00Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
  • Liquid Crystal Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Steroid Compounds (AREA)
  • Furan Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO2010001C 1991-12-16 2010-02-04 1,1'-[1,4-fenylenbis(metylen)]-bis-1,4,8,11-tetraazacyclotetradecan NO2010001I2 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919126677A GB9126677D0 (en) 1991-12-16 1991-12-16 Improvements in chemical compounds
PCT/GB1992/002334 WO1993012096A1 (en) 1991-12-16 1992-12-16 Linked cyclic polyamines with activity against hiv

Publications (2)

Publication Number Publication Date
NO2010001I1 true NO2010001I1 (no) 2010-03-08
NO2010001I2 NO2010001I2 (no) 2012-08-27

Family

ID=10706343

Family Applications (2)

Application Number Title Priority Date Filing Date
NO942254A NO305984B1 (no) 1991-12-16 1994-06-15 Farmasoeytisk preparat aktivt mot HIV, sammenknyttet cykliske forbindelser og fremstilling derav
NO2010001C NO2010001I2 (no) 1991-12-16 2010-02-04 1,1'-[1,4-fenylenbis(metylen)]-bis-1,4,8,11-tetraazacyclotetradecan

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO942254A NO305984B1 (no) 1991-12-16 1994-06-15 Farmasoeytisk preparat aktivt mot HIV, sammenknyttet cykliske forbindelser og fremstilling derav

Country Status (26)

Country Link
US (2) USRE42152E1 (no)
EP (2) EP0619813B1 (no)
JP (1) JP3375961B2 (no)
KR (1) KR100286235B1 (no)
AT (1) ATE273964T1 (no)
AU (1) AU661086B2 (no)
CA (1) CA2125978C (no)
CZ (1) CZ286928B6 (no)
DE (2) DE69233401T2 (no)
DK (1) DK0619813T3 (no)
ES (1) ES2224096T3 (no)
FI (1) FI942849A (no)
GB (1) GB9126677D0 (no)
HK (2) HK1014368A1 (no)
HU (1) HU224013B1 (no)
IL (1) IL103984A (no)
MX (1) MX9207316A (no)
MY (1) MY110897A (no)
NL (1) NL300425I1 (no)
NO (2) NO305984B1 (no)
NZ (1) NZ246179A (no)
PL (1) PL173643B1 (no)
PT (1) PT619813E (no)
RU (1) RU94031208A (no)
WO (1) WO1993012096A1 (no)
ZA (1) ZA929632B (no)

Families Citing this family (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9126677D0 (en) 1991-12-16 1992-02-12 Johnson Matthey Plc Improvements in chemical compounds
GB9318550D0 (en) * 1993-09-07 1993-10-20 Nycomed Salutar Inc Chelants
GB9400411D0 (en) * 1994-01-11 1994-03-09 Johnson Matthey Plc Improvements in chemical compounds
US5663161A (en) * 1995-02-17 1997-09-02 The Research Foundation Of State University Of New York Anti-viral triaza compounds
US5612478A (en) * 1995-03-30 1997-03-18 Johnson Matthey Plc Process for preparing 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane
US5606053A (en) * 1995-05-02 1997-02-25 Johnson Matthey Plc Process for preparing 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane
US6506770B1 (en) 1996-06-06 2003-01-14 Anormed, Inc. Antiviral compounds
GB9511357D0 (en) * 1995-06-06 1995-08-02 Johnson Matthey Plc Improved antiviral compounds
US5608061A (en) * 1995-08-02 1997-03-04 Johnson Matthey Plc Process for preparing 1,4,8,11-tetraazacyclotetradecane
US7087648B1 (en) * 1997-10-27 2006-08-08 The Regents Of The University Of California Methods for modulating macrophage proliferation using polyamine analogs
US6498155B1 (en) 1998-11-17 2002-12-24 Smithkline Beecham Corporation Methods of treating thrombocytopenia
US6365583B1 (en) 1999-02-02 2002-04-02 Anormed, Inc. Methods to enhance white blood cell count
NZ514709A (en) * 1999-03-24 2003-03-28 Anormed Inc Heterocyclic substituted 1,4-benzene dimethanamine derivatives useful for treating disorders mediated by chemokine receptor binding or associated with an abnormal immune response
US6750348B1 (en) * 1999-03-24 2004-06-15 Anormed, Inc. Chemokine receptor binding heterocyclic compounds
JP2002543126A (ja) * 1999-05-03 2002-12-17 スミスクライン・ビーチャム・コーポレイション Cxcr−4受容体アンタゴニスト−トロンボポエチン模倣物
CN100335478C (zh) 1999-12-17 2007-09-05 阿诺麦德股份有限公司 结合趋化因子受体的杂环化合物
CA2400157A1 (en) * 2000-02-22 2001-08-30 Ram W. Sabnis Organic polymeric antireflective coatings deposited by chemical vapor deposition
RU2289581C2 (ru) * 2000-09-15 2006-12-20 Анормед, Инк. Гетероциклические соединения, содержащая их фармацевтическая композиция и их применение
NZ524421A (en) 2000-09-15 2005-02-25 Anormed Inc Chemokine receptor binding heterocyclic compounds
IL154229A0 (en) 2000-09-15 2003-07-31 Anormed Inc Chemokine receptor binding heterocyclic compounds
US6489472B2 (en) 2000-09-29 2002-12-03 Anormed, Inc. Process for preparation of N-1 protected N ring nitrogen containing cyclic polyamines and products thereof
DE10117206A1 (de) * 2001-04-06 2002-10-10 Bayer Ag Verfahren zur Herstellung von halogensubstituierten Dibenzylalkoholen, diese halogensubstituierten Dibenzylalkohole sowie deren Verwendung
US7169750B2 (en) * 2001-07-31 2007-01-30 Anormed, Inc. Methods to mobilize progenitor/stem cells
EP1411918B1 (en) * 2001-07-31 2011-12-28 Genzyme Global S.à.r.l. Methods to mobilize progenitor/stem cells
RU2308451C2 (ru) 2001-09-12 2007-10-20 Анормед, Инк. Способы получения рацемического аминозамещенного 5,6,7,8-тетрагидрохинолина или рацемического аминозамещенного 5,6,7,8-тетрагидроизохинолина, способы их разделения и рацемизации, способ получения кетозамещенного 5,6,7,8-тетрагидрохинолина или кетозамещенного 5,6,7,8-тетрагидроизохинолина, способ получения энантиомера конденсированного бициклического кольца, замещенного первичным амином, производные 5,6,7,8-тетрагидрохинолина
US7354932B2 (en) * 2001-12-21 2008-04-08 Anormed, Inc. Chemokine receptor binding heterocyclic compounds with enhanced efficacy
MXPA04006136A (es) 2001-12-21 2004-11-01 Anormed Inc Compuestos heterociclicos que se unen a receptor de quimiocina con eficacia incrementada.
CA2472711C (en) 2002-01-18 2012-03-20 Yamanouchi Pharmaceutical Co., Ltd. 2-acylaminothiazole derivative or salt thereof
EP1613613B1 (en) * 2003-04-11 2021-06-02 Genzyme Corporation Cxcr4 chemokine receptor binding compounds
US7501518B2 (en) * 2003-04-22 2009-03-10 Genzyme Corporation Methods of making 2,6-diaryl piperidine derivatives
MXPA05011353A (es) 2003-04-22 2005-11-28 Anormed Inc Compuestos heterociclicos que se unen al receptor de quimiocina con eficacia mejorada.
CA2548393A1 (en) * 2003-12-11 2005-06-30 Anormed Inc. Chemokine receptor binding compounds
US7498346B2 (en) * 2003-12-11 2009-03-03 Genzyme Corporation Chemokine receptor binding compounds
ES2614508T3 (es) * 2004-03-15 2017-05-31 Genzyme Corporation Proceso para la síntesis de un antagonista de CXCR4
ATE492523T1 (de) * 2004-08-05 2011-01-15 Sumitomo Chemical Co Verfahren zur herstellung von halogensubstituiertem benzoldimethanol
WO2006020891A2 (en) * 2004-08-13 2006-02-23 Anormed Inc. Chemokine combinations to mobilize progenitor/stem cells
TW200619206A (en) * 2004-09-29 2006-06-16 Anormed Inc Chemokine-binding heterocyclic compound salts, and methods of use thereof
US9789171B2 (en) * 2004-11-05 2017-10-17 The General Hospital Corporation Anti-fugetactic agents for the treatment of ovarian cancer
WO2006138350A2 (en) * 2005-06-15 2006-12-28 Anormed Inc. Chemokine receptor binding compounds
CA2619881A1 (en) * 2005-08-16 2007-02-22 Genzyme Corporation Chemokine receptor binding compounds
WO2007022523A2 (en) 2005-08-19 2007-02-22 Genzyme Corporation Methods to enhance chemotherapy
KR20080074166A (ko) * 2005-11-08 2008-08-12 아스테라스 세이야쿠 가부시키가이샤 혈소판감소증을 치료하는 조성물 및 방법
EP1978008B1 (en) 2006-01-24 2011-07-20 Sumitomo Chemical Company, Limited Method for producing halogen-substituted benzenedimethanol
JP2009527552A (ja) * 2006-02-24 2009-07-30 ジェンザイム・コーポレーション 血流の増加および組織再生の促進またはそのいずれかのための方法
AR063470A1 (es) * 2006-08-02 2009-01-28 Genzyme Corp Terapia combinada
MX2009001445A (es) * 2006-08-07 2009-02-18 Genzyme Corp Terapia de combinacion.
ES2452032T3 (es) * 2006-08-08 2014-03-31 Akarx, Inc. Composiciones y métodos para aumentar los niveles de plaquetas de la sangre en humanos
WO2008109076A1 (en) * 2007-03-02 2008-09-12 Oxigene, Inc. Methods for enhancing the efficacy of vascular disrupting agents
CA2688504A1 (en) 2007-06-18 2008-12-24 Children's Hospital & Research Center At Oakland Method of isolating stem and progenitor cells from placenta
US9822364B2 (en) 2008-03-11 2017-11-21 Yale University Compositions and methods for controlled delivery of inhibitory ribonucleic acids
US9241898B2 (en) 2008-03-11 2016-01-26 Yale University Compositions and methods for controlled delivery of inhibitory ribonucleic acids
EP2149567A1 (en) * 2008-07-18 2010-02-03 Bayer Schering Pharma Aktiengesellschaft Cyclic polyamines for binding phosphatidylserine
US8771677B2 (en) * 2008-12-29 2014-07-08 Vladimir B Serikov Colony-forming unit cell of human chorion and method to obtain and use thereof
JP2014513727A (ja) 2011-05-16 2014-06-05 ジェンザイム・コーポレーション Cxcr4拮抗薬の使用
US10465042B2 (en) 2011-12-02 2019-11-05 Yale University Poly(amine-co-ester) nanoparticles and methods of use thereof
WO2013082529A1 (en) 2011-12-02 2013-06-06 Yale University Enzymatic synthesis of poly(amine-co-esters) and methods of use thereof for gene delivery
US9895451B2 (en) 2011-12-02 2018-02-20 Yale University Formulations for targeted release of agents to low pH tissue environments or cellular compartments and methods of use thereof
WO2014125499A1 (en) 2013-02-13 2014-08-21 Natco Pharma Limited Improved and commercially viable process for the preparation of high pure plerixafor base
PT107018A (pt) * 2013-06-20 2014-12-22 Inst Superior Técnico Síntese e uso de ciclamas com atividade antibacteriana
US20160206592A1 (en) 2013-08-30 2016-07-21 Ramot At Tel-Aviv University Ltd. Method for treating amyotrophic lateral sclerosis by inhibition of cxcr4/cxcl12 signaling
US11918695B2 (en) 2014-05-09 2024-03-05 Yale University Topical formulation of hyperbranched polymer-coated particles
WO2015172153A1 (en) 2014-05-09 2015-11-12 Yale University Topical formulation of hyperbranched polyglycerol-coated particles thereof
US10682422B2 (en) 2014-11-18 2020-06-16 Yale University Formulations for targeted release of agents under low pH conditions and methods of use thereof
WO2016081621A1 (en) 2014-11-18 2016-05-26 Yale University Formulations for targeted release of agents under low ph conditions and methods of use thereof
EP3050574B1 (en) 2015-01-28 2019-10-09 Universite De Bordeaux Use of plerixafor for treating and/or preventing acute exacerbations of chronic obstructive pulmonary disease
EP3288638A1 (en) 2015-04-25 2018-03-07 The General Hospital Corporation Anti-fugetactic agent and anti-cancer agent combination therapy and compositions for the treatment of cancer
EP3302710A4 (en) 2015-06-03 2019-02-20 The University of Queensland MOBILIZERS AND USE THEREOF
WO2017037639A1 (en) 2015-09-02 2017-03-09 Fresenius Kabi Oncology Ltd. A process for the preparation of xylene linked cyclam compounds
JP2018531229A (ja) 2015-09-18 2018-10-25 ザ ジェネラル ホスピタル コーポレーション ドゥーイング ビジネス アズ マサチューセッツ ジェネラル ホスピタル 癌の治療のための抗fugetactic剤の局所的送達
WO2017106328A1 (en) 2015-12-14 2017-06-22 X4 Pharmaceuticals, Inc. Methods for treating cancer
US11357742B2 (en) 2015-12-14 2022-06-14 X4 Pharmaceuticals, Inc. Methods for treating cancer
WO2017106630A1 (en) 2015-12-18 2017-06-22 The General Hospital Corporation Polyacetal polymers, conjugates, particles and uses thereof
US10610527B2 (en) 2015-12-22 2020-04-07 X4 Pharmaceuticals, Inc. Methods for treating immunodeficiency disease
CA3014795A1 (en) 2016-02-16 2017-08-24 Yale University Compositions and methods for treatment of cystic fibrosis
US11136597B2 (en) 2016-02-16 2021-10-05 Yale University Compositions for enhancing targeted gene editing and methods of use thereof
JP2019510785A (ja) 2016-04-08 2019-04-18 エックス4 ファーマシューティカルズ, インコーポレイテッド 癌を処置する方法
WO2017197128A1 (en) 2016-05-11 2017-11-16 Yale University Poly(amine-co-ester) nanoparticles and methods of use thereof
CN109562106B (zh) 2016-06-21 2023-03-21 X4 制药有限公司 Cxcr4抑制剂及其用途
EP3472129A4 (en) 2016-06-21 2019-12-04 X4 Pharmaceuticals, Inc. CXCR4 INHIBITORS AND USES THEREOF
CA3027495A1 (en) 2016-06-21 2017-12-28 X4 Pharmaceuticals, Inc. Cxcr4 inhibitors and uses thereof
JP2019534249A (ja) 2016-09-09 2019-11-28 ザ ジェネラル ホスピタル コーポレイション 癌の治療のための抗化学忌避剤とのhsp融合タンパク質
WO2018049120A1 (en) 2016-09-09 2018-03-15 The General Hospital Corporation Ex vivo antigen-presenting cells or activated cd-positive t cells for treatment of cancer
US11453706B2 (en) 2016-09-09 2022-09-27 The General Hospital Corporation HSP fusion protein with anti-chemorepellant agent for treatment of infectious disease
WO2018053270A1 (en) 2016-09-16 2018-03-22 The General Hospital Corporation Modified natural killer cells for the treatment of cancer
WO2018106738A1 (en) 2016-12-05 2018-06-14 Massachusetts Institute Of Technology Brush-arm star polymers, conjugates and particles, and uses thereof
JP2020515542A (ja) 2017-03-23 2020-05-28 ザ ジェネラル ホスピタル コーポレイション Cxcr4/cxcr7の遮断およびヒトパピローマウイルス関連疾患の治療
WO2018187493A1 (en) 2017-04-04 2018-10-11 Yale University Compositions and methods for in utero delivery
JP2021503008A (ja) 2017-10-31 2021-02-04 マジェンタ セラピューティクス インコーポレイテッドMagenta Therapeutics, Inc. 造血幹細胞および前駆細胞移植療法のための組成物および方法
WO2019089826A1 (en) 2017-10-31 2019-05-09 Magenta Therapeutics Inc. Compositions and methods for the expansion of hematopoietic stem and progenitor cells
JP2021505172A (ja) 2017-12-06 2021-02-18 マジェンタ セラピューティクス インコーポレイテッドMagenta Therapeutics, Inc. 造血幹細胞及び前駆細胞を動員させるための投薬レジメン
US10058573B1 (en) 2017-12-06 2018-08-28 Magenta Therapeutics, Inc. Dosing regimens for the mobilization of hematopoietic stem cells
US11260079B2 (en) 2017-12-06 2022-03-01 Magenta Therapeutics, Inc. Dosing regimens for the mobilization of hematopoietic stem and progenitor cells
US20200338132A1 (en) 2018-01-03 2020-10-29 Magenta Therapeutics Inc. Compositions and methods for the expansion of hematopoietic stem and progenitor cells and treatment of inherited metabolic disorders
US20210189431A1 (en) 2018-08-10 2021-06-24 Yale University Compositions and methods for embryonic gene editing in vitro
US10548889B1 (en) 2018-08-31 2020-02-04 X4 Pharmaceuticals, Inc. Compositions of CXCR4 inhibitors and methods of preparation and use
US11814464B2 (en) 2019-04-29 2023-11-14 Yale University Poly(amine-co-ester) polymers and polyplexes with modified end groups and methods of use thereof
US20220372474A1 (en) 2019-06-21 2022-11-24 Yale University Hydroxymethyl-modified gamma-pna compositions and methods of use thereof
US20220243211A1 (en) 2019-06-21 2022-08-04 Yale University Peptide nucleic acid compositions with modified hoogsteen binding segments and methods of use thereof
WO2021022161A1 (en) 2019-07-31 2021-02-04 Yale University Compositions and methods for treating sickle cell disease
WO2021087406A1 (en) 2019-11-01 2021-05-06 Magenta Therapeutics, Inc. Dosing regimens for the mobilization of hematopoietic stem and progentor cells
EP4143302A1 (en) 2020-04-27 2023-03-08 Magenta Therapeutics, Inc. Methods and compositions for transducing hematopoietic stem and progenitor cells in vivo
MX2022016581A (es) 2020-06-19 2023-02-01 Univ Yale Polimeros de poli(amina-co-ester) con grupos de extremo modificado y liberacion pulmonar mejorada.
US20220031633A1 (en) 2020-07-28 2022-02-03 Yale University Poly(amine-co-ester) polymeric particles for selective pulmonary delivery
WO2022197776A1 (en) 2021-03-16 2022-09-22 Magenta Therapeutics, Inc. Dosing regimens for hematopoietic stem cell mobilization for stem cell transplants in multiple myeloma patients
US20230104658A1 (en) 2021-10-01 2023-04-06 Janssen Pharmaceutica Nv Methods of increasing progenitor cell production
WO2023108076A1 (en) 2021-12-08 2023-06-15 Yale University Surface conjugation to poly(amine-co-ester) nanoparticles for targeting to cells and tissues
WO2023159189A1 (en) 2022-02-18 2023-08-24 Yale University Branched poly(amine-co-ester) polymers for more efficient nucleic expression

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4994560A (en) * 1987-06-24 1991-02-19 The Dow Chemical Company Functionalized polyamine chelants and radioactive rhodium complexes thereof for conjugation to antibodies
DE3728525A1 (de) 1987-08-24 1989-03-16 Schering Ag Mehrkernige substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
US5047572A (en) * 1988-11-18 1991-09-10 Ici Americas Inc. Trisubstituted benzoic acid intermediates
FR2644453A1 (fr) 1989-03-20 1990-09-21 Centre Nat Rech Scient Procede de preparation de tetramines cycliques monofonctionnalisees
SG49726A1 (en) * 1989-10-23 1998-06-15 Nycomed Salutar Inc Compounds
US5021409A (en) * 1989-12-21 1991-06-04 Johnson Matthey Plc Antiviral cyclic polyamines
FR2672051B1 (fr) * 1991-01-24 1993-05-21 Guerbet Sa Nouveaux ligands macrocycliques azotes, procede de preparation, complexes polymetalliques, composition de diagnostic et therapeutique.
GB9105489D0 (en) 1991-03-15 1991-05-01 Johnson Matthey Plc Improvements in chemical compounds
GB9126677D0 (en) 1991-12-16 1992-02-12 Johnson Matthey Plc Improvements in chemical compounds

Also Published As

Publication number Publication date
HK1014368A1 (en) 1999-09-24
CZ286928B6 (cs) 2000-08-16
CZ118894A3 (en) 1995-10-18
NL300425I1 (nl) 2010-01-04
HUT67544A (en) 1995-04-28
GB9126677D0 (en) 1992-02-12
DE122010000001I1 (de) 2010-08-26
DK0619813T3 (da) 2004-12-20
NO942254L (no) 1994-06-15
USRE42152E1 (en) 2011-02-15
NO305984B1 (no) 1999-08-30
EP1223166A1 (en) 2002-07-17
EP0619813B1 (en) 2004-08-18
RU94031208A (ru) 1996-09-10
NO2010001I2 (no) 2012-08-27
EP0619813A1 (en) 1994-10-19
IL103984A (en) 1998-10-30
ZA929632B (en) 1993-06-18
CA2125978C (en) 2005-09-20
HU224013B1 (hu) 2005-04-28
DE69233401D1 (de) 2004-09-23
PT619813E (pt) 2004-12-31
IL103984A0 (en) 1993-05-13
NO942254D0 (no) 1994-06-15
JP3375961B2 (ja) 2003-02-10
ES2224096T3 (es) 2005-03-01
HU9401786D0 (en) 1994-09-28
FI942849A0 (fi) 1994-06-15
JPH07501816A (ja) 1995-02-23
US5583131A (en) 1996-12-10
MY110897A (en) 1999-06-30
MX9207316A (es) 1993-06-01
DE69233401T2 (de) 2005-10-13
NZ246179A (en) 1996-03-26
ATE273964T1 (de) 2004-09-15
CA2125978A1 (en) 1993-06-24
WO1993012096A1 (en) 1993-06-24
PL173643B1 (pl) 1998-04-30
AU661086B2 (en) 1995-07-13
HK1049328A1 (zh) 2003-05-09
KR100286235B1 (ko) 2001-04-16
AU3165593A (en) 1993-07-19
FI942849A (fi) 1994-06-15

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