RU2743343C2 - Имидазолонилхинолины и их применение в качестве ингибиторов киназы атм - Google Patents

Info

Publication number

RU2743343C2

RU2743343C2 RU2017138100A RU2017138100A RU2743343C2 RU 2743343 C2 RU2743343 C2 RU 2743343C2 RU 2017138100 A RU2017138100 A RU 2017138100A RU 2017138100 A RU2017138100 A RU 2017138100A RU 2743343 C2 RU2743343 C2 RU 2743343C2

Authority

RU

Russia

Prior art keywords

methyl

pyrazol

fluoro

het

methoxy

Prior art date

2015-04-02

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• 108091000080 Phosphotransferase Proteins 0.000 title abstract description 19
• 102000020233 phosphotransferase Human genes 0.000 title abstract description 19
• BAHVJMJZUDCTPT-UHFFFAOYSA-N 4-quinolin-2-ylimidazol-2-one Chemical class O=C1N=CC(C=2N=C3C=CC=CC3=CC=2)=N1 BAHVJMJZUDCTPT-UHFFFAOYSA-N 0.000 title abstract description 5
• 239000012827 ATM inhibitor Substances 0.000 title description 4
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• 150000001875 compounds Chemical class 0.000 claims abstract description 198
• 150000003839 salts Chemical class 0.000 claims abstract description 48
• XRKYMMUGXMWDAO-UHFFFAOYSA-N 2-(4-morpholinyl)-6-(1-thianthrenyl)-4-pyranone Chemical compound O1C(C=2C=3SC4=CC=CC=C4SC=3C=CC=2)=CC(=O)C=C1N1CCOCC1 XRKYMMUGXMWDAO-UHFFFAOYSA-N 0.000 claims abstract description 32
• 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 32
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• 125000000217 alkyl group Chemical group 0.000 claims abstract description 18
• 229910052731 fluorine Inorganic materials 0.000 claims abstract description 16
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