HRP20210981T1 - Imidazolonil kinolini i njihova uporaba kao inhibitori atm kinaze - Google Patents
Imidazolonil kinolini i njihova uporaba kao inhibitori atm kinaze Download PDFInfo
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- HRP20210981T1 HRP20210981T1 HRP20210981TT HRP20210981T HRP20210981T1 HR P20210981 T1 HRP20210981 T1 HR P20210981T1 HR P20210981T T HRP20210981T T HR P20210981TT HR P20210981 T HRP20210981 T HR P20210981T HR P20210981 T1 HRP20210981 T1 HR P20210981T1
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- Prior art keywords
- pyrazol
- methyl
- tautomer
- stereoisomer
- solvate
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- BAHVJMJZUDCTPT-UHFFFAOYSA-N 4-quinolin-2-ylimidazol-2-one Chemical class O=C1N=CC(C=2N=C3C=CC=CC3=CC=2)=N1 BAHVJMJZUDCTPT-UHFFFAOYSA-N 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- -1 methoxy, ethoxy, propoxy, piperazinyl Chemical group 0.000 claims 38
- 150000001875 compounds Chemical class 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 14
- 239000012453 solvate Substances 0.000 claims 14
- 125000004432 carbon atom Chemical group C* 0.000 claims 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 239000002246 antineoplastic agent Substances 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 125000003226 pyrazolyl group Chemical group 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000000623 heterocyclic group Chemical class 0.000 claims 2
- 125000002883 imidazolyl group Chemical group 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 125000001425 triazolyl group Chemical group 0.000 claims 2
- 125000001399 1,2,3-triazolyl group Chemical group N1N=NC(=C1)* 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- 206010070834 Sensitisation Diseases 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000005336 allyloxy group Chemical group 0.000 claims 1
- 125000002393 azetidinyl group Chemical group 0.000 claims 1
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 230000005865 ionizing radiation Effects 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 230000008313 sensitization Effects 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 1
- 125000000437 thiazol-2-yl group Chemical group [H]C1=C([H])N=C(*)S1 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Claims (14)
1. Spoj s formulom (I)
[image]
naznačen time što
R1 je metil,
R3 označava nerazgranat ili razgranat alkil koji ima 1, 2 ili 3 C atoma, gdje, neovisno jedan od drugoga, 1, 2, 3, 4 ili 5 H atoma mogu biti zamijenjeni s Hal,
Het1 je odabran iz niza koji čine pirazolil, triazolil i imidazolil, pri čemu Het1 može biti nesupstituiran ili mono- ili disupstituiran, neovisno jedan od drugoga, s alkilom, koji može biti nesupstituiran ili mono- ili polisupstituiran s Hal, -OY, -NYY, Hal i -Het2,
HET označava 5-eročlani monociklički aromatski heterocikl, gdje je ovaj heterocikl povezan s N atomom kostura preko prstenskog C atoma i gdje je ovaj heterocikl odabran od pirazolila, tiazolila i imidazolila i može biti nesupstituiran ili supstituiran s jednim, dva ili tri supstituenta, koji su odabrani, neovisno jedan od drugoga, iz skupine koja sadrži: Hal, A, Het2, -(CY2)p-OY, -(CY2)p-OZ, -(CY2)p-O-Het2, -(CY2)p-O-(CY2)t-Het2, -(CY2)p-O-(CY2)t-NYY, -(CY2)p-O-(CY2)t-OY, -(CY2)p-NYY, -(CY2)p-COOY, -(CY2)p-CO-NYY, -(CY2)p-NY-COY,
A svaki puta neovisno označava nerazgranat ili razgranat alkil koji ima 1, 2, 3, 4, 5, 6, 7, 8, 9 ili 10 C atoma, gdje, neovisno jedan od drugoga, 1, 2, 3, 4, 5, 6 ili 7 H atoma mogu biti zamijenjeni s Hal,
Het2 označava monociklički zasićeni heterocikl koji ima 2, 3, 4, 5, 6 ili 7 C atoma i 1, 2, 3 ili 4 N, O i/ili S atoma, koji mogu biti nesupstituirani ili monosupstituirani s A,
Y označava H ili A,
Z označava nerazgranat ili razgranat alkenil koji ima 2, 3, 4, 5, 6, 7, 8, 9 ili 10 C atoma, gdje, neovisno jedan od drugoga, 1, 2, 3, 4, 5, 6 ili 7 H atoma mogu biti zamijenjeni s Hal,
Hal označava F, Cl, Br ili I, i
p označava 0, 1, 2, 3, 4, 5 ili 6
t označava 1, 2, 3, 4, 5 ili 6,
i/ili njegova farmaceutski upotrebljiva sol, solvat, tautomer ili stereoizomer.
2. Spoj s formulom (I) prema patentnom zahtjevu 1, naznačen time što HET može biti supstituiran s jednim, dva ili tri supstituenta koji su odabrani, neovisno jedan od drugoga, iz skupine koja sadrži: F, Cl, metil, etil, propil, izopropil, metoksi, etoksi, propoksi, piperazinil, tetrahidropiranil, 2-metoksietoksi, 2-hidroksietoksi, fluorometoksi, difluorometoksi, N-metilkarbamoil (-C(=O)-NH-CH3), 2-metilaminoetoksi, 1-metil-azetidin-3-ilmetoksi, trideuteriometoksi, trifluorometoksi, aliloksi i azetidiniloksi, i/ili njegova farmaceutski upotrebljiva sol, solvat, tautomer ili stereoizomer.
3. Spoj s formulom (I) prema patentnom zahtjevu 1 ili 2, naznačen time što je HET odabran iz skupa koji čine: 1H-pirazol-4-il, 1-etil-3-metil-1H-pirazol-4-il, 1,2-dimetil-1H-pirazol-4-il, 1,3-dimetil-1H-pirazol-4-il, 1-metil-1 H-pirazol-4-il, 1-(tetrahidropiran-4-il)-1H-pirazol-4-il, 2-metil-2H-pirazol-3-il, 3-metil-1H-pirazol-4-il, 2-metilol-4-il, 3,5-dimetil-1H-pirazol-4-il, 3-fluoro-1-metilpirazol-4-il, tiazol-2-il, i 1-metil-1H-imidazolil, i/ili njegova farmaceutski upotrebljiva sol, solvat, tautomer ili stereoizomer.
4. Spoj s formulom (I) prema patentnom zahtjevu 1, 2 ili 3, naznačen time što Het1 je pirazolil, koji može biti nesupstituiran ili supstituiran kako je definirano u patentnom zahtjevu 1, i/ili njegova farmaceutski upotrebljiva sol, solvat, tautomer ili stereoizomer.
5. Spoj s formulom (I) prema patentnom zahtjevu 1, 2 ili 3, naznačen time što Het1 je triazolil, poželjno 1,2,3-triazolil, koji može biti nesupstituiran ili supstituiran kako je definirano u patentnom zahtjevu 1, i/ili njegova farmaceutski upotrebljiva sol, solvat, tautomer ili stereoizomer.
6. Spoj s formulom (I) prema jednom od patentnih zahtjeva 1 do 4, naznačen time što Het1 je nesupstituiran ili supstituiran s jednim ili dva supstituenta odabrana, neovisno jedan od drugoga, od metila, etila, amino, metoksi, fluorometila, difluorometila, fluora, azetidinila, i/ili njegova farmaceutski upotrebljiva sol, solvat, tautomer ili stereoizomer.
7. Spoj s formulom (I) prema bilo kojem od patentnih zahtjeva 1 do 4, naznačen time što je Het1 naznačen time što je odabran iz skupa koji čine: 1H-pirazol-4-il, 2H-pirazol-3-il, 1H-pirazol-3-il, 1-metil-1H-pirazol-4-il, 3-metil-1H-pirazol-4-il, 5-metil-1H-pirazol-3-il, 4-metil-1H-pirazol-3-il, 1-fluorometil-1H-pirazol-4-il, 1-difluorometil-1H-pirazol-4-il, 1,3-dimetil-1H-pirazol-4-il, 1-etil-1H-pirazol-4-il, 1-etil-3-metil-1H-pirazolil, 3-fluoro-1-metil-1H-pirazol-4-il, 3-amino-1H-pirazol-5-il, 2H-1,2,3-triazol-4-il, 3H-1,2,3-triazol-4-il-, 1-metil-1H-1,2,3-triazol-4-il, 2-metil-2H-1,2,3-triazol-4-il, 2-amino-1H-imidazol-4-il, i 1-(azetidin-3-il)-3-metil-1H-pirazol-4-il, i/ili njegova farmaceutski upotrebljiva sol, solvat, tautomer ili stereoizomer.
8. Spoj s formulom (I) prema bilo kojem od patentnih zahtjeva 1 do 7, naznačen time što R3 označava metil, i/ili njegova farmaceutski upotrebljiva sol, solvat, tautomer ili stereoizomer.
9. Spoj prema patentnom zahtjevu 1, naznačen time što je odabran iz skupa koji čine:
[image]
[image]
[image]
[image]
i/ili njihova farmaceutski upotrebljiva sol, solvat, tautomer ili stereoizomer.
10. Spoj prema bilo kojem od patentnih zahtjeva 1 do 9 i/ili njegova farmaceutski upotrebljiva sol, solvat, tautomer ili stereoizomer, naznačen time što je za uporabu kao lijek.
11. Spoj prema bilo kojem od patentnih zahtjeva 1 do 9 i/ili njegova farmaceutski upotrebljiva sol, solvat, tautomer ili stereoizomer, naznačen time što je za uporabu u liječenju raka, tumora i/ili metastaza, po izboru u kombinaciji s radioterapijom ili najmanje jednim sredstvom protiv raka.
12. Spoj prema jednom od patentnih zahtjeva 1 do 9 i/ili njegova farmaceutski upotrebljiva sol, solvat, tautomer ili stereoizomer, naznačen time što je za uporabu u senzibilizaciji stanica karcinoma na sredstvo protiv raka i/ili ionizirajuće zračenje.
13. Farmaceutski pripravak naznačen time što sadrži učinkovitu količinu najmanje jednog spoja prema jednom od patentnih zahtjeva 1 do 9 i/ili njegovu farmaceutski upotrebljivu sol, solvat, tautomer ili stereoizomer, po izboru zajedno s najmanje jednim farmaceutski podnošljivim pomoćnim sastojkom.
14. Komplet koji se sastoji od zasebnih pakiranja
(a) učinkovite količine spoja prema jednom od patentnih zahtjeva 1 do 9 i/ili njegove farmaceutski upotrebljive soli, solvata, tautomera ili stereoizomera, i
(b) učinkovite količine sredstva protiv raka.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15000968 | 2015-04-02 | ||
| EP19172903.7A EP3560924B1 (de) | 2015-04-02 | 2016-03-31 | Imidazolonylchinoline und deren verwendung als atm-kinase-inhibitoren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20210981T1 true HRP20210981T1 (hr) | 2021-09-17 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20191396 HRP20191396T1 (hr) | 2015-04-02 | 2019-08-01 | Imidazolonilkinolini i njihova uporaba kao inhibotora atm kinaze |
| HRP20210981TT HRP20210981T1 (hr) | 2015-04-02 | 2021-06-23 | Imidazolonil kinolini i njihova uporaba kao inhibitori atm kinaze |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20191396 HRP20191396T1 (hr) | 2015-04-02 | 2019-08-01 | Imidazolonilkinolini i njihova uporaba kao inhibotora atm kinaze |
Country Status (24)
| Country | Link |
|---|---|
| US (5) | US10457677B2 (hr) |
| EP (3) | EP3868761B1 (hr) |
| JP (2) | JP6791873B2 (hr) |
| KR (2) | KR20240044525A (hr) |
| CN (3) | CN111689963A (hr) |
| AU (3) | AU2016239270B2 (hr) |
| BR (1) | BR122019005502B1 (hr) |
| CA (1) | CA2981365A1 (hr) |
| DK (2) | DK3277681T3 (hr) |
| ES (3) | ES2946507T3 (hr) |
| HR (2) | HRP20191396T1 (hr) |
| HU (2) | HUE054745T2 (hr) |
| IL (3) | IL254714B (hr) |
| LT (2) | LT3277681T (hr) |
| MX (2) | MX2017012613A (hr) |
| PL (2) | PL3560924T3 (hr) |
| PT (2) | PT3560924T (hr) |
| RS (2) | RS62082B1 (hr) |
| RU (1) | RU2743343C2 (hr) |
| SG (2) | SG10202002181UA (hr) |
| SI (2) | SI3560924T1 (hr) |
| TR (1) | TR201911244T4 (hr) |
| WO (1) | WO2016155884A1 (hr) |
| ZA (1) | ZA201707423B (hr) |
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| ES2946507T3 (es) * | 2015-04-02 | 2023-07-20 | Merck Patent Gmbh | Imidazolonilquinolinas y su uso como inhibidores de ATM cinasa |
| GB201516504D0 (en) | 2015-09-17 | 2015-11-04 | Astrazeneca Ab | Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer |
| GB201519406D0 (en) * | 2015-11-03 | 2015-12-16 | Astrazeneca Ab | Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer |
| CN110312717B (zh) * | 2017-02-27 | 2022-04-12 | 上海瑛派药业有限公司 | 取代的稠合杂芳三环化合物作为激酶抑制剂及其应用 |
| JOP20190209A1 (ar) * | 2017-03-16 | 2019-09-12 | Astrazeneca Ab | مركبات إيميدازو [ 4، 5-c ] كينولين-2-أون ديوترومية واستخدامها في علاج السرطان |
| KR20200110377A (ko) | 2018-01-12 | 2020-09-23 | 프로린크스 엘엘시 | 조합 용량의 독성을 최소화하기 위한 프로토콜 및 검증을 위한 조영제 |
| EP3765019A1 (en) | 2018-03-14 | 2021-01-20 | Merck Patent GmbH | Compounds and uses thereof to treat tumors in a subject |
| AU2019250361B2 (en) | 2018-04-12 | 2023-03-23 | Bayer Aktiengesellschaft | Heteroaryl-triazole compounds as pesticides |
| CN110386932A (zh) * | 2018-04-20 | 2019-10-29 | 艾科思莱德制药公司 | 用于抗肿瘤疗法中的双重atm和dna-pk抑制剂 |
| WO2019201283A1 (en) * | 2018-04-20 | 2019-10-24 | Xrad Therapeutics, Inc. | Dual atm and dna-pk inhibitors for use in anti-tumor therapy |
| GB201814487D0 (en) * | 2018-09-06 | 2018-10-24 | Cycle Pharmaceuticals Ltd | Cancer |
| CN109045042A (zh) * | 2018-09-21 | 2018-12-21 | 上海交通大学医学院附属上海儿童医学中心 | Atm抑制剂在制备抑制急性淋巴细胞性白血病复发的药物中的应用 |
| RU2771314C1 (ru) * | 2018-09-30 | 2022-04-29 | Медшайн Дискавери Инк. | Производные хинолинпирролидин-2-она и их применение |
| SG11202110480YA (en) | 2019-03-27 | 2021-10-28 | Merck Patent Gmbh | Imidazolonylquinoline compounds and therapeutic uses thereof |
| BR112022001067A2 (pt) * | 2019-07-30 | 2022-05-24 | Xrad Therapeutics Inc | Inibidores duplos de atm e dna-pk para uso em terapia antitumoral |
| US20230044248A1 (en) | 2019-11-01 | 2023-02-09 | Ares Trading S.A. | COMBINED INHIBITION OF PD-1, TGFBeta AND ATM TOGETHER WITH RADIOTHERAPY FOR THE TREATMENT OF CANCER |
| WO2021113506A1 (en) * | 2019-12-04 | 2021-06-10 | Chdi Foundation, Inc. | Atm kinase inhibitors and compositions and methods of use thereof |
| CN115003672A (zh) * | 2020-01-09 | 2022-09-02 | 南京明德新药研发有限公司 | 喹啉并咪唑类化合物及其应用 |
| WO2021197339A1 (zh) * | 2020-03-30 | 2021-10-07 | 南京明德新药研发有限公司 | 作为atm抑制剂的喹啉并吡咯烷-2-酮类化合物的晶型及其应用 |
| US20230226041A1 (en) * | 2020-06-18 | 2023-07-20 | Merck Patent Gmbh | Compounds for the treatment of viral infections |
| CN116194109A (zh) | 2020-06-24 | 2023-05-30 | 阿斯利康(英国)有限公司 | 抗体-药物缀合物和atm抑制剂的组合 |
| BR112023002078A2 (pt) | 2020-09-18 | 2023-03-28 | Merck Patent Gmbh | Preparação farmacêutica |
| WO2022060377A1 (en) * | 2020-09-21 | 2022-03-24 | Wei Zhong | Substituted 1-(3,3-difluoropiperidin-4-yl)-imidazo[4,5-c] quinolin-2-one compounds with blood-brain barrier penetrable capability |
| EP3992191A1 (en) | 2020-11-03 | 2022-05-04 | Deutsches Krebsforschungszentrum | Imidazo[4,5-c]quinoline compounds and their use as atm kinase inhibitors |
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