BR112022001067A2 - Inibidores duplos de atm e dna-pk para uso em terapia antitumoral - Google Patents

Inibidores duplos de atm e dna-pk para uso em terapia antitumoral

Info

Publication number
BR112022001067A2
BR112022001067A2 BR112022001067A BR112022001067A BR112022001067A2 BR 112022001067 A2 BR112022001067 A2 BR 112022001067A2 BR 112022001067 A BR112022001067 A BR 112022001067A BR 112022001067 A BR112022001067 A BR 112022001067A BR 112022001067 A2 BR112022001067 A2 BR 112022001067A2
Authority
BR
Brazil
Prior art keywords
inhibitors
dna
antitumor therapy
dual atm
atm
Prior art date
Application number
BR112022001067A
Other languages
English (en)
Inventor
Aijun Lu
David Kirsch
Guosheng Wu
Jianmin Fu
Michael Kastan
A Goodnow Robert
Shuang Zhang
Tona Gilmer
Yaode Wang
Yue Sun
Original Assignee
Xrad Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN201910695148.4A external-priority patent/CN112300159A/zh
Application filed by Xrad Therapeutics Inc filed Critical Xrad Therapeutics Inc
Publication of BR112022001067A2 publication Critical patent/BR112022001067A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

inibidores duplos de atm e dna-pk para uso em terapia antitumoral. a presente invenção refere-se a compostos da fórmula (i): e sais farmaceuticamente aceitáveis destes, onde os substituintes são conforme descritos neste documento. estes compostos e suas composições farmacêuticas podem ser úteis no tratamento de doenças oncológicas.
BR112022001067A 2019-07-30 2020-07-30 Inibidores duplos de atm e dna-pk para uso em terapia antitumoral BR112022001067A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201910695148.4A CN112300159A (zh) 2019-07-30 2019-07-30 用于抗肿瘤疗法中的双重atm和dna-pk抑制剂
US201962883325P 2019-08-06 2019-08-06
PCT/US2020/044322 WO2021022078A1 (en) 2019-07-30 2020-07-30 Dual atm and dna-pk inhibitors for use in anti-tumor therapy

Publications (1)

Publication Number Publication Date
BR112022001067A2 true BR112022001067A2 (pt) 2022-05-24

Family

ID=74229877

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022001067A BR112022001067A2 (pt) 2019-07-30 2020-07-30 Inibidores duplos de atm e dna-pk para uso em terapia antitumoral

Country Status (11)

Country Link
US (1) US20220142995A1 (pt)
EP (1) EP4003345A4 (pt)
JP (1) JP2022542285A (pt)
KR (1) KR20220047290A (pt)
CN (1) CN114258301A (pt)
AU (1) AU2020322026A1 (pt)
BR (1) BR112022001067A2 (pt)
IL (1) IL289542A (pt)
MX (1) MX2022001158A (pt)
WO (1) WO2021022078A1 (pt)
ZA (1) ZA202201499B (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4387667A1 (en) * 2021-08-17 2024-06-26 Telix Pharmaceuticals (Innovations) Pty Ltd Combination radiotherapy

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2952992C (en) * 2014-06-17 2019-05-07 Cisen Pharmaceutical Co., Ltd. Pyridino[1,2-a]pyrimidone analogue used as mtor/pi3k inhibitor
WO2016155884A1 (de) * 2015-04-02 2016-10-06 Merck Patent Gmbh Imidazolonylchinoline und deren verwendung als atm kinase inhibitoren
GB201519568D0 (en) * 2015-11-05 2015-12-23 Astrazeneca Ab Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
CN110386932A (zh) * 2018-04-20 2019-10-29 艾科思莱德制药公司 用于抗肿瘤疗法中的双重atm和dna-pk抑制剂
WO2019201283A1 (en) * 2018-04-20 2019-10-24 Xrad Therapeutics, Inc. Dual atm and dna-pk inhibitors for use in anti-tumor therapy

Also Published As

Publication number Publication date
AU2020322026A1 (en) 2022-02-03
ZA202201499B (en) 2023-11-29
EP4003345A1 (en) 2022-06-01
CN114258301A (zh) 2022-03-29
US20220142995A1 (en) 2022-05-12
EP4003345A4 (en) 2023-07-26
IL289542A (en) 2022-03-01
WO2021022078A1 (en) 2021-02-04
JP2022542285A (ja) 2022-09-30
KR20220047290A (ko) 2022-04-15
MX2022001158A (es) 2022-02-22

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