RU2731489C1 - Препарат для инъекций с замедленным высвобождением с содержанием донепезила и способ получения такого препарата - Google Patents

Препарат для инъекций с замедленным высвобождением с содержанием донепезила и способ получения такого препарата Download PDF

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Publication number
RU2731489C1
RU2731489C1 RU2019133524A RU2019133524A RU2731489C1 RU 2731489 C1 RU2731489 C1 RU 2731489C1 RU 2019133524 A RU2019133524 A RU 2019133524A RU 2019133524 A RU2019133524 A RU 2019133524A RU 2731489 C1 RU2731489 C1 RU 2731489C1
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RU
Russia
Prior art keywords
microspheres
donepezil
dispersed phase
release
preparation
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RU2019133524A
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English (en)
Russian (ru)
Inventor
Хееён ЛИ
Ынён СОЛ
Гвонхеок ЮН
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Джи2Джибио, Инк.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
RU2019133524A 2017-11-30 2018-11-30 Препарат для инъекций с замедленным высвобождением с содержанием донепезила и способ получения такого препарата RU2731489C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR10-2017-0163106 2017-11-30
KR20170163106 2017-11-30
PCT/KR2018/015119 WO2019108029A1 (ko) 2017-11-30 2018-11-30 도네페질을 함유하는 서방성 주사제제 및 그 제조방법

Publications (1)

Publication Number Publication Date
RU2731489C1 true RU2731489C1 (ru) 2020-09-03

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RU2019133524A RU2731489C1 (ru) 2017-11-30 2018-11-30 Препарат для инъекций с замедленным высвобождением с содержанием донепезила и способ получения такого препарата

Country Status (10)

Country Link
US (1) US20200101054A1 (ja)
EP (2) EP3590504A4 (ja)
JP (1) JP6905767B2 (ja)
KR (1) KR102047982B1 (ja)
CN (1) CN110582270A (ja)
AU (1) AU2018271379B2 (ja)
BR (1) BR112019021366A2 (ja)
RU (1) RU2731489C1 (ja)
WO (1) WO2019108029A1 (ja)
ZA (1) ZA201808115B (ja)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102181033B1 (ko) * 2020-03-31 2020-11-20 주식회사 휴메딕스 생분해성 고분자 미립자, 이를 포함하는 고분자 필러 및 이의 제조방법
CN112870533B (zh) * 2020-12-21 2022-06-14 科塞尔医疗科技（苏州）有限公司 载药微球制备装置
KR102451185B1 (ko) * 2021-08-05 2022-10-07 환인제약 주식회사 도네페질 함유 지속방출형 미립구
WO2023249461A1 (ko) * 2022-06-23 2023-12-28 주식회사 지투지바이오 도네페질과 파모산을 함유하는 서방성 미립구
KR20240066122A (ko) * 2022-11-07 2024-05-14 주식회사 지투지바이오 덱사메타손 아세테이트를 포함하는 서방형 주사제제 및 그 제조방법

Citations (6)

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KR20050001896A (ko) * 2003-06-26 2005-01-07 주식회사 펩트론 서방성 미립구의 혼합 제형을 연속한 단일 공정으로제조하는 방법
WO2010056065A2 (en) * 2008-11-14 2010-05-20 Ewha University-Industry Collaboration Foundation Method for preparing microspheres and microspheres produced thereby
WO2011011978A1 (zh) * 2009-07-31 2011-02-03 西安力邦医药科技有限责任公司 微球药物载体、其制备方法、组合物及应用
KR101307729B1 (ko) * 2012-11-19 2013-09-11 에스케이케미칼주식회사 초기 약물 방출이 감소된 고분자 미립자를 포함하는 주사용 조성물 및 이의 제조방법
KR101583351B1 (ko) * 2014-11-28 2016-01-07 동국제약 주식회사 초기 방출 억제 및 잔류용매 제거율을 향상시킨 서방출성 미립구 및 이의 제조방법
US20160022583A1 (en) * 2013-04-03 2016-01-28 Dongkook Pharmaceutical Co., Ltd. Pharmaceutical composition for parenteral administration, containing donepezil

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* Cited by examiner, † Cited by third party
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JP3987655B2 (ja) 1998-03-03 2007-10-10 エーザイ・アール・アンド・ディー・マネジメント株式会社 抗痴呆薬を含有した経皮適用製剤又は坐剤
KR100709015B1 (ko) * 2002-11-13 2007-04-18 (주)아모레퍼시픽 지속적 약물방출이 가능한 고분자 미립구 및 그 제조방법
CL2004001884A1 (es) * 2003-08-04 2005-06-03 Pfizer Prod Inc Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros.
CN101167697B (zh) * 2006-10-26 2011-03-30 中国科学院上海药物研究所 多奈哌齐类化合物长效缓控释组合物及其制备方法
CN107213136B (zh) * 2017-06-07 2021-06-01 广州帝奇医药技术有限公司 一种长效缓释药物制剂及其制备方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20050001896A (ko) * 2003-06-26 2005-01-07 주식회사 펩트론 서방성 미립구의 혼합 제형을 연속한 단일 공정으로제조하는 방법
WO2010056065A2 (en) * 2008-11-14 2010-05-20 Ewha University-Industry Collaboration Foundation Method for preparing microspheres and microspheres produced thereby
WO2011011978A1 (zh) * 2009-07-31 2011-02-03 西安力邦医药科技有限责任公司 微球药物载体、其制备方法、组合物及应用
KR101307729B1 (ko) * 2012-11-19 2013-09-11 에스케이케미칼주식회사 초기 약물 방출이 감소된 고분자 미립자를 포함하는 주사용 조성물 및 이의 제조방법
US20160022583A1 (en) * 2013-04-03 2016-01-28 Dongkook Pharmaceutical Co., Ltd. Pharmaceutical composition for parenteral administration, containing donepezil
KR101583351B1 (ko) * 2014-11-28 2016-01-07 동국제약 주식회사 초기 방출 억제 및 잔류용매 제거율을 향상시킨 서방출성 미립구 및 이의 제조방법

Also Published As

Publication number Publication date
EP3590504A4 (en) 2020-12-16
US20200101054A1 (en) 2020-04-02
BR112019021366A2 (pt) 2020-05-05
KR20190064526A (ko) 2019-06-10
AU2018271379B2 (en) 2020-03-05
ZA201808115B (en) 2019-08-28
EP3590504A1 (en) 2020-01-08
CN110582270A (zh) 2019-12-17
KR102047982B1 (ko) 2019-11-22
JP2020524171A (ja) 2020-08-13
WO2019108029A1 (ko) 2019-06-06
EP4119132A1 (en) 2023-01-18
JP6905767B2 (ja) 2021-07-21
AU2018271379A1 (en) 2019-06-13

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