RU2704619C2 - Композиции для модулирования экспрессии sod-1 - Google Patents

Композиции для модулирования экспрессии sod-1 Download PDF

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Publication number
RU2704619C2
RU2704619C2 RU2016142532A RU2016142532A RU2704619C2 RU 2704619 C2 RU2704619 C2 RU 2704619C2 RU 2016142532 A RU2016142532 A RU 2016142532A RU 2016142532 A RU2016142532 A RU 2016142532A RU 2704619 C2 RU2704619 C2 RU 2704619C2
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sod
antisense compound
isis
modified
pharmaceutically acceptable
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RU2016142532A
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Russian (ru)
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RU2016142532A (ru
RU2016142532A3 (OSRAM
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Эрик Э. СВЭЙЗ
Трэйси КОУЛ
Холли КОРДАСИЕВИЦ
Сьюзан М. Фрэйер
Томас П. КОНДОН
Эдвард ВАНЧЕВИЦ
Триша ЛОКХАРТ
Тимоти ВИКЕРС
Приям СИНГХ
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Биоген Ма Инк.
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • C12Y115/01—Oxidoreductases acting on superoxide as acceptor (1.15) with NAD or NADP as acceptor (1.15.1)
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    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
RU2016142532A 2014-04-01 2015-04-01 Композиции для модулирования экспрессии sod-1 RU2704619C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461973803P 2014-04-01 2014-04-01
US61/973,803 2014-04-01
PCT/US2015/023934 WO2015153800A2 (en) 2014-04-01 2015-04-01 Compositions for modulating sod-1 expression

Publications (3)

Publication Number Publication Date
RU2016142532A RU2016142532A (ru) 2018-05-10
RU2016142532A3 RU2016142532A3 (OSRAM) 2018-12-03
RU2704619C2 true RU2704619C2 (ru) 2019-10-30

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US (3) US10385341B2 (OSRAM)
EP (3) EP3126499B1 (OSRAM)
JP (5) JP6622214B2 (OSRAM)
KR (6) KR20230085222A (OSRAM)
CN (2) CN106459972B (OSRAM)
AU (4) AU2015240761B2 (OSRAM)
BR (1) BR112016021848B1 (OSRAM)
CA (1) CA2942394A1 (OSRAM)
CL (3) CL2016002509A1 (OSRAM)
CY (1) CY1123288T1 (OSRAM)
DK (2) DK3757214T3 (OSRAM)
ES (2) ES2926869T3 (OSRAM)
FI (1) FIC20240035I1 (OSRAM)
FR (1) FR24C1039I2 (OSRAM)
HR (2) HRP20201078T1 (OSRAM)
HU (3) HUE050704T2 (OSRAM)
IL (2) IL247714B (OSRAM)
LT (3) LT3126499T (OSRAM)
MX (2) MX373908B (OSRAM)
MY (2) MY175665A (OSRAM)
NL (1) NL301293I2 (OSRAM)
NZ (1) NZ724100A (OSRAM)
PL (2) PL3757214T3 (OSRAM)
PT (2) PT3757214T (OSRAM)
RS (2) RS63487B1 (OSRAM)
RU (1) RU2704619C2 (OSRAM)
SG (3) SG11201608109TA (OSRAM)
SI (2) SI3757214T1 (OSRAM)
SM (2) SMT202200479T1 (OSRAM)
WO (1) WO2015153800A2 (OSRAM)

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TWI841633B (zh) * 2018-11-21 2024-05-11 美商Ionis製藥公司 用於減少朊病毒表現之化合物及方法
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JP2025522433A (ja) 2022-06-15 2025-07-15 アローヘッド ファーマシューティカルズ インコーポレイテッド スーパーオキシドジスムターゼ１（ＳＯＤ１）の発現を阻害するためのＲＮＡｉ剤、その組成物、及び使用の方法
KR20240038469A (ko) 2022-09-16 2024-03-25 김정훈 사용자 콘텐츠 기반 홍보 서비스 제공 장치 및 방법
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