MA55891A - Synthèses en phase liquide convergente d'oligonucléotides - Google Patents

Synthèses en phase liquide convergente d'oligonucléotides

Info

Publication number
MA55891A
MA55891A MA055891A MA55891A MA55891A MA 55891 A MA55891 A MA 55891A MA 055891 A MA055891 A MA 055891A MA 55891 A MA55891 A MA 55891A MA 55891 A MA55891 A MA 55891A
Authority
MA
Morocco
Prior art keywords
oligonucleotides
liquid phase
phase syntheses
convergent
convergent liquid
Prior art date
Application number
MA055891A
Other languages
English (en)
Inventor
Firoz Antia
Yannick Fillon
Robert S Gronke
Takuya Hamagaki
Taisuke Ichimaru
Hong Jiang
William F Kiesman
Hien Nguyen
Xianglin Shi
Daisuke Takahashi
Wuming Yan
Xuan Zhou
Original Assignee
Ajinomoto Kk
Biogen Ma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Kk, Biogen Ma Inc filed Critical Ajinomoto Kk
Publication of MA55891A publication Critical patent/MA55891A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MA055891A 2019-05-08 2020-05-08 Synthèses en phase liquide convergente d'oligonucléotides MA55891A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201962845160P 2019-05-08 2019-05-08

Publications (1)

Publication Number Publication Date
MA55891A true MA55891A (fr) 2022-03-16

Family

ID=70919104

Family Applications (1)

Application Number Title Priority Date Filing Date
MA055891A MA55891A (fr) 2019-05-08 2020-05-08 Synthèses en phase liquide convergente d'oligonucléotides

Country Status (13)

Country Link
US (1) US20220348602A1 (fr)
EP (1) EP3966219A2 (fr)
JP (1) JP2022531876A (fr)
KR (1) KR20220007104A (fr)
CN (1) CN114206897A (fr)
AU (1) AU2020268415A1 (fr)
BR (1) BR112021022219A2 (fr)
CA (1) CA3139545A1 (fr)
EA (1) EA202193010A1 (fr)
IL (1) IL287798A (fr)
MA (1) MA55891A (fr)
MX (1) MX2021013587A (fr)
WO (1) WO2020227618A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013203395A1 (en) 2012-03-30 2013-10-17 Isis Pharmaceuticals, Inc. Compositions and methods for modulating TAU expression for reducing seizure and modifying a neurodegenerative syndrome
WO2022103842A1 (fr) 2020-11-11 2022-05-19 Biogen Ma Inc. Oligonucléotides, réactifs et préparation associée
AU2022314802A1 (en) * 2021-07-23 2024-02-08 Biogen Ma Inc. Methods for reducing tau expression
WO2024083746A1 (fr) 2022-10-17 2024-04-25 Bachem Holding Ag Procédé et composition pour la synthèse d'oligonucléotides
JP7433684B1 (ja) 2023-05-24 2024-02-20 塩野フィネス株式会社 疑似固相保護基、それを用いたヌクレオシド保護体又はオリゴヌクレオチド保護体、オリゴアミダイト前駆体の製造方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0558749A1 (fr) * 1990-11-20 1993-09-08 Sankyo Company Limited Derives d'acide nucleique non codant
US5510476A (en) * 1994-07-07 1996-04-23 Isis Pharmaceuticals, Inc. Carbocation scavenging during oligonucleotide synthesis
SI2548560T1 (sl) 2005-06-23 2015-12-31 Isis Pharmaceuticals, Inc. Sestavki in postopki za moduliranje izrezovanja smn2
HUE046966T2 (hu) 2009-06-17 2020-04-28 Biogen Ma Inc Készítmények és módszerek az SMN2 splicing egy alanynál történõ modulálására
DK2711370T3 (en) * 2011-05-17 2018-02-26 Ajinomoto Kk PROCEDURE FOR THE PREPARATION OF OLIGONUCLEOTIDES
JP6237237B2 (ja) * 2012-02-17 2017-11-29 味の素株式会社 塩基部保護オリゴヌクレオチド
US8846885B2 (en) * 2012-02-17 2014-09-30 Ajinomoto Co., Inc. Oligonucleotide with protected base
IN2014DN10144A (fr) * 2012-05-30 2015-08-21 Hokkaido System Science Co Ltd
EP4137573A3 (fr) 2014-04-01 2023-05-03 Biogen MA Inc. Compositions pour moduler l'expression de sod-1
JP7027889B2 (ja) * 2015-12-16 2022-03-02 味の素株式会社 オリゴヌクレオチドの製造方法、およびヌクレオシド、ヌクレオチドまたはオリゴヌクレオチド
JPWO2017111137A1 (ja) * 2015-12-22 2018-10-18 味の素株式会社 オリゴヌクレオチドの製造方法

Also Published As

Publication number Publication date
WO2020227618A8 (fr) 2020-12-24
US20220348602A1 (en) 2022-11-03
IL287798A (en) 2022-01-01
MX2021013587A (es) 2022-02-11
EA202193010A1 (ru) 2022-03-18
WO2020227618A3 (fr) 2021-01-14
AU2020268415A8 (en) 2022-01-20
JP2022531876A (ja) 2022-07-12
EP3966219A2 (fr) 2022-03-16
CA3139545A1 (fr) 2020-11-12
AU2020268415A1 (en) 2021-12-23
BR112021022219A2 (pt) 2022-03-22
KR20220007104A (ko) 2022-01-18
WO2020227618A2 (fr) 2020-11-12
CN114206897A (zh) 2022-03-18

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