EA202193010A1 - Конвергентные жидкофазные синтезы олигонуклеотидов - Google Patents

Конвергентные жидкофазные синтезы олигонуклеотидов

Info

Publication number
EA202193010A1
EA202193010A1 EA202193010A EA202193010A EA202193010A1 EA 202193010 A1 EA202193010 A1 EA 202193010A1 EA 202193010 A EA202193010 A EA 202193010A EA 202193010 A EA202193010 A EA 202193010A EA 202193010 A1 EA202193010 A1 EA 202193010A1
Authority
EA
Eurasian Patent Office
Prior art keywords
oligonucleotides
phase synthesis
convergent
convergent liquid
liquid
Prior art date
Application number
EA202193010A
Other languages
English (en)
Inventor
Сянлинь Ши
Уильям Ф. Кисман
Фироз Антиа
Янник Филлон
Сюань ЧЖОУ
Умин Янь
Хун Цзянь
Хиен Нгуен
Роберт С. Гронке
Таисуке Ичимару
Такуя Хамагаки
Дайсуке Такахаши
Original Assignee
Байоджен Ма Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Байоджен Ма Инк. filed Critical Байоджен Ма Инк.
Publication of EA202193010A1 publication Critical patent/EA202193010A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical

Abstract

В изобретении описан конвергентный жидкофазный способ производства олигонуклеотидов путем связывания двух или более олигонуклеотидных фрагментов, каждый из которых имеет два или более нуклеотида. Изобретением также предусмотрены стадии реакции, вовлеченные в конвергентный жидкофазный способ.
EA202193010A 2019-05-08 2020-05-08 Конвергентные жидкофазные синтезы олигонуклеотидов EA202193010A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962845160P 2019-05-08 2019-05-08
PCT/US2020/032070 WO2020227618A2 (en) 2019-05-08 2020-05-08 Convergent liquid phase syntheses of oligonucleotides

Publications (1)

Publication Number Publication Date
EA202193010A1 true EA202193010A1 (ru) 2022-03-18

Family

ID=70919104

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202193010A EA202193010A1 (ru) 2019-05-08 2020-05-08 Конвергентные жидкофазные синтезы олигонуклеотидов

Country Status (13)

Country Link
US (1) US20220348602A1 (ru)
EP (1) EP3966219A2 (ru)
JP (1) JP2022531876A (ru)
KR (1) KR20220007104A (ru)
CN (1) CN114206897A (ru)
AU (1) AU2020268415A1 (ru)
BR (1) BR112021022219A2 (ru)
CA (1) CA3139545A1 (ru)
EA (1) EA202193010A1 (ru)
IL (1) IL287798A (ru)
MA (1) MA55891A (ru)
MX (1) MX2021013587A (ru)
WO (1) WO2020227618A2 (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6492003B2 (ja) 2012-03-30 2019-03-27 ワシントン・ユニバーシティＷａｓｈｉｎｇｔｏｎ Ｕｎｉｖｅｒｓｉｔｙ 発作を減少させるためおよび神経変性症候群を改質するためにタウ発現を調節する方法
KR20230106665A (ko) 2020-11-11 2023-07-13 바이오젠 엠에이 인코포레이티드 올리고뉴클레오티드, 시약, 및 그의 제조 방법
CA3227412A1 (en) * 2021-07-23 2023-01-26 Biogen Ma Inc. Methods for reducing tau expression
JP7433684B1 (ja) 2023-05-24 2024-02-20 塩野フィネス株式会社 疑似固相保護基、それを用いたヌクレオシド保護体又はオリゴヌクレオチド保護体、オリゴアミダイト前駆体の製造方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992008729A1 (fr) * 1990-11-20 1992-05-29 Sankyo Company, Limited Derives d'acide nucleique non codant
US5510476A (en) * 1994-07-07 1996-04-23 Isis Pharmaceuticals, Inc. Carbocation scavenging during oligonucleotide synthesis
ES2397113T3 (es) 2005-06-23 2013-03-04 Isis Pharmaceuticals, Inc. Composiciones y procedimientos para modular el corte y empalme de SMN2
EP3305302B1 (en) 2009-06-17 2018-09-19 Biogen MA Inc. Compositions and methods for modulation of smn2 splicing in a subject
US9029528B2 (en) * 2011-05-17 2015-05-12 Ajinomoto Co., Inc. Solution-based method of making oligonucleotides via phosphoramidite coupling
US8846885B2 (en) * 2012-02-17 2014-09-30 Ajinomoto Co., Inc. Oligonucleotide with protected base
EP3296306B1 (en) * 2012-02-17 2022-11-09 Ajinomoto Co., Inc. Base-protected oligonucleotide
WO2013179412A1 (ja) * 2012-05-30 2013-12-05 北海道システム・サイエンス株式会社 高分散性液相支持体を用いたオリゴヌクレオチド合成法
KR20220077933A (ko) 2014-04-01 2022-06-09 바이오젠 엠에이 인코포레이티드 Sod-1 발현을 조절하기 위한 조성물
JP7027889B2 (ja) * 2015-12-16 2022-03-02 味の素株式会社 オリゴヌクレオチドの製造方法、およびヌクレオシド、ヌクレオチドまたはオリゴヌクレオチド
WO2017111137A1 (ja) * 2015-12-22 2017-06-29 味の素株式会社 オリゴヌクレオチドの製造方法

Also Published As

Publication number Publication date
AU2020268415A8 (en) 2022-01-20
EP3966219A2 (en) 2022-03-16
CN114206897A (zh) 2022-03-18
WO2020227618A2 (en) 2020-11-12
CA3139545A1 (en) 2020-11-12
KR20220007104A (ko) 2022-01-18
MX2021013587A (es) 2022-02-11
WO2020227618A3 (en) 2021-01-14
US20220348602A1 (en) 2022-11-03
BR112021022219A2 (pt) 2022-03-22
WO2020227618A8 (en) 2020-12-24
IL287798A (en) 2022-01-01
JP2022531876A (ja) 2022-07-12
MA55891A (fr) 2022-03-16
AU2020268415A1 (en) 2021-12-23

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