|
US3720760A
(en)
|
1968-09-06 |
1973-03-13 |
Pharmacia Ab |
Method for determining the presence of reagin-immunoglobulins(reagin-ig)directed against certain allergens,in aqueous samples
|
|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
JPS6023084B2
(ja)
|
1979-07-11 |
1985-06-05 |
味の素株式会社 |
代用血液
|
|
US4640835A
(en)
|
1981-10-30 |
1987-02-03 |
Nippon Chemiphar Company, Ltd. |
Plasminogen activator derivatives
|
|
EP0092918B1
(en)
|
1982-04-22 |
1988-10-19 |
Imperial Chemical Industries Plc |
Continuous release formulations
|
|
NZ207394A
(en)
|
1983-03-08 |
1987-03-06 |
Commw Serum Lab Commission |
Detecting or determining sequence of amino acids
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4496689A
(en)
|
1983-12-27 |
1985-01-29 |
Miles Laboratories, Inc. |
Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
|
|
US5128326A
(en)
|
1984-12-06 |
1992-07-07 |
Biomatrix, Inc. |
Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same
|
|
US4737456A
(en)
|
1985-05-09 |
1988-04-12 |
Syntex (U.S.A.) Inc. |
Reducing interference in ligand-receptor binding assays
|
|
DE3675588D1
(de)
|
1985-06-19 |
1990-12-20 |
Ajinomoto Kk |
Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
|
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
|
US4791192A
(en)
|
1986-06-26 |
1988-12-13 |
Takeda Chemical Industries, Ltd. |
Chemically modified protein with polyethyleneglycol
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US5260203A
(en)
|
1986-09-02 |
1993-11-09 |
Enzon, Inc. |
Single polypeptide chain binding molecules
|
|
IL85035A0
(en)
|
1987-01-08 |
1988-06-30 |
Int Genetic Eng |
Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
|
|
DE3883899T3
(de)
|
1987-03-18 |
1999-04-22 |
Sb2, Inc., Danville, Calif. |
Geänderte antikörper.
|
|
US5258498A
(en)
|
1987-05-21 |
1993-11-02 |
Creative Biomolecules, Inc. |
Polypeptide linkers for production of biosynthetic proteins
|
|
DE3853515T3
(de)
|
1987-05-21 |
2005-08-25 |
Micromet Ag |
Multifunktionelle proteine mit vorbestimmter zielsetzung.
|
|
US5336603A
(en)
|
1987-10-02 |
1994-08-09 |
Genentech, Inc. |
CD4 adheson variants
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
KR900005995A
(ko)
|
1988-10-31 |
1990-05-07 |
우메모또 요시마사 |
변형 인터류킨-2 및 그의 제조방법
|
|
EP0394827A1
(en)
|
1989-04-26 |
1990-10-31 |
F. Hoffmann-La Roche Ag |
Chimaeric CD4-immunoglobulin polypeptides
|
|
US5112946A
(en)
|
1989-07-06 |
1992-05-12 |
Repligen Corporation |
Modified pf4 compositions and methods of use
|
|
WO1991005548A1
(en)
|
1989-10-10 |
1991-05-02 |
Pitman-Moore, Inc. |
Sustained release composition for macromolecular proteins
|
|
WO1991006570A1
(en)
|
1989-10-25 |
1991-05-16 |
The University Of Melbourne |
HYBRID Fc RECEPTOR MOLECULES
|
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
EP0550436A1
(en)
|
1989-11-06 |
1993-07-14 |
Alkermes Controlled Therapeutics, Inc. |
Protein microspheres and methods of using them
|
|
US6075181A
(en)
|
1990-01-12 |
2000-06-13 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US6150584A
(en)
|
1990-01-12 |
2000-11-21 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US5349053A
(en)
|
1990-06-01 |
1994-09-20 |
Protein Design Labs, Inc. |
Chimeric ligand/immunoglobulin molecules and their uses
|
|
WO1992009690A2
(en)
|
1990-12-03 |
1992-06-11 |
Genentech, Inc. |
Enrichment method for variant proteins with altered binding properties
|
|
WO1992010591A1
(en)
|
1990-12-14 |
1992-06-25 |
Cell Genesys, Inc. |
Chimeric chains for receptor-associated signal transduction pathways
|
|
US5571894A
(en)
|
1991-02-05 |
1996-11-05 |
Ciba-Geigy Corporation |
Recombinant antibodies specific for a growth factor receptor
|
|
US6800738B1
(en)
|
1991-06-14 |
2004-10-05 |
Genentech, Inc. |
Method for making humanized antibodies
|
|
WO1994004679A1
(en)
|
1991-06-14 |
1994-03-03 |
Genentech, Inc. |
Method for making humanized antibodies
|
|
AU675916B2
(en)
|
1991-06-14 |
1997-02-27 |
Genentech Inc. |
Method for making humanized antibodies
|
|
US5844095A
(en)
|
1991-06-27 |
1998-12-01 |
Bristol-Myers Squibb Company |
CTLA4 Ig fusion proteins
|
|
DE69229477T2
(de)
|
1991-09-23 |
1999-12-09 |
Cambridge Antibody Technology Ltd., Melbourn |
Methoden zur Herstellung humanisierter Antikörper
|
|
ES2136092T3
(es)
|
1991-09-23 |
1999-11-16 |
Medical Res Council |
Procedimientos para la produccion de anticuerpos humanizados.
|
|
FI941572L
(fi)
|
1991-10-07 |
1994-05-27 |
Oncologix Inc |
Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä
|
|
NL9101953A
(nl)
|
1991-11-21 |
1993-06-16 |
Seed Capital Investments |
Testinrichting omvattende een plaat met een veelvoud van putjes met een bijbehorende doseerinrichting, alsmede een kit die deze inrichtingen omvat en toepassing van de inrichtingen.
|
|
ATE297465T1
(de)
|
1991-11-25 |
2005-06-15 |
Enzon Inc |
Verfahren zur herstellung von multivalenten antigenbindenden proteinen
|
|
US5869619A
(en)
|
1991-12-13 |
1999-02-09 |
Xoma Corporation |
Modified antibody variable domains
|
|
EP0571613B1
(en)
|
1991-12-13 |
2003-09-17 |
Xoma Corporation |
Methods and materials for preparation of modified antibody variable domains and therapeutic uses thereof
|
|
US5622929A
(en)
|
1992-01-23 |
1997-04-22 |
Bristol-Myers Squibb Company |
Thioether conjugates
|
|
WO1993016185A2
(en)
|
1992-02-06 |
1993-08-19 |
Creative Biomolecules, Inc. |
Biosynthetic binding protein for cancer marker
|
|
US5912015A
(en)
|
1992-03-12 |
1999-06-15 |
Alkermes Controlled Therapeutics, Inc. |
Modulated release from biocompatible polymers
|
|
US5447851B1
(en)
|
1992-04-02 |
1999-07-06 |
Univ Texas System Board Of |
Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells
|
|
DK0672142T3
(da)
|
1992-12-04 |
2001-06-18 |
Medical Res Council |
Multivalente og multispecifikke bindingsproteiner samt fremstilling og anvendelse af disse
|
|
GB9225453D0
(en)
|
1992-12-04 |
1993-01-27 |
Medical Res Council |
Binding proteins
|
|
US5827690A
(en)
|
1993-12-20 |
1998-10-27 |
Genzyme Transgenics Corporatiion |
Transgenic production of antibodies in milk
|
|
US5834252A
(en)
|
1995-04-18 |
1998-11-10 |
Glaxo Group Limited |
End-complementary polymerase reaction
|
|
US5605793A
(en)
|
1994-02-17 |
1997-02-25 |
Affymax Technologies N.V. |
Methods for in vitro recombination
|
|
US5837458A
(en)
|
1994-02-17 |
1998-11-17 |
Maxygen, Inc. |
Methods and compositions for cellular and metabolic engineering
|
|
GB9415379D0
(en)
|
1994-07-29 |
1994-09-21 |
Smithkline Beecham Plc |
Novel compounds
|
|
JPH10503371A
(ja)
|
1994-07-29 |
1998-03-31 |
スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー |
新規化合物
|
|
JPH10511957A
(ja)
|
1995-01-05 |
1998-11-17 |
ザ ボード オブ リージェンツ オブ ザ ユニヴァーシティ オブ ミシガン |
表面改質ナノ微粒子並びにその製造及び使用方法
|
|
US6030613A
(en)
|
1995-01-17 |
2000-02-29 |
The Brigham And Women's Hospital, Inc. |
Receptor specific transepithelial transport of therapeutics
|
|
ATE238668T1
(de)
|
1995-01-17 |
2003-05-15 |
Brigham & Womens Hospital |
Rezeptorspezifischer transepithelialer transport von immunogenen
|
|
US5739277A
(en)
|
1995-04-14 |
1998-04-14 |
Genentech Inc. |
Altered polypeptides with increased half-life
|
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
WO1997007788A2
(en)
|
1995-08-31 |
1997-03-06 |
Alkermes Controlled Therapeutics, Inc. |
Composition for sustained release of an agent
|
|
US5723125A
(en)
|
1995-12-28 |
1998-03-03 |
Tanox Biosystems, Inc. |
Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide
|
|
WO1997033899A1
(en)
|
1996-03-14 |
1997-09-18 |
Human Genome Sciences, Inc. |
Apoptosis inducing molecule i
|
|
JP4046354B2
(ja)
|
1996-03-18 |
2008-02-13 |
ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム |
増大した半減期を有する免疫グロブリン様ドメイン
|
|
WO1997034911A1
(en)
|
1996-03-22 |
1997-09-25 |
Human Genome Sciences, Inc. |
Apoptosis inducing molecule ii
|
|
CN1167795C
(zh)
|
1996-12-26 |
2004-09-22 |
协和发酵工业株式会社 |
肽、dna及抗体
|
|
GB9701425D0
(en)
|
1997-01-24 |
1997-03-12 |
Bioinvent Int Ab |
A method for in vitro molecular evolution of protein function
|
|
US20020012961A1
(en)
|
1999-04-15 |
2002-01-31 |
Genentech, Inc. |
Fibroblast growth factor- 19
|
|
US20020042367A1
(en)
|
1997-11-25 |
2002-04-11 |
Genentech, Inc. |
Fibroblast growth factor-19 (FGF-19) nucleic acids and polypeptides and methods of use for the treatment of obesity and related disorders
|
|
US20060246540A1
(en)
|
1997-08-26 |
2006-11-02 |
Ashkenazi Avi J |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
|
|
KR100502596B1
(ko)
|
1997-09-17 |
2005-07-22 |
제넨테크, 인크. |
분비 폴리펩티드와 막횡단 폴리펩티드 및 이들을 코딩하는핵산
|
|
US20030113718A1
(en)
|
1997-09-17 |
2003-06-19 |
Genentech, Inc. |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
|
|
US20030082540A1
(en)
|
1997-09-17 |
2003-05-01 |
Genentech, Inc. |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
|
|
US6806352B2
(en)
|
1997-09-17 |
2004-10-19 |
Genentech, Inc. |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
|
|
US5989463A
(en)
|
1997-09-24 |
1999-11-23 |
Alkermes Controlled Therapeutics, Inc. |
Methods for fabricating polymer-based controlled release devices
|
|
SE512663C2
(sv)
|
1997-10-23 |
2000-04-17 |
Biogram Ab |
Inkapslingsförfarande för aktiv substans i en bionedbrytbar polymer
|
|
WO1999023105A1
(en)
|
1997-11-03 |
1999-05-14 |
Human Genome Sciences, Inc. |
Vegi, an inhibitor of angiogenesis and tumor growth
|
|
US20050026832A1
(en)
|
1997-11-25 |
2005-02-03 |
Genentech, Inc. |
Fibroblast growth factor-19 (FGF-19) nucleic acids and polypeptides and methods of use for the treatment of obesity and related disorders
|
|
US20040126852A1
(en)
|
1997-11-25 |
2004-07-01 |
Genentech, Inc. |
Fibroblast growth factor-19 (FGF-19) nucleic acids and polypeptides and methods of use for the treatment of obesity
|
|
US20020155543A1
(en)
|
1997-11-25 |
2002-10-24 |
Genentech, Inc. |
Fibroblast growth factor-19 (FGF-19) nucleic acids and polypeptides and methods of use for the treatment of obesity and related disorders
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
AU3369999A
(en)
|
1998-04-02 |
1999-10-25 |
Genentech Inc. |
Antibody variants and fragments thereof
|
|
US20030185846A1
(en)
|
1998-09-16 |
2003-10-02 |
Genentech, Inc. |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
|
|
NZ539776A
(en)
|
1999-01-15 |
2006-12-22 |
Genentech Inc |
Polypeptide variants with altered effector function
|
|
US6737056B1
(en)
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
US7183387B1
(en)
|
1999-01-15 |
2007-02-27 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
AU3924300A
(en)
|
1999-04-02 |
2000-10-23 |
Millennium Pharmaceuticals, Inc. |
Fibroblast growth factor-20
|
|
US7390879B2
(en)
|
1999-06-15 |
2008-06-24 |
Genentech, Inc. |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
|
|
US7129072B1
(en)
|
1999-08-30 |
2006-10-31 |
New York University |
Crystal of fibroblast growth factor receptor 1 in complex with fibroblast growth factor
|
|
JP2001072607A
(ja)
|
1999-09-03 |
2001-03-21 |
Kyowa Hakko Kogyo Co Ltd |
新規血管内皮機能改善法
|
|
US7459540B1
(en)
|
1999-09-07 |
2008-12-02 |
Amgen Inc. |
Fibroblast growth factor-like polypeptides
|
|
AU7368100A
(en)
|
1999-09-10 |
2001-04-10 |
Curagen Corporation |
Fibroblast growth factor polypeptide and nucleic acids encoding same
|
|
US6797695B1
(en)
|
1999-10-22 |
2004-09-28 |
Kyoto University |
Human FGF-20 gene and gene expression products
|
|
CA2392103A1
(en)
|
1999-11-18 |
2001-05-25 |
Chiron Corporation |
Human fgf-21 gene and gene expression products
|
|
US6716626B1
(en)
|
1999-11-18 |
2004-04-06 |
Chiron Corporation |
Human FGF-21 nucleic acids
|
|
WO2001038529A1
(fr)
|
1999-11-19 |
2001-05-31 |
Kyowa Hakko Kogyo Co., Ltd. |
Nouveau polypeptide, nouvel adn, nouvel anticorps et nouvel animal transgenique
|
|
DE10160151A1
(de)
|
2001-01-09 |
2003-06-26 |
Ribopharma Ag |
Verfahren zur Hemmung der Expression eines vorgegebenen Zielgens
|
|
EP1246843A1
(en)
|
2000-01-05 |
2002-10-09 |
ZymoGenetics, Inc. |
Novel fgf homolog zfgf12
|
|
AU2631001A
(en)
|
2000-01-05 |
2001-07-16 |
Zymogenetics Inc. |
Novel fgf homolog zfgf11
|
|
US20020081663A1
(en)
|
2000-01-05 |
2002-06-27 |
Conklin Darrell C. |
Novel FGF homolog ZFGF11
|
|
US20010044525A1
(en)
|
2000-01-05 |
2001-11-22 |
Conklin Darrell C. |
Novel FGF Homolog zFGF12
|
|
US20060160181A1
(en)
|
2000-02-15 |
2006-07-20 |
Amgen Inc. |
Fibroblast Growth Factor-23 molecules and uses thereof
|
|
EP1257645A2
(en)
|
2000-02-15 |
2002-11-20 |
Amgen Inc. |
Fibroblast growth factor-23 molecules and uses thereof
|
|
JP2003531583A
(ja)
|
2000-03-08 |
2003-10-28 |
カイロン コーポレイション |
ヒトfgf−23遺伝子および遺伝子発現産物
|
|
AU2001245535A1
(en)
|
2000-03-08 |
2001-09-17 |
Chiron Corporation |
Human fgf-23 gene and gene expression products
|
|
US20020001825A1
(en)
|
2000-03-31 |
2002-01-03 |
Nobuyuki Itoh |
Fibroblast growth factor-like molecules and uses thereof
|
|
US20030065140A1
(en)
|
2000-04-03 |
2003-04-03 |
Vernet Corine A.M. |
Novel proteins and nucleic acids encoding same
|
|
JP2002112772A
(ja)
|
2000-07-10 |
2002-04-16 |
Takeda Chem Ind Ltd |
新規ポリペプチドおよびそのdna
|
|
DE60141582D1
(de)
|
2000-07-19 |
2010-04-29 |
Advanced Res & Tech Inst |
Neuer fibroblastwachstumsfaktor (fgf23) und methoden zur verwendung
|
|
EP1309685A2
(en)
|
2000-07-20 |
2003-05-14 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
|
|
US6812339B1
(en)
|
2000-09-08 |
2004-11-02 |
Applera Corporation |
Polymorphisms in known genes associated with human disease, methods of detection and uses thereof
|
|
US20070037165A1
(en)
|
2000-09-08 |
2007-02-15 |
Applera Corporation |
Polymorphisms in known genes associated with human disease, methods of detection and uses thereof
|
|
US7265210B2
(en)
|
2000-09-15 |
2007-09-04 |
Genentech, Inc. |
Anti-PRO9821 antibodies
|
|
EP1197755A1
(en)
|
2000-10-11 |
2002-04-17 |
Pepscan Systems B.V. |
Identification of protein binding sites
|
|
US7537902B2
(en)
|
2000-10-24 |
2009-05-26 |
Emory University |
Methods and kits using a molecular interaction between a Smurf-1 WW domain and LIM mineralization protein isoforms
|
|
IL139380A0
(en)
|
2000-10-31 |
2001-11-25 |
Prochon Biotech Ltd |
Active variants of fibroblast growth factor
|
|
US20030045489A1
(en)
|
2000-11-22 |
2003-03-06 |
Murphy John E. |
Methods for modulating angiogenesis
|
|
US20020151496A1
(en)
|
2000-12-08 |
2002-10-17 |
Bringmann Peter W. |
Novel fibroblast growth factors
|
|
DE10100588A1
(de)
|
2001-01-09 |
2002-07-18 |
Ribopharma Ag |
Verfahren zur Hemmung der Expression eines Zielgens
|
|
DE10100587C1
(de)
|
2001-01-09 |
2002-11-21 |
Ribopharma Ag |
Verfahren zur Hemmung der Expression eines Zielgens
|
|
US20030125521A1
(en)
|
2001-06-20 |
2003-07-03 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
|
|
WO2003029456A1
(en)
|
2001-10-01 |
2003-04-10 |
Dyax Corp. |
Multi-chain eukaryotic display vectors and uses thereof
|
|
US20040005709A1
(en)
|
2001-10-24 |
2004-01-08 |
Hoogenboom Henricus Renerus Jacobus Mattheus |
Hybridization control of sequence variation
|
|
WO2003080803A2
(en)
|
2002-03-21 |
2003-10-02 |
Smithkline Beecham Corporation |
Methods of using farnesoid x receptor (fxr) agonists
|
|
US6987121B2
(en)
|
2002-04-25 |
2006-01-17 |
Smithkline Beecham Corporation |
Compositions and methods for hepatoprotection and treatment of cholestasis
|
|
JP2003334088A
(ja)
|
2002-05-22 |
2003-11-25 |
Pharma Design Inc |
ヒト由来の新規Klotho様タンパク質及びその遺伝子
|
|
NZ556507A
(en)
|
2002-06-03 |
2010-03-26 |
Genentech Inc |
Synthetic antibody phage libraries
|
|
AU2003243400B2
(en)
|
2002-06-07 |
2009-10-29 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
|
EP1545584A4
(en)
|
2002-09-18 |
2007-04-04 |
Lilly Co Eli |
METHOD FOR REDUCING MORBIDITY AND MORTALITY OF CRITICAL SICK PATIENTS
|
|
US20050181375A1
(en)
|
2003-01-10 |
2005-08-18 |
Natasha Aziz |
Novel methods of diagnosis of metastatic cancer, compositions and methods of screening for modulators of metastatic cancer
|
|
PL1641483T3
(pl)
|
2003-06-12 |
2008-07-31 |
Lilly Co Eli |
Białka fuzyjne
|
|
WO2005044853A2
(en)
|
2003-11-01 |
2005-05-19 |
Genentech, Inc. |
Anti-vegf antibodies
|
|
CN1890371A
(zh)
|
2003-12-10 |
2007-01-03 |
伊莱利利公司 |
成纤维细胞生长因子的21突变蛋白
|
|
ES2332100T3
(es)
|
2004-05-13 |
2010-01-26 |
Eli Lilly And Company |
Proteinas de fusion del fgf-21.
|
|
JP2006016323A
(ja)
|
2004-06-30 |
2006-01-19 |
Hiroshima Industrial Promotion Organization |
生理活性バイオマテリアル
|
|
AU2005283025B2
(en)
|
2004-09-02 |
2011-06-30 |
Eli Lilly And Company |
Muteins of fibroblast growth factor 21
|
|
EP1789443A1
(en)
|
2004-09-02 |
2007-05-30 |
Eli Lilly And Company |
Muteins of fibroblast growth factor 21
|
|
EP1817335A2
(en)
|
2004-10-29 |
2007-08-15 |
Genentech, Inc. |
Disruptions of genes encoding secreted proteins, compositions and methods relating thereto
|
|
US20060134663A1
(en)
|
2004-11-03 |
2006-06-22 |
Paul Harkin |
Transcriptome microarray technology and methods of using the same
|
|
JP2006158339A
(ja)
|
2004-12-09 |
2006-06-22 |
Kyoto Univ |
βKlotho遺伝子、Cyp7a1遺伝子、及びそれらの利用
|
|
JP2008522617A
(ja)
|
2004-12-14 |
2008-07-03 |
イーライ リリー アンド カンパニー |
線維芽細胞成長因子21の突然変異タンパク質
|
|
US20060275794A1
(en)
|
2005-03-07 |
2006-12-07 |
Invitrogen Corporation |
Collections of matched biological reagents and methods for identifying matched reagents
|
|
WO2007014123A2
(en)
|
2005-07-22 |
2007-02-01 |
Five Prime Therapeutics, Inc. |
Compositions and methods of treating disease with fgfr fusion proteins
|
|
US7612181B2
(en)
|
2005-08-19 |
2009-11-03 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
|
CA2620082A1
(en)
|
2005-08-24 |
2007-03-01 |
Genizon Biosciences Inc. |
Genemap of the human genes associated with crohn's disease
|
|
US20090312265A1
(en)
|
2006-02-10 |
2009-12-17 |
Dermagen Ab |
Novel antimicrobial peptides and use thereof
|
|
US8168169B2
(en)
|
2006-08-09 |
2012-05-01 |
Mclean Hospital Corporation |
Methods and compositions for the treatment of medical disorders
|
|
JP2010502946A
(ja)
|
2006-09-01 |
2010-01-28 |
アメリカン タイプ カルチャー コレクション |
2型糖尿病を診断および処置するための組成物および方法
|
|
US8394927B2
(en)
|
2006-11-03 |
2013-03-12 |
U3 Pharma Gmbh |
FGFR4 antibodies
|
|
EP2457997B1
(en)
|
2007-01-03 |
2016-08-31 |
NeoStem Oncology, LLC |
Stem cell growth media and methods of making and using same
|
|
EP2068909B1
(en)
|
2007-03-30 |
2012-04-25 |
Ambrx, Inc. |
Modified fgf-21 polypeptides and their uses
|
|
ES2422605T3
(es)
|
2007-04-02 |
2013-09-12 |
Genentech Inc |
Anticuerpo contra klotho-beta para utilizar en el tratamiento de tumores, cáncer o trastornos proliferativos celulares
|
|
WO2008123625A1
(ja)
|
2007-04-06 |
2008-10-16 |
National Institute Of Advanced Industrial Science And Technology |
補助因子による受容体の活性化方法並びにリガンド活性の利用方法
|
|
US10555963B2
(en)
|
2007-05-08 |
2020-02-11 |
Tel Hashomer Medical Research Infrastructure And Services Ltd. |
Klotho protein and related compounds for the treatment and diagnosis of cancer
|
|
EP2152295B1
(en)
|
2007-05-08 |
2018-04-18 |
Tel HaShomer Medical Research Infrastructure and Services Ltd. |
Klotho protein and related compounds for the treatment of cancer
|
|
EP2036539A1
(en)
|
2007-09-11 |
2009-03-18 |
Novo Nordisk A/S |
Stable formulations of amylin and its analogues
|
|
WO2009076478A2
(en)
|
2007-12-10 |
2009-06-18 |
The Johns Hopkins University |
Hypomethylated genes in cancer
|
|
EP2080812A1
(en)
|
2008-01-18 |
2009-07-22 |
Transmedi SA |
Compositions and methods of detecting post-stop peptides
|
|
US8420088B2
(en)
|
2008-01-28 |
2013-04-16 |
Novartis Ag |
Methods and compositions using FGF23 fusion polypeptides
|
|
TW200936156A
(en)
|
2008-01-28 |
2009-09-01 |
Novartis Ag |
Methods and compositions using Klotho-FGF fusion polypeptides
|
|
US20090226459A1
(en)
|
2008-01-29 |
2009-09-10 |
Cold Spring Harbor Laboratory |
Role of fgf-19 in cancer diagnosis and treatment
|
|
NZ579566A
(en)
|
2008-03-19 |
2013-01-25 |
Ambrx Inc |
Modified fgf-21 polypeptides and their uses
|
|
US20110015345A1
(en)
|
2008-03-19 |
2011-01-20 |
Ambrx, Inc. |
Modified FGF-23 Polypeptides and Their Uses
|
|
US20110107439A1
(en)
|
2008-03-21 |
2011-05-05 |
Podiceps B.V. |
Diagnostic of pre-symptomatic metabolic syndrome
|
|
JOP20190083A1
(ar)
|
2008-06-04 |
2017-06-16 |
Amgen Inc |
بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها
|
|
FR2933702A1
(fr)
|
2008-07-08 |
2010-01-15 |
Sanofi Aventis |
Antagonistes specifiques du recepteur fgf-r4
|
|
WO2010006214A1
(en)
|
2008-07-09 |
2010-01-14 |
Ambrx, Inc. |
Fgf-21 neutralizing antibodies and their uses
|
|
WO2010017198A2
(en)
|
2008-08-04 |
2010-02-11 |
Five Prime Therapeutics, Inc. |
Fgfr extracellular domain acidic region muteins
|
|
EA032727B1
(ru)
|
2008-10-10 |
2019-07-31 |
Амген Инк. |
Мутантный резистентный к протеолизу полипептид fgf21 и его применение
|
|
WO2010065439A1
(en)
|
2008-12-05 |
2010-06-10 |
Eli Lilly And Company |
Variants of fibroblast growth factor 21
|
|
WO2010080976A1
(en)
|
2009-01-09 |
2010-07-15 |
Sdg, Inc. (An Ohio Corporation) |
Insulin therapies for the treatment of diabetes, diabetes related ailments, and/or diseases or conditions other than diabetes or diabetes related ailments
|
|
WO2010083051A2
(en)
|
2009-01-15 |
2010-07-22 |
ProChon Biotech, Ltd. |
Cartilage particle tissue mixtures optionally combined with a cancellous construct
|
|
CN108530543B
(zh)
|
2009-02-03 |
2023-06-23 |
阿穆尼克斯制药公司 |
延伸重组多肽和包含该延伸重组多肽的组合物
|
|
EP2427207B1
(en)
|
2009-05-05 |
2017-08-16 |
Amgen, Inc |
Fgf21 mutants and uses thereof
|
|
MY156542A
(en)
|
2009-05-05 |
2016-02-26 |
Amgen Inc |
Fgf21 mutants and uses thereof
|
|
US8461111B2
(en)
|
2009-05-20 |
2013-06-11 |
Florida State University Research Foundation |
Fibroblast growth factor mutants having improved functional half-life and methods of their use
|
|
US20120076729A1
(en)
|
2009-06-04 |
2012-03-29 |
Novartis Ag |
Methods of treating cancers
|
|
WO2010142665A1
(en)
|
2009-06-11 |
2010-12-16 |
Novo Nordisk A/S |
Glp-1 and fgf21 combinations for treatment of diabetes type 2
|
|
JP2012530493A
(ja)
|
2009-06-17 |
2012-12-06 |
アムジエン・インコーポレーテツド |
キメラポリペプチドおよびその使用
|
|
CN101993485B
(zh)
|
2009-08-20 |
2013-04-17 |
重庆富进生物医药有限公司 |
促胰岛素分泌肽类似物同源二聚体及其用途
|
|
US8535912B2
(en)
|
2009-10-15 |
2013-09-17 |
Genentech, Inc. |
Chimeric fibroblast growth factors with altered receptor specificity
|
|
US8889621B2
(en)
|
2009-10-30 |
2014-11-18 |
New York University |
Inhibiting binding of FGF23 to the binary FGFR-Klotho complex for the treatment of hypophosphatemia
|
|
SG177025A1
(en)
*
|
2010-06-21 |
2012-01-30 |
Agency Science Tech & Res |
Hepatitis b virus specific antibody and uses thereof
|
|
WO2011068893A1
(en)
|
2009-12-02 |
2011-06-09 |
Amgen Inc. |
BINDING PROTEINS THAT BIND TO HUMAN FGFR1C, HUMAN β-KLOTHO AND BOTH HUMAN FGFR1C AND HUMANβ-KLOTHO
|
|
US20110312881A1
(en)
|
2009-12-21 |
2011-12-22 |
Amunix, Inc. |
Bifunctional polypeptide compositions and methods for treatment of metabolic and cardiovascular diseases
|
|
EP2460527A1
(en)
|
2010-01-21 |
2012-06-06 |
Sanofi |
Pharmaceutical composition for treating a metabolic syndrome
|
|
US20110195077A1
(en)
|
2010-01-29 |
2011-08-11 |
Novartis Ag |
Methods and compositions using fgf23 fusion ppolypeptides
|
|
WO2011130417A2
(en)
|
2010-04-15 |
2011-10-20 |
Amgen Inc. |
HUMAN FGF RECEPTOR AND β-KLOTHO BINDING PROTEINS
|
|
JP5767314B2
(ja)
|
2010-04-16 |
2015-08-19 |
ソーク インスティチュート フォー バイオロジカル スタディーズ |
Fgfを用いて代謝障害を処置するための方法
|
|
JP2013533227A
(ja)
|
2010-06-08 |
2013-08-22 |
ノヴォ ノルディスク アー/エス |
Fgf21類似体および誘導体
|
|
WO2012010553A1
(en)
|
2010-07-20 |
2012-01-26 |
Novo Nordisk A/S |
N-terminal modified fgf21 compounds
|
|
RU2013115747A
(ru)
|
2010-09-09 |
2014-10-20 |
ТРИФОЙЛИУМ АпС |
Введение антиангиогенных агентов в дыхательные пути
|
|
US8993727B2
(en)
|
2010-09-22 |
2015-03-31 |
Amgen Inc. |
Carrier immunoglobulins and uses thereof
|
|
CN102464712A
(zh)
|
2010-11-11 |
2012-05-23 |
重庆富进生物医药有限公司 |
缺失型人成纤维细胞生长因子21变异体及其偶联物
|
|
US9023791B2
(en)
|
2010-11-19 |
2015-05-05 |
Novartis Ag |
Fibroblast growth factor 21 mutations
|
|
US8975223B2
(en)
|
2010-12-22 |
2015-03-10 |
Marcadia Biotech, Inc. |
Methods for treating metabolic disorders and obesity with a peptide comprising the amino acid sequence of SEQ ID No. 146
|
|
WO2012086809A1
(ja)
|
2010-12-24 |
2012-06-28 |
独立行政法人産業技術総合研究所 |
ヒトfgf19活性の正確で高感度な測定方法ならびにヒトfgf19活性の制御剤
|
|
WO2012138919A2
(en)
|
2011-04-08 |
2012-10-11 |
Amgen Inc. |
Method of treating or ameliorating metabolic disorders using growth differentiation factor 15 (gdf-15)
|
|
WO2012140650A2
(en)
|
2011-04-12 |
2012-10-18 |
Hepacore Ltd. |
Conjugates of carboxy polysaccharides with fibroblast growth factors and variants thereof
|
|
WO2012154263A1
(en)
|
2011-05-10 |
2012-11-15 |
Amgen Inc. |
Method of identifying compounds that specifically modulate the interaction of fgfr1 and beta-klotho
|
|
EP2710035B1
(en)
|
2011-05-16 |
2017-04-12 |
F. Hoffmann-La Roche AG |
Fgfr1 agonists and methods of use
|
|
EP2718486A4
(en)
|
2011-06-08 |
2014-12-31 |
Denovo Biopharma Hangzhou Ltd Co |
METHODS AND COMPOSITIONS FOR PREDICTING THE ACTIVITY OF A RETINOID RECEPTOR X MODULATOR
|
|
EP2723391B1
(en)
|
2011-06-24 |
2018-06-13 |
University of Miami |
Fibroblast growth factor receptor inhibition for the treatment of disease
|
|
CA2835607C
(en)
|
2011-07-01 |
2021-07-20 |
Ngm Biopharmaceuticals, Inc. |
Compositions, uses and methods for treatment of metabolic disorders and diseases
|
|
EP2548570A1
(en)
|
2011-07-19 |
2013-01-23 |
Sanofi |
Pharmaceutical composition for treating a metabolic syndrome
|
|
WO2013027191A1
(en)
|
2011-08-25 |
2013-02-28 |
Novartis Ag |
Methods and compositions using fgf23 fusion polypeptides
|
|
JP2014526441A
(ja)
|
2011-08-31 |
2014-10-06 |
アムジエン・インコーポレーテツド |
1型糖尿病の治療における使用のためのfgf21
|
|
UY34347A
(es)
|
2011-09-26 |
2013-04-30 |
Novartis Ag |
Proteínas de función dual para tratar trastornos metabólicos
|
|
UY34346A
(es)
|
2011-09-26 |
2013-04-30 |
Novartis Ag |
Proteínas de fusión para tratar trastornos metabólicos
|
|
AR087973A1
(es)
|
2011-10-04 |
2014-04-30 |
Lilly Co Eli |
Variantes del factor 21 del crecimiento de fibroblastos
|
|
PH12014500932A1
(en)
|
2011-11-11 |
2014-06-09 |
Rinat Neuroscience Corp |
Antibodies specific for trop-2 and their uses
|
|
KR20140119114A
(ko)
|
2012-01-18 |
2014-10-08 |
제넨테크, 인크. |
Fgf19 조절제의 사용 방법
|
|
WO2013131091A1
(en)
|
2012-03-02 |
2013-09-06 |
New York University |
Chimeric fgf21 proteins with enhanced binding affinity for beta-klotho for the treatment of type ii diabetes, obesity and related metabolic disorders
|
|
JP2013194049A
(ja)
|
2012-03-23 |
2013-09-30 |
Kazuo Todokoro |
ヒト造血幹細胞を増幅させるための組成物及び方法
|
|
AU2013243955B2
(en)
|
2012-04-02 |
2018-02-22 |
Modernatx, Inc. |
Modified polynucleotides for the production of oncology-related proteins and peptides
|
|
US9771567B2
(en)
|
2012-04-16 |
2017-09-26 |
Tel Hashomer Medical Research Infrastructure And Services Ltd. |
Klotho variant polypeptides
|
|
MA37506B1
(fr)
|
2012-05-15 |
2017-03-31 |
Lilly Co Eli |
Utilisations thérapeutiques de protéines de facteur de croissance des fibroblastes 21
|
|
US9464126B2
(en)
|
2012-06-07 |
2016-10-11 |
New York University |
Chimeric fibroblast growth factor 21 proteins and methods of use
|
|
US9657075B2
(en)
|
2012-06-07 |
2017-05-23 |
New York University |
Chimeric fibroblast growth factor 23 proteins and methods of use
|
|
US9474785B2
(en)
|
2012-06-07 |
2016-10-25 |
New York University |
Chimeric fibroblast growth factor 19 proteins and methods of use
|
|
EA201492064A1
(ru)
|
2012-06-11 |
2015-02-27 |
Эли Лилли Энд Компани |
Варианты фактора роста фибробластов 21
|
|
TWI513705B
(zh)
|
2012-06-11 |
2015-12-21 |
Lilly Co Eli |
纖維母細胞生長因子21蛋白質
|
|
RU2019102203A
(ru)
|
2012-07-11 |
2019-03-05 |
Блюпринт Медсинс Корпорейшн |
Ингибиторы рецептора фактора роста фибробластов
|
|
AR092076A1
(es)
|
2012-08-22 |
2015-03-18 |
Lilly Co Eli |
Proteinas homodimericas
|
|
CA2880929A1
(en)
|
2012-09-07 |
2014-03-13 |
Sanofi |
Fusion proteins for treating a metabolic syndrome
|
|
US9290557B2
(en)
|
2012-11-28 |
2016-03-22 |
Ngm Biopharmaceuticals, Inc. |
Compositions comprising variants and fusions of FGF19 polypeptides
|
|
AU2013352363B2
(en)
|
2012-11-28 |
2018-04-12 |
Ngm Biopharmaceuticals, Inc. |
Compositions and methods for treatment of metabolic disorders and diseases
|
|
US9925242B2
(en)
|
2012-12-27 |
2018-03-27 |
Ngm Biopharmaceuticals, Inc. |
Methods of using compositions comprising variants and fusions of FGF19 polypeptides for treatment of nonalcoholic steatohepatitis
|
|
US9273107B2
(en)
|
2012-12-27 |
2016-03-01 |
Ngm Biopharmaceuticals, Inc. |
Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
|
|
WO2014130659A1
(en)
|
2013-02-22 |
2014-08-28 |
New York University |
Chimeric fibroblast growth factor 23 proteins and methods of use
|
|
WO2014152090A1
(en)
|
2013-03-14 |
2014-09-25 |
Georgetown University |
Compositions and treatments of metabolic disorders using fgf binding protein 3 and fgf 19
|
|
WO2014149699A1
(en)
|
2013-03-15 |
2014-09-25 |
Eli Lilly And Company |
Bifunctional protein
|
|
WO2015061361A1
(en)
|
2013-10-21 |
2015-04-30 |
Salk Institute For Biological Studies |
Mutated fibroblast growth factor (fgf) 1 and methods of use
|
|
JP6560202B2
(ja)
|
2013-10-28 |
2019-08-21 |
エヌジーエム バイオファーマシューティカルス,インコーポレーテッド |
癌モデル及び関連方法
|
|
TWI728373B
(zh)
|
2013-12-23 |
2021-05-21 |
美商建南德克公司 |
抗體及使用方法
|
|
EP3738981A1
(en)
|
2014-01-24 |
2020-11-18 |
NGM Biopharmaceuticals, Inc. |
Antibodies binding beta klotho domain 2 and methods of use thereof
|
|
US10398758B2
(en)
|
2014-05-28 |
2019-09-03 |
Ngm Biopharmaceuticals, Inc. |
Compositions comprising variants of FGF19 polypeptides and uses thereof for the treatment of hyperglycemic conditions
|
|
AU2015277438B2
(en)
|
2014-06-16 |
2020-02-27 |
Ngm Biopharmaceuticals, Inc. |
Methods and uses for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
|
|
SG11201702757YA
(en)
|
2014-10-23 |
2017-05-30 |
Ngm Biopharmaceuticals Inc |
Pharmaceutical compositions comprising peptide variants and methods of use thereof
|
|
US10434144B2
(en)
|
2014-11-07 |
2019-10-08 |
Ngm Biopharmaceuticals, Inc. |
Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders
|
|
US10800843B2
(en)
|
2015-07-29 |
2020-10-13 |
Ngm Biopharmaceuticals, Inc. |
Beta klotho-binding proteins
|
|
ES2871036T3
(es)
|
2015-11-09 |
2021-10-28 |
Ngm Biopharmaceuticals Inc |
Método para el tratamiento de trastornos relacionados con ácidos biliares
|
|
AU2017315459B2
(en)
|
2016-08-26 |
2023-06-29 |
Ngm Biopharmaceuticals, Inc. |
Methods of treating fibroblast growth factor 19-mediated cancers and tumors
|
|
EP3503906A4
(en)
|
2016-08-29 |
2020-04-08 |
NGM Biopharmaceuticals, Inc. |
METHODS FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH BILAR ACIDS
|