RU2699285C2 - Одноцепочечные белки-агонисты trail-рецептора - Google Patents

Одноцепочечные белки-агонисты trail-рецептора Download PDF

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RU2699285C2
RU2699285C2 RU2016145608A RU2016145608A RU2699285C2 RU 2699285 C2 RU2699285 C2 RU 2699285C2 RU 2016145608 A RU2016145608 A RU 2016145608A RU 2016145608 A RU2016145608 A RU 2016145608A RU 2699285 C2 RU2699285 C2 RU 2699285C2
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trail
seq
cell
receptor agonist
domain
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RU2016145608A
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RU2016145608A3 (enExample
RU2016145608A (ru
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Оливер ХИЛЛ
Кристиан ГИФФЕРС
Майнольф Тиманн
Фриц Г. БЬЮКАНАН
Даррен К. ФИЛЛИПС
Сьюзан Э. ЛЭПП
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Эббви Инк.
Апогеникс Аг
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
RU2016145608A 2014-04-23 2015-04-23 Одноцепочечные белки-агонисты trail-рецептора RU2699285C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461983152P 2014-04-23 2014-04-23
US61/983,152 2014-04-23
PCT/US2015/027270 WO2015164588A1 (en) 2014-04-23 2015-04-23 Single-chain trail-receptor agonist proteins

Publications (3)

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RU2016145608A RU2016145608A (ru) 2018-05-28
RU2016145608A3 RU2016145608A3 (enExample) 2018-12-26
RU2699285C2 true RU2699285C2 (ru) 2019-09-04

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EP (2) EP3366699A1 (enExample)
JP (2) JP6523331B2 (enExample)
KR (2) KR20190135546A (enExample)
CN (2) CN106459221B (enExample)
AR (1) AR100168A1 (enExample)
AU (3) AU2015249649B2 (enExample)
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RU (1) RU2699285C2 (enExample)
SG (3) SG10201806465TA (enExample)
SI (1) SI3134430T1 (enExample)
SM (1) SMT201800286T1 (enExample)
TR (1) TR201806912T4 (enExample)
TW (2) TWI683825B (enExample)
UA (1) UA118286C2 (enExample)
UY (1) UY36095A (enExample)
WO (1) WO2015164588A1 (enExample)

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EP3292143B1 (en) * 2015-05-04 2019-08-21 Apogenix AG Single-chain cd40-receptor agonist proteins
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WO2017068192A1 (en) 2015-10-23 2017-04-27 Apogenix Ag Single-chain cd27-receptor agonist proteins
WO2017068180A1 (en) * 2015-10-23 2017-04-27 Apogenix Ag Single-chain light receptor agonist proteins
WO2017102010A1 (en) * 2015-12-17 2017-06-22 Biontech Rna Pharmaceuticals Gmbh Novel cytokine fusion proteins
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US10501744B2 (en) 2016-05-04 2019-12-10 Indiana University Research And Technology Corporation Presentation of bioactive proteins
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
JP2019517570A (ja) * 2016-06-13 2019-06-24 メリマック ファーマシューティカルズ インコーポレーティッド Ｔｒａｉｌベースの治療剤または細胞死受容体アゴニストを用いて患者を選択および治療する方法
EP3360898A1 (en) 2017-02-14 2018-08-15 Boehringer Ingelheim International GmbH Bispecific anti-tnf-related apoptosis-inducing ligand receptor 2 and anti-cadherin 17 binding molecules for the treatment of cancer
CN111050784B (zh) * 2017-08-11 2024-03-19 伊利诺伊大学理事会 截短的豚鼠l-天冬酰胺酶变体及其使用方法
TW202003553A (zh) 2018-03-15 2020-01-16 美商艾伯維有限公司 用於治療癌症之abbv-621與抗癌劑之組合
TW202002952A (zh) 2018-03-15 2020-01-16 美商艾伯維有限公司 用於治療胰臟癌之abbv-621與抗癌劑之組合
EP4149964A2 (en) 2020-05-15 2023-03-22 Apogenix AG Multi-specific immune modulators
AU2022281108A1 (en) 2021-05-28 2023-12-14 Julius-Maximilians-Universität Würzburg Recombinant proteinaceous binding molecules
WO2023088876A1 (en) 2021-11-16 2023-05-25 Apogenix Ag Multi-specific immune modulators

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IL272612A (en) 2020-03-31
HRP20180950T1 (hr) 2018-08-10
IL248244B (en) 2020-03-31
AU2015249649B2 (en) 2018-10-04
EP3134430B1 (en) 2018-03-21
BR112016024515B1 (pt) 2020-03-31
JP6523331B2 (ja) 2019-05-29
HUE038914T2 (hu) 2018-12-28
RU2016145608A3 (enExample) 2018-12-26
DOP2016000284A (es) 2017-02-15
PE20170299A1 (es) 2017-05-06
SMT201800286T1 (it) 2018-07-17
SI3134430T1 (en) 2018-05-31
CA2946402A1 (en) 2015-10-29
LT3134430T (lt) 2018-05-10
EP3366699A1 (en) 2018-08-29
CA3184067A1 (en) 2015-10-29
CN106459221A (zh) 2017-02-22
TWI683825B (zh) 2020-02-01
PT3134430T (pt) 2018-04-20
US20240174731A1 (en) 2024-05-30
US20210040178A1 (en) 2021-02-11
US20150337027A1 (en) 2015-11-26
PH12016502079A1 (en) 2016-12-19
MA39770A (fr) 2015-10-29
RU2016145608A (ru) 2018-05-28
AR100168A1 (es) 2016-09-14
MY181986A (en) 2021-01-18
CN106459221B (zh) 2020-09-01
KR20170012257A (ko) 2017-02-02
NZ725476A (en) 2023-09-29
CR20160516A (es) 2017-05-10
PH12020500377A1 (en) 2022-11-14
UA118286C2 (uk) 2018-12-26
UY36095A (es) 2015-10-30
JP6714751B2 (ja) 2020-06-24
AU2020202247A1 (en) 2020-04-23
TWI747178B (zh) 2021-11-21
US9908927B2 (en) 2018-03-06
NO2776305T3 (enExample) 2018-01-27
MX2019013587A (es) 2020-01-13
SG11201608767XA (en) 2016-11-29
US20250145688A1 (en) 2025-05-08
BR112016024515A2 (pt) 2017-10-10
KR20190135546A (ko) 2019-12-06
IL248244A0 (en) 2016-11-30
SG10201806465TA (en) 2018-08-30
KR102079919B1 (ko) 2020-02-24
CL2016002683A1 (es) 2017-07-07
AU2018271369B2 (en) 2020-01-02
CN111718424A (zh) 2020-09-29
TW202024123A (zh) 2020-07-01
PH12016502079B1 (en) 2016-12-19
EP3134430A1 (en) 2017-03-01
ECSP16089579A (es) 2018-05-31
AU2015249649A1 (en) 2016-11-10
CY1120281T1 (el) 2019-07-10
US20180222962A1 (en) 2018-08-09
TR201806912T4 (tr) 2018-06-21
PL3134430T3 (pl) 2018-08-31
JP2019162114A (ja) 2019-09-26
SG10202111785VA (en) 2021-12-30
DK3134430T3 (en) 2018-05-22
TW201620928A (zh) 2016-06-16
WO2015164588A1 (en) 2015-10-29
AU2018271369A1 (en) 2018-12-20
MX2016013858A (es) 2017-08-02
MA45069A (fr) 2019-04-03
ES2672368T3 (es) 2018-06-14
CA2946402C (en) 2023-02-28
RS57153B1 (sr) 2018-07-31
JP2017513503A (ja) 2017-06-01

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