MA45069A - Protéines agonistes du récepteur trail monocaténaires - Google Patents

Protéines agonistes du récepteur trail monocaténaires

Info

Publication number
MA45069A
MA45069A MA045069A MA45069A MA45069A MA 45069 A MA45069 A MA 45069A MA 045069 A MA045069 A MA 045069A MA 45069 A MA45069 A MA 45069A MA 45069 A MA45069 A MA 45069A
Authority
MA
Morocco
Prior art keywords
catenary
agonist proteins
trail
receiver agonist
trail receiver
Prior art date
Application number
MA045069A
Other languages
English (en)
Inventor
Fritz G Buchanan
Christian Gieffers
Oliver Hill
Susan E Lappe
Darren C Phillips
Meinolf Thiemann
Original Assignee
Abbvie Inc
Apogenix Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc, Apogenix Ag filed Critical Abbvie Inc
Publication of MA45069A publication Critical patent/MA45069A/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
MA045069A 2014-04-23 2015-04-23 Protéines agonistes du récepteur trail monocaténaires MA45069A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201461983152P 2014-04-23 2014-04-23

Publications (1)

Publication Number Publication Date
MA45069A true MA45069A (fr) 2019-04-03

Family

ID=53055121

Family Applications (2)

Application Number Title Priority Date Filing Date
MA039770A MA39770A (fr) 2014-04-23 2015-04-23 Protéines agonistes du récepteur trail monocaténaires
MA045069A MA45069A (fr) 2014-04-23 2015-04-23 Protéines agonistes du récepteur trail monocaténaires

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MA039770A MA39770A (fr) 2014-04-23 2015-04-23 Protéines agonistes du récepteur trail monocaténaires

Country Status (38)

Country Link
US (5) US9908927B2 (fr)
EP (2) EP3366699A1 (fr)
JP (2) JP6523331B2 (fr)
KR (2) KR20190135546A (fr)
CN (2) CN106459221B (fr)
AR (1) AR100168A1 (fr)
AU (3) AU2015249649B2 (fr)
BR (1) BR112016024515B1 (fr)
CA (2) CA2946402C (fr)
CL (1) CL2016002683A1 (fr)
CR (1) CR20160516A (fr)
CY (1) CY1120281T1 (fr)
DK (1) DK3134430T3 (fr)
DO (1) DOP2016000284A (fr)
EC (1) ECSP16089579A (fr)
ES (1) ES2672368T3 (fr)
HR (1) HRP20180950T1 (fr)
HU (1) HUE038914T2 (fr)
IL (2) IL248244B (fr)
LT (1) LT3134430T (fr)
MA (2) MA39770A (fr)
MX (2) MX2016013858A (fr)
MY (1) MY181986A (fr)
NO (1) NO2776305T3 (fr)
PE (1) PE20170299A1 (fr)
PH (2) PH12020500377A1 (fr)
PL (1) PL3134430T3 (fr)
PT (1) PT3134430T (fr)
RS (1) RS57153B1 (fr)
RU (1) RU2699285C2 (fr)
SG (3) SG10201806465TA (fr)
SI (1) SI3134430T1 (fr)
SM (1) SMT201800286T1 (fr)
TR (1) TR201806912T4 (fr)
TW (2) TWI683825B (fr)
UA (1) UA118286C2 (fr)
UY (1) UY36095A (fr)
WO (1) WO2015164588A1 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3292143B1 (fr) * 2015-05-04 2019-08-21 Apogenix AG Protéines agonistes du récepteur cd40 à chaîne unique
JP6959229B2 (ja) * 2015-10-23 2021-11-02 アポジェニックス アーゲー 一本鎖gitr受容体アゴニストタンパク質
WO2017068192A1 (fr) 2015-10-23 2017-04-27 Apogenix Ag Protéines agonistes du récepteur cd27 à chaîne unique
WO2017068180A1 (fr) * 2015-10-23 2017-04-27 Apogenix Ag Protéines agonistes du récepteur light à chaîne unique
WO2017102010A1 (fr) * 2015-12-17 2017-06-22 Biontech Rna Pharmaceuticals Gmbh Nouvelles protéines de fusion à cytokine
CN109153711B (zh) * 2016-03-01 2022-04-26 伊利诺伊大学理事会 具有降低的l-谷氨酰胺酶活性和增强的稳定性的l-天冬酰胺酶变体和融合蛋白
WO2017161173A1 (fr) * 2016-03-16 2017-09-21 Merrimack Pharmaceuticals, Inc. Molécule trail modifiée pour la thérapie du cancer
US10501744B2 (en) 2016-05-04 2019-12-10 Indiana University Research And Technology Corporation Presentation of bioactive proteins
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Hdac抑制劑與pd-l1抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
JP2019517570A (ja) * 2016-06-13 2019-06-24 メリマック ファーマシューティカルズ インコーポレーティッド Trailベースの治療剤または細胞死受容体アゴニストを用いて患者を選択および治療する方法
EP3360898A1 (fr) 2017-02-14 2018-08-15 Boehringer Ingelheim International GmbH Molécules bispécifiques présentant une immunoréactivité par rapport à tnf-related apoptosis-inducing ligand receptor 2 et à cadherin 17 pour le traitement du cancer
CN111050784B (zh) * 2017-08-11 2024-03-19 伊利诺伊大学理事会 截短的豚鼠l-天冬酰胺酶变体及其使用方法
TW202003553A (zh) 2018-03-15 2020-01-16 美商艾伯維有限公司 用於治療癌症之abbv-621與抗癌劑之組合
TW202002952A (zh) 2018-03-15 2020-01-16 美商艾伯維有限公司 用於治療胰臟癌之abbv-621與抗癌劑之組合
EP4149964A2 (fr) 2020-05-15 2023-03-22 Apogenix AG Modulateurs immunitaires multi-spécifiques
AU2022281108A1 (en) 2021-05-28 2023-12-14 Julius-Maximilians-Universität Würzburg Recombinant proteinaceous binding molecules
WO2023088876A1 (fr) 2021-11-16 2023-05-25 Apogenix Ag Modulateurs immunitaires multi-spécifiques

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001025277A1 (fr) 1999-10-07 2001-04-12 Maxygen Aps Polypeptides antagonistes a chaine unique
DE19963859A1 (de) 1999-12-30 2001-07-12 Apotech Res & Dev Ltd Bi- oder Oligomer eines Di-, Tri-, Quattro- oder Pentamers von rekombinanten Fusionsproteinen
CA2314199A1 (fr) 2000-07-21 2002-01-21 Robert Simoneau Puce c
UA93662C2 (uk) * 2000-12-07 2011-03-10 Эли Лилли Энд Компани Гетерологічний пептидильований глюкагон-подібний білок та його застосування для виготовлення лікарського засобу для лікування пацієнтів, що страждають на ожиріння або інсулінонезалежний цукровий діабет
US7317091B2 (en) 2002-03-01 2008-01-08 Xencor, Inc. Optimized Fc variants
WO2003091447A2 (fr) 2002-04-26 2003-11-06 California Institute Of Technology Acides nucleiques d1-1, polypeptides et methodes associees
DE102004014983A1 (de) 2004-03-26 2005-10-20 Univ Stuttgart Rekombinante Polypeptide der Mitglieder der TNF Ligandenfamilie und deren Verwendung
US20060188498A1 (en) * 2005-02-18 2006-08-24 Genentech, Inc. Methods of using death receptor agonists and EGFR inhibitors
MX2007010484A (es) 2005-04-15 2007-10-15 Rappaport Family Inst For Res Moleculas y metodos para usarlas para tratar enfermedades asociadas con mcp-1/ccr2.
WO2006116260A2 (fr) 2005-04-26 2006-11-02 Medimmune, Inc. Modulation de la fonction d'effecteur d'anticorps par ingenierie de domaine 'charniere'
EP1894940A1 (fr) 2006-08-28 2008-03-05 Apogenix GmbH Protéines de fusion de la superfamille TNF
CA2692802C (fr) 2007-07-10 2017-05-30 Oliver Hill Proteines de fusion collectines de la superfamille des tnf
JP2011523853A (ja) 2008-06-03 2011-08-25 アボット・ラボラトリーズ 二重可変ドメイン免疫グロブリン及びその使用
ES2571879T3 (es) 2008-07-21 2016-05-27 Apogenix Ag Moléculas de una sola cadena de TNFSF
US20110287001A1 (en) 2008-09-22 2011-11-24 Tetralogic Pharmaceuticals Method of treatment
EP2379585A2 (fr) * 2008-10-10 2011-10-26 Anaphore, Inc. Polypeptides qui se lient à trail-ri et trail-r2
JP5844158B2 (ja) 2009-01-09 2016-01-13 アポゲニクス ゲゼルシャフト ミット ベシュレンクテル ハフツングApogenix GmbH 三量体形成融合タンパク質
WO2010085682A2 (fr) * 2009-01-23 2010-07-29 Biogen Idec Ma Inc. Polypeptides fc stabilisés avec une fonction effectrice réduite et procédés d'utilisation
JP2013514795A (ja) * 2009-12-22 2013-05-02 ノバルティス アーゲー 治療における使用のための四価cd47抗体定常領域融合タンパク質
ES2755398T3 (es) 2010-04-13 2020-04-22 Medimmune Llc Andamios multiméricos específicos de TRAIL R2
EP2793947B1 (fr) * 2011-12-23 2021-02-03 Innate Pharma Conjugaison enzymatique de polypeptides
HK1207095A1 (en) 2012-07-18 2016-01-22 阿珀吉尼科斯股份公司 Composition comprising a mixture of cd95-fc isoforms

Also Published As

Publication number Publication date
IL272612A (en) 2020-03-31
HRP20180950T1 (hr) 2018-08-10
IL248244B (en) 2020-03-31
AU2015249649B2 (en) 2018-10-04
EP3134430B1 (fr) 2018-03-21
BR112016024515B1 (pt) 2020-03-31
JP6523331B2 (ja) 2019-05-29
HUE038914T2 (hu) 2018-12-28
RU2016145608A3 (fr) 2018-12-26
DOP2016000284A (es) 2017-02-15
PE20170299A1 (es) 2017-05-06
SMT201800286T1 (it) 2018-07-17
SI3134430T1 (en) 2018-05-31
CA2946402A1 (fr) 2015-10-29
LT3134430T (lt) 2018-05-10
EP3366699A1 (fr) 2018-08-29
CA3184067A1 (fr) 2015-10-29
CN106459221A (zh) 2017-02-22
TWI683825B (zh) 2020-02-01
PT3134430T (pt) 2018-04-20
US20240174731A1 (en) 2024-05-30
US20210040178A1 (en) 2021-02-11
US20150337027A1 (en) 2015-11-26
PH12016502079A1 (en) 2016-12-19
MA39770A (fr) 2015-10-29
RU2016145608A (ru) 2018-05-28
AR100168A1 (es) 2016-09-14
MY181986A (en) 2021-01-18
CN106459221B (zh) 2020-09-01
KR20170012257A (ko) 2017-02-02
NZ725476A (en) 2023-09-29
CR20160516A (es) 2017-05-10
PH12020500377A1 (en) 2022-11-14
UA118286C2 (uk) 2018-12-26
UY36095A (es) 2015-10-30
JP6714751B2 (ja) 2020-06-24
AU2020202247A1 (en) 2020-04-23
TWI747178B (zh) 2021-11-21
US9908927B2 (en) 2018-03-06
NO2776305T3 (fr) 2018-01-27
MX2019013587A (es) 2020-01-13
SG11201608767XA (en) 2016-11-29
US20250145688A1 (en) 2025-05-08
BR112016024515A2 (pt) 2017-10-10
KR20190135546A (ko) 2019-12-06
IL248244A0 (en) 2016-11-30
SG10201806465TA (en) 2018-08-30
RU2699285C2 (ru) 2019-09-04
KR102079919B1 (ko) 2020-02-24
CL2016002683A1 (es) 2017-07-07
AU2018271369B2 (en) 2020-01-02
CN111718424A (zh) 2020-09-29
TW202024123A (zh) 2020-07-01
PH12016502079B1 (en) 2016-12-19
EP3134430A1 (fr) 2017-03-01
ECSP16089579A (es) 2018-05-31
AU2015249649A1 (en) 2016-11-10
CY1120281T1 (el) 2019-07-10
US20180222962A1 (en) 2018-08-09
TR201806912T4 (tr) 2018-06-21
PL3134430T3 (pl) 2018-08-31
JP2019162114A (ja) 2019-09-26
SG10202111785VA (en) 2021-12-30
DK3134430T3 (en) 2018-05-22
TW201620928A (zh) 2016-06-16
WO2015164588A1 (fr) 2015-10-29
AU2018271369A1 (en) 2018-12-20
MX2016013858A (es) 2017-08-02
ES2672368T3 (es) 2018-06-14
CA2946402C (fr) 2023-02-28
RS57153B1 (sr) 2018-07-31
JP2017513503A (ja) 2017-06-01

Similar Documents

Publication Publication Date Title
MA45069A (fr) Protéines agonistes du récepteur trail monocaténaires
EP3650449A4 (fr) Agoniste du récepteur fxr
IL251963A0 (en) Anti-pd-1 antibodies
EP3352472A4 (fr) Récepteur
DK3344654T3 (da) Anti-lag-3-antistoffer
EP3347035A4 (fr) Peptides localisant le cartilage
DK3160994T3 (da) Multispecifikke antigenbindende proteiner
DK3350218T5 (da) Polyomavirus-neutraliserende antistoffer
HUE060878T2 (hu) Anti-transztiretin antitestek
DK3250593T3 (da) Anti-transthyretin-antistoffer
EP3319983C0 (fr) Anticorps de liaison tau
DK3143037T3 (da) Alpha4beta7-integrin-thioether-peptidantagonister
PT3215530T (pt) Anticorpos de il-6 melhorados
LT3684813T (lt) Agonistiniai cd40 antikūnai
DK3099791T3 (da) Protein
EP3353793A4 (fr) Récepteur rf
HRP20182029T1 (hr) Uti-fuzijski proteini
LT3178931T (lt) Anti-orai1 antikūnas
LT3126391T (lt) Hpa-1a antikūnai
LT3628731T (lt) Naujas antipresepsino antikūnas
EP3418079A4 (fr) Récepteur
DK3099793T3 (da) Protein
MA44599A (fr) Récepteur volumétrique
DK3310756T3 (da) Thromboxanreceptorantagonister
UA32617S (uk) Кальян