MA39770A - Protéines agonistes du récepteur trail monocaténaires - Google Patents

Protéines agonistes du récepteur trail monocaténaires

Info

Publication number
MA39770A
MA39770A MA039770A MA39770A MA39770A MA 39770 A MA39770 A MA 39770A MA 039770 A MA039770 A MA 039770A MA 39770 A MA39770 A MA 39770A MA 39770 A MA39770 A MA 39770A
Authority
MA
Morocco
Prior art keywords
receptor agonist
agonist proteins
trail
chain trail
trail receptor
Prior art date
Application number
MA039770A
Other languages
English (en)
Inventor
Fritz G Buchanan
Christian Gieffers
Oliver Hill
Susan E Lappe
Darren C Phillips
Meinolf Thiemann
Original Assignee
Abbvie Inc
Apogenix Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc, Apogenix Ag filed Critical Abbvie Inc
Publication of MA39770A publication Critical patent/MA39770A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Transplantation (AREA)

Abstract

La présente invention concerne des protéines agonistes du récepteur trail spécifique, des acides nucléiques codant pour ces dernières, et des méthodes de traitement d'un sujet ayant une maladie ou un trouble associé(e) au récepteur trail. Les protéines agonistes du récepteur trail de la présente invention comprennent trois domaines trail solubles et un fragment fc. Les protéines agonistes du récepteur trail sont sensiblement non agrégeantes et appropriées pour des applications thérapeutiques, diagnostiques et/ou de recherche.
MA039770A 2014-04-23 2015-04-23 Protéines agonistes du récepteur trail monocaténaires MA39770A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201461983152P 2014-04-23 2014-04-23

Publications (1)

Publication Number Publication Date
MA39770A true MA39770A (fr) 2015-10-29

Family

ID=53055121

Family Applications (2)

Application Number Title Priority Date Filing Date
MA039770A MA39770A (fr) 2014-04-23 2015-04-23 Protéines agonistes du récepteur trail monocaténaires
MA045069A MA45069A (fr) 2014-04-23 2015-04-23 Protéines agonistes du récepteur trail monocaténaires

Family Applications After (1)

Application Number Title Priority Date Filing Date
MA045069A MA45069A (fr) 2014-04-23 2015-04-23 Protéines agonistes du récepteur trail monocaténaires

Country Status (37)

Country Link
US (4) US9908927B2 (fr)
EP (2) EP3134430B1 (fr)
JP (2) JP6523331B2 (fr)
KR (2) KR102079919B1 (fr)
CN (2) CN106459221B (fr)
AR (1) AR100168A1 (fr)
AU (3) AU2015249649B2 (fr)
BR (1) BR112016024515B1 (fr)
CA (2) CA3184067A1 (fr)
CL (1) CL2016002683A1 (fr)
CR (1) CR20160516A (fr)
CY (1) CY1120281T1 (fr)
DK (1) DK3134430T3 (fr)
DO (1) DOP2016000284A (fr)
EC (1) ECSP16089579A (fr)
ES (1) ES2672368T3 (fr)
HR (1) HRP20180950T1 (fr)
HU (1) HUE038914T2 (fr)
IL (2) IL248244B (fr)
LT (1) LT3134430T (fr)
MA (2) MA39770A (fr)
MX (2) MX2016013858A (fr)
MY (1) MY181986A (fr)
NO (1) NO2776305T3 (fr)
PE (1) PE20170299A1 (fr)
PH (1) PH12016502079B1 (fr)
PL (1) PL3134430T3 (fr)
PT (1) PT3134430T (fr)
RS (1) RS57153B1 (fr)
RU (1) RU2699285C2 (fr)
SG (3) SG10201806465TA (fr)
SI (1) SI3134430T1 (fr)
TR (1) TR201806912T4 (fr)
TW (2) TWI747178B (fr)
UA (1) UA118286C2 (fr)
UY (1) UY36095A (fr)
WO (1) WO2015164588A1 (fr)

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Publication number Priority date Publication date Assignee Title
CN107709355B (zh) * 2015-05-04 2021-09-14 阿珀吉尼科斯股份公司 单链cd40受体激动剂蛋白
AU2016342420B2 (en) * 2015-10-23 2020-10-01 Apogenix Ag Single-chain LIGHT receptor agonist proteins
AU2016341402B2 (en) * 2015-10-23 2020-08-27 Apogenix Ag Single-chain GITR-receptor agonist proteins
AU2016341409B2 (en) 2015-10-23 2021-02-25 Apogenix Ag Single-chain CD27-receptor agonist proteins
WO2017102010A1 (fr) * 2015-12-17 2017-06-22 Biontech Rna Pharmaceuticals Gmbh Nouvelles protéines de fusion à cytokine
CN109153711B (zh) * 2016-03-01 2022-04-26 伊利诺伊大学理事会 具有降低的l-谷氨酰胺酶活性和增强的稳定性的l-天冬酰胺酶变体和融合蛋白
MX2018011219A (es) * 2016-03-16 2019-01-10 Merrimack Pharmaceuticals Inc Trail diseñado por ingenieria para terapia de cancer.
US10501744B2 (en) 2016-05-04 2019-12-10 Indiana University Research And Technology Corporation Presentation of bioactive proteins
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
CN109641033A (zh) * 2016-06-13 2019-04-16 梅里麦克制药股份有限公司 用基于trail的治疗剂或死亡受体激动剂选择和治疗患者的方法
EP3360898A1 (fr) 2017-02-14 2018-08-15 Boehringer Ingelheim International GmbH Molécules bispécifiques présentant une immunoréactivité par rapport à tnf-related apoptosis-inducing ligand receptor 2 et à cadherin 17 pour le traitement du cancer
CA3106549A1 (fr) * 2017-08-11 2019-02-14 The Board Of Trustees Of The University Of Illinois Variantes tronquees de la l-asparaginase de cochon d'inde et procedes d'utilisation
WO2019178438A1 (fr) 2018-03-15 2019-09-19 Abbvie Inc. Abbv-621 en combinaison avec des agents anticancéreux pour le traitement du cancer
WO2019178433A1 (fr) 2018-03-15 2019-09-19 Abbvie Inc. Abbv-621 en association avec des agents anticancéreux pour le traitement du cancer du pancréas
EP4149964A2 (fr) 2020-05-15 2023-03-22 Apogenix AG Modulateurs immunitaires multi-spécifiques
WO2022248662A1 (fr) 2021-05-28 2022-12-01 Julius-Maximilians-Universität Würzburg Molécules de liaison protéiques recombinantes
WO2023088876A1 (fr) 2021-11-16 2023-05-25 Apogenix Ag Modulateurs immunitaires multi-spécifiques

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7645700A (en) 1999-10-07 2001-05-10 Maxygen Aps Single-chain antagonist polypeptides
DE19963859A1 (de) 1999-12-30 2001-07-12 Apotech Res & Dev Ltd Bi- oder Oligomer eines Di-, Tri-, Quattro- oder Pentamers von rekombinanten Fusionsproteinen
CA2314199A1 (fr) 2000-07-21 2002-01-21 Robert Simoneau Puce c
MXPA03005036A (es) 2000-12-07 2003-09-05 Lilly Co Eli Proteinas de fusion glp-1.
US7317091B2 (en) 2002-03-01 2008-01-08 Xencor, Inc. Optimized Fc variants
US7538088B2 (en) 2002-04-26 2009-05-26 California Institute Of Technology Method for inhibiting angiogenesis by administration of the extracellular domain of D1-1 polypeptide
DE102004014983A1 (de) 2004-03-26 2005-10-20 Univ Stuttgart Rekombinante Polypeptide der Mitglieder der TNF Ligandenfamilie und deren Verwendung
US20060188498A1 (en) * 2005-02-18 2006-08-24 Genentech, Inc. Methods of using death receptor agonists and EGFR inhibitors
US8388962B2 (en) * 2005-04-15 2013-03-05 Rappaport Family Institute For Research In The Medical Sciences Molecules and methods of using same for treating MCP-1/CCR2 associated diseases
CA2606102C (fr) 2005-04-26 2014-09-30 Medimmune, Inc. Modulation de la fonction d'effecteur d'anticorps par ingenierie de domaine "charniere"
EP1894940A1 (fr) 2006-08-28 2008-03-05 Apogenix GmbH Protéines de fusion de la superfamille TNF
EP2176288B1 (fr) 2007-07-10 2015-11-04 Apogenix GmbH Protéines de fusion collectines de la superfamille des tnf
BRPI0913406A2 (pt) 2008-06-03 2018-01-09 Abbott Lab imunoglobulinas de domínio variável duplo e usos das mesmas
EP2310509B1 (fr) * 2008-07-21 2015-01-21 Apogenix GmbH Molécules à une seule chaîne
US20110287001A1 (en) 2008-09-22 2011-11-24 Tetralogic Pharmaceuticals Method of treatment
EP2379585A2 (fr) * 2008-10-10 2011-10-26 Anaphore, Inc. Polypeptides qui se lient à trail-ri et trail-r2
ES2593049T3 (es) 2009-01-09 2016-12-05 Apogenix Ag Proteínas de fusión que forman trímeros
CA2750533A1 (fr) * 2009-01-23 2010-07-29 Biogen Idec Ma Inc. Polypeptides fc stabilises avec une fonction effectrice reduite et procedes d'utilisation
EP2516458A1 (fr) 2009-12-22 2012-10-31 Novartis AG Protéine hybride tétravalente à région constante d'anticorps anti-cd-47 à utiliser en thérapie
CA2795325A1 (fr) * 2010-04-13 2011-10-20 Medimmune, Llc Echafaudages multimeriques a base de domaine de fibronectine de type iii
US9764038B2 (en) * 2011-12-23 2017-09-19 Innate Pharma Enzymatic conjugation of antibodies
CN104640876A (zh) * 2012-07-18 2015-05-20 阿珀吉尼科斯有限公司 包含CD95-Fc同种型的混合物的组合物

Also Published As

Publication number Publication date
CA2946402C (fr) 2023-02-28
DK3134430T3 (en) 2018-05-22
HUE038914T2 (hu) 2018-12-28
UY36095A (es) 2015-10-30
AR100168A1 (es) 2016-09-14
PE20170299A1 (es) 2017-05-06
SG10201806465TA (en) 2018-08-30
PL3134430T3 (pl) 2018-08-31
IL272612A (en) 2020-03-31
TWI683825B (zh) 2020-02-01
SI3134430T1 (en) 2018-05-31
PH12016502079A1 (en) 2016-12-19
CL2016002683A1 (es) 2017-07-07
UA118286C2 (uk) 2018-12-26
TW202024123A (zh) 2020-07-01
AU2015249649A1 (en) 2016-11-10
TWI747178B (zh) 2021-11-21
RU2016145608A3 (fr) 2018-12-26
US20210040178A1 (en) 2021-02-11
US20180222962A1 (en) 2018-08-09
TW201620928A (zh) 2016-06-16
IL248244B (en) 2020-03-31
CN106459221B (zh) 2020-09-01
MX2016013858A (es) 2017-08-02
AU2018271369A1 (en) 2018-12-20
PT3134430T (pt) 2018-04-20
JP6714751B2 (ja) 2020-06-24
MY181986A (en) 2021-01-18
WO2015164588A1 (fr) 2015-10-29
EP3134430A1 (fr) 2017-03-01
CR20160516A (es) 2017-05-10
CY1120281T1 (el) 2019-07-10
KR20190135546A (ko) 2019-12-06
PH12016502079B1 (en) 2016-12-19
EP3366699A1 (fr) 2018-08-29
SG11201608767XA (en) 2016-11-29
MX2019013587A (es) 2020-01-13
US20150337027A1 (en) 2015-11-26
IL248244A0 (en) 2016-11-30
SG10202111785VA (en) 2021-12-30
HRP20180950T1 (hr) 2018-08-10
JP2019162114A (ja) 2019-09-26
MA45069A (fr) 2019-04-03
BR112016024515B1 (pt) 2020-03-31
TR201806912T4 (tr) 2018-06-21
NZ725476A (en) 2023-09-29
JP2017513503A (ja) 2017-06-01
RU2699285C2 (ru) 2019-09-04
US9908927B2 (en) 2018-03-06
AU2020202247A1 (en) 2020-04-23
RU2016145608A (ru) 2018-05-28
JP6523331B2 (ja) 2019-05-29
ECSP16089579A (es) 2018-05-31
NO2776305T3 (fr) 2018-01-27
LT3134430T (lt) 2018-05-10
KR20170012257A (ko) 2017-02-02
AU2015249649B2 (en) 2018-10-04
US20240174731A1 (en) 2024-05-30
ES2672368T3 (es) 2018-06-14
BR112016024515A2 (pt) 2017-10-10
CA3184067A1 (fr) 2015-10-29
CN106459221A (zh) 2017-02-22
KR102079919B1 (ko) 2020-02-24
CA2946402A1 (fr) 2015-10-29
AU2018271369B2 (en) 2020-01-02
CN111718424A (zh) 2020-09-29
RS57153B1 (sr) 2018-07-31
DOP2016000284A (es) 2017-02-15
EP3134430B1 (fr) 2018-03-21

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