CN106459221B - 单链trail受体激动剂蛋白 - Google Patents

单链trail受体激动剂蛋白 Download PDF

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Publication number
CN106459221B
CN106459221B CN201580031858.7A CN201580031858A CN106459221B CN 106459221 B CN106459221 B CN 106459221B CN 201580031858 A CN201580031858 A CN 201580031858A CN 106459221 B CN106459221 B CN 106459221B
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gly
leu
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glu
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Expired - Fee Related
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Chinese (zh)
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CN106459221A (zh
Inventor
O.希尔
C.吉菲尔斯
M.蒂曼
F.G.布查南
D.C.菲利普斯
S.E.拉普
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Apogenix AG
AbbVie Inc
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Apogenix AG
AbbVie Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Transplantation (AREA)
CN201580031858.7A 2014-04-23 2015-04-23 单链trail受体激动剂蛋白 Expired - Fee Related CN106459221B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202010767219.XA CN111718424A (zh) 2014-04-23 2015-04-23 单链trail受体激动剂蛋白

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461983152P 2014-04-23 2014-04-23
US61/983152 2014-04-23
PCT/US2015/027270 WO2015164588A1 (en) 2014-04-23 2015-04-23 Single-chain trail-receptor agonist proteins

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CN202010767219.XA Division CN111718424A (zh) 2014-04-23 2015-04-23 单链trail受体激动剂蛋白

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CN106459221A CN106459221A (zh) 2017-02-22
CN106459221B true CN106459221B (zh) 2020-09-01

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CN201580031858.7A Expired - Fee Related CN106459221B (zh) 2014-04-23 2015-04-23 单链trail受体激动剂蛋白
CN202010767219.XA Pending CN111718424A (zh) 2014-04-23 2015-04-23 单链trail受体激动剂蛋白

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JP (2) JP6523331B2 (enExample)
KR (2) KR20190135546A (enExample)
CN (2) CN106459221B (enExample)
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UA (1) UA118286C2 (enExample)
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EP3292143B1 (en) * 2015-05-04 2019-08-21 Apogenix AG Single-chain cd40-receptor agonist proteins
JP6959229B2 (ja) * 2015-10-23 2021-11-02 アポジェニックス アーゲー 一本鎖ｇｉｔｒ受容体アゴニストタンパク質
WO2017068192A1 (en) 2015-10-23 2017-04-27 Apogenix Ag Single-chain cd27-receptor agonist proteins
WO2017068180A1 (en) * 2015-10-23 2017-04-27 Apogenix Ag Single-chain light receptor agonist proteins
WO2017102010A1 (en) * 2015-12-17 2017-06-22 Biontech Rna Pharmaceuticals Gmbh Novel cytokine fusion proteins
CN109153711B (zh) * 2016-03-01 2022-04-26 伊利诺伊大学理事会 具有降低的l-谷氨酰胺酶活性和增强的稳定性的l-天冬酰胺酶变体和融合蛋白
WO2017161173A1 (en) * 2016-03-16 2017-09-21 Merrimack Pharmaceuticals, Inc. Engineered trail for cancer therapy
US10501744B2 (en) 2016-05-04 2019-12-10 Indiana University Research And Technology Corporation Presentation of bioactive proteins
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
JP2019517570A (ja) * 2016-06-13 2019-06-24 メリマック ファーマシューティカルズ インコーポレーティッド Ｔｒａｉｌベースの治療剤または細胞死受容体アゴニストを用いて患者を選択および治療する方法
EP3360898A1 (en) 2017-02-14 2018-08-15 Boehringer Ingelheim International GmbH Bispecific anti-tnf-related apoptosis-inducing ligand receptor 2 and anti-cadherin 17 binding molecules for the treatment of cancer
CN111050784B (zh) * 2017-08-11 2024-03-19 伊利诺伊大学理事会 截短的豚鼠l-天冬酰胺酶变体及其使用方法
TW202003553A (zh) 2018-03-15 2020-01-16 美商艾伯維有限公司 用於治療癌症之abbv-621與抗癌劑之組合
TW202002952A (zh) 2018-03-15 2020-01-16 美商艾伯維有限公司 用於治療胰臟癌之abbv-621與抗癌劑之組合
EP4149964A2 (en) 2020-05-15 2023-03-22 Apogenix AG Multi-specific immune modulators
AU2022281108A1 (en) 2021-05-28 2023-12-14 Julius-Maximilians-Universität Würzburg Recombinant proteinaceous binding molecules
WO2023088876A1 (en) 2021-11-16 2023-05-25 Apogenix Ag Multi-specific immune modulators

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IL272612A (en) 2020-03-31
HRP20180950T1 (hr) 2018-08-10
IL248244B (en) 2020-03-31
AU2015249649B2 (en) 2018-10-04
EP3134430B1 (en) 2018-03-21
BR112016024515B1 (pt) 2020-03-31
JP6523331B2 (ja) 2019-05-29
HUE038914T2 (hu) 2018-12-28
RU2016145608A3 (enExample) 2018-12-26
DOP2016000284A (es) 2017-02-15
PE20170299A1 (es) 2017-05-06
SMT201800286T1 (it) 2018-07-17
SI3134430T1 (en) 2018-05-31
CA2946402A1 (en) 2015-10-29
LT3134430T (lt) 2018-05-10
EP3366699A1 (en) 2018-08-29
CA3184067A1 (en) 2015-10-29
CN106459221A (zh) 2017-02-22
TWI683825B (zh) 2020-02-01
PT3134430T (pt) 2018-04-20
US20240174731A1 (en) 2024-05-30
US20210040178A1 (en) 2021-02-11
US20150337027A1 (en) 2015-11-26
PH12016502079A1 (en) 2016-12-19
MA39770A (fr) 2015-10-29
RU2016145608A (ru) 2018-05-28
AR100168A1 (es) 2016-09-14
MY181986A (en) 2021-01-18
KR20170012257A (ko) 2017-02-02
NZ725476A (en) 2023-09-29
CR20160516A (es) 2017-05-10
PH12020500377A1 (en) 2022-11-14
UA118286C2 (uk) 2018-12-26
UY36095A (es) 2015-10-30
JP6714751B2 (ja) 2020-06-24
AU2020202247A1 (en) 2020-04-23
TWI747178B (zh) 2021-11-21
US9908927B2 (en) 2018-03-06
NO2776305T3 (enExample) 2018-01-27
MX2019013587A (es) 2020-01-13
SG11201608767XA (en) 2016-11-29
US20250145688A1 (en) 2025-05-08
BR112016024515A2 (pt) 2017-10-10
KR20190135546A (ko) 2019-12-06
IL248244A0 (en) 2016-11-30
SG10201806465TA (en) 2018-08-30
RU2699285C2 (ru) 2019-09-04
KR102079919B1 (ko) 2020-02-24
CL2016002683A1 (es) 2017-07-07
AU2018271369B2 (en) 2020-01-02
CN111718424A (zh) 2020-09-29
TW202024123A (zh) 2020-07-01
PH12016502079B1 (en) 2016-12-19
EP3134430A1 (en) 2017-03-01
ECSP16089579A (es) 2018-05-31
AU2015249649A1 (en) 2016-11-10
CY1120281T1 (el) 2019-07-10
US20180222962A1 (en) 2018-08-09
TR201806912T4 (tr) 2018-06-21
PL3134430T3 (pl) 2018-08-31
JP2019162114A (ja) 2019-09-26
SG10202111785VA (en) 2021-12-30
DK3134430T3 (en) 2018-05-22
TW201620928A (zh) 2016-06-16
WO2015164588A1 (en) 2015-10-29
AU2018271369A1 (en) 2018-12-20
MX2016013858A (es) 2017-08-02
MA45069A (fr) 2019-04-03
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RS57153B1 (sr) 2018-07-31
JP2017513503A (ja) 2017-06-01

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