RU2621843C2 - Применение силиконового масла, обработанного плазмой, в качестве покрытия в медицинском инъекционном устройстве - Google Patents
Применение силиконового масла, обработанного плазмой, в качестве покрытия в медицинском инъекционном устройстве Download PDFInfo
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- RU2621843C2 RU2621843C2 RU2014116080A RU2014116080A RU2621843C2 RU 2621843 C2 RU2621843 C2 RU 2621843C2 RU 2014116080 A RU2014116080 A RU 2014116080A RU 2014116080 A RU2014116080 A RU 2014116080A RU 2621843 C2 RU2621843 C2 RU 2621843C2
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- Prior art keywords
- coating
- cylinder
- particles
- injection device
- piston
- Prior art date
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- 238000000576 coating method Methods 0.000 title claims abstract description 83
- 229920002545 silicone oil Polymers 0.000 title claims abstract description 38
- 238000010999 medical injection Methods 0.000 title claims abstract description 35
- 239000002245 particle Substances 0.000 claims abstract description 105
- 239000011248 coating agent Substances 0.000 claims abstract description 80
- 238000002347 injection Methods 0.000 claims abstract description 48
- 239000007924 injection Substances 0.000 claims abstract description 48
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 38
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 16
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 16
- 239000011521 glass Substances 0.000 claims description 11
- -1 polydimethylsiloxane Polymers 0.000 claims description 8
- 239000000314 lubricant Substances 0.000 abstract description 9
- 230000002349 favourable effect Effects 0.000 abstract description 5
- 239000000126 substance Substances 0.000 abstract description 5
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- 238000000034 method Methods 0.000 description 35
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- 229920001296 polysiloxane Polymers 0.000 description 20
- 238000009832 plasma treatment Methods 0.000 description 17
- 238000012008 microflow imaging Methods 0.000 description 13
- 238000005259 measurement Methods 0.000 description 12
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 10
- 239000000203 mixture Substances 0.000 description 10
- 230000001050 lubricating effect Effects 0.000 description 8
- 108090000623 proteins and genes Proteins 0.000 description 8
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- 238000003860 storage Methods 0.000 description 7
- 238000003384 imaging method Methods 0.000 description 6
- 230000003993 interaction Effects 0.000 description 6
- 238000001179 sorption measurement Methods 0.000 description 6
- 229910052786 argon Inorganic materials 0.000 description 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 5
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- 229910052760 oxygen Inorganic materials 0.000 description 5
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- 230000008901 benefit Effects 0.000 description 4
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- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 3
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- 230000002776 aggregation Effects 0.000 description 3
- 238000004220 aggregation Methods 0.000 description 3
- 230000008859 change Effects 0.000 description 3
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- 239000003186 pharmaceutical solution Substances 0.000 description 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 3
- 229920000053 polysorbate 80 Polymers 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 108010041986 DNA Vaccines Proteins 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
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- 230000004845 protein aggregation Effects 0.000 description 2
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- 238000005303 weighing Methods 0.000 description 2
- 108020004414 DNA Proteins 0.000 description 1
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- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
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- 229920005549 butyl rubber Polymers 0.000 description 1
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- 102000018358 immunoglobulin Human genes 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
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- 238000012538 light obscuration Methods 0.000 description 1
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- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000003182 parenteral nutrition solution Substances 0.000 description 1
- YHHSONZFOIEMCP-UHFFFAOYSA-O phosphocholine Chemical compound C[N+](C)(C)CCOP(O)(O)=O YHHSONZFOIEMCP-UHFFFAOYSA-O 0.000 description 1
- 229950004354 phosphorylcholine Drugs 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000003380 propellant Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- 238000000197 pyrolysis Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000012798 spherical particle Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000012906 subvisible particle Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/10—Materials for lubricating medical devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/02—Methods for coating medical devices
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M2005/3117—Means preventing contamination of the medicament compartment of a syringe
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
- A61M2005/3131—Syringe barrels specially adapted for improving sealing or sliding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/02—General characteristics of the apparatus characterised by a particular materials
- A61M2205/0222—Materials for reducing friction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04C—ROTARY-PISTON, OR OSCILLATING-PISTON, POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; ROTARY-PISTON, OR OSCILLATING-PISTON, POSITIVE-DISPLACEMENT PUMPS
- F04C2270/00—Control; Monitoring or safety arrangements
- F04C2270/04—Force
- F04C2270/041—Controlled or regulated
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Surgery (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11306236 | 2011-09-27 | ||
| EP11306236.8 | 2011-09-27 | ||
| PCT/EP2012/069119 WO2013045571A2 (en) | 2011-09-27 | 2012-09-27 | Use of plasma treated silicone oil as a coating in a medical injection device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2014116080A RU2014116080A (ru) | 2015-11-10 |
| RU2621843C2 true RU2621843C2 (ru) | 2017-06-07 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014116080A RU2621843C2 (ru) | 2011-09-27 | 2012-09-27 | Применение силиконового масла, обработанного плазмой, в качестве покрытия в медицинском инъекционном устройстве |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20140221934A1 (enExample) |
| EP (2) | EP4218862A1 (enExample) |
| JP (1) | JP6144264B2 (enExample) |
| KR (3) | KR20200003228A (enExample) |
| CN (1) | CN103957966B (enExample) |
| ES (1) | ES2944088T3 (enExample) |
| MX (1) | MX356788B (enExample) |
| RU (1) | RU2621843C2 (enExample) |
| WO (1) | WO2013045571A2 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2253735B1 (en) | 2009-05-13 | 2017-11-22 | SiO2 Medical Products, Inc. | Vessel processing |
| WO2013170052A1 (en) | 2012-05-09 | 2013-11-14 | Sio2 Medical Products, Inc. | Saccharide protective coating for pharmaceutical package |
| US9458536B2 (en) | 2009-07-02 | 2016-10-04 | Sio2 Medical Products, Inc. | PECVD coating methods for capped syringes, cartridges and other articles |
| US11624115B2 (en) | 2010-05-12 | 2023-04-11 | Sio2 Medical Products, Inc. | Syringe with PECVD lubrication |
| US9878101B2 (en) | 2010-11-12 | 2018-01-30 | Sio2 Medical Products, Inc. | Cyclic olefin polymer vessels and vessel coating methods |
| US9272095B2 (en) | 2011-04-01 | 2016-03-01 | Sio2 Medical Products, Inc. | Vessels, contact surfaces, and coating and inspection apparatus and methods |
| US11116695B2 (en) | 2011-11-11 | 2021-09-14 | Sio2 Medical Products, Inc. | Blood sample collection tube |
| CN103930595A (zh) | 2011-11-11 | 2014-07-16 | Sio2医药产品公司 | 用于药物包装的钝化、pH保护性或润滑性涂层、涂布方法以及设备 |
| US20150297800A1 (en) | 2012-07-03 | 2015-10-22 | Sio2 Medical Products, Inc. | SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS |
| JOP20200175A1 (ar) | 2012-07-03 | 2017-06-16 | Novartis Ag | حقنة |
| US9664626B2 (en) | 2012-11-01 | 2017-05-30 | Sio2 Medical Products, Inc. | Coating inspection method |
| US9903782B2 (en) | 2012-11-16 | 2018-02-27 | Sio2 Medical Products, Inc. | Method and apparatus for detecting rapid barrier coating integrity characteristics |
| KR102211950B1 (ko) | 2012-11-30 | 2021-02-04 | 에스아이오2 메디컬 프로덕츠, 인크. | 의료용 주사기 카트리지 등의 pecvd 증착 균일성 제어 |
| US9764093B2 (en) | 2012-11-30 | 2017-09-19 | Sio2 Medical Products, Inc. | Controlling the uniformity of PECVD deposition |
| US9662450B2 (en) | 2013-03-01 | 2017-05-30 | Sio2 Medical Products, Inc. | Plasma or CVD pre-treatment for lubricated pharmaceutical package, coating process and apparatus |
| CA2904611C (en) | 2013-03-11 | 2021-11-23 | Sio2 Medical Products, Inc. | Coated packaging |
| US9937099B2 (en) | 2013-03-11 | 2018-04-10 | Sio2 Medical Products, Inc. | Trilayer coated pharmaceutical packaging with low oxygen transmission rate |
| US20160017490A1 (en) | 2013-03-15 | 2016-01-21 | Sio2 Medical Products, Inc. | Coating method |
| US10278618B2 (en) * | 2013-08-27 | 2019-05-07 | Repro-Med Systems, Inc. | Method of selecting a needle for subcutaneous therapy |
| WO2015148471A1 (en) | 2014-03-28 | 2015-10-01 | Sio2 Medical Products, Inc. | Antistatic coatings for plastic vessels |
| JP2017519553A (ja) * | 2014-05-26 | 2017-07-20 | ベクトン ディキンソン フランス | 潤滑医療注射デバイス内でエマルジョンアジュバントワクチンを貯蔵するための方法 |
| CN108138316A (zh) | 2015-08-18 | 2018-06-08 | Sio2医药产品公司 | 具有低氧气传输速率的药物和其他包装 |
| WO2018011190A1 (en) | 2016-07-11 | 2018-01-18 | Becton Dickinson France | Method for reducing an amount of subvisible particles in a pharmaceutical composition |
| CN108485273A (zh) * | 2018-04-18 | 2018-09-04 | 山东济海医疗科技股份有限公司 | 一次性使用注射器用自润滑活塞的制作方法 |
| DE102018116560A1 (de) * | 2018-07-09 | 2020-01-09 | Gerresheimer Regensburg Gmbh | Verfahren zur beschichtung eines glasspritzenkörpers für eine hypodermische fertigglasspritze, hypodermische fertigglasspritze sowie plasmabehandlungsvorrichtung für glasspritzenkörper hypodermischer fertigglasspritzen |
| WO2022026488A2 (en) | 2020-07-27 | 2022-02-03 | Tribofilm Research, Inc. | Downstream plasma treated siliconized plastic syringe barrel and related syringes and methods |
| EP3978051A1 (en) | 2020-10-02 | 2022-04-06 | Becton, Dickinson and Company | Safety syringe |
| WO2022232355A1 (en) * | 2021-04-29 | 2022-11-03 | Becton, Dickinson And Company | Rubber component with reduced drug potency loss for syringe stopper and container closure system applications |
| EP4392094A1 (en) | 2021-08-24 | 2024-07-03 | Becton Dickinson France | Connected drug delivery device |
| IT202300010506A1 (it) | 2021-09-24 | 2023-03-24 | Stevanato Group Spa | Apparato per la fabbricazione di un dispositivo medico per iniezione |
| IT202200003761A1 (it) | 2022-03-01 | 2023-09-01 | Stevanato Group Spa | Metodo per la fabbricazione di un dispositivo medico per iniezione |
| IT202100024574A1 (it) | 2021-09-24 | 2023-03-24 | Stevanato Group Spa | Metodo per la fabbricazione di un dispositivo medico per iniezione e dispositivo medico così ottenuto |
| EP4445929A1 (en) | 2023-04-14 | 2024-10-16 | Becton, Dickinson and Company | Connected drug delivery device |
| EP4541387A1 (en) | 2023-10-16 | 2025-04-23 | Becton Dickinson France | Sequential-injection syringe |
| KR102828906B1 (ko) * | 2024-11-18 | 2025-07-04 | 주식회사 비에스리서치 | 실리콘 오일이 미적용된 프리필드 시린지 |
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| US4767414A (en) * | 1985-05-16 | 1988-08-30 | Becton, Dickinson And Company | Ionizing plasma lubricant method |
| US4822632A (en) * | 1985-05-16 | 1989-04-18 | Becton, Dickinson And Company | Ionizing plasma lubricant method |
| US5338312A (en) * | 1992-10-02 | 1994-08-16 | Becton, Dickinson And Company | Article having multi-layered lubricant and method therefor |
| US6461334B1 (en) * | 1998-03-06 | 2002-10-08 | Novo Nordisk A/S | Medical article with coated surfaces exhibiting low friction and protein adsorption |
| RU2224499C2 (ru) * | 1998-09-01 | 2004-02-27 | Астразенека Аб | Повышение стабильности растворов для инъекций |
| US20090010985A1 (en) * | 2004-03-02 | 2009-01-08 | Tribofilm Research, Inc. | Article with Lubricated Surface and Method |
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Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1271160A (en) | 1985-05-16 | 1990-07-03 | Joel L. Williams | Ionizing plasma lubricant method |
| US4838857A (en) * | 1985-05-29 | 1989-06-13 | Becton, Dickinson And Company | Medical infusion device |
| US4844986A (en) | 1988-02-16 | 1989-07-04 | Becton, Dickinson And Company | Method for preparing lubricated surfaces and product |
| US5266359A (en) | 1991-01-14 | 1993-11-30 | Becton, Dickinson And Company | Lubricative coating composition, article and assembly containing same and method thereof |
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| JP2002505177A (ja) * | 1998-03-06 | 2002-02-19 | ノボ ノルディスク アクティーゼルスカブ | 低摩擦及び低タンパク質吸着力を示す被覆表層を有する医療製品 |
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| JP2005160888A (ja) | 2003-12-05 | 2005-06-23 | Terumo Corp | シリンジ用ガスケット、シリンジ及びシリンジ用ガスケットの製造方法 |
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2012
- 2012-09-27 EP EP23157103.5A patent/EP4218862A1/en active Pending
- 2012-09-27 CN CN201280056039.4A patent/CN103957966B/zh not_active Ceased
- 2012-09-27 MX MX2014003729A patent/MX356788B/es active IP Right Grant
- 2012-09-27 WO PCT/EP2012/069119 patent/WO2013045571A2/en not_active Ceased
- 2012-09-27 KR KR1020197037831A patent/KR20200003228A/ko not_active Ceased
- 2012-09-27 EP EP12766092.6A patent/EP2760509B1/en active Active
- 2012-09-27 RU RU2014116080A patent/RU2621843C2/ru not_active IP Right Cessation
- 2012-09-27 JP JP2014532386A patent/JP6144264B2/ja active Active
- 2012-09-27 KR KR1020217000165A patent/KR20210005316A/ko not_active Ceased
- 2012-09-27 ES ES12766092T patent/ES2944088T3/es active Active
- 2012-09-27 KR KR1020147010852A patent/KR20140082723A/ko not_active Ceased
- 2012-09-27 US US14/347,677 patent/US20140221934A1/en not_active Abandoned
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2025
- 2025-02-05 US US19/045,859 patent/US20250177654A1/en active Pending
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Also Published As
| Publication number | Publication date |
|---|---|
| US20250177654A1 (en) | 2025-06-05 |
| CN103957966A (zh) | 2014-07-30 |
| US20140221934A1 (en) | 2014-08-07 |
| EP4218862A1 (en) | 2023-08-02 |
| MX356788B (es) | 2018-06-13 |
| KR20210005316A (ko) | 2021-01-13 |
| CN103957966B (zh) | 2017-09-29 |
| EP2760509B1 (en) | 2023-04-05 |
| RU2014116080A (ru) | 2015-11-10 |
| ES2944088T3 (es) | 2023-06-19 |
| WO2013045571A2 (en) | 2013-04-04 |
| JP2014530059A (ja) | 2014-11-17 |
| EP2760509A2 (en) | 2014-08-06 |
| MX2014003729A (es) | 2015-07-06 |
| WO2013045571A3 (en) | 2013-06-06 |
| JP6144264B2 (ja) | 2017-06-07 |
| KR20140082723A (ko) | 2014-07-02 |
| KR20200003228A (ko) | 2020-01-08 |
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| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20180928 |