JP2014530059A5 - - Google Patents
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- Publication number
- JP2014530059A5 JP2014530059A5 JP2014532386A JP2014532386A JP2014530059A5 JP 2014530059 A5 JP2014530059 A5 JP 2014530059A5 JP 2014532386 A JP2014532386 A JP 2014532386A JP 2014532386 A JP2014532386 A JP 2014532386A JP 2014530059 A5 JP2014530059 A5 JP 2014530059A5
- Authority
- JP
- Japan
- Prior art keywords
- injection device
- outer cylinder
- medical injection
- silicone oil
- coating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002245 particle Substances 0.000 claims description 118
- 238000000576 coating method Methods 0.000 claims description 95
- 239000011248 coating agent Substances 0.000 claims description 92
- 238000010999 medical injection Methods 0.000 claims description 70
- 238000002347 injection Methods 0.000 claims description 65
- 239000007924 injection Substances 0.000 claims description 65
- 229920002545 silicone oil Polymers 0.000 claims description 59
- 238000000034 method Methods 0.000 claims description 54
- 239000008194 pharmaceutical composition Substances 0.000 claims description 51
- 239000003814 drug Substances 0.000 claims description 43
- 229940079593 drug Drugs 0.000 claims description 43
- 239000000243 solution Substances 0.000 claims description 33
- 238000009832 plasma treatment Methods 0.000 claims description 24
- 229920001296 polysiloxane Polymers 0.000 claims description 23
- 238000012008 microflow imaging Methods 0.000 claims description 20
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 18
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 18
- 239000000203 mixture Substances 0.000 claims description 14
- 108090000623 proteins and genes Proteins 0.000 claims description 13
- 102000004169 proteins and genes Human genes 0.000 claims description 13
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 12
- 239000011521 glass Substances 0.000 claims description 11
- -1 polydimethylsiloxane Polymers 0.000 claims description 8
- 238000003860 storage Methods 0.000 claims description 8
- 230000007774 longterm Effects 0.000 claims description 7
- 229910052786 argon Inorganic materials 0.000 claims description 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 6
- 239000001301 oxygen Substances 0.000 claims description 6
- 229910052760 oxygen Inorganic materials 0.000 claims description 6
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 5
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 claims description 5
- 239000002953 phosphate buffered saline Substances 0.000 claims description 5
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 5
- 229920000053 polysorbate 80 Polymers 0.000 claims description 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 5
- 108010041986 DNA Vaccines Proteins 0.000 claims description 4
- 238000012538 light obscuration Methods 0.000 claims description 3
- 230000001590 oxidative effect Effects 0.000 claims description 3
- 238000012545 processing Methods 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000010410 layer Substances 0.000 description 24
- 238000005259 measurement Methods 0.000 description 16
- 239000000314 lubricant Substances 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical group O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 239000008215 water for injection Substances 0.000 description 10
- 238000001179 sorption measurement Methods 0.000 description 6
- 229920001971 elastomer Polymers 0.000 description 5
- 230000003993 interaction Effects 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- 230000008901 benefit Effects 0.000 description 4
- 230000036425 denaturation Effects 0.000 description 4
- 238000004925 denaturation Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 230000009467 reduction Effects 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 229960005486 vaccine Drugs 0.000 description 4
- 230000002776 aggregation Effects 0.000 description 3
- 238000004220 aggregation Methods 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 230000004888 barrier function Effects 0.000 description 3
- 230000032798 delamination Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 230000001050 lubricating effect Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000011088 calibration curve Methods 0.000 description 2
- 230000003749 cleanliness Effects 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 239000004033 plastic Substances 0.000 description 2
- 230000004845 protein aggregation Effects 0.000 description 2
- 239000004447 silicone coating Substances 0.000 description 2
- 239000012906 subvisible particle Substances 0.000 description 2
- 108020004414 DNA Proteins 0.000 description 1
- 206010013710 Drug interaction Diseases 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 239000013011 aqueous formulation Substances 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229940040591 biotech drug Drugs 0.000 description 1
- 229920005549 butyl rubber Polymers 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000013626 chemical specie Substances 0.000 description 1
- 239000011247 coating layer Substances 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229920001477 hydrophilic polymer Polymers 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 238000005461 lubrication Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000003182 parenteral nutrition solution Substances 0.000 description 1
- YHHSONZFOIEMCP-UHFFFAOYSA-O phosphocholine Chemical compound C[N+](C)(C)CCOP(O)(O)=O YHHSONZFOIEMCP-UHFFFAOYSA-O 0.000 description 1
- 229950004354 phosphorylcholine Drugs 0.000 description 1
- 229920000052 poly(p-xylylene) Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 230000036544 posture Effects 0.000 description 1
- 229940071643 prefilled syringe Drugs 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- CIBMHJPPKCXONB-UHFFFAOYSA-N propane-2,2-diol Chemical compound CC(C)(O)O CIBMHJPPKCXONB-UHFFFAOYSA-N 0.000 description 1
- 238000000197 pyrolysis Methods 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000000153 supplemental effect Effects 0.000 description 1
- 229940126672 traditional medicines Drugs 0.000 description 1
- 239000012905 visible particle Substances 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11306236 | 2011-09-27 | ||
| EP11306236.8 | 2011-09-27 | ||
| PCT/EP2012/069119 WO2013045571A2 (en) | 2011-09-27 | 2012-09-27 | Use of plasma treated silicone oil as a coating in a medical injection device |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014530059A JP2014530059A (ja) | 2014-11-17 |
| JP2014530059A5 true JP2014530059A5 (enExample) | 2015-03-12 |
| JP6144264B2 JP6144264B2 (ja) | 2017-06-07 |
Family
ID=46934593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014532386A Active JP6144264B2 (ja) | 2011-09-27 | 2012-09-27 | 医療用注射装置においてプラズマ処理したシリコーンオイルのコーティングとしての使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20140221934A1 (enExample) |
| EP (2) | EP4218862A1 (enExample) |
| JP (1) | JP6144264B2 (enExample) |
| KR (3) | KR20200003228A (enExample) |
| CN (1) | CN103957966B (enExample) |
| ES (1) | ES2944088T3 (enExample) |
| MX (1) | MX356788B (enExample) |
| RU (1) | RU2621843C2 (enExample) |
| WO (1) | WO2013045571A2 (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2253735B1 (en) | 2009-05-13 | 2017-11-22 | SiO2 Medical Products, Inc. | Vessel processing |
| WO2013170052A1 (en) | 2012-05-09 | 2013-11-14 | Sio2 Medical Products, Inc. | Saccharide protective coating for pharmaceutical package |
| US9458536B2 (en) | 2009-07-02 | 2016-10-04 | Sio2 Medical Products, Inc. | PECVD coating methods for capped syringes, cartridges and other articles |
| US11624115B2 (en) | 2010-05-12 | 2023-04-11 | Sio2 Medical Products, Inc. | Syringe with PECVD lubrication |
| US9878101B2 (en) | 2010-11-12 | 2018-01-30 | Sio2 Medical Products, Inc. | Cyclic olefin polymer vessels and vessel coating methods |
| US9272095B2 (en) | 2011-04-01 | 2016-03-01 | Sio2 Medical Products, Inc. | Vessels, contact surfaces, and coating and inspection apparatus and methods |
| US11116695B2 (en) | 2011-11-11 | 2021-09-14 | Sio2 Medical Products, Inc. | Blood sample collection tube |
| CN103930595A (zh) | 2011-11-11 | 2014-07-16 | Sio2医药产品公司 | 用于药物包装的钝化、pH保护性或润滑性涂层、涂布方法以及设备 |
| US20150297800A1 (en) | 2012-07-03 | 2015-10-22 | Sio2 Medical Products, Inc. | SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS |
| JOP20200175A1 (ar) | 2012-07-03 | 2017-06-16 | Novartis Ag | حقنة |
| US9664626B2 (en) | 2012-11-01 | 2017-05-30 | Sio2 Medical Products, Inc. | Coating inspection method |
| US9903782B2 (en) | 2012-11-16 | 2018-02-27 | Sio2 Medical Products, Inc. | Method and apparatus for detecting rapid barrier coating integrity characteristics |
| KR102211950B1 (ko) | 2012-11-30 | 2021-02-04 | 에스아이오2 메디컬 프로덕츠, 인크. | 의료용 주사기 카트리지 등의 pecvd 증착 균일성 제어 |
| US9764093B2 (en) | 2012-11-30 | 2017-09-19 | Sio2 Medical Products, Inc. | Controlling the uniformity of PECVD deposition |
| US9662450B2 (en) | 2013-03-01 | 2017-05-30 | Sio2 Medical Products, Inc. | Plasma or CVD pre-treatment for lubricated pharmaceutical package, coating process and apparatus |
| CA2904611C (en) | 2013-03-11 | 2021-11-23 | Sio2 Medical Products, Inc. | Coated packaging |
| US9937099B2 (en) | 2013-03-11 | 2018-04-10 | Sio2 Medical Products, Inc. | Trilayer coated pharmaceutical packaging with low oxygen transmission rate |
| US20160017490A1 (en) | 2013-03-15 | 2016-01-21 | Sio2 Medical Products, Inc. | Coating method |
| US10278618B2 (en) * | 2013-08-27 | 2019-05-07 | Repro-Med Systems, Inc. | Method of selecting a needle for subcutaneous therapy |
| WO2015148471A1 (en) | 2014-03-28 | 2015-10-01 | Sio2 Medical Products, Inc. | Antistatic coatings for plastic vessels |
| JP2017519553A (ja) * | 2014-05-26 | 2017-07-20 | ベクトン ディキンソン フランス | 潤滑医療注射デバイス内でエマルジョンアジュバントワクチンを貯蔵するための方法 |
| CN108138316A (zh) | 2015-08-18 | 2018-06-08 | Sio2医药产品公司 | 具有低氧气传输速率的药物和其他包装 |
| WO2018011190A1 (en) | 2016-07-11 | 2018-01-18 | Becton Dickinson France | Method for reducing an amount of subvisible particles in a pharmaceutical composition |
| CN108485273A (zh) * | 2018-04-18 | 2018-09-04 | 山东济海医疗科技股份有限公司 | 一次性使用注射器用自润滑活塞的制作方法 |
| DE102018116560A1 (de) * | 2018-07-09 | 2020-01-09 | Gerresheimer Regensburg Gmbh | Verfahren zur beschichtung eines glasspritzenkörpers für eine hypodermische fertigglasspritze, hypodermische fertigglasspritze sowie plasmabehandlungsvorrichtung für glasspritzenkörper hypodermischer fertigglasspritzen |
| WO2022026488A2 (en) | 2020-07-27 | 2022-02-03 | Tribofilm Research, Inc. | Downstream plasma treated siliconized plastic syringe barrel and related syringes and methods |
| EP3978051A1 (en) | 2020-10-02 | 2022-04-06 | Becton, Dickinson and Company | Safety syringe |
| WO2022232355A1 (en) * | 2021-04-29 | 2022-11-03 | Becton, Dickinson And Company | Rubber component with reduced drug potency loss for syringe stopper and container closure system applications |
| EP4392094A1 (en) | 2021-08-24 | 2024-07-03 | Becton Dickinson France | Connected drug delivery device |
| IT202300010506A1 (it) | 2021-09-24 | 2023-03-24 | Stevanato Group Spa | Apparato per la fabbricazione di un dispositivo medico per iniezione |
| IT202200003761A1 (it) | 2022-03-01 | 2023-09-01 | Stevanato Group Spa | Metodo per la fabbricazione di un dispositivo medico per iniezione |
| IT202100024574A1 (it) | 2021-09-24 | 2023-03-24 | Stevanato Group Spa | Metodo per la fabbricazione di un dispositivo medico per iniezione e dispositivo medico così ottenuto |
| EP4445929A1 (en) | 2023-04-14 | 2024-10-16 | Becton, Dickinson and Company | Connected drug delivery device |
| EP4541387A1 (en) | 2023-10-16 | 2025-04-23 | Becton Dickinson France | Sequential-injection syringe |
| KR102828906B1 (ko) * | 2024-11-18 | 2025-07-04 | 주식회사 비에스리서치 | 실리콘 오일이 미적용된 프리필드 시린지 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4767414A (en) | 1985-05-16 | 1988-08-30 | Becton, Dickinson And Company | Ionizing plasma lubricant method |
| CA1271160A (en) | 1985-05-16 | 1990-07-03 | Joel L. Williams | Ionizing plasma lubricant method |
| US4822632A (en) | 1985-05-16 | 1989-04-18 | Becton, Dickinson And Company | Ionizing plasma lubricant method |
| US4838857A (en) * | 1985-05-29 | 1989-06-13 | Becton, Dickinson And Company | Medical infusion device |
| US4844986A (en) | 1988-02-16 | 1989-07-04 | Becton, Dickinson And Company | Method for preparing lubricated surfaces and product |
| US5266359A (en) | 1991-01-14 | 1993-11-30 | Becton, Dickinson And Company | Lubricative coating composition, article and assembly containing same and method thereof |
| US5338312A (en) | 1992-10-02 | 1994-08-16 | Becton, Dickinson And Company | Article having multi-layered lubricant and method therefor |
| DE19753766A1 (de) * | 1997-12-04 | 1999-06-17 | Schott Glas | Länglicher Kunststoff-Hohlkörper und Verfahren zu seiner Herstellung |
| JP2002505177A (ja) * | 1998-03-06 | 2002-02-19 | ノボ ノルディスク アクティーゼルスカブ | 低摩擦及び低タンパク質吸着力を示す被覆表層を有する医療製品 |
| US6461334B1 (en) * | 1998-03-06 | 2002-10-08 | Novo Nordisk A/S | Medical article with coated surfaces exhibiting low friction and protein adsorption |
| JP2000015661A (ja) * | 1998-06-30 | 2000-01-18 | Daikyo Seiko Ltd | プラスチック製医薬品用・医療具用成形体の製造方法 |
| SE9802938D0 (sv) * | 1998-09-01 | 1998-09-01 | Astra Ab | Improved stability for injection solutions |
| US7431989B2 (en) * | 2003-05-06 | 2008-10-07 | Tribofilm Research, Inc. | Article with lubricated surface and method |
| JP2005160888A (ja) | 2003-12-05 | 2005-06-23 | Terumo Corp | シリンジ用ガスケット、シリンジ及びシリンジ用ガスケットの製造方法 |
| US8124207B2 (en) * | 2004-03-02 | 2012-02-28 | Sakhrani Vinay G | Article with lubricated surface and method |
| US20080071228A1 (en) * | 2006-09-15 | 2008-03-20 | Becton, Dickinson And Company | Medical Components Having Coated Surfaces Exhibiting Low Friction and Methods of Reducing Sticktion |
| WO2009030975A1 (en) * | 2007-09-03 | 2009-03-12 | Becton Dickinson France | Medical device comprising a siliconized chamber and a coated closure means |
| WO2009053947A2 (en) | 2007-10-22 | 2009-04-30 | Becton Dickinson France | Surface coating to prevent cation leaching |
| JP5647126B2 (ja) * | 2008-09-22 | 2014-12-24 | ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ | 光分解化学的気相堆積法および／または熱化学的気相堆積法を使用して容器の内部を被覆するシステム、装置および方法 |
| KR20110128852A (ko) | 2009-02-12 | 2011-11-30 | 라모트 앳 텔-아비브 유니버시티 리미티드 | 데이터의 인코딩에 의한 플래시 내구성 강화 장치 및 방법 |
| WO2011092536A1 (en) * | 2010-01-26 | 2011-08-04 | Becton Dickinson France | Drug cartrigde different inner surface conditions |
-
2012
- 2012-09-27 EP EP23157103.5A patent/EP4218862A1/en active Pending
- 2012-09-27 CN CN201280056039.4A patent/CN103957966B/zh not_active Ceased
- 2012-09-27 MX MX2014003729A patent/MX356788B/es active IP Right Grant
- 2012-09-27 WO PCT/EP2012/069119 patent/WO2013045571A2/en not_active Ceased
- 2012-09-27 KR KR1020197037831A patent/KR20200003228A/ko not_active Ceased
- 2012-09-27 EP EP12766092.6A patent/EP2760509B1/en active Active
- 2012-09-27 RU RU2014116080A patent/RU2621843C2/ru not_active IP Right Cessation
- 2012-09-27 JP JP2014532386A patent/JP6144264B2/ja active Active
- 2012-09-27 KR KR1020217000165A patent/KR20210005316A/ko not_active Ceased
- 2012-09-27 ES ES12766092T patent/ES2944088T3/es active Active
- 2012-09-27 KR KR1020147010852A patent/KR20140082723A/ko not_active Ceased
- 2012-09-27 US US14/347,677 patent/US20140221934A1/en not_active Abandoned
-
2025
- 2025-02-05 US US19/045,859 patent/US20250177654A1/en active Pending
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