RU2578715C2 - Новые арилированные камфены, способы их получения и их применения - Google Patents
Новые арилированные камфены, способы их получения и их применения Download PDFInfo
- Publication number
- RU2578715C2 RU2578715C2 RU2012106897/04A RU2012106897A RU2578715C2 RU 2578715 C2 RU2578715 C2 RU 2578715C2 RU 2012106897/04 A RU2012106897/04 A RU 2012106897/04A RU 2012106897 A RU2012106897 A RU 2012106897A RU 2578715 C2 RU2578715 C2 RU 2578715C2
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- RU
- Russia
- Prior art keywords
- dimethoxy
- hept
- phenyl
- methyloctan
- dimethylbicyclo
- Prior art date
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- 0 C[C@]([C@]1N[C@]11C(CC2)C(C)C2(C)C1*)N Chemical compound C[C@]([C@]1N[C@]11C(CC2)C(C)C2(C)C1*)N 0.000 description 3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/94—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems condensed with rings other than six-membered or with ring systems containing such rings
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
- A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/215—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring having unsaturation outside the six-membered aromatic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/04—Esters of boric acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Otolaryngology (AREA)
- Nutrition Science (AREA)
- Pulmonology (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Reproductive Health (AREA)
- Emergency Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Oncology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26267709P | 2009-11-19 | 2009-11-19 | |
| US61/262,677 | 2009-11-19 | ||
| PCT/IL2010/000970 WO2011061744A2 (en) | 2009-11-19 | 2010-11-18 | Novel arylated camphenes, processes for their preparation and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2012106897A RU2012106897A (ru) | 2013-12-27 |
| RU2578715C2 true RU2578715C2 (ru) | 2016-03-27 |
Family
ID=43875675
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012106897/04A RU2578715C2 (ru) | 2009-11-19 | 2010-11-18 | Новые арилированные камфены, способы их получения и их применения |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US8722938B2 (enExample) |
| EP (1) | EP2501669B1 (enExample) |
| JP (1) | JP5960058B2 (enExample) |
| KR (1) | KR20120091196A (enExample) |
| CN (1) | CN102648174B (enExample) |
| AU (1) | AU2010320467B2 (enExample) |
| BR (1) | BR112012010518A2 (enExample) |
| CA (1) | CA2774868C (enExample) |
| CL (1) | CL2012001290A1 (enExample) |
| CO (1) | CO6481008A2 (enExample) |
| CR (1) | CR20120247A (enExample) |
| EC (1) | ECSP12011864A (enExample) |
| ES (1) | ES2665519T3 (enExample) |
| IL (1) | IL218216A (enExample) |
| MA (1) | MA33753B1 (enExample) |
| MX (2) | MX355972B (enExample) |
| MY (1) | MY184647A (enExample) |
| NZ (1) | NZ599106A (enExample) |
| PE (1) | PE20121187A1 (enExample) |
| PH (1) | PH12012500897A1 (enExample) |
| RU (1) | RU2578715C2 (enExample) |
| SG (2) | SG10201407706VA (enExample) |
| UA (1) | UA109414C2 (enExample) |
| WO (1) | WO2011061744A2 (enExample) |
| ZA (1) | ZA201200752B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2578715C2 (ru) * | 2009-11-19 | 2016-03-27 | Йиссум Рисерч Дивелопмент Компани Оф Дзе Хебрю Юниверсити Оф Иерусалим, Лтд. | Новые арилированные камфены, способы их получения и их применения |
| KR20170072876A (ko) | 2014-10-27 | 2017-06-27 | 에프. 호프만-라 로슈 아게 | 방사성 표지된 카나비노이드 수용체 2 리간드 |
| US9585867B2 (en) | 2015-08-06 | 2017-03-07 | Charles Everett Ankner | Cannabinod formulation for the sedation of a human or animal |
| US20170038184A1 (en) | 2015-08-06 | 2017-02-09 | Charles E. Ankner | Formulation delivery system |
| MX2018004632A (es) * | 2015-10-16 | 2018-11-09 | Scythian Biosciences Inc | Metodos y composiciones para el tratamiento de una lesion cerebral traumatica. |
| EP3538507A1 (en) | 2016-11-13 | 2019-09-18 | Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. | Process for the preparation of hu-910 and crystalline structure thereof |
| RU2651754C1 (ru) * | 2016-11-25 | 2018-04-23 | Федеральное государственное бюджетное учреждение науки Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) | ПРИМЕНЕНИЕ АЛИФАТИЧЕСКИХ ИМИНОПРОИЗВОДНЫХ КАМФОРЫ В КАЧЕСТВЕ ЭФФЕКТИВНЫХ ИНГИБИТОРОВ РЕПРОДУКЦИИ ВИРУСА ГРИППА штамм A/California/07/09 (H1N1) pdm09 и A/Puerto Rico/8/34 (H1N1) |
| KR102063962B1 (ko) * | 2017-10-25 | 2020-01-08 | 대구대학교 산학협력단 | 캄펜을 유효성분으로 함유하는 골다공증의 예방 또는 치료용 약학적 조성물 |
| EP3840854A4 (en) * | 2018-08-20 | 2022-06-29 | Bessor Pharma, LLC | Novel cannabinoids and cannabinoid acids and their derivatives |
| US20250002435A1 (en) * | 2021-10-10 | 2025-01-02 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Arylated fenchone derivatives, compositions comprising them, processes for their preparation and uses thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2537647A (en) * | 1948-02-21 | 1951-01-09 | Firestone Tire & Rubber Co | Rearrangement of terpenyl aryl ethers |
| WO2008154083A2 (en) * | 2007-05-04 | 2008-12-18 | Proteo Tech Inc. | Compounds, compositions and methods for the treatment of synucleinopathies |
| US7514583B2 (en) * | 2002-05-31 | 2009-04-07 | Proteotech, Inc. | Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as alzheimer's disease, type 2 diabetes, and parkinson's disease |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE876241C (de) * | 1943-04-07 | 1953-05-11 | Lech Chemie Gersthofen | Verfahren zur Herstellung von Riechstoffen aus Terpenphenolen |
| DE828394C (de) * | 1948-10-02 | 1952-01-17 | Chemische Werke Huels G M B H | Verfahren zur Herstellung von UEberzuegen |
| US2647152A (en) * | 1950-07-12 | 1953-07-28 | Firestone Tire & Rubber Co | Terpenylalkylphenols and their preparation |
| US3284359A (en) * | 1963-12-26 | 1966-11-08 | Gen Electric | Barium potassium ferrite magnetic material exhibiting non-vanishing rotational hysteresis in applied magnetic fields |
| GB1306217A (enExample) * | 1969-07-04 | 1973-02-07 | ||
| US3800051A (en) * | 1970-09-21 | 1974-03-26 | Dow Chemical Co | Reducing serum cholesterol with certain substituted phenols |
| US4112000A (en) * | 1974-04-11 | 1978-09-05 | Mar-Pha, Societe D'etude Et D'exploitation De Marques | Terpenophenols |
| GB1504862A (en) * | 1974-04-11 | 1978-03-22 | Mar Pha Etu Expl Marques | Terpeno-phenoxyalkylamines |
| GB1548875A (en) * | 1975-06-23 | 1979-07-18 | Mar Pha Etu Expl Marques | Terpnyl phen (oxy)elkyl amideines and their use in pharmaceutical compositions |
| US5648352A (en) | 1991-09-13 | 1997-07-15 | Merck & Co., Inc. | Piperazinylcamphorsulfonyl oxytocin antagonists |
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| RU2578715C2 (ru) * | 2009-11-19 | 2016-03-27 | Йиссум Рисерч Дивелопмент Компани Оф Дзе Хебрю Юниверсити Оф Иерусалим, Лтд. | Новые арилированные камфены, способы их получения и их применения |
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| US2537647A (en) * | 1948-02-21 | 1951-01-09 | Firestone Tire & Rubber Co | Rearrangement of terpenyl aryl ethers |
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