RU2547931C2 - Модифицированные антигенсвязывающие молекулы с измененной клеточной сигнальной активностью - Google Patents

Модифицированные антигенсвязывающие молекулы с измененной клеточной сигнальной активностью Download PDF

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RU2547931C2
RU2547931C2 RU2012139197/10A RU2012139197A RU2547931C2 RU 2547931 C2 RU2547931 C2 RU 2547931C2 RU 2012139197/10 A RU2012139197/10 A RU 2012139197/10A RU 2012139197 A RU2012139197 A RU 2012139197A RU 2547931 C2 RU2547931 C2 RU 2547931C2
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УМАНА Пабло
МОССНЕР Эккехард
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Роше Гликарт Аг
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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RU2012139197/10A 2005-08-26 2006-08-25 Модифицированные антигенсвязывающие молекулы с измененной клеточной сигнальной активностью RU2547931C2 (ru)

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Application Number Priority Date Filing Date Title
US71145405P 2005-08-26 2005-08-26
US60/711,454 2005-08-26

Related Parent Applications (1)

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RU2008111068/10A Division RU2482132C2 (ru) 2005-08-26 2006-08-25 Модифицированные антигенсвязывающие молекулы с измененной клеточной сигнальной активностью

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RU2012139197A RU2012139197A (ru) 2014-03-20
RU2547931C2 true RU2547931C2 (ru) 2015-04-10

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RU2012139197/10A RU2547931C2 (ru) 2005-08-26 2006-08-25 Модифицированные антигенсвязывающие молекулы с измененной клеточной сигнальной активностью
RU2008111068/10A RU2482132C2 (ru) 2005-08-26 2006-08-25 Модифицированные антигенсвязывающие молекулы с измененной клеточной сигнальной активностью

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US (2) US20070071745A1 (https=)
EP (3) EP2395024B1 (https=)
JP (3) JP5373396B2 (https=)
KR (2) KR101460932B1 (https=)
CN (2) CN101291954B (https=)
AR (1) AR055137A1 (https=)
AU (1) AU2006290433B2 (https=)
BR (2) BR122020020335B1 (https=)
CA (1) CA2619298C (https=)
CL (2) CL2010000822A1 (https=)
IL (1) IL189756A (https=)
NO (2) NO345919B1 (https=)
PH (1) PH12012502376B1 (https=)
RU (2) RU2547931C2 (https=)
SG (1) SG192479A1 (https=)
TW (2) TWI615407B (https=)
WO (1) WO2007031875A2 (https=)
ZA (1) ZA200802500B (https=)

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CA2524305C (en) 2003-05-01 2015-12-08 Imclone Systems Incorporated Fully human antibodies directed against the human insulin-like growth factor-1 receptor
US9296820B2 (en) * 2003-11-05 2016-03-29 Roche Glycart Ag Polynucleotides encoding anti-CD20 antigen binding molecules with increased Fc receptor binding affinity and effector function
PL1871805T3 (pl) 2005-02-07 2020-03-31 Roche Glycart Ag Cząsteczki wiążące antygen, które wiążą egfr, wektory kodujące te cząsteczki oraz ich zastosowania
CA2612449A1 (en) 2005-06-17 2006-12-28 Imclone Systems Incorporated Receptor antagonists for treatment of metastatic bone cancer
AU2006290433B2 (en) * 2005-08-26 2012-06-07 Roche Glycart Ag Modified antigen binding molecules with altered cell signaling activity
AP2008004569A0 (en) 2006-02-03 2008-08-31 Imclone Systems Inc IGR-IR antagonists as adjuvants for treatment of prostrate cancer
AR062223A1 (es) 2006-08-09 2008-10-22 Glycart Biotechnology Ag Moleculas de adhesion al antigeno que se adhieren a egfr, vectores que los codifican, y sus usos de estas
BRPI0813645A2 (pt) 2007-06-25 2014-12-30 Esbatech Alcon Biomed Res Unit Métodos para modificar anticorpos, e anticorpos modificados com propriedades funcionais aperfeiçoadas
AU2008295140A1 (en) * 2007-09-05 2009-03-12 F. Hoffmann-La Roche Ag Combination therapy with type I and type II anti-CD20 antibodies
US20090098118A1 (en) 2007-10-15 2009-04-16 Thomas Friess Combination therapy of a type ii anti-cd20 antibody with an anti-bcl-2 active agent
US20090110688A1 (en) * 2007-10-24 2009-04-30 Georg Fertig Combination therapy of type ii anti-cd20 antibody with a proteasome inhibitor
WO2009086072A2 (en) * 2007-12-21 2009-07-09 Genentech, Inc. Therapy of rituximab-refractory rheumatoid arthritis patients
US20090162359A1 (en) 2007-12-21 2009-06-25 Christian Klein Bivalent, bispecific antibodies
US9266967B2 (en) 2007-12-21 2016-02-23 Hoffmann-La Roche, Inc. Bivalent, bispecific antibodies
EP2260057B1 (en) * 2008-03-13 2016-11-23 Biotest AG Anti-CD4 antibody dosage regimen for treating autoimmune disease
EP2265643B1 (en) * 2008-03-13 2016-10-19 Biotest AG Dosing regimen for treating psoriasis and rheumatoid arthritis
RU2540013C2 (ru) * 2008-03-13 2015-01-27 Биотест Аг Средство для лечения заболевания
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