RU2520759C2 - Предупреждение и лечение субклинической формы болезней, вызываемых цирковирусом свиней (pcvd) - Google Patents

Предупреждение и лечение субклинической формы болезней, вызываемых цирковирусом свиней (pcvd) Download PDF

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RU2520759C2
RU2520759C2 RU2009134222/15A RU2009134222A RU2520759C2 RU 2520759 C2 RU2520759 C2 RU 2520759C2 RU 2009134222/15 A RU2009134222/15 A RU 2009134222/15A RU 2009134222 A RU2009134222 A RU 2009134222A RU 2520759 C2 RU2520759 C2 RU 2520759C2
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pcv2
animals
infection
animal
subclinical form
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RU2009134222/15A
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Russian (ru)
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RU2009134222A (ru
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ФАХИНГЕР Викки
ЭЛЬБЕРС Кнут
КИКСМЁЛЛЕР Марион
ОРВЕЛЛОН Франсуа-Ксавьер
ФРАЙН-ФОН-РИХТХОФЕН Изабелла
ЛИШЕВСКИ Аксель
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Бёрингер Ингельхайм Ветмедика, Инк.
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RU2009134222/15A 2007-02-13 2008-02-11 Предупреждение и лечение субклинической формы болезней, вызываемых цирковирусом свиней (pcvd) RU2520759C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07102250.3 2007-02-13
EP20070102250 EP1958644A1 (en) 2007-02-13 2007-02-13 Prevention and treatment of sub-clinical pcvd
PCT/EP2008/051628 WO2008098909A1 (en) 2007-02-13 2008-02-11 Prevention and treatment of sub-clinical pcvd

Publications (2)

Publication Number Publication Date
RU2009134222A RU2009134222A (ru) 2011-03-20
RU2520759C2 true RU2520759C2 (ru) 2014-06-27

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RU2009134222/15A RU2520759C2 (ru) 2007-02-13 2008-02-11 Предупреждение и лечение субклинической формы болезней, вызываемых цирковирусом свиней (pcvd)

Country Status (23)

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US (5) US7943298B2 (https=)
EP (3) EP1958644A1 (https=)
JP (1) JP5562041B2 (https=)
KR (1) KR101521465B1 (https=)
CN (1) CN101610786B (https=)
AR (1) AR065319A1 (https=)
AU (1) AU2008214639B2 (https=)
BR (1) BRPI0807493A2 (https=)
CA (1) CA2676568C (https=)
CL (1) CL2008000445A1 (https=)
CY (1) CY1114577T1 (https=)
DK (2) DK2114447T3 (https=)
ES (2) ES2434117T3 (https=)
MX (1) MX2009008577A (https=)
MY (1) MY152149A (https=)
PL (1) PL2114447T3 (https=)
PT (1) PT2114447E (https=)
RU (1) RU2520759C2 (https=)
SI (1) SI2114447T1 (https=)
TW (1) TWI438003B (https=)
UA (1) UA100507C2 (https=)
WO (1) WO2008098909A1 (https=)
ZA (1) ZA200904806B (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA95602C2 (ru) 2004-12-30 2011-08-25 Берингер Ингельхейм Ветмедика, Инк. Иммуногенная композиция цвс2 и способы приготовления такой композиции
US7833707B2 (en) 2004-12-30 2010-11-16 Boehringer Ingelheim Vetmedica, Inc. Methods of overexpression and recovery of porcine circovirus type 2 ORF2
US8834891B2 (en) 2005-03-14 2014-09-16 Boehringer Ingelheim Vetmedica, Inc. Immunogenic compositions comprising Lawsonia intracellularis
EP3868400A1 (en) 2005-12-29 2021-08-25 Boehringer Ingelheim Animal Health USA Inc. Multivalent pcv2 immunogenic compositions and methods of producing such compositions
DK3766518T3 (da) 2005-12-29 2026-04-13 Boehringer Ingelheim Animal Health Usa Inc Immunogen pcv2-sammensætning til mindskelse af kliniske symptomer hos grise
US20100136060A1 (en) * 2006-11-22 2010-06-03 Boehringer Ingelheim Vetmedica, Inc. Methods of reducing porcine circovirus-associated disease outbreaks
EP2859900A1 (en) * 2006-12-11 2015-04-15 Boehringer Ingelheim Vetmedica, Inc. Effective method of treatment of porcine circovirus and lawsonia intracellularis infections
PT2094872T (pt) * 2006-12-15 2017-04-27 Boehringer Ingelheim Vetmedica Inc Tratamento de porcos seropositivos para o anticorpo anti-pcv2 com antigénio de pcv2
EP1941903A1 (en) 2007-01-03 2008-07-09 Boehringer Ingelheim Vetmedica Gmbh Prophylaxis and treatment of PRDC
EP1958644A1 (en) 2007-02-13 2008-08-20 Boehringer Ingelheim Vetmedica Gmbh Prevention and treatment of sub-clinical pcvd
US7829274B2 (en) 2007-09-04 2010-11-09 Boehringer Ingelheim Vetmedica, Inc. Reduction of concomitant infections in pigs by the use of PCV2 antigen
KR20100113582A (ko) 2008-01-23 2010-10-21 베링거잉겔하임베트메디카인코퍼레이티드 Pcv2 마이코플라즈마 히오뉴모니에 면역원성 조성물 및 당해 조성물의 생산 방법
EP2254595A4 (en) * 2008-02-15 2012-12-05 Boehringer Ingelheim Vetmed METHODS AND COMPOSITIONS FOR REDUCING THE IMPACT OF ENTERIC DISEASES
WO2010058236A1 (es) * 2008-11-19 2010-05-27 Laboratorio Avi-Mex, S.A. De C.V. Vacuna recombinante de vector viral inactivado
TWI627281B (zh) 2009-09-02 2018-06-21 百靈佳殷格翰家畜藥品公司 降低pcv-2組合物殺病毒活性之方法及具有改良免疫原性之pcv-2組合物
CN103108653B (zh) 2010-07-08 2015-07-22 美国联合生物医学公司 设计肽的pcv2疫苗
US9649370B2 (en) 2013-05-08 2017-05-16 Protatek International, Inc. Vaccine for PCV2 and mycoplasma
US20140348874A1 (en) * 2013-05-22 2014-11-27 Boehringer Ingelheim Espana, S.A. Method for the reduction of pcv-2 in a herd of swine
MX373884B (es) 2013-10-02 2020-03-26 Boehringer Ingelheim Animal Health Usa Inc Variante de la proteína pcv2 orf2 y partículas similares al virus compuestas por ésta.
CN105848675A (zh) 2013-12-03 2016-08-10 英特维特国际股份有限公司 抗猪圆环病毒2型的疫苗
CN108026538B (zh) * 2015-12-28 2021-09-03 财团法人农业科技研究院 猪圆环病毒2型的外鞘蛋白质的制备方法及含该外鞘蛋白质的医药组合物

Family Cites Families (105)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2909462A (en) 1955-12-08 1959-10-20 Bristol Myers Co Acrylic acid polymer laxative compositions
US4708871A (en) 1983-03-08 1987-11-24 Commonwealth Serum Laboratories Commission Antigenically active amino acid sequences
EP0283085B1 (en) * 1987-03-17 1992-11-11 Akzo N.V. Adjuvant mixture
US5069901A (en) 1988-02-03 1991-12-03 Jones Elaine V Preparation of a recombinant subunit vaccine against pseudorabies infection
DK0454735T3 (da) 1989-01-23 1996-10-07 Auspharm Int Ltd Vaccine sammensætning
US5155037A (en) 1989-08-04 1992-10-13 The Texas A&M University System Insect signal sequences useful to improve the efficiency of processing and secretion of foreign genes in insect systems
US5202430A (en) 1990-01-16 1993-04-13 University Of Tennessee Transmissible gastroenteritis virus genes
ES2112274T5 (es) 1990-05-29 2006-03-01 Wyeth Holdings Corporation Vacuna contra la pneumonia en cerdos y metodo para la preparacion de la misma.
US5565205A (en) 1990-08-16 1996-10-15 Solvay Animal Health, Inc. Inactivated Mycoplasma hypopneumoniae bacterin and method of use thereof
GB9023111D0 (en) 1990-10-24 1990-12-05 Wellcome Found Expression system
DK0555366T3 (da) 1990-11-01 2000-08-28 Univ Iowa State Res Found Inc Fremgangsmåde til bakteriel svækkelse og vaccine
KR0138092B1 (ko) 1991-08-26 1998-04-30 제임스 씨. 데세사레 미확인(Mystery) 돼지 질병 관련 바이러스제
US6042830A (en) 1992-08-05 2000-03-28 Boehringer Ingelheim Vetmedica, Inc. Viral agent associated with mystery swine disease
US5580557A (en) 1991-10-09 1996-12-03 Iowa State University Research Foundation, Inc. Live, avirulent salmonella choleraesuis vaccine used for inducing an immune response in animals
US5338543A (en) 1992-02-27 1994-08-16 Ambico, Inc. Thimerosal inactivated mycoplasma hyopneumoniae vaccine
PT968722E (pt) 1994-05-10 2007-09-06 Wyeth Corp Vacina viva melhorada contra brsv.
US5885823A (en) 1995-06-05 1999-03-23 Nobl Laboratories, Inc. Lawsonia intracellularis cultivation, anti-Lawsonia intracellularis vaccines and diagnostic agents
CA2264953C (en) 1996-08-16 2008-09-30 The Texas A & M University System Modifying insect cell gylcosylation pathways with baculovirus expression vectors
EP0835930B1 (en) 1996-10-09 2001-01-31 Akzo Nobel N.V. European vaccine strains of the porcine reproductive and respiratory syndrome virus (PRRSV)
US20060029617A1 (en) 1997-10-03 2006-02-09 Charreyre Catherine E Porcine circovirus and Helicobacter combination vaccines and methods of use
US7192594B2 (en) 1997-10-03 2007-03-20 Merial Limited Postweaning multisystemic wasting syndrome and porcine circovirus from pigs
US6517843B1 (en) * 1999-08-31 2003-02-11 Merial Reduction of porcine circovirus-2 viral load with inactivated PCV-2
UA78180C2 (uk) 1997-10-03 2007-03-15 Меріаль Кільцевий вірус свині типу ii, вакцини та діагностичні реагенти
US7211379B2 (en) 1997-10-03 2007-05-01 Merial Sas Prevention of myocarditis, abortion and intrauterine infection associated with porcine circovirus-2
US6391314B1 (en) 1997-10-03 2002-05-21 Merial Porcine circoviruses vaccines diagnostic reagents
FR2781159B1 (fr) 1998-07-06 2000-10-06 Merial Sas Vaccin circovirus et parvovirus porcin
FR2772047B1 (fr) 1997-12-05 2004-04-09 Ct Nat D Etudes Veterinaires E Sequence genomique et polypeptides de circovirus associe a la maladie de l'amaigrissement du porcelet (map), applications au diagnostic et a la prevention et/ou au traitement de l'infection
US20040062775A1 (en) 1997-12-05 2004-04-01 Agence Francaise De Securite Sanitaire Des Aliments Circovirus sequences associated with piglet weight loss disease (PWD)
DE69837934T2 (de) 1997-12-11 2008-02-21 University Of Saskatchewan, Saskatoon Multisystemisches kümmerwuchssyndrom durch viren in schweinen
EP1064024A4 (en) 1998-03-13 2005-04-06 Univ Georgia Res Found VACCINES AGAINST CIRCOVIRUS INFECTIONS
US6294176B1 (en) 1998-07-10 2001-09-25 Schering-Plough Veterinary Corp. Recombinant raccoonpox virus and uses thereof as a vaccine in mammalian and avian species
WO2000031275A1 (en) 1998-11-19 2000-06-02 Azwell Inc. Recombinant lysophosphatidic acid phosphatase
FR2789695B1 (fr) 1999-02-11 2003-03-07 Merial Sas Vecteurs et vaccins viraux a base d'adenovirus porcins recombines et replicatifs
US6497883B1 (en) 1999-06-10 2002-12-24 Merial Porcine circovirus recombinant poxvirus vaccine
US6943152B1 (en) * 1999-06-10 2005-09-13 Merial DNA vaccine-PCV
GB9921146D0 (en) 1999-09-07 1999-11-10 Smithkline Beecham Biolog Novel composition
WO2001017556A1 (fr) 1999-09-07 2001-03-15 Shionogi & Co., Ltd. Préparations vaccinales administrables par les muqueuses
GB9921147D0 (en) 1999-09-07 1999-11-10 Smithkline Beecham Biolog Novel composition
US6656478B1 (en) 1999-11-12 2003-12-02 Samuel D. Charles Cross-protective salmonella vaccines
NZ519655A (en) 1999-12-21 2004-04-30 Merial Sas Compositions and vaccines containing antigen(s) of cryptosporidium parvum and of another enteric pathogen
US6808900B2 (en) * 2000-06-15 2004-10-26 Manitoba, University Of Cryptosporidium parvum antigens, antibodies thereto and diagnostic and therapeutic compositions thereof
AU2001266940A1 (en) 2000-06-15 2001-12-24 Purdue Research Foundation Vaccine for congenital tremors in pigs
HUP0302068A3 (en) 2000-07-20 2005-05-30 Lauras As Use of cox-2 inhibitors for treating or preventing immunodeficiency and pharmaceutical compositions containing them
MY129765A (en) 2000-12-19 2007-04-30 Wyeth Corp Improved mycoplasma hyopneumoniae bacterin vaccine
US7018638B2 (en) 2000-12-19 2006-03-28 Wyeth Mycoplasma hyopneumoniae bacterin vaccine
JP2002247979A (ja) 2001-02-23 2002-09-03 Nippon Biologicals Inc マレック病ワクチンおよびその製造方法
BRPI0208456B8 (pt) 2001-03-27 2021-05-25 Univ Saskatchewan métodos para cultura de circovírus
US20030096377A1 (en) 2001-06-28 2003-05-22 Virginia Tech Intellectual Properties, Inc. Differential PCR-RFLP assay for detecting and distinguishing between nonpathogenic PCV-1 and pathogenic PCV-2
EP2027873B8 (en) 2001-07-02 2015-11-11 Zoetis Services LLC One dose vaccination with mycoplasma hyopneumoniae
US7361352B2 (en) 2001-08-15 2008-04-22 Acambis, Inc. Influenza immunogen and vaccine
US7276353B2 (en) * 2001-12-12 2007-10-02 Virginia Tech Intellectual Properties, Inc. Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof
US7279166B2 (en) 2001-12-12 2007-10-09 Virginia Tech Intellectual Properties, Inc. Chimeric infectious DNA clones, chimeric porcine circoviruses and uses thereof
US6841364B2 (en) 2002-01-22 2005-01-11 Protatek International, Inc. Infectious cDNA clones of porcine reproductive and respiratory syndrome virus and expression vectors thereof
WO2003068163A2 (en) 2002-02-14 2003-08-21 Novavax, Inc. Optimization of gene sequences of chimeric virus-like particles for expression in insect cells
US20030199581A1 (en) 2002-03-13 2003-10-23 Seligson Allen L. Boswellin compositions enhanced with 3-beta-acetyl-11-keto-beta-boswellic acid ("AKBA") industrial manufacture and uses
US20030215455A1 (en) * 2002-05-14 2003-11-20 Bailey Reynolds Vaccine stabilizer and method of use
US7335362B2 (en) 2002-07-19 2008-02-26 Beth Israel Deaconess Medical Center Methods of treating pre-eclampsia or eclampsia
US7223207B1 (en) 2002-09-13 2007-05-29 Simon Basyuk Exercise and massage device
AU2002951692A0 (en) 2002-09-23 2002-10-17 Vital Biotech (Hong Kong) Limited Improvements in or relating to vaccines
US7408636B2 (en) 2002-10-31 2008-08-05 Chemimage Corporation Method and apparatus for dark field chemical imaging
EP1599164B1 (en) 2003-02-03 2015-04-08 Cerebus Biologicals, Inc. Methods for treating, preventing and detecting helicobacter infection
US7563449B2 (en) 2003-04-21 2009-07-21 Pfizer Inc, Methods for reducing cattle reproductive diseases
CN1458167A (zh) 2003-06-02 2003-11-26 中国农业科学院哈尔滨兽医研究所 截短表达的猪圆环病毒ⅱ型衣壳蛋白抗原及其应用
US7335361B2 (en) * 2003-06-09 2008-02-26 Animal Technology Institute Taiwan Fusion antigen used as vaccine
SI1651265T1 (sl) 2003-07-24 2008-10-31 Merial Ltd Formulacije cepiva, ki obsegajo emulzijo olje v vodi
DE602004023094D1 (de) * 2003-07-25 2009-10-22 Boehringer Ingelheim Vetmed Lawsonia intracellularis europäischen ursprungs unür
FR2861731B1 (fr) * 2003-10-30 2006-02-24 Centre Nat Rech Scient Nouvelle proteine de fixation du phosphate, compositions pharmaceutiques la contenant et ses utilisations
WO2005112995A1 (en) 2004-04-26 2005-12-01 Choongang Vaccine Laboratory Co., Ltd. Inactivated mixed vaccine for porcine respiratory disease and the method of manufacturing thereof
CN1579553A (zh) 2004-05-18 2005-02-16 浙江大学 Ii型猪圆环病毒核酸疫苗的制备方法及其应用
KR100478845B1 (ko) 2004-06-22 2005-03-24 채찬희 돼지 이유자돈 전신성 소모성 증후군 예방 및 치료용 생물학적 조성물
JP2008505114A (ja) 2004-06-30 2008-02-21 アイディー バイオメディカル コーポレイション オブ ケベック コロナウイルス感染を処置するためのワクチン組成物
UA95602C2 (ru) 2004-12-30 2011-08-25 Берингер Ингельхейм Ветмедика, Инк. Иммуногенная композиция цвс2 и способы приготовления такой композиции
US7700285B1 (en) * 2005-12-29 2010-04-20 Boehringer Ingelheim Vetmedica, Inc. PCV2 immunogenic compositions and methods of producing such compositions
US7833707B2 (en) * 2004-12-30 2010-11-16 Boehringer Ingelheim Vetmedica, Inc. Methods of overexpression and recovery of porcine circovirus type 2 ORF2
RU2007130801A (ru) 2005-01-13 2009-02-20 Берингер Ингельхайм Ветмедика Гмбх (De) Улучшенные вакцины против репродуктивно-респираторного синдрома свиней (prrs)
US7300785B2 (en) 2005-02-03 2007-11-27 Universiteit Ghent Culturing circular ssDNA viruses for the production of vaccines
US8834891B2 (en) 2005-03-14 2014-09-16 Boehringer Ingelheim Vetmedica, Inc. Immunogenic compositions comprising Lawsonia intracellularis
EP3088893B1 (en) 2005-04-13 2018-02-14 Merial, Inc. Assay for monitoring porcine circovirus production
US7691368B2 (en) 2005-04-15 2010-04-06 Merial Limited Vaccine formulations
ES2425228T3 (es) 2005-09-09 2013-10-14 Intervet International B.V. Vacuna contra el PCV-2
DK3766518T3 (da) * 2005-12-29 2026-04-13 Boehringer Ingelheim Animal Health Usa Inc Immunogen pcv2-sammensætning til mindskelse af kliniske symptomer hos grise
EP3868400A1 (en) * 2005-12-29 2021-08-25 Boehringer Ingelheim Animal Health USA Inc. Multivalent pcv2 immunogenic compositions and methods of producing such compositions
US20100136060A1 (en) 2006-11-22 2010-06-03 Boehringer Ingelheim Vetmedica, Inc. Methods of reducing porcine circovirus-associated disease outbreaks
EP2859900A1 (en) 2006-12-11 2015-04-15 Boehringer Ingelheim Vetmedica, Inc. Effective method of treatment of porcine circovirus and lawsonia intracellularis infections
PT2094872T (pt) * 2006-12-15 2017-04-27 Boehringer Ingelheim Vetmedica Inc Tratamento de porcos seropositivos para o anticorpo anti-pcv2 com antigénio de pcv2
EP1941903A1 (en) 2007-01-03 2008-07-09 Boehringer Ingelheim Vetmedica Gmbh Prophylaxis and treatment of PRDC
EP1958644A1 (en) * 2007-02-13 2008-08-20 Boehringer Ingelheim Vetmedica Gmbh Prevention and treatment of sub-clinical pcvd
GB0712160D0 (en) * 2007-06-22 2007-08-01 Univ Ghent Methods and compositions in the treatment of procine circoviral infection
US20090017064A1 (en) 2007-07-10 2009-01-15 Wyeth Methods and Compositions for Immunizing Pigs Against Porcine Circovirus
US7829274B2 (en) * 2007-09-04 2010-11-09 Boehringer Ingelheim Vetmedica, Inc. Reduction of concomitant infections in pigs by the use of PCV2 antigen
KR20100113582A (ko) 2008-01-23 2010-10-21 베링거잉겔하임베트메디카인코퍼레이티드 Pcv2 마이코플라즈마 히오뉴모니에 면역원성 조성물 및 당해 조성물의 생산 방법
EP2254595A4 (en) * 2008-02-15 2012-12-05 Boehringer Ingelheim Vetmed METHODS AND COMPOSITIONS FOR REDUCING THE IMPACT OF ENTERIC DISEASES
US8444989B1 (en) 2008-04-18 2013-05-21 Boehringer Ingelheim Vetmedica Gmbh One dose vaccination against mycoplasma infections of pigs
US20100150959A1 (en) 2008-12-15 2010-06-17 Vectogen Pty Ltd. PCV 2-Based Methods and Compositions for the Treatment of Pigs
TWI627281B (zh) 2009-09-02 2018-06-21 百靈佳殷格翰家畜藥品公司 降低pcv-2組合物殺病毒活性之方法及具有改良免疫原性之pcv-2組合物
US20110150770A1 (en) 2009-12-18 2011-06-23 Boehringer Ingelheim Vetmedica, Inc. Multivalent vaccine against porcine teschovirus and other disease causing organisms in swine
EP2547770B1 (en) 2010-03-16 2019-11-27 Virginia Tech Intellectual Properties, Inc. Live attenuated chimeric porcine circovirus vaccine
WO2012033911A2 (en) 2010-09-08 2012-03-15 The Johns Hopkins University Polyionic papilloma virus-like particle (vlp) vaccines
CN103122352B (zh) 2012-09-27 2015-02-11 华中农业大学 一种猪圆环病毒2型重组杆状病毒及制备方法和应用
EP3587439A3 (en) 2013-03-01 2020-03-11 Boehringer Ingelheim Animal Health USA Inc. Improved quantification of vaccine compositions
EP2991676A1 (en) 2013-04-30 2016-03-09 Boehringer Ingelheim Vetmedica, Inc. Orf2 protein of pcv2 subtype a (pcv2a) for use in cross-protection
US20140348874A1 (en) 2013-05-22 2014-11-27 Boehringer Ingelheim Espana, S.A. Method for the reduction of pcv-2 in a herd of swine
WO2015026912A1 (en) 2013-08-23 2015-02-26 Boehringer Ingelheim Vetmedica, Inc. Porcine circovirus type 2 (pcv2) subunit vaccine
MX373884B (es) 2013-10-02 2020-03-26 Boehringer Ingelheim Animal Health Usa Inc Variante de la proteína pcv2 orf2 y partículas similares al virus compuestas por ésta.
CN107531760A (zh) 2015-03-30 2018-01-02 勃林格殷格翰动物保健公司 Pcv2 orf2载体平台

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHAE . A review of porcine circovirus 2-associated syndromes and deseases// Veterinary journal, 2005, вып.169, N3, с.326-336. KIM J ET AL. Association of porcine circovirus 2 with porcine respratiry disease complex// Veterinary journal, 2003, вып.166, N3, с.251-256. Ingelvac® CircoFLEX" 06.07.2006 [Найдено 25.11.2011] [он-лайн], Найдено из Интернет: *

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