RU2485095C2 - Кристаллическое основание миноциклина и способы его получения - Google Patents

Кристаллическое основание миноциклина и способы его получения Download PDF

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Publication number
RU2485095C2
RU2485095C2 RU2009135403/04A RU2009135403A RU2485095C2 RU 2485095 C2 RU2485095 C2 RU 2485095C2 RU 2009135403/04 A RU2009135403/04 A RU 2009135403/04A RU 2009135403 A RU2009135403 A RU 2009135403A RU 2485095 C2 RU2485095 C2 RU 2485095C2
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Prior art keywords
minocycline
base
crystalline
amorphous
peaks
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RU2009135403/04A
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English (en)
Russian (ru)
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RU2009135403A (ru
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Зита МЕНДИШ
Жозе Рафаэль АНТУНИШ
Сусана МАРТУ
Уилльям ХЕГГИ
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Ховионе Интер Лтд.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU2009135403/04A 2007-02-23 2008-02-22 Кристаллическое основание миноциклина и способы его получения RU2485095C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PT103661A PT103661B (pt) 2007-02-23 2007-02-23 Processo de preparação de minociclina base cristalina
PT103661 2007-02-23
PCT/GB2008/000625 WO2008102161A2 (en) 2007-02-23 2008-02-22 Crystalline minocycline base and processes for its preparation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2013112021/04A Division RU2577331C2 (ru) 2007-02-23 2008-02-22 Кристаллическое основание миноциклина и способы его получения

Publications (2)

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RU2009135403A RU2009135403A (ru) 2011-03-27
RU2485095C2 true RU2485095C2 (ru) 2013-06-20

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RU2009135403/04A RU2485095C2 (ru) 2007-02-23 2008-02-22 Кристаллическое основание миноциклина и способы его получения
RU2013112021/04A RU2577331C2 (ru) 2007-02-23 2008-02-22 Кристаллическое основание миноциклина и способы его получения

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US (2) US8258327B2 (enExample)
EP (1) EP2125705B1 (enExample)
JP (4) JP2010519247A (enExample)
KR (1) KR101391132B1 (enExample)
CN (1) CN101679218B (enExample)
AU (1) AU2008217619B2 (enExample)
BR (2) BRPI0807319B1 (enExample)
CA (2) CA2835788C (enExample)
DK (1) DK2125705T3 (enExample)
ES (1) ES2610434T3 (enExample)
HU (1) HUE033030T2 (enExample)
IL (1) IL200544A0 (enExample)
MX (2) MX2009008980A (enExample)
NO (1) NO20092960L (enExample)
NZ (1) NZ579626A (enExample)
PL (1) PL2125705T3 (enExample)
PT (1) PT103661B (enExample)
RU (2) RU2485095C2 (enExample)
WO (1) WO2008102161A2 (enExample)
ZA (1) ZA200906517B (enExample)

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PT103661B (pt) 2007-02-23 2010-09-07 Hovione Farmaciencia S A Processo de preparação de minociclina base cristalina
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CA2769677A1 (en) 2009-07-29 2011-02-03 Foamix Ltd. Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses
CA2769625C (en) 2009-07-29 2017-04-11 Foamix Ltd. Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
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MX359879B (es) 2009-10-02 2018-10-12 Foamix Pharmaceuticals Ltd Composiciones tópicas de tetraciclina.
US9561241B1 (en) 2011-06-28 2017-02-07 Medicis Pharmaceutical Corporation Gastroretentive dosage forms for minocycline
PT106063B (pt) * 2011-12-19 2017-05-30 Inst Superior Tecnico Minociclina cristalina termorresistente produzida por recristalização com dióxido de carbono
CN104151186B (zh) * 2014-08-11 2016-06-15 重庆福安药业(集团)股份有限公司 替加环素杂质的立体选择性制备方法
PT108223B (pt) 2015-02-13 2018-05-08 Hovione Farm S A Novas formas polimórficas de minociclina base e processos para a sua preparação
KR20170134514A (ko) 2015-03-23 2017-12-06 바이오팜엑스 인코포레이티드 피부과 사용을 위한 약학 테트라사이클린 조성물
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2789331C2 (ru) * 2015-02-13 2023-02-01 Ховионе Сциентиа Лимитед Новые полиморфные формы миноциклинового основания и способы их получения
RU2789325C2 (ru) * 2015-02-13 2023-02-01 Ховионе Сциентиа Лимитед Новые полиморфные формы миноциклинового основания и способы их получения

Also Published As

Publication number Publication date
CA2722496A1 (en) 2008-08-28
WO2008102161A2 (en) 2008-08-28
EP2125705A2 (en) 2009-12-02
DK2125705T3 (en) 2017-01-16
PT103661B (pt) 2010-09-07
PL2125705T3 (pl) 2017-02-28
US20100286417A1 (en) 2010-11-11
WO2008102161A9 (en) 2008-11-13
WO2008102161A3 (en) 2009-01-08
US20130030195A1 (en) 2013-01-31
KR20100014520A (ko) 2010-02-10
AU2008217619B2 (en) 2013-01-10
US9416097B2 (en) 2016-08-16
CN101679218B (zh) 2013-10-30
BR122021000846B1 (pt) 2021-08-10
HUE033030T2 (hu) 2017-11-28
PT103661A (pt) 2008-08-25
CN101679218A (zh) 2010-03-24
IL200544A0 (en) 2010-05-17
NO20092960L (no) 2009-11-20
BRPI0807319B1 (pt) 2021-08-10
EP2125705B1 (en) 2016-10-12
US8258327B2 (en) 2012-09-04
RU2577331C2 (ru) 2016-03-20
NZ579626A (en) 2011-12-22
CA2722496C (en) 2014-06-10
JP2010519247A (ja) 2010-06-03
MX2009008980A (es) 2009-11-11
CA2835788A1 (en) 2008-08-28
JP2019142882A (ja) 2019-08-29
BRPI0807319A2 (pt) 2017-05-02
ZA200906517B (en) 2010-09-29
MX340539B (es) 2016-07-13
KR101391132B1 (ko) 2014-05-02
JP2017039742A (ja) 2017-02-23
JP2014169319A (ja) 2014-09-18
CA2835788C (en) 2018-03-27
AU2008217619A1 (en) 2008-08-28
RU2009135403A (ru) 2011-03-27
ES2610434T3 (es) 2017-04-27
RU2013112021A (ru) 2014-09-27

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