RU2485095C2 - Кристаллическое основание миноциклина и способы его получения - Google Patents

Кристаллическое основание миноциклина и способы его получения Download PDF

Info

Publication number
RU2485095C2
RU2485095C2 RU2009135403/04A RU2009135403A RU2485095C2 RU 2485095 C2 RU2485095 C2 RU 2485095C2 RU 2009135403/04 A RU2009135403/04 A RU 2009135403/04A RU 2009135403 A RU2009135403 A RU 2009135403A RU 2485095 C2 RU2485095 C2 RU 2485095C2
Authority
RU
Russia
Prior art keywords
minocycline
base
crystalline
amorphous
peaks
Prior art date
Application number
RU2009135403/04A
Other languages
English (en)
Russian (ru)
Other versions
RU2009135403A (ru
Inventor
Зита МЕНДИШ
Жозе Рафаэль АНТУНИШ
Сусана МАРТУ
Уилльям ХЕГГИ
Original Assignee
Ховионе Интер Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ховионе Интер Лтд. filed Critical Ховионе Интер Лтд.
Publication of RU2009135403A publication Critical patent/RU2009135403A/ru
Application granted granted Critical
Publication of RU2485095C2 publication Critical patent/RU2485095C2/ru

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU2009135403/04A 2007-02-23 2008-02-22 Кристаллическое основание миноциклина и способы его получения RU2485095C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PT103661 2007-02-23
PT103661A PT103661B (pt) 2007-02-23 2007-02-23 Processo de preparação de minociclina base cristalina
PCT/GB2008/000625 WO2008102161A2 (en) 2007-02-23 2008-02-22 Crystalline minocycline base and processes for its preparation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2013112021/04A Division RU2577331C2 (ru) 2007-02-23 2008-02-22 Кристаллическое основание миноциклина и способы его получения

Publications (2)

Publication Number Publication Date
RU2009135403A RU2009135403A (ru) 2011-03-27
RU2485095C2 true RU2485095C2 (ru) 2013-06-20

Family

ID=39432804

Family Applications (2)

Application Number Title Priority Date Filing Date
RU2009135403/04A RU2485095C2 (ru) 2007-02-23 2008-02-22 Кристаллическое основание миноциклина и способы его получения
RU2013112021/04A RU2577331C2 (ru) 2007-02-23 2008-02-22 Кристаллическое основание миноциклина и способы его получения

Family Applications After (1)

Application Number Title Priority Date Filing Date
RU2013112021/04A RU2577331C2 (ru) 2007-02-23 2008-02-22 Кристаллическое основание миноциклина и способы его получения

Country Status (20)

Country Link
US (2) US8258327B2 (enExample)
EP (1) EP2125705B1 (enExample)
JP (4) JP2010519247A (enExample)
KR (1) KR101391132B1 (enExample)
CN (1) CN101679218B (enExample)
AU (1) AU2008217619B2 (enExample)
BR (2) BR122021000846B1 (enExample)
CA (2) CA2722496C (enExample)
DK (1) DK2125705T3 (enExample)
ES (1) ES2610434T3 (enExample)
HU (1) HUE033030T2 (enExample)
IL (1) IL200544A0 (enExample)
MX (2) MX2009008980A (enExample)
NO (1) NO20092960L (enExample)
NZ (1) NZ579626A (enExample)
PL (1) PL2125705T3 (enExample)
PT (1) PT103661B (enExample)
RU (2) RU2485095C2 (enExample)
WO (1) WO2008102161A2 (enExample)
ZA (1) ZA200906517B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2789331C2 (ru) * 2015-02-13 2023-02-01 Ховионе Сциентиа Лимитед Новые полиморфные формы миноциклинового основания и способы их получения

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL152486A0 (en) 2002-10-25 2003-05-29 Meir Eini Alcohol-free cosmetic and pharmaceutical foam carrier
US20060140984A1 (en) 2002-10-25 2006-06-29 Foamix Ltd. Cosmetic and pharmaceutical foam
US9668972B2 (en) 2002-10-25 2017-06-06 Foamix Pharmaceuticals Ltd. Nonsteroidal immunomodulating kit and composition and uses thereof
US10117812B2 (en) 2002-10-25 2018-11-06 Foamix Pharmaceuticals Ltd. Foamable composition combining a polar solvent and a hydrophobic carrier
US7700076B2 (en) 2002-10-25 2010-04-20 Foamix, Ltd. Penetrating pharmaceutical foam
US9211259B2 (en) 2002-11-29 2015-12-15 Foamix Pharmaceuticals Ltd. Antibiotic kit and composition and uses thereof
US9265725B2 (en) 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US7704518B2 (en) 2003-08-04 2010-04-27 Foamix, Ltd. Foamable vehicle and pharmaceutical compositions thereof
US20080138296A1 (en) 2002-10-25 2008-06-12 Foamix Ltd. Foam prepared from nanoemulsions and uses
US9192615B2 (en) 2008-08-06 2015-11-24 Medicis Pharmaceutical Corporation Method for the treatment of acne and certain dosage forms thereof
US8722650B1 (en) 2005-06-24 2014-05-13 Medicis Pharmaceutical Corporation Extended-release minocycline dosage forms
US20080242642A1 (en) 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US20080260655A1 (en) 2006-11-14 2008-10-23 Dov Tamarkin Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
PT103661B (pt) 2007-02-23 2010-09-07 Hovione Farmaciencia S A Processo de preparação de minociclina base cristalina
US8636982B2 (en) 2007-08-07 2014-01-28 Foamix Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
WO2009069006A2 (en) 2007-11-30 2009-06-04 Foamix Ltd. Foam containing benzoyl peroxide
WO2009072007A2 (en) 2007-12-07 2009-06-11 Foamix Ltd. Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof
PT104350A (pt) 2009-01-23 2010-07-23 Hovione Farmaci Ncia S A Processo de isolamento de tigeciclina
US20120087872A1 (en) 2009-04-28 2012-04-12 Foamix Ltd. Foamable Vehicles and Pharmaceutical Compositions Comprising Aprotic Polar Solvents and Uses Thereof
PT104644B (pt) 2009-06-26 2012-11-06 Hovione Farmaciencia S A Formulação tópica contendo uma tetraciclina e método de tratamento de infecções cutâneas usando a mesma
WO2011013009A2 (en) 2009-07-29 2011-02-03 Foamix Ltd. Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
CA2769677A1 (en) 2009-07-29 2011-02-03 Foamix Ltd. Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses
US9849142B2 (en) 2009-10-02 2017-12-26 Foamix Pharmaceuticals Ltd. Methods for accelerated return of skin integrity and for the treatment of impetigo
AU2010302350B2 (en) 2009-10-02 2015-06-18 Journey Medical Corporation Surfactant-free water-free foamable compositions, breakable foams and gels and their uses
US12661407B2 (en) 2010-04-08 2026-06-23 Journey Medical Corporation Compositions, gels and foams with rheology modulators and uses thereof
US9561241B1 (en) 2011-06-28 2017-02-07 Medicis Pharmaceutical Corporation Gastroretentive dosage forms for minocycline
PT106063B (pt) 2011-12-19 2017-05-30 Inst Superior Tecnico Minociclina cristalina termorresistente produzida por recristalização com dióxido de carbono
CN104151186B (zh) * 2014-08-11 2016-06-15 重庆福安药业(集团)股份有限公司 替加环素杂质的立体选择性制备方法
PT108223B (pt) * 2015-02-13 2018-05-08 Hovione Farm S A Novas formas polimórficas de minociclina base e processos para a sua preparação
AU2016235237B2 (en) 2015-03-23 2021-03-11 BioPharmX, Inc. Pharmaceutical tetracycline composition for dermatological use
WO2017097891A1 (en) * 2015-12-10 2017-06-15 Sandoz Ag Crystalline eravacycline
MX2020012139A (es) 2016-09-08 2021-01-29 Vyne Pharmaceuticals Inc Composiciones y metodos para tratar rosacea y acne.
CN113557008A (zh) 2018-10-29 2021-10-26 弗劳恩霍夫应用研究促进协会 具有持续活性的四环素类络合物
WO2021191273A1 (en) 2020-03-24 2021-09-30 Hovione Scientia Limited Compositions for use in treating meibomian gland dysfunction
US20220062308A1 (en) 2020-08-27 2022-03-03 Hovione Scientia Limited Methods and compositions for treating rosacea
CN117105812B (zh) * 2023-08-16 2025-09-26 常州市第四制药厂有限公司 一种米诺环素无菌软膏剂及制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US299111A (en) * 1884-05-27 Process of and apparatus
US3226436A (en) * 1963-05-17 1965-12-28 American Cyanamid Co 7-and 9-alkylamino-6-deoxytetracycline
US4918208A (en) * 1987-07-28 1990-04-17 Nippon Kayaku Kabushiki Kaisha Process for producing 7-dimethylamino-6-demethyl-6-deoxytetracycline
US5202449A (en) * 1987-07-28 1993-04-13 Nippon Kayaku Kabushiki Kaisha Process for purifying 7-dimethylamino-6-demethyl-6-deoxytetracycline

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3148212A (en) * 1961-12-22 1964-09-08 American Cyanamid Co Reductive alkylation process
US3526629A (en) * 1968-04-02 1970-09-01 American Cyanamid Co Beta-hydroxyethylpiperazinocarboxymethyl - 7 - dimethylamino - 6 - deoxy-6-demethyltetracycline
JPS5245716B1 (enExample) * 1970-07-10 1977-11-17
NL158172B (nl) * 1972-09-18 1978-10-16 Farmaceutici Italia Werkwijze voor het bereiden van tetracyclinederivaten met een substituent op de 7-plaats.
CN85101404A (zh) * 1985-05-16 1987-01-17 帝人株式会社 头孢菌素衍生物的生产过程
JPH0737433B2 (ja) 1987-06-11 1995-04-26 協和醗酵工業株式会社 ７−アミノ−６−デメチル−６−デオキシテトラサイクリンの製造法
JPH04235188A (ja) * 1990-06-19 1992-08-24 Takeda Chem Ind Ltd ペネム化合物の結晶、その製造方法および抗菌剤
US5262173A (en) * 1992-03-02 1993-11-16 American Cyanamid Company Pulsatile once-a-day delivery systems for minocycline
DE4235133A1 (de) * 1992-10-19 1994-04-21 Bayer Ag Kristallines (R)-(-)-2-Cycloheptyl-N-methylsulfonyl-[4-(2-chinolinyl-methoxy)-phenyl]-acetamid
JP3623531B2 (ja) * 1993-06-07 2005-02-23 ビーエーエスエフ アクチェンゲゼルシャフト 結晶質ｌ−アスコルビン酸−２−燐酸エステルマグネシウム塩の製造法
BR9609872A (pt) * 1995-07-17 1999-03-23 Warner Lambert Co Hemi sal de cálcio de ácido (R-(R*R*)]-2-(4-fluorfenil-)-beta delta-diidróxi-5-(1-metiletil)-3-fenil-4- [(fenilamino) carbonil]-1H- pirrol-1heptanóico (atorvasta-tina)c ristalino
NZ504834A (en) 1997-12-22 2001-12-21 Schering Corp Tricyclic amide molecular dispersion composition with enhanced bioavailability
AU1405600A (en) * 1998-12-01 2000-06-19 Atropos Limited A medical device comprising an evertable sleeve
CL2004001884A1 (es) * 2003-08-04 2005-06-03 Pfizer Prod Inc Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros.
AR057649A1 (es) * 2005-05-27 2007-12-12 Wyeth Corp Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas
CA2616224A1 (en) * 2005-07-21 2007-02-01 Paratek Pharmaceuticals, Inc. 10-substituted tetracyclines and methods of use thereof
PT103661B (pt) 2007-02-23 2010-09-07 Hovione Farmaciencia S A Processo de preparação de minociclina base cristalina

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US299111A (en) * 1884-05-27 Process of and apparatus
US3226436A (en) * 1963-05-17 1965-12-28 American Cyanamid Co 7-and 9-alkylamino-6-deoxytetracycline
US4918208A (en) * 1987-07-28 1990-04-17 Nippon Kayaku Kabushiki Kaisha Process for producing 7-dimethylamino-6-demethyl-6-deoxytetracycline
US5202449A (en) * 1987-07-28 1993-04-13 Nippon Kayaku Kabushiki Kaisha Process for purifying 7-dimethylamino-6-demethyl-6-deoxytetracycline

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BERNARDI ET. AL. «Tetracycline derivatives» IL FARMACO, EDIZIONE SCIENTIFICA 1975, V.30, No: 9, p.736-741. *
CAIRA M R., «CRYSTALLINE POLYMORPHISM OF ORGANIC COMPOUNDS» TOPICS IN CURRENT CHEMISTRY, 1998 V.198, p.163-208. *
CAIRA M R., «CRYSTALLINE POLYMORPHISM OF ORGANIC COMPOUNDS» TOPICS IN CURRENT CHEMISTRY, 1998 V.198, p.163-208. Church et al. «Synthesis of 7-Dimethylamino-6-demethyl-6-deoxy tetracycline (Minocycline) via 9-nitro-6-demethyl-6-deoxytetra cycline» J. Org. Chem.1971, Vol.36, №5 p.723-725. BERNARDI ET. AL. «Tetracycline derivatives» IL FARMACO, EDIZIONE SCIENTIFICA 1975, V.30, No: 9, p.736-741. ХИМИЧЕСКАЯ ЭНЦИКЛОПЕДИЯ. /Под ред. И.Л.Кнунянца и др. - М.: Советская энциклопедия, т.2; 1990, с.525, 527-529. *
Church et al. «Synthesis of 7-Dimethylamino-6-demethyl-6-deoxy tetracycline (Minocycline) via 9-nitro-6-demethyl-6-deoxytetra cycline» J. Org. Chem.1971, Vol.36, No.5 p.723-725. *
ХИМИЧЕСКАЯ ЭНЦИКЛОПЕДИЯ. /Под ред. И.Л.Кнунянца и др. - М.: Советская энциклопедия, т.2; 1990, с.525, 527-529. *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2789331C2 (ru) * 2015-02-13 2023-02-01 Ховионе Сциентиа Лимитед Новые полиморфные формы миноциклинового основания и способы их получения
RU2789325C2 (ru) * 2015-02-13 2023-02-01 Ховионе Сциентиа Лимитед Новые полиморфные формы миноциклинового основания и способы их получения

Also Published As

Publication number Publication date
EP2125705A2 (en) 2009-12-02
US20100286417A1 (en) 2010-11-11
PT103661A (pt) 2008-08-25
EP2125705B1 (en) 2016-10-12
US9416097B2 (en) 2016-08-16
WO2008102161A2 (en) 2008-08-28
PT103661B (pt) 2010-09-07
BRPI0807319B1 (pt) 2021-08-10
KR20100014520A (ko) 2010-02-10
JP2017039742A (ja) 2017-02-23
BRPI0807319A2 (pt) 2017-05-02
RU2577331C2 (ru) 2016-03-20
JP2014169319A (ja) 2014-09-18
DK2125705T3 (en) 2017-01-16
US8258327B2 (en) 2012-09-04
NZ579626A (en) 2011-12-22
NO20092960L (no) 2009-11-20
PL2125705T3 (pl) 2017-02-28
KR101391132B1 (ko) 2014-05-02
BR122021000846B1 (pt) 2021-08-10
MX340539B (es) 2016-07-13
CA2835788C (en) 2018-03-27
ES2610434T3 (es) 2017-04-27
ZA200906517B (en) 2010-09-29
CA2722496C (en) 2014-06-10
WO2008102161A3 (en) 2009-01-08
AU2008217619B2 (en) 2013-01-10
CA2835788A1 (en) 2008-08-28
AU2008217619A1 (en) 2008-08-28
US20130030195A1 (en) 2013-01-31
CN101679218A (zh) 2010-03-24
RU2009135403A (ru) 2011-03-27
IL200544A0 (en) 2010-05-17
JP2019142882A (ja) 2019-08-29
RU2013112021A (ru) 2014-09-27
CN101679218B (zh) 2013-10-30
WO2008102161A9 (en) 2008-11-13
JP2010519247A (ja) 2010-06-03
CA2722496A1 (en) 2008-08-28
HUE033030T2 (hu) 2017-11-28
MX2009008980A (es) 2009-11-11

Similar Documents

Publication Publication Date Title
RU2577331C2 (ru) Кристаллическое основание миноциклина и способы его получения
JP6535748B2 (ja) ベンズイミダゾール誘導体の新規結晶形及びその製造方法
US5354760A (en) Crystalline Tiagabine monohydrate, its preparation and use
EP2882753B1 (en) Process for the preparation of pemetrexed and lysin salt thereof
WO2022200426A1 (en) Preparation method of quinoline derivative compounds
HK1248691A1 (zh) 3-甲酰基利福霉素sv的3-(4-肉桂基-1-呱嗪基)氨基衍生物的用途和制备方法
CA2530964A1 (en) Crystalline form of rabeprazole sodium
WO2012001357A1 (en) Crystalline form of prulifloxacin and processes for its preparation
KR20100125124A (ko) 피타바스타틴 헤미칼슘염의 신규한 결정형 및 그의 제조방법

Legal Events

Date Code Title Description
PC41 Official registration of the transfer of exclusive right

Effective date: 20151007