KR101391132B1 - 결정형 미노사이클린 염기 및 이의 제조방법 - Google Patents

결정형 미노사이클린 염기 및 이의 제조방법 Download PDF

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Publication number
KR101391132B1
KR101391132B1 KR1020097019750A KR20097019750A KR101391132B1 KR 101391132 B1 KR101391132 B1 KR 101391132B1 KR 1020097019750 A KR1020097019750 A KR 1020097019750A KR 20097019750 A KR20097019750 A KR 20097019750A KR 101391132 B1 KR101391132 B1 KR 101391132B1
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South Korea
Prior art keywords
minocycline
minocycline base
base
crystalline
organic solvent
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Expired - Fee Related
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KR1020097019750A
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English (en)
Korean (ko)
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KR20100014520A (ko
Inventor
지타 멘데스
조세 라파엘 안투네스
수사나 마르토
윌리암 헤기에
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호비온 인터 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020097019750A 2007-02-23 2008-02-22 결정형 미노사이클린 염기 및 이의 제조방법 Expired - Fee Related KR101391132B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PT103661A PT103661B (pt) 2007-02-23 2007-02-23 Processo de preparação de minociclina base cristalina
PT103661 2007-02-23

Publications (2)

Publication Number Publication Date
KR20100014520A KR20100014520A (ko) 2010-02-10
KR101391132B1 true KR101391132B1 (ko) 2014-05-02

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KR1020097019750A Expired - Fee Related KR101391132B1 (ko) 2007-02-23 2008-02-22 결정형 미노사이클린 염기 및 이의 제조방법

Country Status (20)

Country Link
US (2) US8258327B2 (enExample)
EP (1) EP2125705B1 (enExample)
JP (4) JP2010519247A (enExample)
KR (1) KR101391132B1 (enExample)
CN (1) CN101679218B (enExample)
AU (1) AU2008217619B2 (enExample)
BR (2) BR122021000846B1 (enExample)
CA (2) CA2722496C (enExample)
DK (1) DK2125705T3 (enExample)
ES (1) ES2610434T3 (enExample)
HU (1) HUE033030T2 (enExample)
IL (1) IL200544A0 (enExample)
MX (2) MX2009008980A (enExample)
NO (1) NO20092960L (enExample)
NZ (1) NZ579626A (enExample)
PL (1) PL2125705T3 (enExample)
PT (1) PT103661B (enExample)
RU (2) RU2577331C2 (enExample)
WO (1) WO2008102161A2 (enExample)
ZA (1) ZA200906517B (enExample)

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AU2003279493B2 (en) 2002-10-25 2009-08-20 Foamix Pharmaceuticals Ltd. Cosmetic and pharmaceutical foam
US9668972B2 (en) 2002-10-25 2017-06-06 Foamix Pharmaceuticals Ltd. Nonsteroidal immunomodulating kit and composition and uses thereof
US7704518B2 (en) 2003-08-04 2010-04-27 Foamix, Ltd. Foamable vehicle and pharmaceutical compositions thereof
US9211259B2 (en) 2002-11-29 2015-12-15 Foamix Pharmaceuticals Ltd. Antibiotic kit and composition and uses thereof
US10117812B2 (en) 2002-10-25 2018-11-06 Foamix Pharmaceuticals Ltd. Foamable composition combining a polar solvent and a hydrophobic carrier
US9265725B2 (en) 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US20080242642A1 (en) 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US8722650B1 (en) 2005-06-24 2014-05-13 Medicis Pharmaceutical Corporation Extended-release minocycline dosage forms
US20080260655A1 (en) 2006-11-14 2008-10-23 Dov Tamarkin Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
PT103661B (pt) 2007-02-23 2010-09-07 Hovione Farmaciencia S A Processo de preparação de minociclina base cristalina
US8636982B2 (en) 2007-08-07 2014-01-28 Foamix Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
WO2009069006A2 (en) 2007-11-30 2009-06-04 Foamix Ltd. Foam containing benzoyl peroxide
WO2009072007A2 (en) 2007-12-07 2009-06-11 Foamix Ltd. Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof
WO2010017310A1 (en) 2008-08-06 2010-02-11 Medicis Pharmaceutical Corporation Method for the treatment of acne and certain dosage forms thereof
PT104350A (pt) * 2009-01-23 2010-07-23 Hovione Farmaci Ncia S A Processo de isolamento de tigeciclina
CA2760186C (en) 2009-04-28 2019-10-29 Foamix Ltd. Foamable vehicle and pharmaceutical compositions comprising aprotic polar solvents and uses thereof
PT104644B (pt) 2009-06-26 2012-11-06 Hovione Farmaciencia S A Formulação tópica contendo uma tetraciclina e método de tratamento de infecções cutâneas usando a mesma
WO2011013009A2 (en) 2009-07-29 2011-02-03 Foamix Ltd. Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
WO2011013008A2 (en) 2009-07-29 2011-02-03 Foamix Ltd. Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses
CN102686205A (zh) 2009-10-02 2012-09-19 弗艾米克斯有限公司 局部四环素组合物
US9849142B2 (en) 2009-10-02 2017-12-26 Foamix Pharmaceuticals Ltd. Methods for accelerated return of skin integrity and for the treatment of impetigo
US9561241B1 (en) 2011-06-28 2017-02-07 Medicis Pharmaceutical Corporation Gastroretentive dosage forms for minocycline
PT106063B (pt) * 2011-12-19 2017-05-30 Inst Superior Tecnico Minociclina cristalina termorresistente produzida por recristalização com dióxido de carbono
CN104151186B (zh) * 2014-08-11 2016-06-15 重庆福安药业(集团)股份有限公司 替加环素杂质的立体选择性制备方法
PT108223B (pt) 2015-02-13 2018-05-08 Hovione Farm S A Novas formas polimórficas de minociclina base e processos para a sua preparação
EP3273940B1 (en) 2015-03-23 2020-12-16 Biopharmx, Inc. Pharmaceutical tetracycline composition for dermatological use
WO2017097891A1 (en) * 2015-12-10 2017-06-15 Sandoz Ag Crystalline eravacycline
CA2978573A1 (en) 2016-09-08 2018-03-08 Foamix Pharmaceuticals Ltd. Compositions and methods for treating rosacea and acne
WO2021191273A1 (en) 2020-03-24 2021-09-30 Hovione Scientia Limited Compositions for use in treating meibomian gland dysfunction
US20220062308A1 (en) 2020-08-27 2022-03-03 Hovione Scientia Limited Methods and compositions for treating rosacea
CN117105812B (zh) * 2023-08-16 2025-09-26 常州市第四制药厂有限公司 一种米诺环素无菌软膏剂及制备方法

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Also Published As

Publication number Publication date
AU2008217619A1 (en) 2008-08-28
NZ579626A (en) 2011-12-22
RU2009135403A (ru) 2011-03-27
CA2835788C (en) 2018-03-27
RU2013112021A (ru) 2014-09-27
JP2014169319A (ja) 2014-09-18
WO2008102161A2 (en) 2008-08-28
JP2010519247A (ja) 2010-06-03
RU2577331C2 (ru) 2016-03-20
CN101679218B (zh) 2013-10-30
ES2610434T3 (es) 2017-04-27
CN101679218A (zh) 2010-03-24
JP2017039742A (ja) 2017-02-23
BRPI0807319A2 (pt) 2017-05-02
CA2722496A1 (en) 2008-08-28
MX340539B (es) 2016-07-13
KR20100014520A (ko) 2010-02-10
CA2835788A1 (en) 2008-08-28
RU2485095C2 (ru) 2013-06-20
HUE033030T2 (hu) 2017-11-28
EP2125705B1 (en) 2016-10-12
WO2008102161A9 (en) 2008-11-13
BR122021000846B1 (pt) 2021-08-10
PT103661B (pt) 2010-09-07
JP2019142882A (ja) 2019-08-29
EP2125705A2 (en) 2009-12-02
WO2008102161A3 (en) 2009-01-08
PL2125705T3 (pl) 2017-02-28
BRPI0807319B1 (pt) 2021-08-10
CA2722496C (en) 2014-06-10
US20130030195A1 (en) 2013-01-31
AU2008217619B2 (en) 2013-01-10
DK2125705T3 (en) 2017-01-16
IL200544A0 (en) 2010-05-17
US20100286417A1 (en) 2010-11-11
MX2009008980A (es) 2009-11-11
NO20092960L (no) 2009-11-20
US8258327B2 (en) 2012-09-04
PT103661A (pt) 2008-08-25
ZA200906517B (en) 2010-09-29
US9416097B2 (en) 2016-08-16

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