RU2432354C2 - Производные 3-алкил-5-(4-алкил-5-оксотетрагидрофуран-2-ил)пирролидин-2-она в качестве промежуточных соединений в синтезе ингибиторов ренина - Google Patents
Производные 3-алкил-5-(4-алкил-5-оксотетрагидрофуран-2-ил)пирролидин-2-она в качестве промежуточных соединений в синтезе ингибиторов ренина Download PDFInfo
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- RU2432354C2 RU2432354C2 RU2008119276/04A RU2008119276A RU2432354C2 RU 2432354 C2 RU2432354 C2 RU 2432354C2 RU 2008119276/04 A RU2008119276/04 A RU 2008119276/04A RU 2008119276 A RU2008119276 A RU 2008119276A RU 2432354 C2 RU2432354 C2 RU 2432354C2
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- 0 C*N(C(CC1C)C(CC2*)OC2=O)C1=O Chemical compound C*N(C(CC1C)C(CC2*)OC2=O)C1=O 0.000 description 1
- FCHNYQRZRXLSAK-UHFFFAOYSA-O CC(C)(CCC1)CC1[NH2+]I Chemical compound CC(C)(CCC1)CC1[NH2+]I FCHNYQRZRXLSAK-UHFFFAOYSA-O 0.000 description 1
- WDKMSDRISDJXSI-UHFFFAOYSA-N CCc(cc1)cc(OCCCOC)c1OC Chemical compound CCc(cc1)cc(OCCCOC)c1OC WDKMSDRISDJXSI-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0521083.6 | 2005-10-17 | ||
| GBGB0521083.6A GB0521083D0 (en) | 2005-10-17 | 2005-10-17 | Organic compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2008119276A RU2008119276A (ru) | 2009-11-27 |
| RU2432354C2 true RU2432354C2 (ru) | 2011-10-27 |
Family
ID=35451886
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008119276/04A RU2432354C2 (ru) | 2005-10-17 | 2006-10-16 | Производные 3-алкил-5-(4-алкил-5-оксотетрагидрофуран-2-ил)пирролидин-2-она в качестве промежуточных соединений в синтезе ингибиторов ренина |
Country Status (30)
| Country | Link |
|---|---|
| US (2) | US7772405B2 (xx) |
| EP (1) | EP1948643B1 (xx) |
| JP (3) | JP5356031B2 (xx) |
| KR (1) | KR101294432B1 (xx) |
| CN (2) | CN101111493B (xx) |
| AR (1) | AR058089A1 (xx) |
| AU (1) | AU2006303489B2 (xx) |
| BR (1) | BRPI0617492A2 (xx) |
| CA (2) | CA2829487A1 (xx) |
| CY (1) | CY1114308T1 (xx) |
| DK (1) | DK1948643T3 (xx) |
| EC (1) | ECSP088368A (xx) |
| ES (1) | ES2427098T3 (xx) |
| GB (1) | GB0521083D0 (xx) |
| HK (1) | HK1120509A1 (xx) |
| HR (1) | HRP20130793T1 (xx) |
| IL (1) | IL190330A (xx) |
| JO (1) | JO2926B1 (xx) |
| MY (1) | MY145466A (xx) |
| NO (1) | NO342854B1 (xx) |
| NZ (1) | NZ567042A (xx) |
| PE (2) | PE20070792A1 (xx) |
| PL (1) | PL1948643T3 (xx) |
| PT (1) | PT1948643E (xx) |
| RU (1) | RU2432354C2 (xx) |
| SI (1) | SI1948643T1 (xx) |
| TN (1) | TNSN08170A1 (xx) |
| TW (1) | TWI395733B (xx) |
| WO (1) | WO2007045420A2 (xx) |
| ZA (1) | ZA200802632B (xx) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0521083D0 (en) * | 2005-10-17 | 2005-11-23 | Novartis Ag | Organic compounds |
| DE102005052195A1 (de) * | 2005-10-28 | 2007-05-03 | Reuter Chemischer Apparatebau Kg | Verfahren zur Herstellung von chiralen Octensäurederivaten |
| AU2008234834B2 (en) * | 2007-04-03 | 2012-01-19 | Novartis Ag | New methods |
| BRPI0813739A2 (pt) * | 2007-06-19 | 2019-09-24 | Novartis Ag | compostos orgânicos |
| DE102007049039A1 (de) * | 2007-10-11 | 2009-04-16 | Reuter Chemischer Apparatebau Kg | Verfahren zur Herstellung von 8-Hydrazino-8-Aryl-Octanoylderivaten und deren Verwendung |
| EP2189442B1 (en) * | 2008-11-20 | 2014-10-01 | Krka Tovarna Zdravil, D.D., Novo Mesto | Process and intermediates for the preparation of aliskiren |
| EP2464623B1 (en) * | 2009-08-11 | 2020-11-04 | Novartis AG | The ring opening of lactones and lactams |
| WO2011051853A1 (en) * | 2009-10-29 | 2011-05-05 | CarboDesign LLC | Manufacturing process for preparing enaniomerically pure 8- aryloctanoic acid derivatives such as aliskiren |
| US20110137047A1 (en) * | 2009-12-07 | 2011-06-09 | CarboDesign LLC | Process for enantiomerically pure 8-Aryloctanoic acids as Aliskiren |
| CN101774986B (zh) | 2010-01-06 | 2012-03-28 | 浙江天宇药业股份有限公司 | 一种制备阿利克伦及其中间体的方法 |
| CN102241650B (zh) * | 2010-05-14 | 2014-05-07 | 浙江九洲药业股份有限公司 | 用于制备阿立克仑的中间体化合物及相关制备方法 |
| CN102485722B (zh) * | 2010-12-06 | 2014-05-07 | 博瑞生物医药技术(苏州)有限公司 | 阿利克仑、其中间体和药用盐及制备方法 |
| CN102775393B (zh) * | 2011-05-09 | 2014-08-27 | 上海现代制药股份有限公司 | 一种药物中间体的制备方法 |
| US8703976B2 (en) | 2011-10-02 | 2014-04-22 | Milan Soukup | Manufacturing process for 8-aryloctanoic acids such as Aliskiren |
| CN102746182B (zh) * | 2012-07-27 | 2014-09-03 | 浙江普洛医药科技有限公司 | 一种阿利克伦的制备方法 |
| CN103059012B (zh) * | 2013-01-30 | 2016-06-22 | 浙江海翔药业股份有限公司 | 1,8-二羰基-4,5-环氧化合物及其制备方法 |
| CN106220528B (zh) * | 2014-02-28 | 2018-05-08 | 华润双鹤药业股份有限公司 | 阿利吉仑的4-位差向异构体、其制备方法及用途 |
| CN105294612A (zh) * | 2014-06-05 | 2016-02-03 | 山东威智医药工业有限公司 | 阿利克仑中间体及其制备方法和应用 |
| US10087190B1 (en) * | 2017-04-24 | 2018-10-02 | Purdue Research Foundation | Lactones |
| CN114315749B (zh) * | 2021-12-13 | 2024-04-26 | 湖南华腾医药有限公司 | 一种连续流微反应器合成阿利克仑中间体的方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY119161A (en) | 1994-04-18 | 2005-04-30 | Novartis Ag | Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities |
| US5659065A (en) | 1994-04-18 | 1997-08-19 | Novartis Corporation | Alpha-aminoalkanoic acids and reduction products |
| US5606078A (en) | 1994-04-18 | 1997-02-25 | Ciba-Geigy Corporation | 3,5-Disubstituted tetrahydrofuran-2-ones |
| EP1200384B1 (de) | 1999-07-29 | 2004-04-28 | Speedel Pharma AG | 2-alkyl-5-halogen-pent-4-encarbonsäuren und deren herstellung |
| FR2801051B1 (fr) * | 1999-11-17 | 2001-12-14 | Adir | Nouveaux composes aminopyrroline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| US6310904B1 (en) | 2000-05-31 | 2001-10-30 | Honeywell International, Inc. | Measurement method to facilitate production of self-aligning laser gyroscope block |
| EP1215201B1 (en) | 2000-12-14 | 2006-10-18 | Speedel Pharma AG | Process for the preparation of aryloctanoyl amides |
| US7164031B2 (en) * | 2001-09-07 | 2007-01-16 | Basf Aktiengesellschaft | Method for the production of 2-pyrrolidone |
| GB0212410D0 (en) * | 2002-05-29 | 2002-07-10 | Novartis Ag | Organic compounds |
| RU2413716C2 (ru) * | 2003-11-26 | 2011-03-10 | Новартис Аг | АМИДЫ δ-АМИНО-γ-ГИДРОКСИ-ω-АРИЛАЛКАНОВОЙ КИСЛОТЫ |
| PA8619901A1 (es) * | 2003-12-12 | 2005-11-25 | Wyeth Corp | Quinolinas utiles en el tratamiento de enfermedades cardiovasculares |
| EP1717226B1 (en) * | 2004-03-19 | 2009-01-21 | Speedel Experimenta AG | 2,7-substituted 5-amino-4-hydroxy-8-(1h-indol-5-yl)-octan amide derivatives as renin inhibitors for the treatment of hypertension |
| EP1582523A1 (en) * | 2004-04-02 | 2005-10-05 | Ludwig-Maximilians-Universität München | Method of preparing organomagnesium compounds |
| GB0419361D0 (en) | 2004-08-31 | 2004-10-06 | Novartis Ag | Organic compounds |
| GB0511686D0 (en) * | 2005-06-08 | 2005-07-13 | Novartis Ag | Organic compounds |
| GB0521083D0 (en) * | 2005-10-17 | 2005-11-23 | Novartis Ag | Organic compounds |
-
2005
- 2005-10-17 GB GBGB0521083.6A patent/GB0521083D0/en not_active Ceased
-
2006
- 2006-10-13 AR ARP060104497A patent/AR058089A1/es not_active Application Discontinuation
- 2006-10-15 JO JO2006369A patent/JO2926B1/en active
- 2006-10-16 TW TW095138055A patent/TWI395733B/zh not_active IP Right Cessation
- 2006-10-16 NZ NZ567042A patent/NZ567042A/en not_active IP Right Cessation
- 2006-10-16 CA CA2829487A patent/CA2829487A1/en not_active Abandoned
- 2006-10-16 CN CN2006800035979A patent/CN101111493B/zh not_active Expired - Fee Related
- 2006-10-16 SI SI200631641T patent/SI1948643T1/sl unknown
- 2006-10-16 US US12/088,457 patent/US7772405B2/en active Active
- 2006-10-16 WO PCT/EP2006/009970 patent/WO2007045420A2/en active Application Filing
- 2006-10-16 CA CA2625034A patent/CA2625034C/en not_active Expired - Fee Related
- 2006-10-16 EP EP06828821.6A patent/EP1948643B1/en active Active
- 2006-10-16 PT PT68288216T patent/PT1948643E/pt unknown
- 2006-10-16 ES ES06828821T patent/ES2427098T3/es active Active
- 2006-10-16 KR KR1020087009098A patent/KR101294432B1/ko active IP Right Grant
- 2006-10-16 AU AU2006303489A patent/AU2006303489B2/en not_active Ceased
- 2006-10-16 PE PE2006001252A patent/PE20070792A1/es active IP Right Grant
- 2006-10-16 PL PL06828821T patent/PL1948643T3/pl unknown
- 2006-10-16 CN CN201210566662.6A patent/CN103121995B/zh not_active Expired - Fee Related
- 2006-10-16 RU RU2008119276/04A patent/RU2432354C2/ru not_active IP Right Cessation
- 2006-10-16 JP JP2008535948A patent/JP5356031B2/ja active Active
- 2006-10-16 DK DK06828821.6T patent/DK1948643T3/da active
- 2006-10-16 PE PE2011001455A patent/PE20120581A1/es active IP Right Grant
- 2006-10-16 BR BRPI0617492-2A patent/BRPI0617492A2/pt not_active Application Discontinuation
-
2008
- 2008-03-20 IL IL190330A patent/IL190330A/en active IP Right Grant
- 2008-03-25 ZA ZA200802632A patent/ZA200802632B/xx unknown
- 2008-04-15 MY MYPI20081108A patent/MY145466A/en unknown
- 2008-04-15 EC EC2008008368A patent/ECSP088368A/es unknown
- 2008-04-16 TN TNP2008000170A patent/TNSN08170A1/en unknown
- 2008-05-16 NO NO20082263A patent/NO342854B1/no not_active IP Right Cessation
- 2008-12-19 HK HK08113800.5A patent/HK1120509A1/xx not_active IP Right Cessation
-
2010
- 2010-06-25 US US12/823,699 patent/US8198465B2/en active Active
-
2012
- 2012-09-26 JP JP2012213001A patent/JP5792139B2/ja active Active
-
2013
- 2013-08-22 HR HRP20130793TT patent/HRP20130793T1/hr unknown
- 2013-09-02 CY CY20131100754T patent/CY1114308T1/el unknown
-
2014
- 2014-05-21 JP JP2014105430A patent/JP2014196312A/ja not_active Withdrawn
Non-Patent Citations (1)
| Title |
|---|
| DONG, HUA ет al. "Practical synthesis of an orally active rennin inhibitor aliskiren", TETRAHEDRON LETTERS, 46(37), 6337-6340, 28.07.2005 MEALY, N.E. et al. "Aliskiren fumarate", DRUGS OF THE FUTURE, 26(12), 1139-1148, 2001. * |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC41 | Official registration of the transfer of exclusive right |
Effective date: 20180220 |
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| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20191017 |