RU2412934C2 - Применение антагонистов crth2 в терапии - Google Patents

Применение антагонистов crth2 в терапии Download PDF

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RU2412934C2
RU2412934C2 RU2006109769/04A RU2006109769A RU2412934C2 RU 2412934 C2 RU2412934 C2 RU 2412934C2 RU 2006109769/04 A RU2006109769/04 A RU 2006109769/04A RU 2006109769 A RU2006109769 A RU 2006109769A RU 2412934 C2 RU2412934 C2 RU 2412934C2
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acetic acid
alkyl
fluoro
compound
methyl
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RU2006109769/04A
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Russian (ru)
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RU2006109769A (ru
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Девид МИДЛЕМИС (GB)
Девид МИДЛЕМИС
Марк Ричард ЭШТОН (GB)
Марк Ричард Эштон
Эдвард Эндрю БОЙД (GB)
Эдвард Эндрю Бойд
Фредерик Артур БРУКФИЛД (GB)
Фредерик Артур Брукфилд
Эрик Рой ПЕТИФЕР (GB)
Эрик Рой ПЕТИФЕР
Марк ВИТТАКЕР (GB)
Марк ВИТТАКЕР
Кристофер ПАЛМЕР (GB)
Кристофер Палмер
Мик ХАНТЕР (GB)
Мик ХАНТЕР
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Оксаген Лимитед
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    • A61K31/47Quinolines; Isoquinolines
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    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
RU2006109769/04A 2003-10-23 2004-10-19 Применение антагонистов crth2 в терапии RU2412934C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0324763.2A GB0324763D0 (en) 2003-10-23 2003-10-23 Use of compounds in therapy
GB0324763.2 2003-10-23

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RU2006109769A RU2006109769A (ru) 2007-11-27
RU2412934C2 true RU2412934C2 (ru) 2011-02-27

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US (5) US7582672B2 (OSRAM)
EP (2) EP2060258A1 (OSRAM)
JP (1) JP4313819B2 (OSRAM)
KR (1) KR20060096145A (OSRAM)
CN (1) CN101141956B (OSRAM)
AT (1) ATE439129T1 (OSRAM)
AU (1) AU2004287245B2 (OSRAM)
BR (1) BRPI0415374B8 (OSRAM)
CA (1) CA2543199C (OSRAM)
CY (1) CY1109980T1 (OSRAM)
DE (1) DE602004022579D1 (OSRAM)
DK (1) DK1682121T3 (OSRAM)
ES (1) ES2330113T3 (OSRAM)
GB (1) GB0324763D0 (OSRAM)
HR (1) HRP20090577T1 (OSRAM)
IL (1) IL175085A0 (OSRAM)
NO (1) NO335228B1 (OSRAM)
NZ (1) NZ547319A (OSRAM)
PL (1) PL1682121T3 (OSRAM)
PT (1) PT1682121E (OSRAM)
RU (1) RU2412934C2 (OSRAM)
SI (1) SI1682121T1 (OSRAM)
UA (1) UA86602C2 (OSRAM)
WO (1) WO2005044260A1 (OSRAM)
ZA (1) ZA200603235B (OSRAM)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2616000C2 (ru) * 2011-03-07 2017-04-12 Атопикс Терапьютикс Лимитед Аморфная (5-фтор-2-метил-3-хинолин-2-илметилиндол-1-ил)-уксусная кислота
US11091806B2 (en) 2015-07-23 2021-08-17 Merck Sharp & Dohme Corp. Genetic markers associated with response to CRTH2 receptor antagonists
RU2756270C2 (ru) * 2016-07-21 2021-09-29 Чиа Тай Тянцин Фармасьютикал Груп Ко., Лтд. Производное индола, используемое в качестве ингибитора CRTH2

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0301010D0 (sv) 2003-04-07 2003-04-07 Astrazeneca Ab Novel compounds
SA04250253B1 (ar) 2003-08-21 2009-11-10 استرازينيكا ايه بي احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن
GB0324763D0 (en) * 2003-10-23 2003-11-26 Oxagen Ltd Use of compounds in therapy
GB0415320D0 (en) 2004-07-08 2004-08-11 Astrazeneca Ab Novel compounds
GB0418830D0 (en) 2004-08-24 2004-09-22 Astrazeneca Ab Novel compounds
ATE517085T1 (de) 2004-11-23 2011-08-15 Astrazeneca Ab Zur behandlung von atemwegserkrankungen geeignete phenoxyessigsäurederivate
ATE518834T1 (de) 2004-12-27 2011-08-15 Actelion Pharmaceuticals Ltd 2,3,4,9-tetrahydro-1h-carbazol-derivative als crth2-rezeptorantagonisten
GB0504150D0 (en) * 2005-03-01 2005-04-06 Oxagen Ltd Microcrystalline material
GB0505048D0 (en) 2005-03-11 2005-04-20 Oxagen Ltd Compounds with PGD antagonist activity
GB0512944D0 (en) * 2005-06-24 2005-08-03 Argenta Discovery Ltd Indolizine compounds
JP5072594B2 (ja) 2005-07-22 2012-11-14 塩野義製薬株式会社 Pgd2受容体アンタゴニスト活性を有するインドール誘導体
WO2007010965A1 (ja) 2005-07-22 2007-01-25 Shionogi & Co., Ltd. Pgd2受容体アンタゴニスト活性を有するアザインドール酸誘導体
GB0518783D0 (en) * 2005-09-14 2005-10-26 Argenta Discovery Ltd Indolizine compounds
WO2007044309A2 (en) * 2005-10-05 2007-04-19 Vasix Corporation Device and method for inhibiting age complex formation
TW200745003A (en) 2005-10-06 2007-12-16 Astrazeneca Ab Novel compounds
JP5155171B2 (ja) 2005-10-06 2013-02-27 アストラゼネカ・アクチエボラーグ 新規化合物
EP1963259B1 (en) * 2005-12-15 2012-02-15 AstraZeneca AB Substituted diphenylethers, -amines, -sulfides and -methanes for the treatment of respiratory disease
GB0605743D0 (en) * 2006-03-22 2006-05-03 Oxagen Ltd Salts with CRTH2 antagonist activity
PT2037967T (pt) 2006-06-16 2017-03-14 Univ Pennsylvania Antagonistas do recetor de prostaglandina d2 para o tratamento da alopecia androgenética
MX2009000801A (es) 2006-07-22 2009-02-03 Oxagen Ltd Compuestos que tienen actividad antagonista crth2.
KR101411820B1 (ko) 2006-08-07 2014-06-24 액테리온 파마슈티칼 리미티드 (3-아미노-1,2,3,4-테트라하이드로-9h-카르바졸-9-일)-아세트산 유도체
MX2009006762A (es) * 2006-12-21 2009-08-20 Argenta Discovery Ltd Antagonistas crth2.
JP2010522149A (ja) * 2007-03-21 2010-07-01 アージェンタ オーラル セラピューティクス リミテッド Crth2アンタゴニストとしてのインドリジン酢酸誘導体
CA2685202C (en) 2007-03-23 2017-11-28 The Board Of Regents Of The University Of Texas System Methods for treating allergic asthma
ATE544751T1 (de) * 2007-03-29 2012-02-15 Pulmagen Therapeutics Asthma Ltd Chinolinderivate als crth2-rezeptorliganden
UA100983C2 (ru) 2007-07-05 2013-02-25 Астразенека Аб Бифенилоксипропановая кислота как модулятор crth2 и интермедиаты
WO2009061730A2 (en) 2007-11-05 2009-05-14 Array Biopharma Inc. 4-heteroaryl-substituted phenoxyphenylacetic acid
US20110124683A1 (en) * 2007-11-13 2011-05-26 Oxagen Limited Use of CRTH2 Antagonist Compounds
GB0722203D0 (en) * 2007-11-13 2007-12-19 Oxagen Ltd Use of CRTH2 antagonist compounds
GB0722216D0 (en) * 2007-11-13 2007-12-27 Oxagen Ltd Use of crth2 antagonist compounds
DK2229358T3 (da) * 2007-12-14 2011-07-04 Pulmagen Therapeutics Asthma Ltd Indoler og deres terapeutiske anvendelse
DK2250161T3 (da) * 2008-01-18 2014-01-27 Atopix Therapeutics Ltd Forbindelser med CRTH2-antagonistaktivitet
US7750027B2 (en) * 2008-01-18 2010-07-06 Oxagen Limited Compounds having CRTH2 antagonist activity
JP2011509990A (ja) * 2008-01-22 2011-03-31 オキサジェン リミテッド Crth2アンタゴニスト活性を有する化合物
US8168673B2 (en) 2008-01-22 2012-05-01 Oxagen Limited Compounds having CRTH2 antagonist activity
US8168678B2 (en) 2008-02-01 2012-05-01 Panmira Pharmaceuticals, Inc. N,N-disubstituted aminoalkylbiphenyl antagonists of prostaglandin D2 receptors
EP2257536A4 (en) 2008-02-14 2011-03-23 Amira Pharmaceuticals Inc CYCLIC DIARYL ETHERS AS ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS
WO2009108720A2 (en) 2008-02-25 2009-09-03 Amira Pharmaceuticals, Inc. Antagonists of prostaglandin d2 receptors
EP2268611A2 (en) 2008-04-02 2011-01-05 Amira Pharmaceuticals, Inc. Aminoalkylphenyl antagonists of prostaglandin d2 receptors
JP2011526281A (ja) 2008-06-24 2011-10-06 アミラ ファーマシューティカルズ,インク. プロスタグランジンd2受容体のシクロアルカン[b]インドールアンタゴニスト
MX2010014172A (es) 2008-07-03 2011-02-22 Amira Pharmaceuticals Inc Antagonistas de receptores de prostaglandina d2.
GB2463788B (en) 2008-09-29 2010-12-15 Amira Pharmaceuticals Inc Heteroaryl antagonists of prostaglandin D2 receptors
WO2010039977A2 (en) 2008-10-01 2010-04-08 Amira Pharmaceuticals, Inc. Heteroaryl antagonists of prostaglandin d2 receptors
US8524748B2 (en) 2008-10-08 2013-09-03 Panmira Pharmaceuticals, Llc Heteroalkyl biphenyl antagonists of prostaglandin D2 receptors
GB2465062B (en) 2008-11-06 2011-04-13 Amira Pharmaceuticals Inc Cycloalkane(B)azaindole antagonists of prostaglandin D2 receptors
WO2010057118A2 (en) 2008-11-17 2010-05-20 Amira Pharmaceuticals, Inc. Heterocyclic antagonists of prostaglandin d2 receptors
US20120004233A1 (en) * 2009-01-26 2012-01-05 Amira Pharmaceuticals, Inc Tricyclic compounds as antagonists of prostaglandin d2 receptors
EP2393492A1 (en) * 2009-02-09 2011-12-14 Boehringer Ingelheim International GmbH New pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
CA2768492A1 (en) * 2009-07-31 2011-02-03 Panmira Pharmaceuticals, Llc Ophthalmic pharmaceutical compositions of dp2 receptor antagonists
EP2480225A4 (en) * 2009-07-31 2013-05-01 Panmira Pharmaceuticals Llc DERMAL FORMULATIONS FROM DP2 RECEPTOR ANTAGONISTS
CN102596902A (zh) 2009-08-05 2012-07-18 潘米拉制药公司 Dp2拮抗剂及其用途
CA2782085A1 (en) 2010-01-06 2011-07-14 Panmira Pharmaceuticals, Llc Dp2 antagonist and uses thereof
PL2558447T3 (pl) 2010-03-22 2015-03-31 Idorsia Pharmaceuticals Ltd Pochodne 3-(heteroaryloamino)-1,2,3,4-tetrahydro-9h-karbazolu i ich zastosowanie jako modulatorów receptora prostaglandyny D2
US9397745B2 (en) * 2010-05-18 2016-07-19 Qualcomm Incorporated Hybrid satellite and mesh network system for aircraft and ship internet service
EP2627178B1 (en) 2010-10-11 2018-05-02 Merck Sharp & Dohme Corp. Quinazolinone-type compounds as crth2 antagonists
RU2589709C2 (ru) * 2010-12-23 2016-07-10 Мерк Шарп Энд Домэ Корп. Хиноксалины и азахиноксалины в качестве модуляторов рецептора crth2
US9096595B2 (en) 2011-04-14 2015-08-04 Actelion Pharmaceuticals Ltd 7-(heteroaryl-amino)-6,7,8,9-tetrahydropyrido[1,2-a]indol acetic acid derivatives and their use as prostaglandin D2 receptor modulators
CN103086943B (zh) * 2011-11-04 2015-04-15 山东亨利医药科技有限责任公司 作为crth2受体拮抗剂的吲哚类衍生物
GB201121557D0 (en) 2011-12-15 2012-01-25 Oxagen Ltd Process
SG11201402796SA (en) 2011-12-16 2014-06-27 Atopix Therapeutics Ltd Combination of crth2 antagonist and a proton pump inhibitor for the treatment of eosinophilic esophagitis
JP6186933B2 (ja) * 2013-06-21 2017-08-30 富士通株式会社 接合シート及びその製造方法、並びに放熱機構及びその製造方法
GB201322273D0 (en) * 2013-12-17 2014-01-29 Atopix Therapeutics Ltd Process
HUE039614T2 (hu) 2014-03-17 2019-01-28 Idorsia Pharmaceuticals Ltd Azaindol-ecetsav-származékok és prosztaglandin D2 receptor modulátorokként történõ alkalmazásuk
KR20160133536A (ko) 2014-03-18 2016-11-22 액테리온 파마슈티칼 리미티드 아자인돌 아세트산 유도체 및 프로스타글란딘 d2 수용체 조절제로서의 이의 용도
GB201407807D0 (en) 2014-05-02 2014-06-18 Atopix Therapeutics Ltd Polymorphic form
GB201407820D0 (en) 2014-05-02 2014-06-18 Atopix Therapeutics Ltd Polymorphic form
TWI695831B (zh) * 2014-09-13 2020-06-11 香港商南北兄弟藥業投資有限公司 Crth2拮抗劑化合物及其用途
WO2016128565A1 (en) 2015-02-13 2016-08-18 Institut National De La Sante Et De La Recherche Medicale (Inserm) Ptgdr-1 and/or ptgdr-2 antagonists for preventing and/or treating systemic lupus erythematosus
HK1256553A1 (zh) 2015-07-30 2019-09-27 The Trustees Of The University Of Pennsylvania 用於检测pgd2对毛发生长抑制的易感性的人dp-2基因的单核苷酸多态性等位基因
MX379014B (es) 2015-09-15 2025-03-10 Idorsia Pharmaceuticals Ltd Formas cristalinas.
WO2018014867A1 (zh) 2016-07-21 2018-01-25 正大天晴药业集团股份有限公司 作为crth2抑制剂的三并环类化合物
CN108101829B (zh) * 2017-11-19 2020-05-12 华南理工大学 一种吲哚化合物、其制备方法及应用
JP7296970B2 (ja) 2018-01-19 2023-06-23 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド インドール誘導体の結晶形とその調製方法および使用
EP3902795A1 (en) 2018-12-27 2021-11-03 Chiesi Farmaceutici S.p.A. Pharmaceutical composition comprising spherical agglomerates of timapiprant
CA3230066A1 (en) * 2021-09-03 2023-03-09 Xiaoqiang Xu Indole compound, and preparation method therefor and use thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3577142A (en) * 1969-02-28 1971-05-04 Westinghouse Learning Corp Code translation system
SU1277894A3 (ru) * 1979-03-07 1986-12-15 Пфайзер Корпорейшн (Фирма) Способ получени 3-/1-имидазолилалкил/индолов или их фармацевтически приемлемых кислотно-аддитивных солей
EA000987B1 (ru) * 1995-06-21 2000-08-28 Сионоги Энд Ко., Лтд. Бициклические аминопроизводные и содержащие их антагонисты pgd2
US20020022218A1 (en) * 2000-07-07 2002-02-21 Baiyong Li Methods for the identification of compounds useful for the treatment of disease states medicated by prostaglandin D2

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4324418Y1 (OSRAM) 1965-04-06 1968-10-15
US3489767A (en) 1966-01-12 1970-01-13 Sumitomo Chemical Co 1-(phenylsulfonyl)-3-indolyl aliphatic acid derivatives
US3557142A (en) * 1968-02-20 1971-01-19 Sterling Drug Inc 4,5,6,7-tetrahydro-indole-lower-alkanoic acids and esters
BE790679A (fr) 1971-11-03 1973-04-27 Ici Ltd Derives de l'indole
GB1407658A (en) 1973-03-06 1975-09-24 Ici Ltd Process for the manufacture of indole derivatives
GB1460348A (en) 1974-02-04 1977-01-06 Ici Ltd Quinazoline derivativesa
US4363912A (en) 1980-12-15 1982-12-14 Pfizer Inc. Indole thromboxane synthetase inhibitors
US4966911A (en) * 1984-11-20 1990-10-30 Washington Research Foundation Immunoregulatory agents
GB8607294D0 (en) 1985-04-17 1986-04-30 Ici America Inc Heterocyclic amide derivatives
WO1993012786A1 (en) 1986-07-10 1993-07-08 Howard Harry R Jr Indolinone derivatives
US5236945A (en) 1990-06-11 1993-08-17 Pfizer Inc. 1H-indazole-3-acetic acids as aldose reductase inhibitors
GB9122590D0 (en) * 1991-10-24 1991-12-04 Lilly Industries Ltd Pharmaceutical compounds
US5612360A (en) * 1992-06-03 1997-03-18 Eli Lilly And Company Angiotensin II antagonists
GB9317764D0 (en) 1993-08-26 1993-10-13 Pfizer Ltd Therapeutic compound
JP3228381B2 (ja) * 1993-10-29 2001-11-12 ソニー株式会社 Avセレクタ
US5641800A (en) 1994-07-21 1997-06-24 Eli Lilly And Company 1H-indole-1-functional sPLA2 inhibitors
IL117208A0 (en) 1995-02-23 1996-06-18 Nissan Chemical Ind Ltd Indole type thiazolidines
WO1997046677A1 (fr) 1996-06-05 1997-12-11 Bml, Inc. PROTEINE SPECIFIQUE DU Th2 HUMAIN, GENE (B19) CODANT POUR CETTE PROTEINE, TRANSFORMANT, VECTEUR DE RECOMBINAISON ET ANTICORPS MONOCLONAL S'Y RAPPORTANT
US6916841B2 (en) 1998-02-25 2005-07-12 Genetics Institute, Llc Inhibitors of phospholipase enzymes
SK12742000A3 (sk) 1998-02-25 2001-05-10 Genetics Institute, Inc. Inhibítory fosfolipázových enzýmov, farmaceutický prostriedok s ich obsahom a ich použitie
IL138711A0 (en) * 1998-03-31 2001-10-31 Inst Pharmaceutical Discovery Substituted indolealkanoic acids
GB9825524D0 (en) * 1998-11-20 1999-01-13 Oxford Biomedica Ltd Vector
TNSN99224A1 (fr) * 1998-12-01 2005-11-10 Inst For Pharm Discovery Inc Methodes de reduction des niveaux de glucose et triglyceride en serum et pour suppression de l'antigenese utilisant les acides la indolealkanoique
US6884593B1 (en) 1999-08-23 2005-04-26 Bml, Inc. Method of identifying properties of substance with respect to human prostaglandin D2 receptors
AU2001232785A1 (en) * 2000-01-14 2001-07-24 The Institutes For Pharmaceutical Discovery, Llc Methods for lowering uric acid levels
WO2001051849A1 (en) 2000-01-14 2001-07-19 Koninklijke Philips Electronics N.V. Display device
US6521659B2 (en) * 2000-03-02 2003-02-18 Institute For Pharmaceutical Discovery, Llc Compositions containing a substituted indolealkanoic acid and an angiotensin converting enzyme inhibitor
JP2001247570A (ja) 2000-03-08 2001-09-11 Japan Tobacco Inc インドール酢酸化合物及びその製造方法
SE0200356D0 (sv) 2002-02-05 2002-02-05 Astrazeneca Ab Novel use
SE0200411D0 (sv) 2002-02-05 2002-02-05 Astrazeneca Ab Novel use
AU2003231509A1 (en) * 2002-05-16 2003-12-02 Shionogi And Co., Ltd. Compound exhibiting pgd 2 receptor antagonism
JPWO2003097042A1 (ja) 2002-05-16 2005-09-15 塩野義製薬株式会社 Pgd2受容体拮抗剤
SE0201635D0 (sv) 2002-05-30 2002-05-30 Astrazeneca Ab Novel compounds
TW200307542A (en) 2002-05-30 2003-12-16 Astrazeneca Ab Novel compounds
US7364647B2 (en) 2002-07-17 2008-04-29 Eksigent Technologies Llc Laminated flow device
JP2006514640A (ja) 2002-12-10 2006-05-11 ワイス プラスミノゲンアクティベータインヒビターのインヒビターとしての置換3−アルキル及び3−アリールアルキル1h−イル酢酸誘導体
ES2401079T3 (es) 2002-12-20 2013-04-16 Amgen Inc. Moduladores del asma y de la inflamación alérgica
JP4324418B2 (ja) 2003-08-05 2009-09-02 株式会社日立国際電気 基板処理装置および半導体デバイスの製造方法
BRPI0415437A (pt) 2003-10-14 2006-12-05 Oxagen Ltd composto, processo para a preparação e uso do mesmo, composição farmacêutica, processo para a preparação da mesma, e, produto
GB0324763D0 (en) * 2003-10-23 2003-11-26 Oxagen Ltd Use of compounds in therapy
GB0504150D0 (en) * 2005-03-01 2005-04-06 Oxagen Ltd Microcrystalline material
GB0505048D0 (en) * 2005-03-11 2005-04-20 Oxagen Ltd Compounds with PGD antagonist activity
WO2006110051A1 (en) * 2005-04-12 2006-10-19 Auckland Uniservices Ltd Pressure assisted thermal sterilisation or pasteurisation method and apparatus
PL65781Y1 (pl) 2005-08-16 2012-02-29 Katarzyna Kawczyńska Wkładka kosmetyczna
GB0605743D0 (en) * 2006-03-22 2006-05-03 Oxagen Ltd Salts with CRTH2 antagonist activity
MX2009000801A (es) * 2006-07-22 2009-02-03 Oxagen Ltd Compuestos que tienen actividad antagonista crth2.
US20110124683A1 (en) 2007-11-13 2011-05-26 Oxagen Limited Use of CRTH2 Antagonist Compounds
DK2250161T3 (da) 2008-01-18 2014-01-27 Atopix Therapeutics Ltd Forbindelser med CRTH2-antagonistaktivitet
US7750027B2 (en) * 2008-01-18 2010-07-06 Oxagen Limited Compounds having CRTH2 antagonist activity
US8168673B2 (en) * 2008-01-22 2012-05-01 Oxagen Limited Compounds having CRTH2 antagonist activity
JP2011509990A (ja) * 2008-01-22 2011-03-31 オキサジェン リミテッド Crth2アンタゴニスト活性を有する化合物

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3577142A (en) * 1969-02-28 1971-05-04 Westinghouse Learning Corp Code translation system
SU1277894A3 (ru) * 1979-03-07 1986-12-15 Пфайзер Корпорейшн (Фирма) Способ получени 3-/1-имидазолилалкил/индолов или их фармацевтически приемлемых кислотно-аддитивных солей
EA000987B1 (ru) * 1995-06-21 2000-08-28 Сионоги Энд Ко., Лтд. Бициклические аминопроизводные и содержащие их антагонисты pgd2
US20020022218A1 (en) * 2000-07-07 2002-02-21 Baiyong Li Methods for the identification of compounds useful for the treatment of disease states medicated by prostaglandin D2

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J. of Medicinal Chemistry American Chemical Society, v.6, №33, 1990, p.1781-1790. *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2616000C2 (ru) * 2011-03-07 2017-04-12 Атопикс Терапьютикс Лимитед Аморфная (5-фтор-2-метил-3-хинолин-2-илметилиндол-1-ил)-уксусная кислота
US11091806B2 (en) 2015-07-23 2021-08-17 Merck Sharp & Dohme Corp. Genetic markers associated with response to CRTH2 receptor antagonists
RU2756270C2 (ru) * 2016-07-21 2021-09-29 Чиа Тай Тянцин Фармасьютикал Груп Ко., Лтд. Производное индола, используемое в качестве ингибитора CRTH2

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